3tgx

IL-21:IL21R complex

Method: X-RAY DIFFRACTION
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

Interleukin-21 receptor

Homo sapiens

UniProt Q9HBE5

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 其他组合 异源复合物 蛋白 2 其他聚合物 1 Interleukin-21 × 1 (Q9HBE4) ;alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 alpha-D-mannopyranose × 1 NICKEL (II) ION × 1 SULFATE ION × 4 与蛋白数一致
2 其他组合 异源复合物 蛋白 2 其他聚合物 1 Interleukin-21 × 1 (Q9HBE4) ;alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 alpha-D-mannopyranose × 1 SULFATE ION × 6 与蛋白数一致
3 其他组合 异源复合物 蛋白 2 其他聚合物 1 Interleukin-21 × 1 (Q9HBE4) ;alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 alpha-D-mannopyranose × 1 NICKEL (II) ION × 1 SULFATE ION × 4 与蛋白数一致
4 其他组合 异源复合物 蛋白 2 其他聚合物 1 Interleukin-21 × 1 (Q9HBE4) ;alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 alpha-D-mannopyranose × 1 NICKEL (II) ION × 1 SULFATE ION × 6 与蛋白数一致
5 其他组合 异源复合物 蛋白 2 其他聚合物 1 Interleukin-21 × 1 (Q9HBE4) ;alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 alpha-D-mannopyranose × 1 SULFATE ION × 4 与蛋白数一致
6 其他组合 异源复合物 蛋白 2 其他聚合物 1 Interleukin-21 × 1 (Q9HBE4) ;alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 alpha-D-mannopyranose × 1 SULFATE ION × 6 与蛋白数一致
7 其他组合 异源复合物 蛋白 2 其他聚合物 1 Interleukin-21 × 1 (Q9HBE4) ;alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 alpha-D-mannopyranose × 1 SULFATE ION × 4 与蛋白数一致
8 其他组合 异源复合物 蛋白 2 其他聚合物 1 Interleukin-21 × 1 (Q9HBE4) ;alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 alpha-D-mannopyranose × 1 NICKEL (II) ION × 1 SULFATE ION × 5 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 IL21R_HUMAN
Isoform —
PDB实体 1
链与序列区间 作者链 A; PDB构建体 1–213; UniProt 20–232 作者链 C; PDB构建体 1–213; UniProt 20–232 作者链 E; PDB构建体 1–213; UniProt 20–232 作者链 G; PDB构建体 1–213; UniProt 20–232 作者链 I; PDB构建体 1–213; UniProt 20–232 作者链 K; PDB构建体 1–213; UniProt 20–232 作者链 M; PDB构建体 1–213; UniProt 20–232 作者链 O; PDB构建体 1–213; UniProt 20–232

Interleukin-21

Homo sapiens

UniProt Q9HBE4

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 其他组合 异源复合物 蛋白 2 其他聚合物 1 Interleukin-21 receptor × 1 (Q9HBE5) ;alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 alpha-D-mannopyranose × 1 NICKEL (II) ION × 1 SULFATE ION × 4 与蛋白数一致
2 其他组合 异源复合物 蛋白 2 其他聚合物 1 Interleukin-21 receptor × 1 (Q9HBE5) ;alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 alpha-D-mannopyranose × 1 SULFATE ION × 6 与蛋白数一致
3 其他组合 异源复合物 蛋白 2 其他聚合物 1 Interleukin-21 receptor × 1 (Q9HBE5) ;alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 alpha-D-mannopyranose × 1 NICKEL (II) ION × 1 SULFATE ION × 4 与蛋白数一致
4 其他组合 异源复合物 蛋白 2 其他聚合物 1 Interleukin-21 receptor × 1 (Q9HBE5) ;alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 alpha-D-mannopyranose × 1 NICKEL (II) ION × 1 SULFATE ION × 6 与蛋白数一致
5 其他组合 异源复合物 蛋白 2 其他聚合物 1 Interleukin-21 receptor × 1 (Q9HBE5) ;alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 alpha-D-mannopyranose × 1 SULFATE ION × 4 与蛋白数一致
6 其他组合 异源复合物 蛋白 2 其他聚合物 1 Interleukin-21 receptor × 1 (Q9HBE5) ;alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 alpha-D-mannopyranose × 1 SULFATE ION × 6 与蛋白数一致
7 其他组合 异源复合物 蛋白 2 其他聚合物 1 Interleukin-21 receptor × 1 (Q9HBE5) ;alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 alpha-D-mannopyranose × 1 SULFATE ION × 4 与蛋白数一致
8 其他组合 异源复合物 蛋白 2 其他聚合物 1 Interleukin-21 receptor × 1 (Q9HBE5) ;alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose ; × 1 alpha-D-mannopyranose × 1 NICKEL (II) ION × 1 SULFATE ION × 5 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 IL21_HUMAN
Isoform —
PDB实体 2
链与序列区间 作者链 B; PDB构建体 2–134; UniProt 23–155 作者链 D; PDB构建体 2–134; UniProt 23–155 作者链 F; PDB构建体 2–134; UniProt 23–155 作者链 H; PDB构建体 2–134; UniProt 23–155 作者链 J; PDB构建体 2–134; UniProt 23–155 作者链 L; PDB构建体 2–134; UniProt 23–155 作者链 N; PDB构建体 2–134; UniProt 23–155 作者链 P; PDB构建体 2–134; UniProt 23–155

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id3tgx
沉积日期 deposition_date2011-08-18
结构标题 titleIL-21:IL21R complex
关键词 keywordsClass I cytokine, Class I cytokine Receptor, sugarbridge, Fibronectin domain, Signaling, CYTOKINE-CYTOKINE RECEPTOR complex; CYTOKINE/CYTOKINE RECEPTOR
实验方法 methodX-RAY DIFFRACTION
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

3tgx__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

3tgx__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

3tgx__assembly_1__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)24.63 Å
Rg(电子密度)23.70 Å
总 Rg24.47 Å
原子数2745
残基数323
排除体积48513 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 3tgx__assembly_1__model_1 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
2 1 3tgx__assembly_2__model_1 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
3 1 3tgx__assembly_3__model_1 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
4 1 3tgx__assembly_4__model_1 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
5 1 3tgx__assembly_5__model_1 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
6 1 3tgx__assembly_6__model_1 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
7 1 3tgx__assembly_7__model_1 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
8 1 3tgx__assembly_8__model_1 dimeric (2) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (8)

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6. 折叠分类 (SCOP + CATH) 32 domains

SCOP 2.08 (8 domains)

结构域编号 domain_idd3tgxb_
类 Class classa — All alpha proteins
折叠类型 Fold folda.26 — 4-helical cytokines
超家族 Superfamily superfamilya.26.1 — 4-helical cytokines
家族 Family familya.26.1.2 — Short-chain cytokines
结构域编号 domain_idd3tgxd_
类 Class classa — All alpha proteins
折叠类型 Fold folda.26 — 4-helical cytokines
超家族 Superfamily superfamilya.26.1 — 4-helical cytokines
家族 Family familya.26.1.2 — Short-chain cytokines
结构域编号 domain_idd3tgxf_
类 Class classa — All alpha proteins
折叠类型 Fold folda.26 — 4-helical cytokines
超家族 Superfamily superfamilya.26.1 — 4-helical cytokines
家族 Family familya.26.1.2 — Short-chain cytokines
结构域编号 domain_idd3tgxh_
类 Class classa — All alpha proteins
折叠类型 Fold folda.26 — 4-helical cytokines
超家族 Superfamily superfamilya.26.1 — 4-helical cytokines
家族 Family familya.26.1.2 — Short-chain cytokines
结构域编号 domain_idd3tgxj_
类 Class classa — All alpha proteins
折叠类型 Fold folda.26 — 4-helical cytokines
超家族 Superfamily superfamilya.26.1 — 4-helical cytokines
家族 Family familya.26.1.2 — Short-chain cytokines
结构域编号 domain_idd3tgxl_
类 Class classa — All alpha proteins
折叠类型 Fold folda.26 — 4-helical cytokines
超家族 Superfamily superfamilya.26.1 — 4-helical cytokines
家族 Family familya.26.1.2 — Short-chain cytokines
结构域编号 domain_idd3tgxn_
类 Class classa — All alpha proteins
折叠类型 Fold folda.26 — 4-helical cytokines
超家族 Superfamily superfamilya.26.1 — 4-helical cytokines
家族 Family familya.26.1.2 — Short-chain cytokines
结构域编号 domain_idd3tgxp_
类 Class classa — All alpha proteins
折叠类型 Fold folda.26 — 4-helical cytokines
超家族 Superfamily superfamilya.26.1 — 4-helical cytokines
家族 Family familya.26.1.2 — Short-chain cytokines

CATH v4.4 (24 domains)

结构域编号 domain_id3tgxA01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3tgxA02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3tgxB00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology1250 — Growth Hormone; Chain: A;
同源超家族 H-superfamily homologous superfamily70 — Interleukin-15/Interleukin-21
结构域编号 domain_id3tgxC01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3tgxC02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3tgxD00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology1250 — Growth Hormone; Chain: A;
同源超家族 H-superfamily homologous superfamily70 — Interleukin-15/Interleukin-21
结构域编号 domain_id3tgxE01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3tgxE02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3tgxF00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology1250 — Growth Hormone; Chain: A;
同源超家族 H-superfamily homologous superfamily70 — Interleukin-15/Interleukin-21
结构域编号 domain_id3tgxG01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3tgxG02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3tgxH00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology1250 — Growth Hormone; Chain: A;
同源超家族 H-superfamily homologous superfamily70 — Interleukin-15/Interleukin-21
结构域编号 domain_id3tgxI01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3tgxI02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3tgxJ00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology1250 — Growth Hormone; Chain: A;
同源超家族 H-superfamily homologous superfamily70 — Interleukin-15/Interleukin-21
结构域编号 domain_id3tgxK01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3tgxK02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3tgxL00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology1250 — Growth Hormone; Chain: A;
同源超家族 H-superfamily homologous superfamily70 — Interleukin-15/Interleukin-21
结构域编号 domain_id3tgxM01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3tgxM02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3tgxN00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology1250 — Growth Hormone; Chain: A;
同源超家族 H-superfamily homologous superfamily70 — Interleukin-15/Interleukin-21
结构域编号 domain_id3tgxO01
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3tgxO02
类 Class class2 — Mainly Beta
架构 Architecture architecture60 — Sandwich
拓扑 Topology topology40 — Immunoglobulin-like
同源超家族 H-superfamily homologous superfamily10 — Immunoglobulins
结构域编号 domain_id3tgxP00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology1250 — Growth Hormone; Chain: A;
同源超家族 H-superfamily homologous superfamily70 — Interleukin-15/Interleukin-21
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7. 引用文献 (1)