Glr4197 protein
Gloeobacter violaceus
State in the Current Structure
| Assembly | Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Associated Components | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|
| 1 | Protein homooligomer Homooligomer Protein × 5 PDB declaration: pentameric（5） Consistent with protein copy count | Chain A； UniProt 44–359 Chain B； UniProt 44–359 Chain C； UniProt 44–359 Chain D； UniProt 44–359 Chain E； UniProt 44–359 | Fragment：UNP residues 44-359 Mutation：C27S,K33C,N245C | PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 15 LMT DODECYL-BETA-D-MALTOSIDE × 6 NA SODIUM ION × 1 CL CHLORIDE ION × 5 | X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；pH 4；293 K；15% PEG4000, 0.4 M sodium thiocyanate, 0.1 M sodium acetate, pH 4.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K | Resolution 2.90 Å R-free 0.221 |
| 2 | Protein homooligomer Homooligomer Protein × 5 PDB declaration: pentameric（5） Consistent with protein copy count | Chain F； UniProt 44–359 Chain G； UniProt 44–359 Chain H； UniProt 44–359 Chain I； UniProt 44–359 Chain J； UniProt 44–359 | Fragment：UNP residues 44-359 Mutation：C27S,K33C,N245C | PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 15 LMT DODECYL-BETA-D-MALTOSIDE × 6 NA SODIUM ION × 1 CL CHLORIDE ION × 5 | X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；pH 4；293 K；15% PEG4000, 0.4 M sodium thiocyanate, 0.1 M sodium acetate, pH 4.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K | Resolution 2.90 Å R-free 0.221 |
Other States of the Same Protein in the Database
Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.
| Other PDB | Difference from Current Entry 3UUB | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 2XQ3 Pentameric ligand gated ion channel GLIC in complex with Br-lidocaine Deposited 2010-09-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain B
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain C
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain D
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain E
43–359（317 aa）
Fragment：RESIDUES 43-359
|
Not recorded | BR BROMIDE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；277 K；9% PEG 4000, 50 MM CH3COONA, 200 MM (NH4)2SO4, PH 4.0, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 277K.
|
Resolution 3.50 Å R-free 0.257 |
| 2XQ4 Pentameric ligand gated ion channel GLIC in complex with tetramethylarsonium (TMAs) Deposited 2010-09-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain B
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain C
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain D
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain E
43–359（317 aa）
Fragment：RESIDUES 43-359
|
Not recorded | ARS ARSENIC × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；277 K；9% PEG 4000, 50 MM CH3COONA, 200 MM (NH4)2SO4, PH 4.0, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 277K.
|
Resolution 3.60 Å R-free 0.272 |
| 2XQ5 Pentameric ligand gated ion channel GLIC in complex with tetraethylarsonium (TEAs) Deposited 2010-09-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain B
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain C
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain D
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain E
43–359（317 aa）
Fragment：RESIDUES 43-359
|
Not recorded | ARS ARSENIC × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；277 K；9% PEG 4000, 50 MM CH3COONA, 200 MM (NH4)2SO4, PH 4.0, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 277K.
|
Resolution 3.50 Å R-free 0.266 |
| 2XQ6 Pentameric ligand gated ion channel GLIC in complex with cesium ion (Cs+) Deposited 2010-09-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain B
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain C
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain D
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain E
43–359（317 aa）
Fragment：RESIDUES 43-359
|
Not recorded | CS CESIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；277 K；9% PEG4000, 50MM CH3COONA, 225MM (NH4)2SO4, PH4.0, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 277.15K, VAPOR DIFFUSION, HANGING DROP
|
Resolution 3.70 Å R-free 0.258 |
| 2XQ7 Pentameric ligand gated ion channel GLIC in complex with cadmium ion (Cd2+) Deposited 2010-09-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain B
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain C
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain D
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain E
43–359（317 aa）
Fragment：RESIDUES 43-359
|
Not recorded | CD CADMIUM ION × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；277.15 K；9% PEG 4000, 50MM CH3COONA, 200MM (NH4)2SO4, PH 4.0, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 277.15K, VAPOR DIFFUSION, HANGING DROP.
|
Resolution 3.40 Å R-free 0.266 |
| 2XQ8 Pentameric ligand gated ion channel GLIC in complex with zinc ion (Zn2+) Deposited 2010-09-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain B
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain C
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain D
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain E
43–359（317 aa）
Fragment：RESIDUES 43-359
|
Not recorded | ZN ZINC ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；277 K；9% PEG4000, 50MM CH3COONA, 200MM (NH4)2SO4, PH4.0, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 277.15K, VAPOR DIFFUSION, HANGING DROP
|
Resolution 3.60 Å R-free 0.248 |
| 2XQ9 Pentameric ligand gated ion channel GLIC mutant E221A in complex with tetraethylarsonium (TEAs) Deposited 2010-09-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain B
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain C
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain D
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain E
43–359（317 aa）
Fragment：RESIDUES 43-359
|
Mutation：YES Mutation：YES Mutation：YES Mutation：YES Mutation：YES | ARS ARSENIC × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；277 K；9% PEG 4000, 50MM CH3COONA, 200MM (NH4)2SO4, PH 4.0, VAPOR DIFFUSION, TEMPERATURE 277.15K, VAPOR DIFFUSION, HANGING DROP.
|
Resolution 3.20 Å R-free 0.257 |
| 2XQA Pentameric ligand gated ion channel GLIC in complex with tetrabutylantimony (TBSb) Deposited 2010-09-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain B
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain C
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain D
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain E
43–359（317 aa）
Fragment：RESIDUES 43-359
|
Not recorded | SB ANTIMONY (III) ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；277.15 K；9% PEG4000, 50MM CH3COONA, 200MM (NH4)2SO4, PH4.0, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 277.15K, VAPOR DIFFUSION, HANGING DROP
|
Resolution 3.70 Å R-free 0.274 |
| 3EAM An open-pore structure of a bacterial pentameric ligand-gated ion channel Deposited 2008-08-26 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Fragment：UNP residues 43-359
Chain B
43–359（317 aa）
Fragment：UNP residues 43-359
Chain C
43–359（317 aa）
Fragment：UNP residues 43-359
Chain D
43–359（317 aa）
Fragment：UNP residues 43-359
Chain E
43–359（317 aa）
Fragment：UNP residues 43-359
|
Not recorded | LMT DODECYL-BETA-D-MALTOSIDE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；298 K；PEG 4000, NH4SCN, NaAc, pH 4.6, vapor diffusion, hanging drop, temperature 298K
|
Resolution 2.90 Å R-free 0.231 |
| 3EHZ X-ray structure of the pentameric ligand gated ion channel of Gloebacter violaceus (GLIC) in a presumptive open conformation Deposited 2008-09-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
50–359（310 aa）
Fragment：UNP residues 50-359
Chain B
50–359（310 aa）
Fragment：UNP residues 50-359
Chain C
50–359（310 aa）
Fragment：UNP residues 50-359
Chain D
50–359（310 aa）
Fragment：UNP residues 50-359
Chain E
50–359（310 aa）
Fragment：UNP residues 50-359
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；277.15 K；9% PEG4000, 50mM CH3COONa, 200mM (NH4)2SO4, pH4.0, vapor diffusion, hanging drop, temperature 277.15K, VAPOR DIFFUSION, HANGING DROP
|
Resolution 3.10 Å R-free 0.266 |
| 3EI0 Structure of the E221A mutant of the Gloebacter violaceus pentameric ligand gated ion channnel (GLIC) Deposited 2008-09-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
50–359（310 aa）
Fragment：UNP residues 50-359
Chain B
50–359（310 aa）
Fragment：UNP residues 50-359
Chain C
50–359（310 aa）
Fragment：UNP residues 50-359
Chain D
50–359（310 aa）
Fragment：UNP residues 50-359
Chain E
50–359（310 aa）
Fragment：UNP residues 50-359
|
Mutation：E221A Mutation：E221A Mutation：E221A Mutation：E221A Mutation：E221A | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；277.15 K；9% PEG4000, 50mM CH3COONa, 500mM (NH4)2SO4, pH4.0, vapor diffusion, hanging drop, temperature 277.15K, VAPOR DIFFUSION, HANGING DROP
|
Resolution 3.50 Å R-free 0.276 |
| 3IGQ Crystal structure of the extracellular domain of a bacterial pentameric ligand-gated ion channel Deposited 2009-07-28 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
44–235（192 aa）
Fragment：extracellular N-terminal fragment, UNP residues 44-235
Chain B
44–235（192 aa）
Fragment：extracellular N-terminal fragment, UNP residues 44-235
Chain C
44–235（192 aa）
Fragment：extracellular N-terminal fragment, UNP residues 44-235
|
Mutation：F116G, Y119T, P120E, F121S Mutation：F116G, Y119T, P120E, F121S Mutation：F116G, Y119T, P120E, F121S | ACY ACETIC ACID × 6 NA SODIUM ION × 6 HG MERCURY (II) ION × 6 CL CHLORIDE ION × 6 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.30 Å R-free 0.255 |
| 3IGQ Crystal structure of the extracellular domain of a bacterial pentameric ligand-gated ion channel Deposited 2009-07-28 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain D
44–235（192 aa）
Fragment：extracellular N-terminal fragment, UNP residues 44-235
Chain E
44–235（192 aa）
Fragment：extracellular N-terminal fragment, UNP residues 44-235
Chain F
44–235（192 aa）
Fragment：extracellular N-terminal fragment, UNP residues 44-235
|
Mutation：F116G, Y119T, P120E, F121S Mutation：F116G, Y119T, P120E, F121S Mutation：F116G, Y119T, P120E, F121S | ACY ACETIC ACID × 6 NA SODIUM ION × 6 HG MERCURY (II) ION × 6 CL CHLORIDE ION × 6 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.30 Å R-free 0.255 |
| 3LSV Structure of the A237F mutant of the pentameric ligand gated ion channel from Gloeobacter Violaceus Deposited 2010-02-13 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Chain B
44–359（316 aa）
Chain C
44–359（316 aa）
Chain D
44–359（316 aa）
Chain E
44–359（316 aa）
|
Mutation：A279F Mutation：A279F Mutation：A279F Mutation：A279F Mutation：A279F | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；293 K；PEG 4000 ~25%, NaSCN ~400 mM, NaAc ph 4 100 mM, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 3.15 Å R-free 0.224 |
| 3P4W Structure of desflurane bound to a pentameric ligand-gated ion channel, GLIC Deposited 2010-10-07 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Fragment：residues in UNP 44-359
Chain B
44–359（316 aa）
Fragment：residues in UNP 44-359
Chain C
44–359（316 aa）
Fragment：residues in UNP 44-359
Chain D
44–359（316 aa）
Fragment：residues in UNP 44-359
Chain E
44–359（316 aa）
Fragment：residues in UNP 44-359
|
Not recorded | LMT DODECYL-BETA-D-MALTOSIDE × 6 DSF (2S)-2-(difluoromethoxy)-1,1,1,2-tetrafluoroethane × 5 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；293 K；pH 4, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 3.20 Å R-free 0.206 |
| 3P50 Structure of propofol bound to a pentameric ligand-gated ion channel, GLIC Deposited 2010-10-07 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Fragment：residues in UNP 44-359
Chain B
44–359（316 aa）
Fragment：residues in UNP 44-359
Chain C
44–359（316 aa）
Fragment：residues in UNP 44-359
Chain D
44–359（316 aa）
Fragment：residues in UNP 44-359
Chain E
44–359（316 aa）
Fragment：residues in UNP 44-359
|
Not recorded | LMT DODECYL-BETA-D-MALTOSIDE × 6 PFL 2,6-BIS(1-METHYLETHYL)PHENOL × 5 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；293 K；pH 4.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 3.30 Å R-free 0.203 |
| 3TLS The GLIC pentameric Ligand-Gated Ion Channel E19'P mutant in a locally-closed conformation (LC2 subtype) Deposited 2011-08-30 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Fragment：UNP residues 44-359
Chain B
44–359（316 aa）
Fragment：UNP residues 44-359
Chain C
44–359（316 aa）
Fragment：UNP residues 44-359
Chain D
44–359（316 aa）
Fragment：UNP residues 44-359
Chain E
44–359（316 aa）
Fragment：UNP residues 44-359
|
Mutation：E285P Mutation：E285P Mutation：E285P Mutation：E285P Mutation：E285P | CL CHLORIDE ION × 5 LMT DODECYL-BETA-D-MALTOSIDE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 4；293 K；pH 4, VAPOR DIFFUSION, temperature 293K
|
Resolution 3.20 Å R-free 0.230 |
| 3TLT The GLIC pentameric Ligand-Gated Ion Channel H11'F mutant in a locally-closed conformation (LC1 subtype) Deposited 2011-08-30 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Fragment：UNP residues 44-359
Chain B
44–359（316 aa）
Fragment：UNP residues 44-359
Chain C
44–359（316 aa）
Fragment：UNP residues 44-359
Chain D
44–359（316 aa）
Fragment：UNP residues 44-359
Chain E
44–359（316 aa）
Fragment：UNP residues 44-359
|
Mutation：H277F Mutation：H277F Mutation：H277F Mutation：H277F Mutation：H277F | CL CHLORIDE ION × 5 LMT DODECYL-BETA-D-MALTOSIDE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 4；293 K；pH 4, VAPOR DIFFUSION, temperature 293K
|
Resolution 3.30 Å R-free 0.243 |
| 3TLU The GLIC pentameric Ligand-Gated Ion Channel Loop2-24' oxidized mutant in a locally-closed conformation (LC1 subtype) Deposited 2011-08-30 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Fragment：UNP residues 44-359
Chain B
44–359（316 aa）
Fragment：UNP residues 44-359
Chain C
44–359（316 aa）
Fragment：UNP residues 44-359
Chain D
44–359（316 aa）
Fragment：UNP residues 44-359
Chain E
44–359（316 aa）
Fragment：UNP residues 44-359
|
Mutation：C69S/K75C/K290C Mutation：C69S/K75C/K290C Mutation：C69S/K75C/K290C Mutation：C69S/K75C/K290C Mutation：C69S/K75C/K290C | CL CHLORIDE ION × 5 LMT DODECYL-BETA-D-MALTOSIDE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 4；293 K；pH 4, VAPOR DIFFUSION, temperature 293K
|
Resolution 2.85 Å R-free 0.223 |
| 3TLV The GLIC pentameric Ligand-Gated Ion Channel Loop2-22' oxidized mutant in a locally-closed conformation (LC3 subtype) Deposited 2011-08-30 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Fragment：UNP residues 44-359
Chain B
44–359（316 aa）
Fragment：UNP residues 44-359
Chain C
44–359（316 aa）
Fragment：UNP residues 44-359
Chain D
44–359（316 aa）
Fragment：UNP residues 44-359
Chain E
44–359（316 aa）
Fragment：UNP residues 44-359
|
Mutation：C69S/K75C/L288C Mutation：C69S/K75C/L288C Mutation：C69S/K75C/L288C Mutation：C69S/K75C/L288C Mutation：C69S/K75C/L288C | LMT DODECYL-BETA-D-MALTOSIDE × 1 CL CHLORIDE ION × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 4；293 K；pH 4, VAPOR DIFFUSION, temperature 293K
|
Resolution 2.90 Å R-free 0.229 |
| 3TLW The GLIC pentameric Ligand-Gated Ion Channel Loop2-21' oxidized mutant in a locally-closed conformation (LC2 subtype) Deposited 2011-08-30 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Fragment：UNP residues 44-359
Chain B
44–359（316 aa）
Fragment：UNP residues 44-359
Chain C
44–359（316 aa）
Fragment：UNP residues 44-359
Chain D
44–359（316 aa）
Fragment：UNP residues 44-359
Chain E
44–359（316 aa）
Fragment：UNP residues 44-359
|
Mutation：C69S/K75C/N287C Mutation：C69S/K75C/N287C Mutation：C69S/K75C/N287C Mutation：C69S/K75C/N287C Mutation：C69S/K75C/N287C | CL CHLORIDE ION × 5 LMT DODECYL-BETA-D-MALTOSIDE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 4；293 K；pH 4, VAPOR DIFFUSION, temperature 293K
|
Resolution 2.60 Å R-free 0.225 |
| 3UU3 The GLIC pentameric Ligand-Gated Ion Channel Loop2-20' oxidized mutant in a locally-closed conformation (LC1 subtype) Deposited 2011-11-28 | Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Fragment：UNP residues 44-359
Chain B
44–359（316 aa）
Fragment：UNP residues 44-359
Chain C
44–359（316 aa）
Fragment：UNP residues 44-359
Chain D
44–359（316 aa）
Fragment：UNP residues 44-359
Chain E
44–359（316 aa）
Fragment：UNP residues 44-359
|
Mutation：C27S,K33C,T244C Mutation：C27S,K33C,T244C Mutation：C27S,K33C,T244C Mutation：C27S,K33C,T244C Mutation：C27S,K33C,T244C | LMT DODECYL-BETA-D-MALTOSIDE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；293 K；15% PEG4000, 0.4 M sodium thiocyanate, 0.1 M sodium acetate, pH 4.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 3.15 Å R-free 0.272 |
| 3UU4 The GLIC pentameric Ligand-Gated Ion Channel Loop2-21' mutant reduced in the crystal in a locally-closed conformation (LC1 subtype) Deposited 2011-11-28 | Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Fragment：UNP residues 44-359
Chain B
44–359（316 aa）
Fragment：UNP residues 44-359
Chain C
44–359（316 aa）
Fragment：UNP residues 44-359
Chain D
44–359（316 aa）
Fragment：UNP residues 44-359
Chain E
44–359（316 aa）
Fragment：UNP residues 44-359
|
Mutation：C27S,K33C,N245C Mutation：C27S,K33C,N245C Mutation：C27S,K33C,N245C Mutation：C27S,K33C,N245C Mutation：C27S,K33C,N245C | LMT DODECYL-BETA-D-MALTOSIDE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；293 K；15% PEG4000, 0.4 M sodium thiocyanate, 0.1 M sodium acetate, pH 4.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 3.05 Å R-free 0.241 |
| 3UU5 The GLIC pentameric Ligand-Gated Ion Channel Loop2-20' mutant reduced in solution Deposited 2011-11-28 | Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Fragment：UNP residues 44-359
Chain B
44–359（316 aa）
Fragment：UNP residues 44-359
Chain C
44–359（316 aa）
Fragment：UNP residues 44-359
Chain D
44–359（316 aa）
Fragment：UNP residues 44-359
Chain E
44–359（316 aa）
Fragment：UNP residues 44-359
|
Mutation：C27S,K33C,T244C Mutation：C27S,K33C,T244C Mutation：C27S,K33C,T244C Mutation：C27S,K33C,T244C Mutation：C27S,K33C,T244C | PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 14 CL CHLORIDE ION × 5 LMT DODECYL-BETA-D-MALTOSIDE × 6 NA SODIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；293 K；15% PEG4000, 0.4 M sodium thiocyanate, 0.1 M sodium acetate, pH 4.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.90 Å R-free 0.218 |
| 3UU6 The GLIC pentameric Ligand-Gated Ion Channel Loop2-22' mutant reduced in solution Deposited 2011-11-28 | Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Fragment：UNP residues 44-359
Chain B
44–359（316 aa）
Fragment：UNP residues 44-359
Chain C
44–359（316 aa）
Fragment：UNP residues 44-359
Chain D
44–359（316 aa）
Fragment：UNP residues 44-359
Chain E
44–359（316 aa）
Fragment：UNP residues 44-359
|
Mutation：C27S,K33C,L246C Mutation：C27S,K33C,L246C Mutation：C27S,K33C,L246C Mutation：C27S,K33C,L246C Mutation：C27S,K33C,L246C | PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 CL CHLORIDE ION × 5 LMT DODECYL-BETA-D-MALTOSIDE × 6 NA SODIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；293 K；15% PEG4000, 0.4 M sodium thiocyanate, 0.1 M sodium acetate, pH 4.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.98 Å R-free 0.241 |
| 3UU8 The GLIC pentameric Ligand-Gated Ion Channel Loop2-24' mutant reduced in solution Deposited 2011-11-28 | Different mutation/modification Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Fragment：UNP residues 44-359
Chain B
44–359（316 aa）
Fragment：UNP residues 44-359
Chain C
44–359（316 aa）
Fragment：UNP residues 44-359
Chain D
44–359（316 aa）
Fragment：UNP residues 44-359
Chain E
44–359（316 aa）
Fragment：UNP residues 44-359
|
Mutation：C27S,K33C,K248C Mutation：C27S,K33C,K248C Mutation：C27S,K33C,K248C Mutation：C27S,K33C,K248C Mutation：C27S,K33C,K248C | PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 15 CL CHLORIDE ION × 5 LMT DODECYL-BETA-D-MALTOSIDE × 6 NA SODIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；293 K；15% PEG4000, 0.4 M sodium thiocyanate, 0.1 M sodium acetate, pH 4.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 3.25 Å R-free 0.234 |
| 4F8H X-ray Structure of the Anesthetic Ketamine Bound to the GLIC Pentameric Ligand-gated Ion Channel Deposited 2012-05-17 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Fragment：UNP residues 43-359
Chain B
43–359（317 aa）
Fragment：UNP residues 43-359
Chain C
43–359（317 aa）
Fragment：UNP residues 43-359
Chain D
43–359（317 aa）
Fragment：UNP residues 43-359
Chain E
43–359（317 aa）
Fragment：UNP residues 43-359
|
Not recorded | RKE (R)-ketamine × 5 LMD tetradecyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；10-12% PEG 4000, 225 mM ammonium sulfate, 50 mM sodium acetate buffer (pH 3.9 - 4.1), VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 2.99 Å R-free 0.219 |
| 4HFB The GLIC pentameric Ligand-Gated Ion Channel F14'A ethanol-sensitive mutant (Apo) Deposited 2012-10-05 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Chain B
44–359（316 aa）
Chain C
44–359（316 aa）
Chain D
44–359（316 aa）
Chain E
44–359（316 aa）
|
Mutation：F280A Mutation：F280A Mutation：F280A Mutation：F280A Mutation：F280A | ACT ACETATE ION × 10 CL CHLORIDE ION × 5 NA SODIUM ION × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；291 K；12-15% PEG4K, 0.1M Na Acetate 0.4M NaSCN, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.75 Å R-free 0.222 |
| 4HFC The GLIC pentameric Ligand-Gated Ion Channel F14'A ethanol-sensitive mutant complexed to 2-bromo-ethanol Deposited 2012-10-05 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Fragment：unp residues 44-359
Chain B
44–359（316 aa）
Fragment：unp residues 44-359
Chain C
44–359（316 aa）
Fragment：unp residues 44-359
Chain D
44–359（316 aa）
Fragment：unp residues 44-359
Chain E
44–359（316 aa）
Fragment：unp residues 44-359
|
Mutation：F280A Mutation：F280A Mutation：F280A Mutation：F280A Mutation：F280A | LMT DODECYL-BETA-D-MALTOSIDE × 6 BRJ 2-BROMOETHANOL × 5 CL CHLORIDE ION × 7 NA SODIUM ION × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 ACT ACETATE ION × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；291 K；12-15% PEG4K, 0.1M Na Acetate pH4, 0.4M NaSCN, 200 mM 2-bromo-ethanol, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 3.05 Å R-free 0.220 |
| 4HFD The GLIC pentameric Ligand-Gated Ion Channel F14'A ethanol-sensitive mutant complexed to bromoform Deposited 2012-10-05 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Chain B
44–359（316 aa）
Chain C
44–359（316 aa）
Chain D
44–359（316 aa）
Chain E
44–359（316 aa）
|
Mutation：F280A Mutation：F280A Mutation：F280A Mutation：F280A Mutation：F280A | LMT DODECYL-BETA-D-MALTOSIDE × 6 MBR TRIBROMOMETHANE × 15 CL CHLORIDE ION × 7 NA SODIUM ION × 6 ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；291 K；12-15% PEG4K, 0.1M Na Acetate, 0.4M NaSCN, 2% bromoform, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 3.10 Å R-free 0.208 |
| 4HFE The GLIC pentameric Ligand-Gated Ion Channel F14'A ethanol-sensitive mutant complexed to ethanol Deposited 2012-10-05 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Fragment：unp residues 44-359
Chain B
44–359（316 aa）
Fragment：unp residues 44-359
Chain C
44–359（316 aa）
Fragment：unp residues 44-359
Chain D
44–359（316 aa）
Fragment：unp residues 44-359
Chain E
44–359（316 aa）
Fragment：unp residues 44-359
|
Mutation：F280A Mutation：F280A Mutation：F280A Mutation：F280A Mutation：F280A | ACT ACETATE ION × 10 CL CHLORIDE ION × 7 NA SODIUM ION × 6 EOH ETHANOL × 5 LMT DODECYL-BETA-D-MALTOSIDE × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 UNL UNKNOWN LIGAND × 10 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；291 K；12-15% PEG4K, 0.1M Na Acetate, 0.4M NaSCN, 0.2M Ethanol, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.80 Å R-free 0.215 |
| 4HFH The GLIC pentameric Ligand-Gated Ion Channel (wild-type) complexed to bromoform Deposited 2012-10-05 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Chain B
44–359（316 aa）
Chain C
44–359（316 aa）
Chain D
44–359（316 aa）
Chain E
44–359（316 aa）
|
Not recorded | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 UNL UNKNOWN LIGAND × 10 CL CHLORIDE ION × 7 NA SODIUM ION × 5 LMT DODECYL-BETA-D-MALTOSIDE × 6 MBR TRIBROMOMETHANE × 10 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；291 K；12-15% PEG4K, 0.1M Na Acetate, 0.4M NaSCN, 2% bromoform, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.65 Å R-free 0.213 |
| 4HFI The GLIC pentameric Ligand-Gated Ion Channel at 2.4 A resolution Deposited 2012-10-05 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Chain B
44–359（316 aa）
Chain C
44–359（316 aa）
Chain D
44–359（316 aa）
Chain E
44–359（316 aa）
|
Not recorded | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 15 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；291 K；12-15% PEG4K, 0.1M Na Acetate pH4, 0.4M NaSCN, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.40 Å R-free 0.216 |
| 4IL4 The pentameric ligand-gated ion channel GLIC in complex with Se-DDM Deposited 2012-12-29 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Fragment：UNP residues 44-359
Chain B
44–359（316 aa）
Fragment：UNP residues 44-359
Chain C
44–359（316 aa）
Fragment：UNP residues 44-359
Chain D
44–359（316 aa）
Fragment：UNP residues 44-359
Chain E
44–359（316 aa）
Fragment：UNP residues 44-359
|
Not recorded | ACT ACETATE ION × 10 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LSM dodecyl 4-O-alpha-D-glucopyranosyl-1-seleno-beta-D-glucopyranoside × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；291 K；12.5-15% PEG4000, 0.1M NaAcetate pH4, 0.4M NaSCN, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 3.30 Å R-free 0.209 |
| 4IL9 The pentameric ligand-gated ion channel GLIC A237F in complex with bromide Deposited 2012-12-29 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–358（315 aa）
Fragment：UNP residues 44-358
Chain B
44–358（315 aa）
Fragment：UNP residues 44-358
Chain C
44–358（315 aa）
Fragment：UNP residues 44-358
Chain D
44–358（315 aa）
Fragment：UNP residues 44-358
Chain E
44–358（315 aa）
Fragment：UNP residues 44-358
|
Mutation：A237F Mutation：A237F Mutation：A237F Mutation：A237F Mutation：A237F | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 UNL UNKNOWN LIGAND × 10 BR BROMIDE ION × 12 LMT DODECYL-BETA-D-MALTOSIDE × 6 NA SODIUM ION × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；290 K；12-15% PEG 4K, 0.1M Na Acetate pH 4, 0.2M NaSCN, 0.2M NaBr, VAPOR DIFFUSION, HANGING DROP, temperature 290K
|
Resolution 2.83 Å R-free 0.214 |
| 4ILA The pentameric ligand-gated ion channel GLIC A237F in complex with Cesium Deposited 2012-12-29 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–358（315 aa）
Fragment：UNP residues 44-358
Chain B
44–358（315 aa）
Fragment：UNP residues 44-358
Chain C
44–358（315 aa）
Fragment：UNP residues 44-358
Chain D
44–358（315 aa）
Fragment：UNP residues 44-358
Chain E
44–358（315 aa）
Fragment：UNP residues 44-358
|
Mutation：A237F Mutation：A237F Mutation：A237F Mutation：A237F Mutation：A237F | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 UNL UNKNOWN LIGAND × 10 CS CESIUM ION × 27 CL CHLORIDE ION × 5 LMT DODECYL-BETA-D-MALTOSIDE × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；290 K；12-15% PEG 4K, 0.1M Na Acetate pH 4, 0.2M NaSCN, 0.2M CsCl, VAPOR DIFFUSION, HANGING DROP, temperature 290K
|
Resolution 3.50 Å R-free 0.208 |
| 4ILB The pentameric ligand-gated ion channel GLIC A237F in complex with Rubidium Deposited 2012-12-29 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–358（315 aa）
Fragment：UNP residues 44-358
Chain B
44–358（315 aa）
Fragment：UNP residues 44-358
Chain C
44–358（315 aa）
Fragment：UNP residues 44-358
Chain D
44–358（315 aa）
Fragment：UNP residues 44-358
Chain E
44–358（315 aa）
Fragment：UNP residues 44-358
|
Mutation：A237F Mutation：A237F Mutation：A237F Mutation：A237F Mutation：A237F | LMT DODECYL-BETA-D-MALTOSIDE × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 UNL UNKNOWN LIGAND × 10 CL CHLORIDE ION × 5 NA SODIUM ION × 6 RB RUBIDIUM ION × 1 ACT ACETATE ION × 10 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；290 K；12-15% PEG 4K, 0.1M Na Acetate pH4, 0.2M NaSCN, 0.2M RbCl, VAPOR DIFFUSION, HANGING DROP, temperature 290K
|
Resolution 3.15 Å R-free 0.226 |
| 4ILC The GLIC pentameric ligand-gated ion channel in complex with sulfates Deposited 2012-12-29 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–358（315 aa）
Fragment：UNP residues 44-358
Chain B
44–358（315 aa）
Fragment：UNP residues 44-358
Chain C
44–358（315 aa）
Fragment：UNP residues 44-358
Chain D
44–358（315 aa）
Fragment：UNP residues 44-358
Chain E
44–358（315 aa）
Fragment：UNP residues 44-358
|
Not recorded | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 UNL UNKNOWN LIGAND × 10 CL CHLORIDE ION × 5 LMT DODECYL-BETA-D-MALTOSIDE × 6 NA SODIUM ION × 6 SO4 SULFATE ION × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；290 K；12-15% PEG 4K, 0.1M Na Acetate pH4, 0.2M NH4SO4, VAPOR DIFFUSION, HANGING DROP, temperature 290K
|
Resolution 2.99 Å R-free 0.236 |
| 4IRE Crystal structure of GLIC with mutations at the loop C region Deposited 2013-01-14 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Fragment：UNP residues 43-359
Chain B
43–359（317 aa）
Fragment：UNP residues 43-359
Chain C
43–359（317 aa）
Fragment：UNP residues 43-359
Chain D
43–359（317 aa）
Fragment：UNP residues 43-359
Chain E
43–359（317 aa）
Fragment：UNP residues 43-359
|
Mutation：D91N, E177Q, D178N Mutation：D91N, E177Q, D178N Mutation：D91N, E177Q, D178N Mutation：D91N, E177Q, D178N Mutation：D91N, E177Q, D178N | LMD tetradecyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 OXL OXALATE ION × 17 ACT ACETATE ION × 10 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 3.9；277 K；10-12% PEG 4000, 225 mM ammonium sulfate, 50 mM sodium acetate buffer (pH 3.9 - 4.1), VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 3.19 Å R-free 0.243 |
| 4LMJ GLIC Liganded-closed-channel Conformation, Mutant T25'A Deposited 2013-07-10 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Fragment：UNP residues 44-359
Chain B
44–359（316 aa）
Fragment：UNP residues 44-359
Chain C
44–359（316 aa）
Fragment：UNP residues 44-359
Chain D
44–359（316 aa）
Fragment：UNP residues 44-359
Chain E
44–359（316 aa）
Fragment：UNP residues 44-359
|
Mutation：T291A Mutation：T291A Mutation：T291A Mutation：T291A Mutation：T291A | CL CHLORIDE ION × 5 LMT DODECYL-BETA-D-MALTOSIDE × 1 NA SODIUM ION × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；298 K；10-12% PEG4000, 225 mM ammonium sulfate, pH 4.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 3.44 Å R-free 0.255 |
| 4LMK GLIC Liganded-closed-channel Conformation, Mutant Y27'A Deposited 2013-07-10 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Fragment：UNP residues 44-359
Chain B
44–359（316 aa）
Fragment：UNP residues 44-359
Chain C
44–359（316 aa）
Fragment：UNP residues 44-359
Chain D
44–359（316 aa）
Fragment：UNP residues 44-359
Chain E
44–359（316 aa）
Fragment：UNP residues 44-359
|
Mutation：T293A Mutation：T293A Mutation：T293A Mutation：T293A Mutation：T293A | CL CHLORIDE ION × 5 LMT DODECYL-BETA-D-MALTOSIDE × 1 NA SODIUM ION × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；298 K；10-12% PEG4000, 225 mM ammonium sulfate, pH 4.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 3.22 Å R-free 0.238 |
| 4LML GLIC double mutant I9'A T25'A Deposited 2013-07-10 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Fragment：UNP residues 44-359
Chain B
44–359（316 aa）
Fragment：UNP residues 44-359
Chain C
44–359（316 aa）
Fragment：UNP residues 44-359
Chain D
44–359（316 aa）
Fragment：UNP residues 44-359
Chain E
44–359（316 aa）
Fragment：UNP residues 44-359
|
Mutation：I275A,T291A Mutation：I275A,T291A Mutation：I275A,T291A Mutation：I275A,T291A Mutation：I275A,T291A | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；298 K；10-12% PEG4000, 225 mM ammonium sulfate, pH 4.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 3.80 Å R-free 0.302 |
| 4NPP The GLIC-His10 wild-type structure in equilibrium between the open and locally-closed (LC) forms Deposited 2013-11-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Chain B
44–359（316 aa）
Chain C
44–359（316 aa）
Chain D
44–359（316 aa）
Chain E
44–359（316 aa）
|
Not recorded | NI NICKEL (II) ION × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；293 K；15-20% PEG2kmme, 50mM NiCl2, 0.1M Na Acetate pH4, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 3.35 Å R-free 0.248 |
| 4NPQ The resting-state conformation of the GLIC ligand-gated ion channel Deposited 2013-11-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Chain B
44–359（316 aa）
Chain C
44–359（316 aa）
Chain D
44–359（316 aa）
Chain E
44–359（316 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；13-15% PEG4000, 200mM KSCN, 10mM CaCl2, 3% Trimethylamine-N-oxyde dihydrate, 0.1M Na Hepes pH7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 4.35 Å R-free 0.244 |
| 4NPQ The resting-state conformation of the GLIC ligand-gated ion channel Deposited 2013-11-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain F
44–359（316 aa）
Chain G
44–359（316 aa）
Chain H
44–359（316 aa）
Chain I
44–359（316 aa）
Chain J
44–359（316 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；13-15% PEG4000, 200mM KSCN, 10mM CaCl2, 3% Trimethylamine-N-oxyde dihydrate, 0.1M Na Hepes pH7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 4.35 Å R-free 0.244 |
| 4NPQ The resting-state conformation of the GLIC ligand-gated ion channel Deposited 2013-11-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain K
44–359（316 aa）
Chain L
44–359（316 aa）
Chain M
44–359（316 aa）
Chain N
44–359（316 aa）
Chain O
44–359（316 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；13-15% PEG4000, 200mM KSCN, 10mM CaCl2, 3% Trimethylamine-N-oxyde dihydrate, 0.1M Na Hepes pH7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 4.35 Å R-free 0.244 |
| 4NPQ The resting-state conformation of the GLIC ligand-gated ion channel Deposited 2013-11-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain P
44–359（316 aa）
Chain Q
44–359（316 aa）
Chain R
44–359（316 aa）
Chain S
44–359（316 aa）
Chain T
44–359（316 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；13-15% PEG4000, 200mM KSCN, 10mM CaCl2, 3% Trimethylamine-N-oxyde dihydrate, 0.1M Na Hepes pH7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 4.35 Å R-free 0.244 |
| 4QH1 The GLIC pentameric Ligand-Gated Ion Channel (wild-type) in complex with bromoacetate Deposited 2014-05-26 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Chain B
44–359（316 aa）
Chain C
44–359（316 aa）
Chain D
44–359（316 aa）
Chain E
44–359（316 aa）
|
Not recorded | BR BROMIDE ION × 5 BXA bromoacetic acid × 10 NA SODIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；291 K；400 mM Sodium Isothiocyanate, 100 mM Sodium acetate, 16% glycerol, 12-15% PEG4000
2% DMSO, pH 4.6, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 3.40 Å R-free 0.225 |
| 4QH4 The GLIC pentameric Ligand-Gated Ion Channel (wild-type) crystallized in acetate buffer at pH3 Deposited 2014-05-26 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Chain B
44–359（316 aa）
Chain C
44–359（316 aa）
Chain D
44–359（316 aa）
Chain E
44–359（316 aa）
|
Not recorded | LMT DODECYL-BETA-D-MALTOSIDE × 6 ACT ACETATE ION × 3 NA SODIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；291 K；400 mM Sodium Isothiocyanate 100 mM Sodium acetate,
16% glycerol, 12-15% PEG4000, 2% DMSO, pH 4.6, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 3.20 Å R-free 0.224 |
| 4QH5 The GLIC pentameric Ligand-Gated Ion Channel (wild-type) crystallized in phosphate buffer Deposited 2014-05-26 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Chain B
44–359（316 aa）
Chain C
44–359（316 aa）
Chain D
44–359（316 aa）
Chain E
44–359（316 aa）
|
Not recorded | LMT DODECYL-BETA-D-MALTOSIDE × 6 CL CHLORIDE ION × 5 NA SODIUM ION × 4 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；291 K；400 mM Sodium Isothiocyanate, 100 mM Sodium acetate, 16% glycerol, 12-15% PEG4000, 2% DMSO, pH 4.6, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 3.00 Å R-free 0.216 |
| 4X5T alpha 1 glycine receptor transmembrane structure fused to the extracellular domain of GLIC Deposited 2014-12-05 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–235（192 aa）
Chain B
44–235（192 aa）
Chain C
44–235（192 aa）
Chain D
44–235（192 aa）
Chain E
44–235（192 aa）
|
Not recorded | NI NICKEL (II) ION × 6 CL CHLORIDE ION × 6 ACT ACETATE ION × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 3；291 K；16 % PEG 2000MME, 50 mM NiCl2, 4% DMSO, 11% ethylene glycol and 0.1 M NaAcetate pH 3.0
|
Resolution 3.50 Å R-free 0.270 |
| 4YEU ELIC-GLIC chimera in the resting conformation Deposited 2015-02-24 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
236–357（122 aa）
Chain B
236–357（122 aa）
Chain C
236–357（122 aa）
Chain D
236–357（122 aa）
Chain E
236–357（122 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；PEG 4000, Ammonium Sulfate, Sodium ADA
|
Resolution 4.60 Å R-free 0.248 |
| 4ZZB The GLIC pentameric Ligand-Gated Ion Channel Locally-closed form complexed to xenon Deposited 2015-05-22 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Fragment：UNP residues 44-359
Chain B
44–359（316 aa）
Fragment：UNP residues 44-359
Chain C
44–359（316 aa）
Fragment：UNP residues 44-359
Chain D
44–359（316 aa）
Fragment：UNP residues 44-359
Chain E
44–359（316 aa）
Fragment：UNP residues 44-359
|
Mutation：C27S K33C L246C Mutation：C27S K33C L246C Mutation：C27S K33C L246C Mutation：C27S K33C L246C Mutation：C27S K33C L246C | LMT DODECYL-BETA-D-MALTOSIDE × 1 CL CHLORIDE ION × 5 NA SODIUM ION × 5 ACT ACETATE ION × 6 XE XENON × 21 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；290 K；12-15 % PEG4000
0.1M Na Acetate pH4
0.4M NaSCN
15% glycerol
5% DMSO
|
Resolution 3.40 Å R-free 0.223 |
| 4ZZC The GLIC pentameric Ligand-Gated Ion Channel open form complexed to xenon Deposited 2015-05-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: Pentameric |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 CL CHLORIDE ION × 5 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 XE XENON × 30 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；290 K；12-15% PEG4000
0.1M Na Acetate pH4
0.4M NaSCN
15% glycerol
5% DMSO
|
Resolution 3.10 Å R-free 0.228 |
| 5HCJ Cationic Ligand-Gated Ion Channel Deposited 2016-01-04 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Fragment：UNP residues 44-359
Chain B
44–359（316 aa）
Fragment：UNP residues 44-359
Chain C
44–359（316 aa）
Fragment：UNP residues 44-359
Chain D
44–359（316 aa）
Fragment：UNP residues 44-359
Chain E
44–359（316 aa）
Fragment：UNP residues 44-359
|
Mutation：C27S, K33C, L246C Mutation：C27S, K33C, L246C Mutation：C27S, K33C, L246C Mutation：C27S, K33C, L246C Mutation：C27S, K33C, L246C | LMT DODECYL-BETA-D-MALTOSIDE × 1 CL CHLORIDE ION × 5 NA SODIUM ION × 1 MBR TRIBROMOMETHANE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；291 K；PEG4000 12-15%, NaSCN 0.4M, 15% glycerol, NaAcetate pH 4 0.1M
|
Resolution 2.95 Å R-free 0.218 |
| 5HCM The GLIC pentameric Ligand-Gated Ion Channel 2-21' cross-linked mutant complexed to bromoform Deposited 2016-01-04 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Fragment：UNP residues 44-359
Chain B
44–359（316 aa）
Fragment：UNP residues 44-359
Chain C
44–359（316 aa）
Fragment：UNP residues 44-359
Chain D
44–359（316 aa）
Fragment：UNP residues 44-359
Chain E
44–359（316 aa）
Fragment：UNP residues 44-359
|
Mutation：C27S, K33C, N245C Mutation：C27S, K33C, N245C Mutation：C27S, K33C, N245C Mutation：C27S, K33C, N245C Mutation：C27S, K33C, N245C | LMT DODECYL-BETA-D-MALTOSIDE × 1 MBR TRIBROMOMETHANE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；291 K；PEG 4000 12-15%, 0.1 M Na Acetate pH4, 0.4M NaSCN, 15% glycerol
|
Resolution 3.15 Å R-free 0.240 |
| 5HEG Pentameric ligand-gated ion channel GLIC mutant P246G Deposited 2016-01-06 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Chain B
44–359（316 aa）
Chain C
44–359（316 aa）
Chain D
44–359（316 aa）
Chain E
44–359（316 aa）
|
Mutation：P246G Mutation：P246G Mutation：P246G Mutation：P246G Mutation：P246G | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4；277 K；Ammonium sulfate, PEG 4000
|
Resolution 3.21 Å R-free 0.258 |
| 5HEH Pentameric ligand-gated ion channel GLIC mutant P246A Deposited 2016-01-06 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Chain B
44–359（316 aa）
Chain C
44–359（316 aa）
Chain D
44–359（316 aa）
Chain E
44–359（316 aa）
|
Mutation：P246A Mutation：P246A Mutation：P246A Mutation：P246A Mutation：P246A | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4；277 K；PEG 4000, Ammonium Sulfate
|
Resolution 3.30 Å R-free 0.280 |
| 5IUX GLIC-V135C bimane labelled X-ray structure Deposited 2016-03-18 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | LMT DODECYL-BETA-D-MALTOSIDE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 ACT ACETATE ION × 10 6E3 2,3,5,6-tetramethyl-1H,7H-pyrazolo[1,2-a]pyrazole-1,7-dione × 2 BR BROMIDE ION × 5 NA SODIUM ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；293 K；12% PEG4K, 15% DMSO, 100 mM Acetate de Sodium pH4, 200 mM Sodium isothiocyanate, 2% DMSO
|
Resolution 2.60 Å R-free 0.237 |
| 5J0Z Crystal structure of GLIC in complex with DHA Deposited 2016-03-28 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
47–357（311 aa）
Chain B
47–357（311 aa）
Chain C
47–357（311 aa）
Chain D
47–357（311 aa）
Chain E
47–357（311 aa）
|
Not recorded | CL CHLORIDE ION × 3 LMT DODECYL-BETA-D-MALTOSIDE × 6 SO4 SULFATE ION × 6 ACT ACETATE ION × 2 HXA DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID × 5 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4；277 K；225 mM ammonium sulfate, 50 mM sodium acetate pH 4.0, 7.5-10% PEG 4000
|
Resolution 3.25 Å R-free 0.261 |
| 5L47 X-ray structure of the 2-22' locally-closed mutant of GLIC in complex with cyanoselenobarbital (seleniated barbiturate) Deposited 2016-05-25 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | CL CHLORIDE ION × 5 ACT ACETATE ION × 5 NA SODIUM ION × 4 6JA 2-[5-ethyl-2,4,6-tris(oxidanylidene)-1,3-diazinan-5-yl]ethyl selenocyanate × 1 D12 DODECANE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；291 K；100 mM Na Acetate pH4, 200 mM Na SCN, 12-15% PEG4000, 3% DMSO, 16% glycerol
|
Resolution 3.30 Å R-free 0.230 |
| 5L4E X-ray structure of the 2-22' locally-closed mutant of GLIC in complex with thiopental Deposited 2016-05-25 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | D12 DODECANE × 1 CL CHLORIDE ION × 5 EDP 5-ethyl-5-[(2R)-pentan-2-yl]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；291 K；100 mM NaAcetate pH4
200 NaSCN
12-15% PEG4000
16% glycerol
3%DMSO
|
Resolution 3.50 Å R-free 0.249 |
| 5L4H X-ray structure of the 2-22' locally-closed mutant of GLIC in complex with 5-(2-BROMO-ETHYL)-5-ETHYL-PYRIMIDINE-2,4,6-TRIONE (brominated barbiturate) Deposited 2016-05-25 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | CL CHLORIDE ION × 5 LMT DODECYL-BETA-D-MALTOSIDE × 1 6JW 5-(2-bromoethyl)-5-ethyl-1,3-diazinane-2,4,6-trione × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；100 mM NaAcetate pH4, 200 mM NaSCN, 12-15% PEG4000, 16% glycerol, 3% DMSO
|
Resolution 3.30 Å R-free 0.235 |
| 5MUO X-ray structure of the 2-22' locally-closed mutant of GLIC in complex with propofol Deposited 2017-01-13 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Fragment：UNP RESIDUES 44-359
Chain B
44–359（316 aa）
Fragment：UNP RESIDUES 44-359
Chain C
44–359（316 aa）
Fragment：UNP RESIDUES 44-359
Chain D
44–359（316 aa）
Fragment：UNP RESIDUES 44-359
Chain E
44–359（316 aa）
Fragment：UNP RESIDUES 44-359
|
Mutation：YES Mutation：YES Mutation：YES Mutation：YES Mutation：YES | LMT DODECYL-BETA-D-MALTOSIDE × 1 CL CHLORIDE ION × 5 ACT ACETATE ION × 4 PFL 2,6-BIS(1-METHYLETHYL)PHENOL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；293 K；PH 4, VAPOR DIFFUSION, TEMPERATURE 293K
|
Resolution 3.19 Å R-free 0.204 |
| 5MUR X-ray structure of the F14'A mutant of GLIC in complex with propofol Deposited 2017-01-13 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Fragment：UNP residues 43-359
Chain B
43–359（317 aa）
Fragment：UNP residues 43-359
Chain C
43–359（317 aa）
Fragment：UNP residues 43-359
Chain D
43–359（317 aa）
Fragment：UNP residues 43-359
Chain E
43–359（317 aa）
Fragment：UNP residues 43-359
|
Not recorded | ACT ACETATE ION × 10 CL CHLORIDE ION × 5 NA SODIUM ION × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 PFL 2,6-BIS(1-METHYLETHYL)PHENOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；100 mM Na acetate pH4
12-15% PEG4K
200 mM NaSCN
16% glycerol
2% DMSO
|
Resolution 3.10 Å R-free 0.204 |
| 5MVM X-ray structure of the F14'A -N15'A double mutant of GLIC in complex with propofol Deposited 2017-01-16 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | LMT DODECYL-BETA-D-MALTOSIDE × 6 ACT ACETATE ION × 10 CL CHLORIDE ION × 5 NA SODIUM ION × 7 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 15 PFL 2,6-BIS(1-METHYLETHYL)PHENOL × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；400mM NaSCN
100mM NaAcetate pH4
12-15% PEG4K
16% glycerol
2% DMSO
|
Resolution 3.10 Å R-free 0.208 |
| 5MVN X-ray structure of the M205W mutant of GLIC in complex with propofol Deposited 2017-01-16 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 15 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 PFL 2,6-BIS(1-METHYLETHYL)PHENOL × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；400 mM NaSCN
100 mM NaAcetate pH4
12-15 % PEG4K
16 % glycerol
2 % DMSO
|
Resolution 3.49 Å R-free 0.232 |
| 5MZQ X-ray structure of the M205W mutant of GLIC in complex with bromoform Deposited 2017-02-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | ACT ACETATE ION × 10 PC8 1,2-DIOCTANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 2IL (3R)-3-(dodecanoyloxy)tetradecanoic acid × 5 D12 DODECANE × 11 CL CHLORIDE ION × 7 NA SODIUM ION × 6 MBR TRIBROMOMETHANE × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；100 mM NaAct pH4
400 mM NaSCN
16% glycerol 2% DMSO
12-15 % PEG4K
|
Resolution 2.80 Å R-free 0.219 |
| 5MZR X-ray structure of the H235Q mutant of GLIC in complex with propofol Deposited 2017-02-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Mutation：H235Q Mutation：H235Q Mutation：H235Q Mutation：H235Q Mutation：H235Q | PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 15 CL CHLORIDE ION × 7 NA SODIUM ION × 6 ACT ACETATE ION × 10 LMT DODECYL-BETA-D-MALTOSIDE × 6 PFL 2,6-BIS(1-METHYLETHYL)PHENOL × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；294 K；100 mM NaAct pH4
400 mM NaSCN
16% glycerol
2% DMSO
12-15% PEG4K
|
Resolution 2.65 Å R-free 0.210 |
| 5MZT X-ray structure of the H235Q mutant of GLIC in complex with bromoform Deposited 2017-02-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Fragment：H235Q
Chain B
43–359（317 aa）
Fragment：H235Q
Chain C
43–359（317 aa）
Fragment：H235Q
Chain D
43–359（317 aa）
Fragment：H235Q
Chain E
43–359（317 aa）
Fragment：H235Q
|
Not recorded | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 15 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 MBR TRIBROMOMETHANE × 10 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；294 K；100 mM NaAct pH 4
400 mM NaSCN
16% glycerol
2% DMSO
|
Resolution 2.65 Å R-free 0.211 |
| 5NJY X-ray structure of the H235Q mutant of GLIC Deposited 2017-03-30 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；400 mM NaSCN
100 mM Na Acetate pH 4
12-15% PEG4000
2% DMSO
16% Glycerol
|
Resolution 2.95 Å R-free 0.243 |
| 5NKJ X-ray structure of the N239C mutant of GLIC Deposited 2017-03-31 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain B
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain C
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain D
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain E
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
|
Mutation：YES Mutation：YES Mutation：YES Mutation：YES Mutation：YES | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；293 K；PH 4, VAPOR DIFFUSION, TEMPERATURE 293K
|
Resolution 3.74 Å R-free 0.256 |
| 5OSA GLIC-GABAAR alpha1 chimera crystallized at pH4.6 Deposited 2017-08-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–236（193 aa）
Chain B
44–236（193 aa）
Chain C
44–236（193 aa）
Chain D
44–236（193 aa）
Chain E
44–236（193 aa）
|
Not recorded | ACT ACETATE ION × 8 CL CHLORIDE ION × 7 D12 DODECANE × 8 Y01 CHOLESTEROL HEMISUCCINATE × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.6；289.15 K；100 mM NaCl, 100 mM sodium acetate pH 4.6, 12 % PEG 6000
|
Resolution 2.75 Å R-free 0.229 |
| 5OSB GLIC-GABAAR alpha1 chimera crystallized in complex with THDOC at pH4.5 Deposited 2017-08-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–236（193 aa）
Chain B
44–236（193 aa）
Chain C
44–236（193 aa）
Chain D
44–236（193 aa）
Chain E
44–236（193 aa）
|
Not recorded | A8Z Tetrahydrodeoxycorticosterone × 5 ACT ACETATE ION × 5 CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.5；289 K；12-16% PEG4000, 100mM NaCl, 100 mM Li2SO4, 100mM sodium acetate pH4-4.5
|
Resolution 3.80 Å R-free 0.290 |
| 5OSC GLIC-GABAAR alpha1 chimera crystallized in complex with pregnenolone sulfate at pH 4.5 Deposited 2017-08-17 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–236（193 aa）
Chain B
44–236（193 aa）
Chain C
44–236（193 aa）
Chain D
44–236（193 aa）
Chain E
44–236（193 aa）
|
Not recorded | ACT ACETATE ION × 8 CL CHLORIDE ION × 5 A8W Pregnenolone sulfate × 5 Y01 CHOLESTEROL HEMISUCCINATE × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.5；289 K；12-16% PEG 4000, 100 mM NaCl, 100 mM Li2S04, 100 mM sodium acetate pH 4-5
|
Resolution 3.10 Å R-free 0.246 |
| 5V6N Crystal Structure of the highly open channel-stabilized mutant C27S + K33C + I9'A + N21'C of GLIC under reducing conditions. Deposited 2017-03-17 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
50–359（310 aa）
Fragment：unp residues 50-359
Chain B
50–359（310 aa）
Fragment：unp residues 50-359
Chain C
50–359（310 aa）
Fragment：unp residues 50-359
Chain D
50–359（310 aa）
Fragment：unp residues 50-359
Chain E
50–359（310 aa）
Fragment：unp residues 50-359
|
Mutation：C69S, K75C, I275A, N287C Mutation：C69S, K75C, I275A, N287C Mutation：C69S, K75C, I275A, N287C Mutation：C69S, K75C, I275A, N287C Mutation：C69S, K75C, I275A, N287C | LMT DODECYL-BETA-D-MALTOSIDE × 5 NA SODIUM ION × 1 SO4 SULFATE ION × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；200-250 mM (NH4)2SO4,
10-12% (wt/vol) PEG-4000
50 mM sodium acetate, pH 3.9-4.2
|
Resolution 3.35 Å R-free 0.284 |
| 5V6O Crystal Structure of the highly open channel-stabilized mutant G-2'I + I9'A of GLIC Deposited 2017-03-17 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
50–359（310 aa）
Fragment：unp residues 50-359
Chain B
50–359（310 aa）
Fragment：unp residues 50-359
Chain C
50–359（310 aa）
Fragment：unp residues 50-359
Chain D
50–359（310 aa）
Fragment：unp residues 50-359
Chain E
50–359（310 aa）
Fragment：unp residues 50-359
|
Mutation：C27S, K33C Mutation：C27S, K33C Mutation：C27S, K33C Mutation：C27S, K33C Mutation：C27S, K33C | LMT DODECYL-BETA-D-MALTOSIDE × 6 CL CHLORIDE ION × 5 NA SODIUM ION × 1 SO4 SULFATE ION × 10 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；Sodium Acetate 50 mM pH 3.9-4.2
Ammonium Sulfate 200-250 mM
PEG 4000 10-12%
|
Resolution 3.12 Å R-free 0.280 |
| 6EMX X-ray structure of the N15'C mutant of GLIC in complex with bromoform Deposited 2017-10-03 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | CL CHLORIDE ION × 4 NA SODIUM ION × 6 MBR TRIBROMOMETHANE × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；291 K；12-14% PEGK
400mM NaSCN
100 mM NaAcetate pH 4
15% glycerol
3% DMSO
|
Resolution 3.20 Å R-free 0.268 |
| 6F0I GLIC mutant E26A Deposited 2017-11-20 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | ACT ACETATE ION × 10 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；pH 4；291.15 K；PEG 4000, 15% Glycerol, 0.1M Sodium acetate, 0.4M Thiocyanate, 3% DMSO
|
Resolution 3.00 Å R-free 0.223 |
| 6F0J GLIC mutant E26A Deposited 2017-11-20 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | ACT ACETATE ION × 10 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；292 K；12% PEG4K, 15% glycerol, 100 mM Acetate de Sodium pH4, 400 mM Sodium isothiocyanate, 3% DMSO
|
Resolution 3.15 Å R-free 0.222 |
| 6F0M GLIC mutant E35Q Deposited 2017-11-20 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 CL CHLORIDE ION × 7 NA SODIUM ION × 6 ACT ACETATE ION × 10 LMT DODECYL-BETA-D-MALTOSIDE × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；293 K；12% PEG4K, 15% glycerol, 100 mM Acetate de Sodium pH4, 400 mM Sodium isothiocyanate, 3% DMSO
|
Resolution 2.65 Å R-free 0.222 |
| 6F0N GLIC mutant E82A Deposited 2017-11-20 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；293 K；12% PEG4K, 15% glycerol, 100 mM Acetate de Sodium pH4, 400 mM Sodium isothiocyanate, 3% DMSO
|
Resolution 3.20 Å R-free 0.233 |
| 6F0R GLIC mutant E82Q Deposited 2017-11-20 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 CL CHLORIDE ION × 4 LMT DODECYL-BETA-D-MALTOSIDE × 6 NA SODIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；293 K；12% PEG4K, 15% glycerol, 100 mM Acetate de Sodium pH4, 400 mM Sodium isothiocyanate, 3% DMSO
|
Resolution 2.50 Å R-free 0.254 |
| 6F0U GLIC mutant E35A Deposited 2017-11-20 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；293 K；12% PEG4K, 15% glycerol, 100 mM Acetate de Sodium pH4, 400 mM Sodium isothiocyanate, 3% DMSO
|
Resolution 2.35 Å R-free 0.233 |
| 6F0V GLIC mutant E82Q Deposited 2017-11-20 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | CL CHLORIDE ION × 7 NA SODIUM ION × 6 ACT ACETATE ION × 10 LMT DODECYL-BETA-D-MALTOSIDE × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；293 K；12% PEG4K, 15% glycerol, 100 mM Acetate de Sodium pH4, 200 mM Sodium isothiocyanate, 3% DMSO
|
Resolution 2.85 Å R-free 0.221 |
| 6F0Z GLIC mutant D88N Deposited 2017-11-21 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | CL CHLORIDE ION × 7 NA SODIUM ION × 6 ACT ACETATE ION × 10 LMT DODECYL-BETA-D-MALTOSIDE × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；293 K；12% PEG4K, 15% glycerol, 100 mM Acetate de Sodium pH4, 400 mM Sodium isothiocyanate, 3% DMSO
|
Resolution 2.50 Å R-free 0.226 |
| 6F10 GLIC mutant D88N Deposited 2017-11-21 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | CL CHLORIDE ION × 7 NA SODIUM ION × 6 ACT ACETATE ION × 10 LMT DODECYL-BETA-D-MALTOSIDE × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；293 K；100 mM NaAcetate pH4 400 mM NaSCN 12-15% PEG4000 15% glycerol 3%DMSO
|
Resolution 2.85 Å R-free 0.223 |
| 6F11 GLIC mutant D86A Deposited 2017-11-21 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | CL CHLORIDE ION × 7 NA SODIUM ION × 6 ACT ACETATE ION × 10 LMT DODECYL-BETA-D-MALTOSIDE × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；293 K；100 mM NaAcetate pH4 400 mM NaSCN 12-15% PEG 4000 15% glycerol 3%DMSO
|
Resolution 2.95 Å R-free 0.215 |
| 6F12 GLIC mutant E181A Deposited 2017-11-21 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | CL CHLORIDE ION × 7 NA SODIUM ION × 6 ACT ACETATE ION × 10 LMT DODECYL-BETA-D-MALTOSIDE × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；293 K；100 mM NaAcetate pH4 400 NaSCN 12-15% PEG4000 15% glycerol 3%DMSO
|
Resolution 3.20 Å R-free 0.213 |
| 6F13 GLIC mutant E75A Deposited 2017-11-21 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 14 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；293 K；100 mM NaAcetate pH 4 200mM NaSCN 12-15% PEG4000 15% glycerol 3%DMSO
|
Resolution 2.70 Å R-free 0.223 |
| 6F15 GLIC mutant H127Q Deposited 2017-11-21 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；293 K；100 mM NaAcetate pH 4 400mM NaSCN 12-15% PEG4000 165% glycerol 3%DMSO
|
Resolution 2.85 Å R-free 0.229 |
| 6F16 GLIC mutant H277Q Deposited 2017-11-21 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；293 K；100 mM NaAcetate pH 4 400 NaSCN 12-15% PEG4000 15% glycerol 3%DMSO
|
Resolution 2.60 Å R-free 0.219 |
| 6F7A Gloeobacter Ligand-gated Ion Channel (GLIC) closed state crystallized in an ultra-swollen lipidic mesophase Deposited 2017-12-07 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
47–357（311 aa）
Chain B
47–357（311 aa）
Chain C
47–357（311 aa）
Chain D
47–357（311 aa）
Chain E
47–357（311 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIPIDIC CUBIC PHASE；298 K；0.2 M (NH4)SO4, 0.02M NaCl, 0.02M Na Act 4 pH, 33%v/v PEG200
|
Resolution 6.00 Å R-free 0.318 |
| 6HJ3 Xray structure of GLIC in complex with fumarate Deposited 2018-08-31 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 15 CL CHLORIDE ION × 12 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 FUM FUMARIC ACID × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；30 mM Na fumarate pH 4
12-15% PEG4000
400 mM Na Isothiocyanate
15% glycerol
2% DMSO
|
Resolution 2.70 Å R-free 0.216 |
| 6HJA Xray structure of GLIC in complex with glutarate Deposited 2018-09-03 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
1–359（359 aa）
Chain B
1–359（359 aa）
Chain C
1–359（359 aa）
Chain D
1–359（359 aa）
Chain E
1–359（359 aa）
|
Not recorded | PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 14 CL CHLORIDE ION × 11 D12 DODECANE × 6 GUA GLUTARIC ACID × 5 NA SODIUM ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；100 mM Na-Acetate pH4
400 mM Na-Isothiocyanate
12-15% PEG4000
2% DMSO
16% Glycerol
|
Resolution 2.70 Å R-free 0.219 |
| 6HJB Xray structure of GLIC in complex with malonate Deposited 2018-09-03 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
1–359（359 aa）
Chain B
1–359（359 aa）
Chain C
1–359（359 aa）
Chain D
1–359（359 aa）
Chain E
1–359（359 aa）
|
Not recorded | PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 11 CL CHLORIDE ION × 11 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 MLA MALONIC ACID × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；100 mM Na-malonate pH4
400 mM Na-Isothiocyanate
12-15% PEG4000
2% DMSO
16% Glycerol
|
Resolution 3.00 Å R-free 0.199 |
| 6HJI Xray structure of GLIC in complex with crotonate Deposited 2018-09-03 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 15 CL CHLORIDE ION × 12 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 BEO BUTENOIC ACID × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；100 mM Na-crotonate pH4
400 mM Na-Isothiocyanate
12-15% PEG4000
2% DMSO
15% glycerol
|
Resolution 2.80 Å R-free 0.204 |
| 6HJZ Xray structure of GLIC in complex with succinate Deposited 2018-09-04 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 15 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 SIN SUCCINIC ACID × 10 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；100 mM NaSuccinate pH4
400 mM NaIsothiocynate
12-15% PEG4000
2% DMSO
15% glycerol
|
Resolution 2.50 Å R-free 0.227 |
| 6HJZ Xray structure of GLIC in complex with succinate Deposited 2018-09-04 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain F
43–359（317 aa）
Chain G
43–359（317 aa）
Chain H
43–359（317 aa）
Chain I
43–359（317 aa）
Chain J
43–359（317 aa）
|
Not recorded | PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 15 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 SIN SUCCINIC ACID × 10 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；100 mM NaSuccinate pH4
400 mM NaIsothiocynate
12-15% PEG4000
2% DMSO
15% glycerol
|
Resolution 2.50 Å R-free 0.227 |
| 6HPP X-ray structure of GLIC in complex with propionate Deposited 2018-09-21 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 PPI PROPANOIC ACID × 10 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；100 mM Na-propionate, pH 4
400 mM NaIsothiocyanate
12-15% PEG4000
2% DMSO
15% glycreol
|
Resolution 3.20 Å R-free 0.201 |
| 6HY5 THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT Q193C Deposited 2018-10-19 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
47–357（311 aa）
Chain B
47–357（311 aa）
Chain C
47–357（311 aa）
Chain D
47–357（311 aa）
Chain E
47–357（311 aa）
|
Not recorded | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；pH 4；291 K；12-15% PEG4K, 0.1M NA ACETATE PH4,
0.4M NASCN, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 291K
|
Resolution 2.58 Å R-free 0.205 |
| 6HY9 THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT Q193M Deposited 2018-10-19 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Fragment：UNP RESIDUES 44-359
Chain B
44–359（316 aa）
Fragment：UNP RESIDUES 44-359
Chain C
44–359（316 aa）
Fragment：UNP RESIDUES 44-359
Chain D
44–359（316 aa）
Fragment：UNP RESIDUES 44-359
Chain E
44–359（316 aa）
Fragment：UNP RESIDUES 44-359
|
Mutation：YES Mutation：YES Mutation：YES Mutation：YES Mutation：YES | CL CHLORIDE ION × 5 LMT DODECYL-BETA-D-MALTOSIDE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；pH 4；291 K；PH 4, VAPOR DIFFUSION, TEMPERATURE 291K. 12-14.5% PEG4K; 15% GLycerol; 400 mM NaSCN; 3% DMSO; 100mM NaAcetate pH 4.
|
Resolution 2.95 Å R-free 0.227 |
| 6HYA THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT Q193L Deposited 2018-10-19 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain B
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain C
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain D
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain E
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
|
Mutation：YES Mutation：YES Mutation：YES Mutation：YES Mutation：YES | CL CHLORIDE ION × 5 LMT DODECYL-BETA-D-MALTOSIDE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；pH 4；293 K；PH 4, VAPOR DIFFUSION, TEMPERATURE 293K;12-14.5% PEG4K; 15% GLycerol; 400 mM NaSCN; 3% DMSO; 100mM NaAcetate pH 4.
|
Resolution 3.39 Å R-free 0.212 |
| 6HYR THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT Q193C+MMTS Deposited 2018-10-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
47–357（311 aa）
Chain B
47–357（311 aa）
Chain C
47–357（311 aa）
Chain D
47–357（311 aa）
Chain E
47–357（311 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | LMT DODECYL-BETA-D-MALTOSIDE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；291 K；12-14.5% PEG4K; 15% GLycerol; 400 mM NaSCN; 3% DMSO; 100mM NaAcetate pH 4.
|
Resolution 3.50 Å R-free 0.241 |
| 6HYV THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT Y119A Deposited 2018-10-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | LMT DODECYL-BETA-D-MALTOSIDE × 11 ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 CL CHLORIDE ION × 7 NA SODIUM ION × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；291 K；12-14.5% PEG4K; 15% GLycerol; 400 mM NaSCN; 3% DMSO; 100mM NaAcetate pH 4
|
Resolution 2.80 Å R-free 0.221 |
| 6HYW THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT Y119F Deposited 2018-10-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；291 K；12-14.5% PEG4K; 15% GLycerol; 400 mM NaSCN; 3% DMSO; 100mM NaAcetate pH 4.
|
Resolution 2.80 Å R-free 0.212 |
| 6HYX THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT Y197F-P250C Deposited 2018-10-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain B
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain C
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain D
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain E
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
|
Mutation：YES Mutation：YES Mutation：YES Mutation：YES Mutation：YES | CL CHLORIDE ION × 5 NA SODIUM ION × 7 LMT DODECYL-BETA-D-MALTOSIDE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；pH 4；293 K；PH 4, VAPOR DIFFUSION, TEMPERATURE 293K.12-14.5% PEG4K; 15% GLycerol; 400 mM NaSCN; 3% DMSO; 100mM NaAcetate pH 4
|
Resolution 3.00 Å R-free 0.224 |
| 6HYZ THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT K248C Deposited 2018-10-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 15 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；291 K；12-14.5% PEG4K; 15% GLycerol; 400 mM NaSCN; 3% DMSO; 100mM NaAcetate pH 4
|
Resolution 3.05 Å R-free 0.234 |
| 6HZ0 THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT K248A Deposited 2018-10-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 15 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；291 K；12-14.5% PEG4K; 15% GLycerol; 400 mM NaSCN; 3% DMSO; 100mM NaAcetate pH 4.
|
Resolution 2.75 Å R-free 0.238 |
| 6HZ1 THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT E243C Deposited 2018-10-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Chain B
44–359（316 aa）
Chain C
44–359（316 aa）
Chain D
44–359（316 aa）
Chain E
44–359（316 aa）
|
Not recorded | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 15 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；pH 4；291 K；12-15% PEG4K, 0.1M NA ACETATE PH4,
0.4M NASCN, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 291K
|
Resolution 2.50 Å R-free 0.216 |
| 6HZ3 THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT E243G Deposited 2018-10-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain B
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain C
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain D
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain E
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
|
Mutation：YES Mutation：YES Mutation：YES Mutation：YES Mutation：YES | CL CHLORIDE ION × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；pH 4；293 K；PH 4, VAPOR DIFFUSION, TEMPERATURE 293K,12-14.5% PEG4K; 15% GLycerol; 400 mM NaSCN; 3% DMSO; 100mM NaAcetate pH 4
|
Resolution 3.15 Å R-free 0.249 |
| 6HZW THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL 2.22 resolution Deposited 2018-10-24 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 15 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 11 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；291 K；12-14.5% PEG4K; 15% GLycerol; 400 mM NaSCN; 3% DMSO; 100mM NaAcetate pH 4.
|
Resolution 2.22 Å R-free 0.220 |
| 6I08 THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT E243C-I201W Deposited 2018-10-25 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain B
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain C
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain D
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain E
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
|
Mutation：YES Mutation：YES Mutation：YES Mutation：YES Mutation：YES | CL CHLORIDE ION × 5 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 LMT DODECYL-BETA-D-MALTOSIDE × 1 NA SODIUM ION × 7 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；pH 4；293 K；PH 4, VAPOR DIFFUSION, TEMPERATURE 293K 12-14.5% PEG4K; 15% GLycerol; 400 mM NaSCN; 3% DMSO; 100mM NaAcetate pH 4.
|
Resolution 3.00 Å R-free 0.228 |
| 6ZGD GLIC pentameric ligand-gated ion channel, pH 7 Deposited 2020-06-18 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Chain B
44–359（316 aa）
Chain C
44–359（316 aa）
Chain D
44–359（316 aa）
Chain E
44–359（316 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE；blot for 1.5 s
force -1
|
Resolution 4.10 Å |
| 6ZGJ GLIC pentameric ligand-gated ion channel, pH 5 Deposited 2020-06-18 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Chain B
44–359（316 aa）
Chain C
44–359（316 aa）
Chain D
44–359（316 aa）
Chain E
44–359（316 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE；blot for 1.5 s
force -1
|
Resolution 3.40 Å |
| 6ZGK GLIC pentameric ligand-gated ion channel, pH 3 Deposited 2020-06-18 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Chain B
44–359（316 aa）
Chain C
44–359（316 aa）
Chain D
44–359（316 aa）
Chain E
44–359（316 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 3
cryo-EM vitrification conditions
Cryogen ETHANE；blot for 1.5 s
force -1
|
Resolution 3.60 Å |
| 8ATG Pentameric ligand-gated ion channel GLIC with bound lipids Deposited 2022-08-23 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
44–359（316 aa）
Chain B
44–359（316 aa）
Chain C
44–359（316 aa）
Chain D
44–359（316 aa）
Chain E
44–359（316 aa）
|
Not recorded | POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 25 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.90 Å |
| 8I41 Cryo-EM structure of nanodisc (asolectin) reconstituted GLIC at pH 7.5 Deposited 2023-01-18 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
47–359（313 aa）
Chain B
47–359（313 aa）
Chain C
47–359（313 aa）
Chain D
47–359（313 aa）
Chain E
47–359（313 aa）
|
Not recorded | PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 25 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.42 Å |
| 8I42 Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 7.5 Deposited 2023-01-18 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
47–358（312 aa）
Chain B
47–358（312 aa）
Chain C
47–358（312 aa）
Chain D
47–358（312 aa）
Chain E
47–358（312 aa）
|
Not recorded | PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 40 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.92 Å |
| 8I47 Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 5.5 Deposited 2023-01-18 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
47–358（312 aa）
Chain B
47–358（312 aa）
Chain C
47–358（312 aa）
Chain D
47–358（312 aa）
Chain E
47–358（312 aa）
|
Not recorded | PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 30 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 5.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.70 Å |
| 8I48 Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 4 in closed state Deposited 2023-01-18 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
47–358（312 aa）
Chain B
47–358（312 aa）
Chain C
47–358（312 aa）
Chain D
47–358（312 aa）
Chain E
47–358（312 aa）
|
Not recorded | CL CHLORIDE ION × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 40 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.74 Å |
| 8JJ3 Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 2.5 Deposited 2023-05-29 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
47–358（312 aa）
Chain B
47–358（312 aa）
Chain C
47–358（312 aa）
Chain D
47–358（312 aa）
Chain E
47–358（312 aa）
|
Not recorded | CL CHLORIDE ION × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 45 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 2.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.65 Å |
| 8WCQ Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 4 in intermediate state Deposited 2023-09-13 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
47–358（312 aa）
Chain B
47–358（312 aa）
Chain C
47–358（312 aa）
Chain D
47–358（312 aa）
Chain E
47–358（312 aa）
|
Not recorded | CL CHLORIDE ION × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 40 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.35 Å |
| 8WCR Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 4 in open state Deposited 2023-09-13 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
47–358（312 aa）
Chain B
47–358（312 aa）
Chain C
47–358（312 aa）
Chain D
47–358（312 aa）
Chain E
47–358（312 aa）
|
Not recorded | CL CHLORIDE ION × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 45 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.74 Å |
| 9LAG Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 4 in iiiii conformation Deposited 2025-01-02 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
47–358（312 aa）
Chain B
47–358（312 aa）
Chain C
47–358（312 aa）
Chain D
47–358（312 aa）
Chain E
47–358（312 aa）
|
Not recorded | PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 30 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.96 Å |
| 9LAI Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 4 in iiiio conformation Deposited 2025-01-02 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
47–358（312 aa）
Chain B
47–358（312 aa）
Chain C
47–358（312 aa）
Chain D
47–358（312 aa）
Chain E
47–358（312 aa）
|
Not recorded | CL CHLORIDE ION × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 24 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.08 Å |
| 9LAJ Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 4 in iiioo conformation Deposited 2025-01-02 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
47–358（312 aa）
Chain B
47–358（312 aa）
Chain C
47–358（312 aa）
Chain D
47–358（312 aa）
Chain E
47–358（312 aa）
|
Not recorded | CL CHLORIDE ION × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 23 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.16 Å |
| 9LAK Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 4 in iiooo conformation Deposited 2025-01-02 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
47–358（312 aa）
Chain B
47–358（312 aa）
Chain C
47–358（312 aa）
Chain D
47–358（312 aa）
Chain E
47–358（312 aa）
|
Not recorded | CL CHLORIDE ION × 3 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 19 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.21 Å |
| 9LB9 Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 4 in ioooo conformation Deposited 2025-01-03 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
47–358（312 aa）
Chain B
47–358（312 aa）
Chain C
47–358（312 aa）
Chain D
47–358（312 aa）
Chain E
47–358（312 aa）
|
Not recorded | CL CHLORIDE ION × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 22 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.16 Å |
| 9LBA Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 4 in ooooo conformation Deposited 2025-01-03 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
47–358（312 aa）
Chain B
47–358（312 aa）
Chain C
47–358（312 aa）
Chain D
47–358（312 aa）
Chain E
47–358（312 aa）
|
Not recorded | CL CHLORIDE ION × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 35 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.85 Å |
| 9LBB Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 4 in iioio conformation Deposited 2025-01-03 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
47–358（312 aa）
Chain B
47–358（312 aa）
Chain C
47–358（312 aa）
Chain D
47–358（312 aa）
Chain E
47–358（312 aa）
|
Not recorded | PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.45 Å |
| 9LBC Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 4 in ioioo conformation Deposited 2025-01-03 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
47–358（312 aa）
Chain B
47–358（312 aa）
Chain C
47–358（312 aa）
Chain D
47–358（312 aa）
Chain E
47–358（312 aa）
|
Not recorded | PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 5 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.40 Å |
| 9LBD Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC F116A mutant at pH 2.5 Deposited 2025-01-03 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
47–358（312 aa）
Chain B
47–358（312 aa）
Chain C
47–358（312 aa）
Chain D
47–358（312 aa）
Chain E
47–358（312 aa）
|
Mutation：F116A Mutation：F116A Mutation：F116A Mutation：F116A Mutation：F116A | CL CHLORIDE ION × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 25 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 2.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.14 Å |
| 9LBE Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC Y251A mutant at pH 2.5 in ioooo conformation Deposited 2025-01-03 | Different construct Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric |
Chain A
47–358（312 aa）
Chain B
47–358（312 aa）
Chain C
47–358（312 aa）
Chain D
47–358（312 aa）
Chain E
47–358（312 aa）
|
Mutation：Y251 Mutation：Y251 Mutation：Y251 Mutation：Y251 Mutation：Y251 | CL CHLORIDE ION × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 21 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 2.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.87 Å |
129 other PDB entries and 134 assemblies. Open the comparison page and filter oligomeric states
View Construct and Data Evidence
| UniProt name | Q7NDN8_GLOVI |
| Isoform | — |
| PDB entities | 1 |
| Chains and sequence ranges | Author chain A； PDBConstruct 6–321； UniProt 44–359 Author chain B； PDBConstruct 6–321； UniProt 44–359 Author chain C； PDBConstruct 6–321； UniProt 44–359 Author chain D； PDBConstruct 6–321； UniProt 44–359 Author chain E； PDBConstruct 6–321； UniProt 44–359 Author chain F； PDBConstruct 6–321； UniProt 44–359 Author chain G； PDBConstruct 6–321； UniProt 44–359 Author chain H； PDBConstruct 6–321； UniProt 44–359 Author chain I； PDBConstruct 6–321； UniProt 44–359 Author chain J； PDBConstruct 6–321； UniProt 44–359 |
