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4x5t

alpha 1 glycine receptor transmembrane structure fused to the extracellular domain of GLIC

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Proton-gated ion channel,GLRA1 protein,GLRA1 protein

Homo sapiens

UniProt Q14C71

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Homooligomer Protein 5 NICKEL (II) ION × 6 CHLORIDE ION × 6 ACETATE ION × 5 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
4x5t

1 assemblies

View Construct and Data Evidence
UniProt name Q14C71_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 193–283； UniProt 165–255 Author chain A； PDBConstruct 287–315； UniProt 327–355 Author chain B； PDBConstruct 193–283； UniProt 165–255 Author chain B； PDBConstruct 287–315； UniProt 327–355 Author chain C； PDBConstruct 193–283； UniProt 165–255 Author chain C； PDBConstruct 287–315； UniProt 327–355 Author chain D； PDBConstruct 193–283； UniProt 165–255 Author chain D； PDBConstruct 287–315； UniProt 327–355 Author chain E； PDBConstruct 193–283； UniProt 165–255 Author chain E； PDBConstruct 287–315； UniProt 327–355

Proton-gated ion channel,GLRA1 protein,GLRA1 protein

Homo sapiens

UniProt Q7NDN8

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Homooligomer Protein 5 NICKEL (II) ION × 6 CHLORIDE ION × 6 ACETATE ION × 5 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers
2xq3 2xq4 2xq5 2xq6 2xq7 2xq8 2xq9 2xqa 3eam 3ehz 3ei0 3igq

131 assemblies; showing the first 12

Heteromeric or nucleic-acid complex
4x5t 4yeu 5osa 5osb 5osc

5 assemblies

View Construct and Data Evidence
UniProt name GLIC_GLOVI
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–192； UniProt 44–235 Author chain B； PDBConstruct 1–192； UniProt 44–235 Author chain C； PDBConstruct 1–192； UniProt 44–235 Author chain D； PDBConstruct 1–192； UniProt 44–235 Author chain E； PDBConstruct 1–192； UniProt 44–235

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id4x5t
Deposition date deposition_date2014-12-05
Structure title titlealpha 1 glycine receptor transmembrane structure fused to the extracellular domain of GLIC
Keywords keywordsCys-loop, receptor pentameric, glycine receptor, transmembrane receptor, signaling protein; SIGNALING PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4x5t__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4x5t__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

4x5t__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）37.31 Å
Rg (electron density)36.56 Å
Total Rg36.89 Å
Atom count11480
Residues1536
Excluded volume204990 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 4x5t__assembly_1__model_1 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 10 domains

CATH v4.4 (10 domains)

Domain ID domain_id4x5tA01
Class class2 — Mainly Beta
Architecture architecture70 — Distorted Sandwich
Topology topology170 — Acetylcholine Binding Protein; Chain: A,
Homologous superfamily homologous superfamily10 — Neurotransmitter-gated ion-channel ligand-binding domain
Domain ID domain_id4x5tA02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily390 — Neurotransmitter-gated ion-channel transmembrane domain
Domain ID domain_id4x5tB01
Class class2 — Mainly Beta
Architecture architecture70 — Distorted Sandwich
Topology topology170 — Acetylcholine Binding Protein; Chain: A,
Homologous superfamily homologous superfamily10 — Neurotransmitter-gated ion-channel ligand-binding domain
Domain ID domain_id4x5tB02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily390 — Neurotransmitter-gated ion-channel transmembrane domain
Domain ID domain_id4x5tC01
Class class2 — Mainly Beta
Architecture architecture70 — Distorted Sandwich
Topology topology170 — Acetylcholine Binding Protein; Chain: A,
Homologous superfamily homologous superfamily10 — Neurotransmitter-gated ion-channel ligand-binding domain
Domain ID domain_id4x5tC02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily390 — Neurotransmitter-gated ion-channel transmembrane domain
Domain ID domain_id4x5tD01
Class class2 — Mainly Beta
Architecture architecture70 — Distorted Sandwich
Topology topology170 — Acetylcholine Binding Protein; Chain: A,
Homologous superfamily homologous superfamily10 — Neurotransmitter-gated ion-channel ligand-binding domain
Domain ID domain_id4x5tD02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily390 — Neurotransmitter-gated ion-channel transmembrane domain
Domain ID domain_id4x5tE01
Class class2 — Mainly Beta
Architecture architecture70 — Distorted Sandwich
Topology topology170 — Acetylcholine Binding Protein; Chain: A,
Homologous superfamily homologous superfamily10 — Neurotransmitter-gated ion-channel ligand-binding domain
Domain ID domain_id4x5tE02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily390 — Neurotransmitter-gated ion-channel transmembrane domain
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7. Citations (1)