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4cc7

Crystal structure of the sixth or C-terminal SH3 domain of human Tuba in complex with proline-rich peptides of N-WASP. Space group P41

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

DYNAMIN-BINDING PROTEIN

HOMO SAPIENS

UniProt Q6XZF7

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 NEURAL WISKOTT-ALDRICH SYNDROME PROTEIN × 1 （O00401） GLYCEROL × 1 CHLORIDE ION × 2 water × 1 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 NEURAL WISKOTT-ALDRICH SYNDROME PROTEIN × 1 （O00401） GLYCEROL × 1 CHLORIDE ION × 3 water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 NEURAL WISKOTT-ALDRICH SYNDROME PROTEIN × 1 （O00401） CHLORIDE ION × 2 water × 2 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 NEURAL WISKOTT-ALDRICH SYNDROME PROTEIN × 1 （O00401） CHLORIDE ION × 2 water × 2 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 2 NEURAL WISKOTT-ALDRICH SYNDROME PROTEIN × 1 （O00401） CHLORIDE ION × 1 water × 1 Consistent with protein count
6 Protein heterocomplex Heteromer Protein 2 NEURAL WISKOTT-ALDRICH SYNDROME PROTEIN × 1 （O00401） GLYCEROL × 1 CHLORIDE ION × 3 MAGNESIUM ION × 1 water × 2 Consistent with protein count
7 Protein heterocomplex Heteromer Protein 2 NEURAL WISKOTT-ALDRICH SYNDROME PROTEIN × 1 （O00401） GLYCEROL × 1 CHLORIDE ION × 4 MAGNESIUM ION × 1 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1ug1 1uhc 4glm 4glm 4glm 4glm

6 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
4cc2 4cc2 4cc3 4cc3 4cc3 4cc3 4cc4 4cc4 4cc4 4cc7 4cc7 4cc7

16 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name DNMBP_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 3–67； UniProt 1513–1577 Author chain C； PDBConstruct 3–67； UniProt 1513–1577 Author chain E； PDBConstruct 3–67； UniProt 1513–1577 Author chain G； PDBConstruct 3–67； UniProt 1513–1577 Author chain I； PDBConstruct 3–67； UniProt 1513–1577 Author chain K； PDBConstruct 3–67； UniProt 1513–1577 Author chain M； PDBConstruct 3–67； UniProt 1513–1577

NEURAL WISKOTT-ALDRICH SYNDROME PROTEIN

OrganismNot specified

UniProt O00401

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 DYNAMIN-BINDING PROTEIN × 1 （Q6XZF7） GLYCEROL × 1 CHLORIDE ION × 2 water × 1 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 DYNAMIN-BINDING PROTEIN × 1 （Q6XZF7） GLYCEROL × 1 CHLORIDE ION × 3 water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 DYNAMIN-BINDING PROTEIN × 1 （Q6XZF7） CHLORIDE ION × 2 water × 2 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 DYNAMIN-BINDING PROTEIN × 1 （Q6XZF7） CHLORIDE ION × 2 water × 2 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 2 DYNAMIN-BINDING PROTEIN × 1 （Q6XZF7） CHLORIDE ION × 1 water × 1 Consistent with protein count
6 Protein heterocomplex Heteromer Protein 2 DYNAMIN-BINDING PROTEIN × 1 （Q6XZF7） GLYCEROL × 1 CHLORIDE ION × 3 MAGNESIUM ION × 1 water × 2 Consistent with protein count
7 Protein heterocomplex Heteromer Protein 2 DYNAMIN-BINDING PROTEIN × 1 （Q6XZF7） GLYCEROL × 1 CHLORIDE ION × 4 MAGNESIUM ION × 1 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2ff3 2lnh 2vcp 2vcp 4cc2 4cc2 4cc7 4cc7 4cc7 4cc7 4cc7 4cc7

16 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name WASL_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–12； UniProt 346–357 Author chain D； PDBConstruct 1–12； UniProt 346–357 Author chain F； PDBConstruct 1–12； UniProt 346–357 Author chain H； PDBConstruct 1–12； UniProt 346–357 Author chain J； PDBConstruct 1–12； UniProt 346–357 Author chain L； PDBConstruct 1–12； UniProt 346–357 Author chain N； PDBConstruct 1–12； UniProt 346–357

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id4cc7
Deposition date deposition_date2013-10-18
Structure title titleCrystal structure of the sixth or C-terminal SH3 domain of human Tuba in complex with proline-rich peptides of N-WASP. Space group P41
Keywords keywordsSTRUCTURAL PROTEIN, SRC HOMOLOGY 3, PROLINE-RICH PEPTIDE, ACTIN CYTOSKELETON, CORTICAL TENSION, CELL-CELL CONTACTS; STRUCTURAL PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4cc7__assembly_2__model_1

Assembly 2 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4cc7__assembly_2__model_1 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

4cc7__assembly_2__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）12.71 Å
Rg (electron density)11.34 Å
Total Rg12.91 Å
Atom count604
Residues75
Excluded volume10818 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 4cc7__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 4cc7__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 4cc7__assembly_3__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 4cc7__assembly_4__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
5 1 4cc7__assembly_5__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
6 1 4cc7__assembly_6__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
7 1 4cc7__assembly_7__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (6)

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6. Fold Classification (SCOP + CATH) 7 domains

CATH v4.4 (7 domains)

Domain ID domain_id4cc7A00
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology30 — SH3 type barrels.
Homologous superfamily homologous superfamily40 — SH3 Domains
Domain ID domain_id4cc7C00
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology30 — SH3 type barrels.
Homologous superfamily homologous superfamily40 — SH3 Domains
Domain ID domain_id4cc7E00
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology30 — SH3 type barrels.
Homologous superfamily homologous superfamily40 — SH3 Domains
Domain ID domain_id4cc7G00
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology30 — SH3 type barrels.
Homologous superfamily homologous superfamily40 — SH3 Domains
Domain ID domain_id4cc7I00
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology30 — SH3 type barrels.
Homologous superfamily homologous superfamily40 — SH3 Domains
Domain ID domain_id4cc7K00
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology30 — SH3 type barrels.
Homologous superfamily homologous superfamily40 — SH3 Domains
Domain ID domain_id4cc7M00
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology30 — SH3 type barrels.
Homologous superfamily homologous superfamily40 — SH3 Domains
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7. Citations (1)