← Back to search
4drb

The crystal structure of FANCM bound MHF complex

Method: X-RAY DIFFRACTION
▼

1. Protein Identity and Related Structures Protein Identity & Related Structures

Centromere protein S

Homo sapiens

UniProt Q8N2Z9

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 5 Fanconi anemia group M protein × 1 （Q8IYD8） Centromere protein X × 2 （A8MT69） water × 5 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 5 Fanconi anemia group M protein × 1 （Q8IYD8） Centromere protein X × 2 （A8MT69） water × 5 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 5 Fanconi anemia group M protein × 1 （Q8IYD8） Centromere protein X × 2 （A8MT69） water × 5 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
28op 4dra 4dra 4drb 4drb 4drb 4e44 4e45 4e45 4e45 4ndy 4ndy

28 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name CENPS_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 7–120； UniProt 1–114 Author chain B； PDBConstruct 7–120； UniProt 1–114 Author chain D； PDBConstruct 7–120； UniProt 1–114 Author chain E； PDBConstruct 7–120； UniProt 1–114 Author chain G； PDBConstruct 7–120； UniProt 1–114 Author chain H； PDBConstruct 7–120； UniProt 1–114

Fanconi anemia group M protein

Homo sapiens

UniProt Q8IYD8

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 5 Centromere protein S × 2 （Q8N2Z9） Centromere protein X × 2 （A8MT69） water × 5 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 5 Centromere protein S × 2 （Q8N2Z9） Centromere protein X × 2 （A8MT69） water × 5 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 5 Centromere protein S × 2 （Q8N2Z9） Centromere protein X × 2 （A8MT69） water × 5 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
4bxo 4day 4drb 4drb 4drb 4e45 4e45 4e45 4m6w 9el5 9hjo

11 assemblies

View Construct and Data Evidence
UniProt name FANCM_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain C； PDBConstruct 2–141； UniProt 661–800 Author chain F； PDBConstruct 2–141； UniProt 661–800 Author chain I； PDBConstruct 2–141； UniProt 661–800

Centromere protein X

Homo sapiens

UniProt A8MT69

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 5 Centromere protein S × 2 （Q8N2Z9） Fanconi anemia group M protein × 1 （Q8IYD8） water × 5 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 5 Centromere protein S × 2 （Q8N2Z9） Fanconi anemia group M protein × 1 （Q8IYD8） water × 5 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 5 Centromere protein S × 2 （Q8N2Z9） Fanconi anemia group M protein × 1 （Q8IYD8） water × 5 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
28op 4dra 4dra 4drb 4drb 4drb 4e44 4e45 4e45 4e45 4ndy 4ndy

28 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name CENPX_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain J； PDBConstruct 4–84； UniProt 1–81 Author chain K； PDBConstruct 4–84； UniProt 1–81 Author chain L； PDBConstruct 4–84； UniProt 1–81 Author chain M； PDBConstruct 4–84； UniProt 1–81 Author chain N； PDBConstruct 4–84； UniProt 1–81 Author chain O； PDBConstruct 4–84； UniProt 1–81

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

▼

2. Structure Basics 2. Structure Basics

Entry ID entry_id4drb
Deposition date deposition_date2012-02-17
Structure title titleThe crystal structure of FANCM bound MHF complex
Keywords keywords;DNA repair, DNA binding complex, Histone fold, DNA damage repair, DNA binding, DNA BINDING-PROTEIN BINDING complex, DNA BINDING PROTEIN-PROTEIN BINDING complex ;; DNA BINDING PROTEIN/PROTEIN BINDING
Experimental Method methodX-RAY DIFFRACTION
▼

3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4drb__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4drb__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

4drb__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）24.02 Å
Rg (electron density)22.83 Å
Total Rg23.61 Å
Atom count3538
Residues449
Excluded volume62804 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 4drb__assembly_1__model_1 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 4drb__assembly_2__model_1 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 4drb__assembly_3__model_1 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
▶

4. Crystallography and Experiment 4. Crystallography & Experiment

▶

5. Entities and Polymers Entities & Polymers (4)

▼

6. Fold Classification (SCOP + CATH) 18 domains

CATH v4.4 (18 domains)

Domain ID domain_id4drbA00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology20 — Histone, subunit A
Homologous superfamily homologous superfamily10 — Histone, subunit A
Domain ID domain_id4drbB00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology20 — Histone, subunit A
Homologous superfamily homologous superfamily10 — Histone, subunit A
Domain ID domain_id4drbD00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology20 — Histone, subunit A
Homologous superfamily homologous superfamily10 — Histone, subunit A
Domain ID domain_id4drbE00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology20 — Histone, subunit A
Homologous superfamily homologous superfamily10 — Histone, subunit A
Domain ID domain_id4drbG00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology20 — Histone, subunit A
Homologous superfamily homologous superfamily10 — Histone, subunit A
Domain ID domain_id4drbH00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology20 — Histone, subunit A
Homologous superfamily homologous superfamily10 — Histone, subunit A
Domain ID domain_id4drbJ01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homologous superfamily homologous superfamily4980 —
Domain ID domain_id4drbJ02
Class class6 — Special
Architecture architecture10 — Helix non-globular
Topology topology130 — GTP Cyclohydrolase I; Chain A, domain 1
Homologous superfamily homologous superfamily30 —
Domain ID domain_id4drbK01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homologous superfamily homologous superfamily4980 —
Domain ID domain_id4drbK02
Class class6 — Special
Architecture architecture10 — Helix non-globular
Topology topology130 — GTP Cyclohydrolase I; Chain A, domain 1
Homologous superfamily homologous superfamily30 —
Domain ID domain_id4drbL01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homologous superfamily homologous superfamily4980 —
Domain ID domain_id4drbL02
Class class6 — Special
Architecture architecture10 — Helix non-globular
Topology topology130 — GTP Cyclohydrolase I; Chain A, domain 1
Homologous superfamily homologous superfamily30 —
Domain ID domain_id4drbM01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homologous superfamily homologous superfamily4980 —
Domain ID domain_id4drbM02
Class class6 — Special
Architecture architecture10 — Helix non-globular
Topology topology130 — GTP Cyclohydrolase I; Chain A, domain 1
Homologous superfamily homologous superfamily30 —
Domain ID domain_id4drbN01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homologous superfamily homologous superfamily4980 —
Domain ID domain_id4drbN02
Class class6 — Special
Architecture architecture10 — Helix non-globular
Topology topology130 — GTP Cyclohydrolase I; Chain A, domain 1
Homologous superfamily homologous superfamily30 —
Domain ID domain_id4drbO01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homologous superfamily homologous superfamily4980 —
Domain ID domain_id4drbO02
Class class6 — Special
Architecture architecture10 — Helix non-globular
Topology topology130 — GTP Cyclohydrolase I; Chain A, domain 1
Homologous superfamily homologous superfamily30 —
▶

7. Citations (1)