Homo sapiens
| Assembly | Physical composition | Protein state | Molecular copy count | Associated components | Data consistency |
|---|---|---|---|---|---|
| 1 | Protein heterocomplex | Heteromer | Protein 4 | CG peptide × 2 SULFATE ION × 6 water × 2 | Consistent with protein count |
| UniProt name | TYSY_HUMAN |
| Isoform | — |
| PDB entities | 1 |
| Chains and sequence ranges | Author chain A； PDBConstruct 41–323； UniProt 29–311 |
The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.
| Entry ID entry_id | 4fgt |
| Deposition date deposition_date | 2012-06-04 |
| Structure title title | Allosteric peptidic inhibitor of human thymidylate synthase that stabilizes inactive conformation of the enzyme. |
| Keywords keywords | ;dimer, mutant K47A of hTS, inactive hTS conformation, hTS complex with peptidic inhibitor, transferase-transferase inhibitor complex ;; transferase/transferase inhibitor |
| Experimental Method method | X-RAY DIFFRACTION |
This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.
Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)
| Rg（Guinier） | 24.70 Å |
| Rg (electron density) | 23.53 Å |
| Total Rg | 24.45 Å |
| Atom count | 4444 |
| Residues | 538 |
| Excluded volume | 79231 ų |
| Maximum q | 0.500 Å⁻¹ |
| Domain ID domain_id | 4fgtA00 |
| Class class | 3 — Alpha Beta |
| Architecture architecture | 30 — 2-Layer Sandwich |
| Topology topology | 572 — Thymidylate Synthase; Chain A |
| Homologous superfamily homologous superfamily | 10 — Thymidylate synthase/dCMP hydroxymethylase domain |