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4g2o

Human Thymidylate Synthase M190K with bound Purpurogallin

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Thymidylate synthase

Homo sapiens

UniProt P04818

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 2,3,4,6-tetrahydroxy-5H-benzo[7]annulen-5-one × 1 SULFATE ION × 2 water × 1 Consistent with protein count
2 Protein homooligomer Homooligomer Protein 2 2,3,4,6-tetrahydroxy-5H-benzo[7]annulen-5-one × 2 SULFATE ION × 4 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
3egy 3ehi 4g2o 4g6w 4gd7 4up1 4up1 4up1 4up1 6oju 6oju 6oju

13 assemblies; showing the first 12

Homodimer
1hvy 1hvy 1hw3 1hw4 1hzw 1i00 1ju6 1ju6 1juj 1juj 1ypv 2rd8

103 assemblies; showing the first 12

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
3n5e 4fgt

2 assemblies

View Construct and Data Evidence
UniProt name TYSY_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain X； PDBConstruct 1–313； UniProt 1–313

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id4g2o
Deposition date deposition_date2012-07-12
Structure title titleHuman Thymidylate Synthase M190K with bound Purpurogallin
Keywords keywordsMethyltransferase, Transferase, TRANSFERASE-TRANSFERASE INHIBITOR complex; TRANSFERASE/TRANSFERASE INHIBITOR
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4g2o__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4g2o__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

4g2o__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）20.12 Å
Rg (electron density)18.78 Å
Total Rg19.76 Å
Atom count2181
Residues271
Excluded volume38593 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 4g2o__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 4g2o__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (1 domains)

Domain ID domain_idd4g2ox_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.117 — Thymidylate synthase/dCMP hydroxymethylase
Superfamily Superfamily superfamilyd.117.1 — Thymidylate synthase/dCMP hydroxymethylase
Family Family familyd.117.1.1 — Thymidylate synthase/dCMP hydroxymethylase

CATH v4.4 (1 domains)

Domain ID domain_id4g2oX00
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology572 — Thymidylate Synthase; Chain A
Homologous superfamily homologous superfamily10 — Thymidylate synthase/dCMP hydroxymethylase domain
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7. Citations (1)