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4mgi

Selective activation of Epac1 and Epac2

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Rap guanine nucleotide exchange factor 4

Mus musculus

UniProt Q9EQZ6

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Ras-related protein Rap-1b × 1 （P61224） ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE × 2 SULFATE ION × 1 water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 4 Ras-related protein Rap-1b × 2 （P61224） ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE × 4 SULFATE ION × 2 water × 4 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2byv 4f7z

2 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
4mgi 4mgi 4mgk 4mgk 4mgy 4mgy 4mgz 4mgz 4mh0 4mh0

10 assemblies

View Construct and Data Evidence
UniProt name RPGF4_MOUSE
Isoform —
PDB entities 1
Chains and sequence ranges Author chain E； PDBConstruct 7–694； UniProt 324–1011

Ras-related protein Rap-1b

Homo sapiens

UniProt P61224

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Rap guanine nucleotide exchange factor 4 × 1 （Q9EQZ6） ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE × 2 SULFATE ION × 1 water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 4 Rap guanine nucleotide exchange factor 4 × 2 （Q9EQZ6） ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE × 4 SULFATE ION × 2 water × 4 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
3brw

1 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
3cf6 3cf6 4dxa 4hdo 4hdq 4m8n 4m8n 4mgi 4mgi 4mgk 4mgk 4mgy

38 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name RAP1B_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain R； PDBConstruct 1–167； UniProt 1–167

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id4mgi
Deposition date deposition_date2013-08-28
Structure title titleSelective activation of Epac1 and Epac2
Keywords keywordsGuanine Nucleotide Exchange Factor, Nucleotide Binding, SIGNALING PROTEIN-GTP-BINDING PROTEIN complex; SIGNALING PROTEIN/GTP-BINDING PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4mgi__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4mgi__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

4mgi__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）32.30 Å
Rg (electron density)31.75 Å
Total Rg32.36 Å
Atom count6287
Residues777
Excluded volume112320 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 4mgi__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 4mgi__assembly_2__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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6. Fold Classification (SCOP + CATH) 7 domains

SCOP 2.08 (1 domains)

Domain ID domain_idd4mgir_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family familyc.37.1.8 — G proteins

CATH v4.4 (6 domains)

Domain ID domain_id4mgiE01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology8 — Helicase, Ruva Protein; domain 3
Homologous superfamily homologous superfamily1240 —
Domain ID domain_id4mgiE02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily10 — Jelly Rolls
Domain ID domain_id4mgiE03
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology870 — Son of sevenless (SoS) protein; Chain S, domain 1
Homologous superfamily homologous superfamily10 — Son of sevenless (SoS) protein Chain: S domain 1
Domain ID domain_id4mgiE04
Class class3 — Alpha Beta
Architecture architecture10 — Roll
Topology topology20 — Ubiquitin-like (UB roll)
Homologous superfamily homologous superfamily90 — Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Domain ID domain_id4mgiE05
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology840 — Son of Sevenless (SoS) protein; Chain S, domain 2
Homologous superfamily homologous superfamily10 — Ras guanine-nucleotide exchange factors catalytic domain
Domain ID domain_id4mgiR00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
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7. Citations (1)