4o9r

Human Smoothened Receptor structure in complex with cyclopamine

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Smoothened homolog/Soluble cytochrome b562 chimeric protein

Escherichia coli

UniProt P0ABE7

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Monomer Protein 1 Cyclopamine × 1 Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name C562_ECOLX
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A; PDBConstruct 248–353; UniProt 23–128

Smoothened homolog/Soluble cytochrome b562 chimeric protein

Escherichia coli

UniProt Q99835

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Monomer Protein 1 Cyclopamine × 1 Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name SMO_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A; PDBConstruct 4–247; UniProt 190–433 Author chain A; PDBConstruct 354–468; UniProt 441–555

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id4o9r
Deposition date deposition_date2014-01-02
Structure title titleHuman Smoothened Receptor structure in complex with cyclopamine
Keywords keywords;serial femtosecond crystallography, human SMO receptor, cyclopamine, novel protein engineering, GPCR network, PSI-Biology, free electron laser, Structural Genomics, membrane protein, XFEL, LCP, room temperature structure, GPCR, membrane, SIGNALING PROTEIN ;; SIGNALING PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4o9r__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4o9r__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

4o9r__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg(Guinier)32.77 Å
Rg (electron density)32.13 Å
Total Rg32.43 Å
Atom count3419
Residues441
Excluded volume61263 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 4o9r__assembly_1__model_1 monomeric (1) Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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7. Citations (1)