4qvy

yCP beta5-A49T-mutant in complex with bortezomib

Method: X-RAY DIFFRACTION

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1. Protein Identity and Related Structures Protein Identity & Related Structures

PROTEASOME SUBUNIT ALPHA TYPE-2

OrganismNot specified

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	PROTEASOME SUBUNIT ALPHA TYPE-3 × 2 （P23638） PROTEASOME SUBUNIT ALPHA TYPE-4 × 2 （P40303） PROTEASOME SUBUNIT ALPHA TYPE-5 × 2 （P32379） PROTEASOME SUBUNIT ALPHA TYPE-6 × 2 （P40302） PROBABLE PROTEASOME SUBUNIT ALPHA TYPE-7 × 2 （P21242） PROTEASOME SUBUNIT ALPHA TYPE-1 × 2 （P21243） PROTEASOME SUBUNIT BETA TYPE-2 × 2 （P25043） PROTEASOME SUBUNIT BETA TYPE-3 × 2 （P25451） PROTEASOME SUBUNIT BETA TYPE-4 × 2 （P22141） PROTEASOME SUBUNIT BETA TYPE-5 × 2 （P30656） PROTEASOME SUBUNIT BETA TYPE-6 × 2 （P23724） PROTEASOME SUBUNIT BETA TYPE-7 × 2 （P30657） PROTEASOME SUBUNIT BETA TYPE-1 × 2 （P38624） MAGNESIUM ION × 9 CHLORIDE ION × 4 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6 water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSA2_YEAST
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–250； UniProt 1–250 Author chain O； PDBConstruct 1–250； UniProt 1–250

PROTEASOME SUBUNIT ALPHA TYPE-3

OrganismNot specified

UniProt P23638

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	PROTEASOME SUBUNIT ALPHA TYPE-2 × 2 （P23639） PROTEASOME SUBUNIT ALPHA TYPE-4 × 2 （P40303） PROTEASOME SUBUNIT ALPHA TYPE-5 × 2 （P32379） PROTEASOME SUBUNIT ALPHA TYPE-6 × 2 （P40302） PROBABLE PROTEASOME SUBUNIT ALPHA TYPE-7 × 2 （P21242） PROTEASOME SUBUNIT ALPHA TYPE-1 × 2 （P21243） PROTEASOME SUBUNIT BETA TYPE-2 × 2 （P25043） PROTEASOME SUBUNIT BETA TYPE-3 × 2 （P25451） PROTEASOME SUBUNIT BETA TYPE-4 × 2 （P22141） PROTEASOME SUBUNIT BETA TYPE-5 × 2 （P30656） PROTEASOME SUBUNIT BETA TYPE-6 × 2 （P23724） PROTEASOME SUBUNIT BETA TYPE-7 × 2 （P30657） PROTEASOME SUBUNIT BETA TYPE-1 × 2 （P38624） MAGNESIUM ION × 9 CHLORIDE ION × 4 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6 water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSA3_YEAST
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain B； PDBConstruct 1–258； UniProt 1–258 Author chain P； PDBConstruct 1–258； UniProt 1–258

PROTEASOME SUBUNIT ALPHA TYPE-4

OrganismNot specified

UniProt P40303

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	PROTEASOME SUBUNIT ALPHA TYPE-2 × 2 （P23639） PROTEASOME SUBUNIT ALPHA TYPE-3 × 2 （P23638） PROTEASOME SUBUNIT ALPHA TYPE-5 × 2 （P32379） PROTEASOME SUBUNIT ALPHA TYPE-6 × 2 （P40302） PROBABLE PROTEASOME SUBUNIT ALPHA TYPE-7 × 2 （P21242） PROTEASOME SUBUNIT ALPHA TYPE-1 × 2 （P21243） PROTEASOME SUBUNIT BETA TYPE-2 × 2 （P25043） PROTEASOME SUBUNIT BETA TYPE-3 × 2 （P25451） PROTEASOME SUBUNIT BETA TYPE-4 × 2 （P22141） PROTEASOME SUBUNIT BETA TYPE-5 × 2 （P30656） PROTEASOME SUBUNIT BETA TYPE-6 × 2 （P23724） PROTEASOME SUBUNIT BETA TYPE-7 × 2 （P30657） PROTEASOME SUBUNIT BETA TYPE-1 × 2 （P38624） MAGNESIUM ION × 9 CHLORIDE ION × 4 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6 water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSA4_YEAST
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain C； PDBConstruct 1–254； UniProt 1–254 Author chain Q； PDBConstruct 1–254； UniProt 1–254

PROTEASOME SUBUNIT ALPHA TYPE-5

OrganismNot specified

UniProt P32379

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	PROTEASOME SUBUNIT ALPHA TYPE-2 × 2 （P23639） PROTEASOME SUBUNIT ALPHA TYPE-3 × 2 （P23638） PROTEASOME SUBUNIT ALPHA TYPE-4 × 2 （P40303） PROTEASOME SUBUNIT ALPHA TYPE-6 × 2 （P40302） PROBABLE PROTEASOME SUBUNIT ALPHA TYPE-7 × 2 （P21242） PROTEASOME SUBUNIT ALPHA TYPE-1 × 2 （P21243） PROTEASOME SUBUNIT BETA TYPE-2 × 2 （P25043） PROTEASOME SUBUNIT BETA TYPE-3 × 2 （P25451） PROTEASOME SUBUNIT BETA TYPE-4 × 2 （P22141） PROTEASOME SUBUNIT BETA TYPE-5 × 2 （P30656） PROTEASOME SUBUNIT BETA TYPE-6 × 2 （P23724） PROTEASOME SUBUNIT BETA TYPE-7 × 2 （P30657） PROTEASOME SUBUNIT BETA TYPE-1 × 2 （P38624） MAGNESIUM ION × 9 CHLORIDE ION × 4 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6 water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSA5_YEAST
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain D； PDBConstruct 1–260； UniProt 1–260 Author chain R； PDBConstruct 1–260； UniProt 1–260

PROTEASOME SUBUNIT ALPHA TYPE-6

OrganismNot specified

UniProt P40302

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	PROTEASOME SUBUNIT ALPHA TYPE-2 × 2 （P23639） PROTEASOME SUBUNIT ALPHA TYPE-3 × 2 （P23638） PROTEASOME SUBUNIT ALPHA TYPE-4 × 2 （P40303） PROTEASOME SUBUNIT ALPHA TYPE-5 × 2 （P32379） PROBABLE PROTEASOME SUBUNIT ALPHA TYPE-7 × 2 （P21242） PROTEASOME SUBUNIT ALPHA TYPE-1 × 2 （P21243） PROTEASOME SUBUNIT BETA TYPE-2 × 2 （P25043） PROTEASOME SUBUNIT BETA TYPE-3 × 2 （P25451） PROTEASOME SUBUNIT BETA TYPE-4 × 2 （P22141） PROTEASOME SUBUNIT BETA TYPE-5 × 2 （P30656） PROTEASOME SUBUNIT BETA TYPE-6 × 2 （P23724） PROTEASOME SUBUNIT BETA TYPE-7 × 2 （P30657） PROTEASOME SUBUNIT BETA TYPE-1 × 2 （P38624） MAGNESIUM ION × 9 CHLORIDE ION × 4 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6 water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSA6_YEAST
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain E； PDBConstruct 1–234； UniProt 1–234 Author chain S； PDBConstruct 1–234； UniProt 1–234

PROBABLE PROTEASOME SUBUNIT ALPHA TYPE-7

OrganismNot specified

UniProt P21242

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	PROTEASOME SUBUNIT ALPHA TYPE-2 × 2 （P23639） PROTEASOME SUBUNIT ALPHA TYPE-3 × 2 （P23638） PROTEASOME SUBUNIT ALPHA TYPE-4 × 2 （P40303） PROTEASOME SUBUNIT ALPHA TYPE-5 × 2 （P32379） PROTEASOME SUBUNIT ALPHA TYPE-6 × 2 （P40302） PROTEASOME SUBUNIT ALPHA TYPE-1 × 2 （P21243） PROTEASOME SUBUNIT BETA TYPE-2 × 2 （P25043） PROTEASOME SUBUNIT BETA TYPE-3 × 2 （P25451） PROTEASOME SUBUNIT BETA TYPE-4 × 2 （P22141） PROTEASOME SUBUNIT BETA TYPE-5 × 2 （P30656） PROTEASOME SUBUNIT BETA TYPE-6 × 2 （P23724） PROTEASOME SUBUNIT BETA TYPE-7 × 2 （P30657） PROTEASOME SUBUNIT BETA TYPE-1 × 2 （P38624） MAGNESIUM ION × 9 CHLORIDE ION × 4 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6 water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSA7_YEAST
Isoform	—
PDB entities	6
Chains and sequence ranges	Author chain F； PDBConstruct 1–288； UniProt 1–288 Author chain T； PDBConstruct 1–288； UniProt 1–288

PROTEASOME SUBUNIT ALPHA TYPE-1

OrganismNot specified

UniProt P21243

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	PROTEASOME SUBUNIT ALPHA TYPE-2 × 2 （P23639） PROTEASOME SUBUNIT ALPHA TYPE-3 × 2 （P23638） PROTEASOME SUBUNIT ALPHA TYPE-4 × 2 （P40303） PROTEASOME SUBUNIT ALPHA TYPE-5 × 2 （P32379） PROTEASOME SUBUNIT ALPHA TYPE-6 × 2 （P40302） PROBABLE PROTEASOME SUBUNIT ALPHA TYPE-7 × 2 （P21242） PROTEASOME SUBUNIT BETA TYPE-2 × 2 （P25043） PROTEASOME SUBUNIT BETA TYPE-3 × 2 （P25451） PROTEASOME SUBUNIT BETA TYPE-4 × 2 （P22141） PROTEASOME SUBUNIT BETA TYPE-5 × 2 （P30656） PROTEASOME SUBUNIT BETA TYPE-6 × 2 （P23724） PROTEASOME SUBUNIT BETA TYPE-7 × 2 （P30657） PROTEASOME SUBUNIT BETA TYPE-1 × 2 （P38624） MAGNESIUM ION × 9 CHLORIDE ION × 4 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6 water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSA1_YEAST
Isoform	—
PDB entities	7
Chains and sequence ranges	Author chain G； PDBConstruct 1–252； UniProt 1–252 Author chain U； PDBConstruct 1–252； UniProt 1–252

PROTEASOME SUBUNIT BETA TYPE-2

OrganismNot specified

UniProt P25043

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	PROTEASOME SUBUNIT ALPHA TYPE-2 × 2 （P23639） PROTEASOME SUBUNIT ALPHA TYPE-3 × 2 （P23638） PROTEASOME SUBUNIT ALPHA TYPE-4 × 2 （P40303） PROTEASOME SUBUNIT ALPHA TYPE-5 × 2 （P32379） PROTEASOME SUBUNIT ALPHA TYPE-6 × 2 （P40302） PROBABLE PROTEASOME SUBUNIT ALPHA TYPE-7 × 2 （P21242） PROTEASOME SUBUNIT ALPHA TYPE-1 × 2 （P21243） PROTEASOME SUBUNIT BETA TYPE-3 × 2 （P25451） PROTEASOME SUBUNIT BETA TYPE-4 × 2 （P22141） PROTEASOME SUBUNIT BETA TYPE-5 × 2 （P30656） PROTEASOME SUBUNIT BETA TYPE-6 × 2 （P23724） PROTEASOME SUBUNIT BETA TYPE-7 × 2 （P30657） PROTEASOME SUBUNIT BETA TYPE-1 × 2 （P38624） MAGNESIUM ION × 9 CHLORIDE ION × 4 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6 water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSB2_YEAST
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain H； PDBConstruct 1–232； UniProt 30–261 Author chain V； PDBConstruct 1–232； UniProt 30–261

PROTEASOME SUBUNIT BETA TYPE-3

OrganismNot specified

UniProt P25451

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	PROTEASOME SUBUNIT ALPHA TYPE-2 × 2 （P23639） PROTEASOME SUBUNIT ALPHA TYPE-3 × 2 （P23638） PROTEASOME SUBUNIT ALPHA TYPE-4 × 2 （P40303） PROTEASOME SUBUNIT ALPHA TYPE-5 × 2 （P32379） PROTEASOME SUBUNIT ALPHA TYPE-6 × 2 （P40302） PROBABLE PROTEASOME SUBUNIT ALPHA TYPE-7 × 2 （P21242） PROTEASOME SUBUNIT ALPHA TYPE-1 × 2 （P21243） PROTEASOME SUBUNIT BETA TYPE-2 × 2 （P25043） PROTEASOME SUBUNIT BETA TYPE-4 × 2 （P22141） PROTEASOME SUBUNIT BETA TYPE-5 × 2 （P30656） PROTEASOME SUBUNIT BETA TYPE-6 × 2 （P23724） PROTEASOME SUBUNIT BETA TYPE-7 × 2 （P30657） PROTEASOME SUBUNIT BETA TYPE-1 × 2 （P38624） MAGNESIUM ION × 9 CHLORIDE ION × 4 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6 water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSB3_YEAST
Isoform	—
PDB entities	9
Chains and sequence ranges	Author chain I； PDBConstruct 1–205； UniProt 1–205 Author chain W； PDBConstruct 1–205； UniProt 1–205

PROTEASOME SUBUNIT BETA TYPE-4

OrganismNot specified

UniProt P22141

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	PROTEASOME SUBUNIT ALPHA TYPE-2 × 2 （P23639） PROTEASOME SUBUNIT ALPHA TYPE-3 × 2 （P23638） PROTEASOME SUBUNIT ALPHA TYPE-4 × 2 （P40303） PROTEASOME SUBUNIT ALPHA TYPE-5 × 2 （P32379） PROTEASOME SUBUNIT ALPHA TYPE-6 × 2 （P40302） PROBABLE PROTEASOME SUBUNIT ALPHA TYPE-7 × 2 （P21242） PROTEASOME SUBUNIT ALPHA TYPE-1 × 2 （P21243） PROTEASOME SUBUNIT BETA TYPE-2 × 2 （P25043） PROTEASOME SUBUNIT BETA TYPE-3 × 2 （P25451） PROTEASOME SUBUNIT BETA TYPE-5 × 2 （P30656） PROTEASOME SUBUNIT BETA TYPE-6 × 2 （P23724） PROTEASOME SUBUNIT BETA TYPE-7 × 2 （P30657） PROTEASOME SUBUNIT BETA TYPE-1 × 2 （P38624） MAGNESIUM ION × 9 CHLORIDE ION × 4 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6 water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSB4_YEAST
Isoform	—
PDB entities	10
Chains and sequence ranges	Author chain J； PDBConstruct 1–198； UniProt 1–198 Author chain X； PDBConstruct 1–198； UniProt 1–198

PROTEASOME SUBUNIT BETA TYPE-5

Saccharomyces cerevisiae

UniProt P30656

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	PROTEASOME SUBUNIT ALPHA TYPE-2 × 2 （P23639） PROTEASOME SUBUNIT ALPHA TYPE-3 × 2 （P23638） PROTEASOME SUBUNIT ALPHA TYPE-4 × 2 （P40303） PROTEASOME SUBUNIT ALPHA TYPE-5 × 2 （P32379） PROTEASOME SUBUNIT ALPHA TYPE-6 × 2 （P40302） PROBABLE PROTEASOME SUBUNIT ALPHA TYPE-7 × 2 （P21242） PROTEASOME SUBUNIT ALPHA TYPE-1 × 2 （P21243） PROTEASOME SUBUNIT BETA TYPE-2 × 2 （P25043） PROTEASOME SUBUNIT BETA TYPE-3 × 2 （P25451） PROTEASOME SUBUNIT BETA TYPE-4 × 2 （P22141） PROTEASOME SUBUNIT BETA TYPE-6 × 2 （P23724） PROTEASOME SUBUNIT BETA TYPE-7 × 2 （P30657） PROTEASOME SUBUNIT BETA TYPE-1 × 2 （P38624） MAGNESIUM ION × 9 CHLORIDE ION × 4 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6 water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSB5_YEAST
Isoform	—
PDB entities	11
Chains and sequence ranges	Author chain K； PDBConstruct 1–212； UniProt 76–287 Author chain Y； PDBConstruct 1–212； UniProt 76–287

PROTEASOME SUBUNIT BETA TYPE-6

OrganismNot specified

UniProt P23724

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	PROTEASOME SUBUNIT ALPHA TYPE-2 × 2 （P23639） PROTEASOME SUBUNIT ALPHA TYPE-3 × 2 （P23638） PROTEASOME SUBUNIT ALPHA TYPE-4 × 2 （P40303） PROTEASOME SUBUNIT ALPHA TYPE-5 × 2 （P32379） PROTEASOME SUBUNIT ALPHA TYPE-6 × 2 （P40302） PROBABLE PROTEASOME SUBUNIT ALPHA TYPE-7 × 2 （P21242） PROTEASOME SUBUNIT ALPHA TYPE-1 × 2 （P21243） PROTEASOME SUBUNIT BETA TYPE-2 × 2 （P25043） PROTEASOME SUBUNIT BETA TYPE-3 × 2 （P25451） PROTEASOME SUBUNIT BETA TYPE-4 × 2 （P22141） PROTEASOME SUBUNIT BETA TYPE-5 × 2 （P30656） PROTEASOME SUBUNIT BETA TYPE-7 × 2 （P30657） PROTEASOME SUBUNIT BETA TYPE-1 × 2 （P38624） MAGNESIUM ION × 9 CHLORIDE ION × 4 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6 water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSB6_YEAST
Isoform	—
PDB entities	12
Chains and sequence ranges	Author chain L； PDBConstruct 1–222； UniProt 20–241 Author chain Z； PDBConstruct 1–222； UniProt 20–241

PROTEASOME SUBUNIT BETA TYPE-7

OrganismNot specified

UniProt P30657

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	PROTEASOME SUBUNIT ALPHA TYPE-2 × 2 （P23639） PROTEASOME SUBUNIT ALPHA TYPE-3 × 2 （P23638） PROTEASOME SUBUNIT ALPHA TYPE-4 × 2 （P40303） PROTEASOME SUBUNIT ALPHA TYPE-5 × 2 （P32379） PROTEASOME SUBUNIT ALPHA TYPE-6 × 2 （P40302） PROBABLE PROTEASOME SUBUNIT ALPHA TYPE-7 × 2 （P21242） PROTEASOME SUBUNIT ALPHA TYPE-1 × 2 （P21243） PROTEASOME SUBUNIT BETA TYPE-2 × 2 （P25043） PROTEASOME SUBUNIT BETA TYPE-3 × 2 （P25451） PROTEASOME SUBUNIT BETA TYPE-4 × 2 （P22141） PROTEASOME SUBUNIT BETA TYPE-5 × 2 （P30656） PROTEASOME SUBUNIT BETA TYPE-6 × 2 （P23724） PROTEASOME SUBUNIT BETA TYPE-1 × 2 （P38624） MAGNESIUM ION × 9 CHLORIDE ION × 4 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6 water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSB7_YEAST
Isoform	—
PDB entities	13
Chains and sequence ranges	Author chain M； PDBConstruct 1–246； UniProt 21–266 Author chain a； PDBConstruct 1–246； UniProt 21–266

PROTEASOME SUBUNIT BETA TYPE-1

OrganismNot specified

UniProt P38624

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 28	PROTEASOME SUBUNIT ALPHA TYPE-2 × 2 （P23639） PROTEASOME SUBUNIT ALPHA TYPE-3 × 2 （P23638） PROTEASOME SUBUNIT ALPHA TYPE-4 × 2 （P40303） PROTEASOME SUBUNIT ALPHA TYPE-5 × 2 （P32379） PROTEASOME SUBUNIT ALPHA TYPE-6 × 2 （P40302） PROBABLE PROTEASOME SUBUNIT ALPHA TYPE-7 × 2 （P21242） PROTEASOME SUBUNIT ALPHA TYPE-1 × 2 （P21243） PROTEASOME SUBUNIT BETA TYPE-2 × 2 （P25043） PROTEASOME SUBUNIT BETA TYPE-3 × 2 （P25451） PROTEASOME SUBUNIT BETA TYPE-4 × 2 （P22141） PROTEASOME SUBUNIT BETA TYPE-5 × 2 （P30656） PROTEASOME SUBUNIT BETA TYPE-6 × 2 （P23724） PROTEASOME SUBUNIT BETA TYPE-7 × 2 （P30657） MAGNESIUM ION × 9 CHLORIDE ION × 4 N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE × 6 water × 28	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSB1_YEAST
Isoform	—
PDB entities	14
Chains and sequence ranges	Author chain N； PDBConstruct 1–196； UniProt 20–215 Author chain b； PDBConstruct 1–196； UniProt 20–215

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	4qvy
Deposition date deposition_date	2014-07-16
Structure title title	yCP beta5-A49T-mutant in complex with bortezomib
Keywords keywords	Cancer, Proteasome, Bortezomib, Drug Resistance, Binding Analysis, HYDROLASE-HYDROLASE INHIBITOR complex; HYDROLASE/HYDROLASE INHIBITOR
Experimental Method method	X-RAY DIFFRACTION

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4qvy__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4qvy__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

4qvy__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	60.38 Å
Rg (electron density)	59.91 Å
Total Rg	60.12 Å
Atom count	49551
Residues	6344
Excluded volume	882300 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`4qvy__assembly_1__model_1`	28-meric （28）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (18)

Entity 1 Entity 1 polymer

Description description	PROTEASOME SUBUNIT ALPHA TYPE-2
Molecular weight formula_weight	27191.8 kDa
EC 编号 ec_number	3.4.25.1
Mutation mutation	A49T
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,O
Atom count atom_count	49977

MTDRYSFSLTTFSPSGKLGQIDYALTAVKQGVTSLGIKATNGVVIATEKKSSSPLAMSETLSKVSLLTPDIGAVYSGMGPDYRVLVDKSRKVAHTSYKRIYGEYPPTKLLVSEVAKIMQEATQSGGVRPFGVSLLIAGHDEFNGFSLYQVDPSGSYFPWKATAIGKGSVAAKTFLEKRWNDELELEDAIHIALLTLKESVEGEFNGDTIELAIIGDENPDLLGYTGIPTDKGPRFRKLTSQEINDRLEAL

Entity 2 Entity 2 polymer

Description description	PROTEASOME SUBUNIT ALPHA TYPE-3
Molecular weight formula_weight	28748.2 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B,P

MGSRRYDSRTTIFSPEGRLYQVEYALESISHAGTAIGIMASDGIVLAAERKVTSTLLEQDTSTEKLYKLNDKIAVAVAGLTADAEILINTARIHAQNYLKTYNEDIPVEILVRRLSDIKQGYTQHGGLRPFGVSFIYAGYDDRYGYQLYTSNPSGNYTGWKAISVGANTSAAQTLLQMDYKDDMKVDDAIELALKTLSKTTDSSALTYDRLEFATIRKGANDGEVYQKIFKPQEIKDILVKTGITKKDEDEEADEDMK

Entity 3 Entity 3 polymer

Description description	PROTEASOME SUBUNIT ALPHA TYPE-4
Molecular weight formula_weight	28478.1 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	C,Q

MSGYDRALSIFSPDGHIFQVEYALEAVKRGTCAVGVKGKNCVVLGCERRSTLKLQDTRITPSKVSKIDSHVVLSFSGLNADSRILIEKARVEAQSHRLTLEDPVTVEYLTRYVAGVQQRYTQSGGVRPFGVSTLIAGFDPRDDEPKLYQTEPSGIYSSWSAQTIGRNSKTVREFLEKNYDRKEPPATVEECVKLTVRSLLEVVQTGAKNIEITVVKPDSDIVALSSEEINQYVTQIEQEKQEQQEQDKKKKSNH

Entity 4 Entity 4 polymer

Description description	PROTEASOME SUBUNIT ALPHA TYPE-5
Molecular weight formula_weight	28649.1 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	D,R

MFLTRSEYDRGVSTFSPEGRLFQVEYSLEAIKLGSTAIGIATKEGVVLGVEKRATSPLLESDSIEKIVEIDRHIGCAMSGLTADARSMIEHARTAAVTHNLYYDEDINVESLTQSVCDLALRFGEGASGEERLMSRPFGVALLIAGHDADDGYQLFHAEPSGTFYRYNAKAIGSGSEGAQAELLNEWHSSLTLKEAELLVLKILKQVMEEKLDENNAQLSCITKQDGFKIYDNEKTAELIKELKEKEAAESPEEADVEMS

Entity 5 Entity 5 polymer

Description description	PROTEASOME SUBUNIT ALPHA TYPE-6
Molecular weight formula_weight	25634.0 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	E,S

MFRNNYDGDTVTFSPTGRLFQVEYALEAIKQGSVTVGLRSNTHAVLVALKRNADELSSYQKKIIKCDEHMGLSLAGLAPDARVLSNYLRQQCNYSSLVFNRKLAVERAGHLLCDKAQKNTQSYGGRPYGVGLLIIGYDKSGAHLLEFQPSGNVTELYGTAIGARSQGAKTYLERTLDTFIKIDGNPDELIKAGVEAISQSLRDESLTVDNLSIAIVGKDTPFTIYDGEAVAKYI

Entity 6 Entity 6 polymer

Description description	PROBABLE PROTEASOME SUBUNIT ALPHA TYPE-7
Molecular weight formula_weight	31575.1 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	F,T

MTSIGTGYDLSNSVFSPDGRNFQVEYAVKAVENGTTSIGIKCNDGVVFAVEKLITSKLLVPQKNVKIQVVDRHIGCVYSGLIPDGRHLVNRGREEAASFKKLYKTPIPIPAFADRLGQYVQAHTLYNSVRPFGVSTIFGGVDKNGAHLYMLEPSGSYWGYKGAATGKGRQSAKAELEKLVDHHPEGLSAREAVKQAAKIIYLAHEDNKEKDFELEISWCSLSETNGLHKFVKGDLLQEAIDFAQKEINGDDDEDEDDSDNVMSSDDENAPVATNANATTDQEGDIHLE

Entity 7 Entity 7 polymer

Description description	PROTEASOME SUBUNIT ALPHA TYPE-1
Molecular weight formula_weight	28033.8 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	G,U

MSGAAAASAAGYDRHITIFSPEGRLYQVEYAFKATNQTNINSLAVRGKDCTVVISQKKVPDKLLDPTTVSYIFCISRTIGMVVNGPIPDARNAALRAKAEAAEFRYKYGYDMPCDVLAKRMANLSQIYTQRAYMRPLGVILTFVSVDEELGPSIYKTDPAGYYVGYKATATGPKQQEITTNLENHFKKSKIDHINEESWEKVVEFAITHMIDALGTEFSKNDLEVGVATKDKFFTLSAENIEERLVAIAEQD

Entity 8 Entity 8 polymer

Description description	PROTEASOME SUBUNIT BETA TYPE-2
Molecular weight formula_weight	25114.5 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	H,V

TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICDIQEEQVDITA

Entity 9 Entity 9 polymer

Description description	PROTEASOME SUBUNIT BETA TYPE-3
Molecular weight formula_weight	22627.8 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	I,W

MSDPSSINGGIVVAMTGKDCVAIACDLRLGSQSLGVSNKFEKIFHYGHVFLGITGLATDVTTLNEMFRYKTNLYKLKEERAIEPETFTQLVSSSLYERRFGPYFVGPVVAGINSKSGKPFIAGFDLIGCIDEAKDFIVSGTASDQLFGMCESLYEPNLEPEDLFETISQALLNAADRDALSGWGAVVYIIKKDEVVKRYLKMRQD

Entity 10 Entity 10 polymer

Description description	PROTEASOME SUBUNIT BETA TYPE-4
Molecular weight formula_weight	22545.7 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	J,X

MDIILGIRVQDSVILASSKAVTRGISVLKDSDDKTRQLSPHTLMSFAGEAGDTVQFAEYIQANIQLYSIREDYELSPQAVSSFVRQELAKSIRSRRPYQVNVLIGGYDKKKNKPELYQIDYLGTKVELPYGAHGYSGFYTFSLLDHHYRPDMTTEEGLDLLKLCVQELEKRMPMDFKGVIVKIVDKDGIRQVDDFQAQ

Entity 11 Entity 11 polymer

Description description	PROTEASOME SUBUNIT BETA TYPE-5
Molecular weight formula_weight	23355.3 kDa
EC 编号 ec_number	3.4.25.1
Mutation mutation	YES
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	K,Y

TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGTADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG

Source Source

Source organism organism	Saccharomyces cerevisiae
Common name common_name	;Baker's yeast ;
NCBI taxonomy ID ncbi_taxonomy_id	559292
Host organism host_organism	SACCHAROMYCES CEREVISIAE

Entity 12 Entity 12 polymer

Description description	PROTEASOME SUBUNIT BETA TYPE-6
Molecular weight formula_weight	24883.9 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	L,Z

QFNPYGDNGGTILGIAGEDFAVLAGDTRNITDYSINSRYEPKVFDCGDNIVMSANGFAADGDALVKRFKNSVKWYHFDHNDKKLSINSAARNIQHLLYGKRFFPYYVHTIIAGLDEDGKGAVYSFDPVGSYEREQCRAGGAAASLIMPFLDNQVNFKNQYEPGTNGKVKKPLKYLSVEEVIKLVRDSFTSATERHIQVGDGLEILIVTKDGVRKEFYELKRD

Entity 13 Entity 13 polymer

Description description	PROTEASOME SUBUNIT BETA TYPE-7
Molecular weight formula_weight	27200.9 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	M,a

TQIANAGASPMVNTQQPIVTGTSVISMKYDNGVIIAADNLGSYGSLLRFNGVERLIPVGDNTVVGISGDISDMQHIERLLKDLVTENAYDNPLADAEEALEPSYIFEYLATVMYQRRSKMNPLWNAIIVAGVQSNGDQFLRYVNLLGVTYSSPTLATGFGAHMANPLLRKVVDRESDIPKTTVQVAEEAIVNAMRVLYYRDARSSRNFSLAIIDKNTGLTFKKNLQVENMKWDFAKDIKGYGTQKI

Entity 14 Entity 14 polymer

Description description	PROTEASOME SUBUNIT BETA TYPE-1
Molecular weight formula_weight	21517.2 kDa
EC 编号 ec_number	3.4.25.1
Source method src_method	nat
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	N,b

TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAASVFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVHKLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLSQAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL

Entity 15 Entity 15 non-polymer

Description description	MAGNESIUM ION
Molecular weight formula_weight	24.3 kDa
Source method src_method	syn
Copy count entity_count	9

Entity 16 Entity 16 non-polymer

Description description	CHLORIDE ION
Molecular weight formula_weight	35.5 kDa
Source method src_method	syn
Copy count entity_count	4

Entity 17 Entity 17 non-polymer

Description description	N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE
Molecular weight formula_weight	384.2 kDa
Source method src_method	syn
Copy count entity_count	6

Entity 18 Entity 18 water

Description description	water
Molecular weight formula_weight	18.0 kDa
Source method src_method	nat
Copy count entity_count	426

▼

6. Fold Classification (SCOP + CATH) 56 domains

SCOP 2.08 (28 domains)

Domain ID domain_id	d4qvya_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

Domain ID domain_id	d4qvyb_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

Domain ID domain_id	d4qvyc1
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.0 — automated matches

Domain ID domain_id	d4qvyc2
Class class	l — Artifacts
Fold Fold fold	l.1 — Tags
Superfamily Superfamily superfamily	l.1.1 — Tags
Family Family family	l.1.1.1 — Tags

Domain ID domain_id	d4qvyd_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

Domain ID domain_id	d4qvye_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

Domain ID domain_id	d4qvyf_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

Domain ID domain_id	d4qvyg_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

Domain ID domain_id	d4qvyh_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

Domain ID domain_id	d4qvyi_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

Domain ID domain_id	d4qvyj_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

Domain ID domain_id	d4qvyk_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

Domain ID domain_id	d4qvyl_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

Domain ID domain_id	d4qvym_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

Domain ID domain_id	d4qvyn_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

Domain ID domain_id	d4qvyo_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

Domain ID domain_id	d4qvyp_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

Domain ID domain_id	d4qvyq1
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.0 — automated matches

Domain ID domain_id	d4qvyq2
Class class	l — Artifacts
Fold Fold fold	l.1 — Tags
Superfamily Superfamily superfamily	l.1.1 — Tags
Family Family family	l.1.1.1 — Tags

Domain ID domain_id	d4qvyr_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

Domain ID domain_id	d4qvys_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

Domain ID domain_id	d4qvyt_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

Domain ID domain_id	d4qvyu_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

Domain ID domain_id	d4qvyv_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

Domain ID domain_id	d4qvyw_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

Domain ID domain_id	d4qvyx_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

Domain ID domain_id	d4qvyy_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

Domain ID domain_id	d4qvyz_
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.153 — Ntn hydrolase-like
Superfamily Superfamily superfamily	d.153.1 — N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family Family family	d.153.1.4 — Proteasome subunits

CATH v4.4 (28 domains)

Domain ID domain_id	4qvyA00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	4qvyB00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	4qvyC00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	4qvyD00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	4qvyE00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	4qvyF00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	4qvyG00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	4qvyH00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	4qvyI00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	4qvyJ00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	4qvyK00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	4qvyL00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	4qvyM00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	4qvyN00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	4qvyO00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	4qvyP00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	4qvyQ00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	4qvyR00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	4qvyS00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	4qvyT00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	4qvyU00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	4qvyV00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	4qvyW00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	4qvyX00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	4qvyY00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	4qvyZ00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	4qvya00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

Domain ID domain_id	4qvyb00
Class class	3 — Alpha Beta
Architecture architecture	60 — 4-Layer Sandwich
Topology topology	20 — Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homologous superfamily homologous superfamily	10 — Aminohydrolase, N-terminal nucleophile (Ntn) domain

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Unit-cell length a length_a	135.320 Å
Unit-cell length b length_b	300.900 Å
Unit-cell length c length_c	144.920 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	112.81 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	4

Space group space_group	P 1 21 1
Space-group number int_tables_number	4
Crystal system crystal_system	—

Resolution resolution	2.510 Å
Low-resolution limit resolution_low	15.000 Å
R factor r_factor	0.1946
R_work r_work	0.1933
R_free r_free	0.2189

yCP beta5-A49T-mutant in complex with bortezomib

1. Protein Identity and Related Structures Protein Identity & Related Structures

PROTEASOME SUBUNIT ALPHA TYPE-2

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

PROTEASOME SUBUNIT ALPHA TYPE-3

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

PROTEASOME SUBUNIT ALPHA TYPE-4

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

PROTEASOME SUBUNIT ALPHA TYPE-5

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

PROTEASOME SUBUNIT ALPHA TYPE-6

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

PROBABLE PROTEASOME SUBUNIT ALPHA TYPE-7

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

PROTEASOME SUBUNIT ALPHA TYPE-1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

PROTEASOME SUBUNIT BETA TYPE-2

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

PROTEASOME SUBUNIT BETA TYPE-3

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

PROTEASOME SUBUNIT BETA TYPE-4

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer