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4uf5

Crystal structure of UCH-L5 in complex with inhibitory fragment of INO80G

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5

HOMO SAPIENS

UniProt Q9Y5K5

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 NUCLEAR FACTOR RELATED TO KAPPA-B-BINDING PROTEIN × 1 （Q6P4R8） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
3a7s 3rii 3rii 3ris 3ris 3ris 3ris 3tb3 3tb3

9 assemblies

Homodimer
3a7s 3rii 3ris 3ris

4 assemblies

Homotetramer
3ihr

1 assemblies

Other homooligomers

None

Heteromeric or nucleic-acid complex
4uel 4uem 4uf5 4uf6 4uf6 4uf6 4uf6 4wlp 4wlp 9e7k

10 assemblies

View Construct and Data Evidence
UniProt name UCHL5_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 4–331； UniProt 1–328

NUCLEAR FACTOR RELATED TO KAPPA-B-BINDING PROTEIN

HOMO SAPIENS

UniProt Q6P4R8

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5 × 1 （Q9Y5K5） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer
3u21

1 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
4uf5 4uf6 4uf6 4uf6 4uf6 4wlp 4wlp

7 assemblies

View Construct and Data Evidence
UniProt name NFRKB_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 4–134； UniProt 40–170

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id4uf5
Deposition date deposition_date2014-12-23
Structure title titleCrystal structure of UCH-L5 in complex with inhibitory fragment of INO80G
Keywords keywordsHYDROLASE, DEUBIQUITINATING ENZYME; HYDROLASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4uf5__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4uf5__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

4uf5__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）25.58 Å
Rg (electron density)24.64 Å
Total Rg25.55 Å
Atom count3296
Residues403
Excluded volume58645 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 4uf5__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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6. Fold Classification (SCOP + CATH) 1 domains

CATH v4.4 (1 domains)

Domain ID domain_id4uf5A01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology532 — Ubiquitin C-terminal Hydrolase UCH-l3
Homologous superfamily homologous superfamily10 — Peptidase C12, ubiquitin carboxyl-terminal hydrolase
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7. Citations (1)