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4zjs

Crystal structure of a chimeric acetylcholine binding protein from Aplysia Californica (Ac-AChBP) containing the main immunogenic region (MIR) from the human alpha 1 subunit of the muscle nicotinic acetylcholine receptor in complex with anatoxin-A.

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

;Acetylcholine receptor subunit alpha,Soluble acetylcholine receptor,Acetylcholine receptor subunit alpha,Soluble acetylcholine receptor ;

Aplysia californica

UniProt P02708

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Homooligomer Protein 5 1-[(1R,6R)-9-azabicyclo[4.2.1]non-2-en-2-yl]ethanone × 3 water × 5 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
4zjs 9dmg 9dmh 9dmj 9dmk 9dml 9dmq 9dms 9dmt 9dmv 9gu0 9gu1

14 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name ACHA_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 10–39； UniProt 21–50 Author chain A； PDBConstruct 70–90； UniProt 106–126 Author chain B； PDBConstruct 10–39； UniProt 21–50 Author chain B； PDBConstruct 70–90； UniProt 106–126 Author chain C； PDBConstruct 10–39； UniProt 21–50 Author chain C； PDBConstruct 70–90； UniProt 106–126 Author chain D； PDBConstruct 10–39； UniProt 21–50 Author chain D； PDBConstruct 70–90； UniProt 106–126 Author chain E； PDBConstruct 10–39； UniProt 21–50 Author chain E； PDBConstruct 70–90； UniProt 106–126

;Acetylcholine receptor subunit alpha,Soluble acetylcholine receptor,Acetylcholine receptor subunit alpha,Soluble acetylcholine receptor ;

Aplysia californica

UniProt Q8WSF8

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Homooligomer Protein 5 1-[(1R,6R)-9-azabicyclo[4.2.1]non-2-en-2-yl]ethanone × 3 water × 5 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers
2br7 2byn 2byq 2byr 2byr 2bys 2bys 2ph9 2w8f 2w8f 2w8g 2wnc

92 assemblies; showing the first 12

Heteromeric or nucleic-acid complex
2br8 2byp 2c9t 2pgz 2uz6 2uz6 2wn9 2wnj 3sh1 3sh1 3sio 3sio

29 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name Q8WSF8_APLCA
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 40–69； UniProt 48–77 Author chain A； PDBConstruct 91–228； UniProt 99–236 Author chain B； PDBConstruct 40–69； UniProt 48–77 Author chain B； PDBConstruct 91–228； UniProt 99–236 Author chain C； PDBConstruct 40–69； UniProt 48–77 Author chain C； PDBConstruct 91–228； UniProt 99–236 Author chain D； PDBConstruct 40–69； UniProt 48–77 Author chain D； PDBConstruct 91–228； UniProt 99–236 Author chain E； PDBConstruct 40–69； UniProt 48–77 Author chain E； PDBConstruct 91–228； UniProt 99–236

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id4zjs
Deposition date deposition_date2015-04-29
Structure title titleCrystal structure of a chimeric acetylcholine binding protein from Aplysia Californica (Ac-AChBP) containing the main immunogenic region (MIR) from the human alpha 1 subunit of the muscle nicotinic acetylcholine receptor in complex with anatoxin-A.
Keywords keywordsanatoxin-A, nicotinic, receptor, acetylcholine, IMMUNE SYSTEM; IMMUNE SYSTEM
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4zjs__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4zjs__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

4zjs__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）31.15 Å
Rg (electron density)29.52 Å
Total Rg30.39 Å
Atom count8080
Residues1028
Excluded volume142920 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 4zjs__assembly_1__model_1 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 10 domains

SCOP 2.08 (5 domains)

Domain ID domain_idd4zjsa_
Class classb — All beta proteins
Fold Fold foldb.96 — Nicotinic receptor ligand binding domain-like
Superfamily Superfamily superfamilyb.96.1 — Nicotinic receptor ligand binding domain-like
Family Family familyb.96.1.0 — automated matches
Domain ID domain_idd4zjsb_
Class classb — All beta proteins
Fold Fold foldb.96 — Nicotinic receptor ligand binding domain-like
Superfamily Superfamily superfamilyb.96.1 — Nicotinic receptor ligand binding domain-like
Family Family familyb.96.1.0 — automated matches
Domain ID domain_idd4zjsc_
Class classb — All beta proteins
Fold Fold foldb.96 — Nicotinic receptor ligand binding domain-like
Superfamily Superfamily superfamilyb.96.1 — Nicotinic receptor ligand binding domain-like
Family Family familyb.96.1.0 — automated matches
Domain ID domain_idd4zjsd_
Class classb — All beta proteins
Fold Fold foldb.96 — Nicotinic receptor ligand binding domain-like
Superfamily Superfamily superfamilyb.96.1 — Nicotinic receptor ligand binding domain-like
Family Family familyb.96.1.0 — automated matches
Domain ID domain_idd4zjse_
Class classb — All beta proteins
Fold Fold foldb.96 — Nicotinic receptor ligand binding domain-like
Superfamily Superfamily superfamilyb.96.1 — Nicotinic receptor ligand binding domain-like
Family Family familyb.96.1.0 — automated matches

CATH v4.4 (5 domains)

Domain ID domain_id4zjsA00
Class class2 — Mainly Beta
Architecture architecture70 — Distorted Sandwich
Topology topology170 — Acetylcholine Binding Protein; Chain: A,
Homologous superfamily homologous superfamily10 — Neurotransmitter-gated ion-channel ligand-binding domain
Domain ID domain_id4zjsB00
Class class2 — Mainly Beta
Architecture architecture70 — Distorted Sandwich
Topology topology170 — Acetylcholine Binding Protein; Chain: A,
Homologous superfamily homologous superfamily10 — Neurotransmitter-gated ion-channel ligand-binding domain
Domain ID domain_id4zjsC00
Class class2 — Mainly Beta
Architecture architecture70 — Distorted Sandwich
Topology topology170 — Acetylcholine Binding Protein; Chain: A,
Homologous superfamily homologous superfamily10 — Neurotransmitter-gated ion-channel ligand-binding domain
Domain ID domain_id4zjsD00
Class class2 — Mainly Beta
Architecture architecture70 — Distorted Sandwich
Topology topology170 — Acetylcholine Binding Protein; Chain: A,
Homologous superfamily homologous superfamily10 — Neurotransmitter-gated ion-channel ligand-binding domain
Domain ID domain_id4zjsE00
Class class2 — Mainly Beta
Architecture architecture70 — Distorted Sandwich
Topology topology170 — Acetylcholine Binding Protein; Chain: A,
Homologous superfamily homologous superfamily10 — Neurotransmitter-gated ion-channel ligand-binding domain
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7. Citations (1)