4zjs

Crystal structure of a chimeric acetylcholine binding protein from Aplysia Californica (Ac-AChBP) containing the main immunogenic region (MIR) from the human alpha 1 subunit of the muscle nicotinic acetylcholine receptor in complex with anatoxin-A.

Method: X-RAY DIFFRACTION
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

;Acetylcholine receptor subunit alpha,Soluble acetylcholine receptor,Acetylcholine receptor subunit alpha,Soluble acetylcholine receptor ;

Aplysia californica

UniProt P02708

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 信息不足 同源多聚体 蛋白 5 1-[(1R,6R)-9-azabicyclo[4.2.1]non-2-en-2-yl]ethanone × 3 water × 5 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 ACHA_HUMAN
Isoform —
PDB实体 1
链与序列区间 作者链 A; PDB构建体 10–39; UniProt 21–50 作者链 A; PDB构建体 70–90; UniProt 106–126 作者链 B; PDB构建体 10–39; UniProt 21–50 作者链 B; PDB构建体 70–90; UniProt 106–126 作者链 C; PDB构建体 10–39; UniProt 21–50 作者链 C; PDB构建体 70–90; UniProt 106–126 作者链 D; PDB构建体 10–39; UniProt 21–50 作者链 D; PDB构建体 70–90; UniProt 106–126 作者链 E; PDB构建体 10–39; UniProt 21–50 作者链 E; PDB构建体 70–90; UniProt 106–126

;Acetylcholine receptor subunit alpha,Soluble acetylcholine receptor,Acetylcholine receptor subunit alpha,Soluble acetylcholine receptor ;

Aplysia californica

UniProt Q8WSF8

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 信息不足 同源多聚体 蛋白 5 1-[(1R,6R)-9-azabicyclo[4.2.1]non-2-en-2-yl]ethanone × 3 water × 5 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 Q8WSF8_APLCA
Isoform —
PDB实体 1
链与序列区间 作者链 A; PDB构建体 40–69; UniProt 48–77 作者链 A; PDB构建体 91–228; UniProt 99–236 作者链 B; PDB构建体 40–69; UniProt 48–77 作者链 B; PDB构建体 91–228; UniProt 99–236 作者链 C; PDB构建体 40–69; UniProt 48–77 作者链 C; PDB构建体 91–228; UniProt 99–236 作者链 D; PDB构建体 40–69; UniProt 48–77 作者链 D; PDB构建体 91–228; UniProt 99–236 作者链 E; PDB构建体 40–69; UniProt 48–77 作者链 E; PDB构建体 91–228; UniProt 99–236

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id4zjs
沉积日期 deposition_date2015-04-29
结构标题 titleCrystal structure of a chimeric acetylcholine binding protein from Aplysia Californica (Ac-AChBP) containing the main immunogenic region (MIR) from the human alpha 1 subunit of the muscle nicotinic acetylcholine receptor in complex with anatoxin-A.
关键词 keywordsanatoxin-A, nicotinic, receptor, acetylcholine, IMMUNE SYSTEM; IMMUNE SYSTEM
实验方法 methodX-RAY DIFFRACTION
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

4zjs__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

4zjs__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

4zjs__assembly_1__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)31.15 Å
Rg(电子密度)29.52 Å
总 Rg30.39 Å
原子数8080
残基数1028
排除体积142920 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 4zjs__assembly_1__model_1 pentameric (5) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (3)

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6. 折叠分类 (SCOP + CATH) 10 domains

SCOP 2.08 (5 domains)

结构域编号 domain_idd4zjsa_
类 Class classb — All beta proteins
折叠类型 Fold foldb.96 — Nicotinic receptor ligand binding domain-like
超家族 Superfamily superfamilyb.96.1 — Nicotinic receptor ligand binding domain-like
家族 Family familyb.96.1.0 — automated matches
结构域编号 domain_idd4zjsb_
类 Class classb — All beta proteins
折叠类型 Fold foldb.96 — Nicotinic receptor ligand binding domain-like
超家族 Superfamily superfamilyb.96.1 — Nicotinic receptor ligand binding domain-like
家族 Family familyb.96.1.0 — automated matches
结构域编号 domain_idd4zjsc_
类 Class classb — All beta proteins
折叠类型 Fold foldb.96 — Nicotinic receptor ligand binding domain-like
超家族 Superfamily superfamilyb.96.1 — Nicotinic receptor ligand binding domain-like
家族 Family familyb.96.1.0 — automated matches
结构域编号 domain_idd4zjsd_
类 Class classb — All beta proteins
折叠类型 Fold foldb.96 — Nicotinic receptor ligand binding domain-like
超家族 Superfamily superfamilyb.96.1 — Nicotinic receptor ligand binding domain-like
家族 Family familyb.96.1.0 — automated matches
结构域编号 domain_idd4zjse_
类 Class classb — All beta proteins
折叠类型 Fold foldb.96 — Nicotinic receptor ligand binding domain-like
超家族 Superfamily superfamilyb.96.1 — Nicotinic receptor ligand binding domain-like
家族 Family familyb.96.1.0 — automated matches

CATH v4.4 (5 domains)

结构域编号 domain_id4zjsA00
类 Class class2 — Mainly Beta
架构 Architecture architecture70 — Distorted Sandwich
拓扑 Topology topology170 — Acetylcholine Binding Protein; Chain: A,
同源超家族 H-superfamily homologous superfamily10 — Neurotransmitter-gated ion-channel ligand-binding domain
结构域编号 domain_id4zjsB00
类 Class class2 — Mainly Beta
架构 Architecture architecture70 — Distorted Sandwich
拓扑 Topology topology170 — Acetylcholine Binding Protein; Chain: A,
同源超家族 H-superfamily homologous superfamily10 — Neurotransmitter-gated ion-channel ligand-binding domain
结构域编号 domain_id4zjsC00
类 Class class2 — Mainly Beta
架构 Architecture architecture70 — Distorted Sandwich
拓扑 Topology topology170 — Acetylcholine Binding Protein; Chain: A,
同源超家族 H-superfamily homologous superfamily10 — Neurotransmitter-gated ion-channel ligand-binding domain
结构域编号 domain_id4zjsD00
类 Class class2 — Mainly Beta
架构 Architecture architecture70 — Distorted Sandwich
拓扑 Topology topology170 — Acetylcholine Binding Protein; Chain: A,
同源超家族 H-superfamily homologous superfamily10 — Neurotransmitter-gated ion-channel ligand-binding domain
结构域编号 domain_id4zjsE00
类 Class class2 — Mainly Beta
架构 Architecture architecture70 — Distorted Sandwich
拓扑 Topology topology170 — Acetylcholine Binding Protein; Chain: A,
同源超家族 H-superfamily homologous superfamily10 — Neurotransmitter-gated ion-channel ligand-binding domain
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7. 引用文献 (1)