5cro

REFINED STRUCTURE OF CRO REPRESSOR PROTEIN FROM BACTERIOPHAGE LAMBDA

Method: X-RAY DIFFRACTION

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1. 蛋白身份与相关结构 Protein Identity & Related Structures

CRO REPRESSOR PROTEIN

物种未注明

当前结构中的状态

Assembly	物理组成	蛋白状态	分子拷贝数	共同组分	数据核对
1	蛋白同源多聚体	同源多聚体	蛋白 2	PHOSPHATE ION × 2 water × 2	与蛋白数一致
2	蛋白同源多聚体	同源多聚体	蛋白 2	water × 2	与蛋白数一致
3	蛋白同源多聚体	同源多聚体	蛋白 24	PHOSPHATE ION × 12 water × 24	与蛋白数一致
4	蛋白同源多聚体	同源多聚体	蛋白 4	PHOSPHATE ION × 2 water × 4	与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据

UniProt名称	RCRO_LAMBD
Isoform	—
PDB实体	1
链与序列区间	作者链 A； PDB构建体 1–66； UniProt 1–66 作者链 B； PDB构建体 1–66； UniProt 1–66 作者链 C； PDB构建体 1–66； UniProt 1–66 作者链 O； PDB构建体 1–66； UniProt 1–66

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id	5cro
沉积日期 deposition_date	1998-04-17
结构标题 title	REFINED STRUCTURE OF CRO REPRESSOR PROTEIN FROM BACTERIOPHAGE LAMBDA
关键词 keywords	GENE REGULATING PROTEIN, TRANSCRIPTION REGULATION; GENE REGULATING PROTEIN
实验方法 method	X-RAY DIFFRACTION

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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

5cro__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

5cro__assembly_1__model_1 | I(q)

100 个绘图点；横轴和纵轴均采用对数尺度。

5cro__assembly_1__model_1 | P(r) · Pending

P(r) 将按相同 assembly/model 分别计算和展示。

Rg（Guinier）	17.81 Å
Rg（电子密度）	16.69 Å
总 Rg	17.66 Å
原子数	958
残基数	121
排除体积	17105 Å³
最大 q	0.500 Å⁻¹

Assembly	Model	结构单元	聚集说明	状态	CRYSOL	操作
1	1	`5cro__assembly_1__model_1`	dimeric （2）	成功	4.1.3-1-20251215 (887e7ef)	查看下载
2	1	`5cro__assembly_2__model_1`	dimeric （2）	成功	4.1.3-1-20251215 (887e7ef)	查看下载
3	1	`5cro__assembly_3__model_1`	24-meric （24）	成功	4.1.3-1-20251215 (887e7ef)	查看下载
4	1	`5cro__assembly_4__model_1`	tetrameric （4）	成功	4.1.3-1-20251215 (887e7ef)	查看下载

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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (3)

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6. 折叠分类 (SCOP + CATH) 8 domains

SCOP 2.08 (4 domains)

结构域编号 domain_id	d5croa_
类 Class class	a — All alpha proteins
折叠类型 Fold fold	a.35 — lambda repressor-like DNA-binding domains
超家族 Superfamily superfamily	a.35.1 — lambda repressor-like DNA-binding domains
家族 Family family	a.35.1.2 — Phage repressors

结构域编号 domain_id	d5crob_
类 Class class	a — All alpha proteins
折叠类型 Fold fold	a.35 — lambda repressor-like DNA-binding domains
超家族 Superfamily superfamily	a.35.1 — lambda repressor-like DNA-binding domains
家族 Family family	a.35.1.2 — Phage repressors

结构域编号 domain_id	d5croc_
类 Class class	a — All alpha proteins
折叠类型 Fold fold	a.35 — lambda repressor-like DNA-binding domains
超家族 Superfamily superfamily	a.35.1 — lambda repressor-like DNA-binding domains
家族 Family family	a.35.1.2 — Phage repressors

结构域编号 domain_id	d5croo_
类 Class class	a — All alpha proteins
折叠类型 Fold fold	a.35 — lambda repressor-like DNA-binding domains
超家族 Superfamily superfamily	a.35.1 — lambda repressor-like DNA-binding domains
家族 Family family	a.35.1.2 — Phage repressors

CATH v4.4 (4 domains)

结构域编号 domain_id	5croA00
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	240 — CRO Repressor
同源超家族 H-superfamily homologous superfamily	10 — CRO Repressor

结构域编号 domain_id	5croB00
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	240 — CRO Repressor
同源超家族 H-superfamily homologous superfamily	10 — CRO Repressor

结构域编号 domain_id	5croC00
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	240 — CRO Repressor
同源超家族 H-superfamily homologous superfamily	10 — CRO Repressor

结构域编号 domain_id	5croO00
类 Class class	3 — Alpha Beta
架构 Architecture architecture	30 — 2-Layer Sandwich
拓扑 Topology topology	240 — CRO Repressor
同源超家族 H-superfamily homologous superfamily	10 — CRO Repressor

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7. 引用文献 (19)

Refined structure of Cro repressor protein from bacteriophage lambda suggests both flexibility and plasticity.

J.Mol.Biol. (1998)

PMID: 9653036 · DOI: 10.1006/jmbi.1998.1849 PRIMARY

Different Interactions Used by Cro Repressor in Specific and Nonspecific DNA Binding

J.Biol.Chem. (1986)

Use of Protein Sequence and Structure to Infer Distant Evolutionary Relationships

Chem.Scr. (1986)

The Structure of Cro Repressor Protein

Biological Macromolecules and Assemblies. V.2: Nucleic Acids and Interactive Proteins (1985)

Cro Repressor Protein and its Interaction with DNA

Cold Spring Harbor Symp.Quant.Biol. (1983)

Many Gene-Regulatory Proteins Appear to Have a Similar Alpha-Helical Fold that Binds DNA and Evolved from a Common Precursor

J.Mol.Evol. (1983)

High Resolution Structural Studies of Cro Repressor Protein and Implications for DNA Recognition

J.Biomol.Struct.Dyn. (1983)

DNA-Binding Proteins

Science (1983)

Comparison of the Structures of Cro and Lambda Repressor Proteins from Bacteriophage Lambda

J.Mol.Biol. (1983)

Crystallographic Data for Complexes of the Cro Repressor with DNA

J.Mol.Biol. (1983)

Structural Studies of Protein-Nucleic Acid Interactions

Annu.Rev.Biophys.Bioeng. (1983)

How Does Cro Repressor Recognize its DNA Target Sites?

Trends Biochem.Sci. (1983)

The Molecular Basis of DNA-Protein Recognition Inferred from the Structure of Cro Repressor

Nature (1982)

Structural Similarity in the DNA-Binding Domains of Catabolite Gene Activator and Cro Repressor Proteins

Proc.Natl.Acad.Sci.USA (1982)

Structure of the DNA-Binding Region of Lac Repressor Inferred from its Homology with Cro Repressor

Proc.Natl.Acad.Sci.USA (1982)

Proposed Alpha-Helical Super-Secondary Structure Associated with Protein-DNA Recognition

J.Mol.Biol. (1982)

Structure of the Cro Repressor from Bacteriophage Lambda and its Interaction with DNA

Nature (1981)

The Structure of a Repressor. Crystallographic Data for the Cro Regulatory Protein of Bacteriophage Lambda

J.Mol.Biol. (1979)

Amino Acid Sequence of Cro Regulatory Protein of Bacteriophage Lambda

Nature (1977)

晶胞边长 a length_a	91.600 Å
晶胞边长 b length_b	91.600 Å
晶胞边长 c length_c	268.500 Å
晶胞夹角 α angle_alpha	90.00 °
晶胞夹角 β angle_beta	90.00 °
晶胞夹角 γ angle_gamma	120.00 °
晶胞分子数 Z z_pdb	72

空间群 space_group	H 3 2
空间群编号 int_tables_number	155
晶系 crystal_system	—

分辨率 resolution	2.300 Å
最低分辨率 resolution_low	20.000 Å
R 因子 r_factor	—
R_work r_work	0.1930
R_free r_free	—

描述 description	CRO REPRESSOR PROTEIN
分子量 formula_weight	7375.5 kDa
来源方法 src_method	nat
拷贝数 entity_count	4

聚合物类型 type	polypeptide(L)
链编号 strand_id	O,A,B,C
原子数 atom_count	1940

REFINED STRUCTURE OF CRO REPRESSOR PROTEIN FROM BACTERIOPHAGE LAMBDA

1. 蛋白身份与相关结构 Protein Identity & Related Structures

CRO REPRESSOR PROTEIN

当前结构中的状态

数据库中的同蛋白其他状态

2. 结构基本信息 2. Structure Basics

3. Official assembly/model 理论 SAXS Official SAXS Profiles

5cro__assembly_1__model_1

5cro__assembly_1__model_1 | I(q)

5cro__assembly_1__model_1 | P(r) · Pending

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

衍射实验 Diffraction

5. 实体与聚合物信息 Entities & Polymers (3)

实体 1 Entity 1 polymer

聚合物 Polymer

实体 2 Entity 2 non-polymer

实体 3 Entity 3 water

6. 折叠分类 (SCOP + CATH) 8 domains

SCOP 2.08 (4 domains)

CATH v4.4 (4 domains)

7. 引用文献 (19)

描述 description	PHOSPHATE ION
分子量 formula_weight	95.0 kDa
来源方法 src_method	syn
拷贝数 entity_count	2

描述 description	water
分子量 formula_weight	18.0 kDa
来源方法 src_method	nat
拷贝数 entity_count	33

REFINED STRUCTURE OF CRO REPRESSOR PROTEIN FROM BACTERIOPHAGE LAMBDA

1. 蛋白身份与相关结构 Protein Identity & Related Structures

CRO REPRESSOR PROTEIN

当前结构中的状态

数据库中的同蛋白其他状态

单体

同源二聚体

同源四聚体

其他同源多聚体

异源或核酸复合物

2. 结构基本信息 2. Structure Basics

3. Official assembly/model 理论 SAXS Official SAXS Profiles

5cro__assembly_1__model_1

5cro__assembly_1__model_1 | I(q)

5cro__assembly_1__model_1 | P(r) · Pending

4. 晶体学与实验 4. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

精修参数 Refinement

衍射实验 Diffraction

5. 实体与聚合物信息 Entities & Polymers (3)

实体 1 Entity 1 polymer

聚合物 Polymer

实体 2 Entity 2 non-polymer

实体 3 Entity 3 water

6. 折叠分类 (SCOP + CATH) 8 domains

SCOP 2.08 (4 domains)

CATH v4.4 (4 domains)

7. 引用文献 (19)