5d4c

Crystal structure of Thermus thermophilus product complex for transcription initiation with ATP and CTP

Method: X-RAY DIFFRACTION

1. 蛋白身份与相关结构 Protein Identity & Related Structures

DNA-directed RNA polymerase subunit alpha

物种未注明

UniProt Q9Z9H6

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–DNA 异源复合物 蛋白 6 DNA 2 DNA-directed RNA polymerase subunit beta × 1 (Q8RQE9) ;DNA-directed RNA polymerase subunit beta' ; × 1 (Q8RQE8) DNA-directed RNA polymerase subunit omega × 1 (Q8RQE7) RNA polymerase sigma factor SigA × 1 (Q5SKW1) ;DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*AP*GP*AP*G)-3') ; × 1 DNA (27-MER) × 1 MAGNESIUM ION × 5 ZINC ION × 2 CYTIDINE-5'-MONOPHOSPHATE × 1 CYTIDINE-5'-TRIPHOSPHATE × 1 ADENOSINE-5'-TRIPHOSPHATE × 1 water × 6 与全部聚合物一致
2 蛋白–DNA 异源复合物 蛋白 6 DNA 2 DNA-directed RNA polymerase subunit beta × 1 (Q8RQE9) ;DNA-directed RNA polymerase subunit beta' ; × 1 (Q8RQE8) DNA-directed RNA polymerase subunit omega × 1 (Q8RQE7) RNA polymerase sigma factor SigA × 1 (Q5SKW1) ;DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*AP*GP*AP*G)-3') ; × 1 DNA (27-MER) × 1 MAGNESIUM ION × 6 ZINC ION × 2 CYTIDINE-5'-MONOPHOSPHATE × 1 CYTIDINE-5'-TRIPHOSPHATE × 1 ADENOSINE-5'-TRIPHOSPHATE × 1 water × 6 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 RPOA_THETH
Isoform
PDB实体 1
链与序列区间 作者链 A; PDB构建体 1–315; UniProt 1–315 作者链 B; PDB构建体 1–315; UniProt 1–315 作者链 K; PDB构建体 1–315; UniProt 1–315 作者链 L; PDB构建体 1–315; UniProt 1–315

DNA-directed RNA polymerase subunit beta

物种未注明

UniProt Q8RQE9

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–DNA 异源复合物 蛋白 6 DNA 2 DNA-directed RNA polymerase subunit alpha × 2 (Q9Z9H6) ;DNA-directed RNA polymerase subunit beta' ; × 1 (Q8RQE8) DNA-directed RNA polymerase subunit omega × 1 (Q8RQE7) RNA polymerase sigma factor SigA × 1 (Q5SKW1) ;DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*AP*GP*AP*G)-3') ; × 1 DNA (27-MER) × 1 MAGNESIUM ION × 5 ZINC ION × 2 CYTIDINE-5'-MONOPHOSPHATE × 1 CYTIDINE-5'-TRIPHOSPHATE × 1 ADENOSINE-5'-TRIPHOSPHATE × 1 water × 6 与全部聚合物一致
2 蛋白–DNA 异源复合物 蛋白 6 DNA 2 DNA-directed RNA polymerase subunit alpha × 2 (Q9Z9H6) ;DNA-directed RNA polymerase subunit beta' ; × 1 (Q8RQE8) DNA-directed RNA polymerase subunit omega × 1 (Q8RQE7) RNA polymerase sigma factor SigA × 1 (Q5SKW1) ;DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*AP*GP*AP*G)-3') ; × 1 DNA (27-MER) × 1 MAGNESIUM ION × 6 ZINC ION × 2 CYTIDINE-5'-MONOPHOSPHATE × 1 CYTIDINE-5'-TRIPHOSPHATE × 1 ADENOSINE-5'-TRIPHOSPHATE × 1 water × 6 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 RPOB_THET8
Isoform
PDB实体 2
链与序列区间 作者链 C; PDB构建体 1–1119; UniProt 1–1119 作者链 M; PDB构建体 1–1119; UniProt 1–1119

;DNA-directed RNA polymerase subunit beta' ;

物种未注明

UniProt Q8RQE8

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–DNA 异源复合物 蛋白 6 DNA 2 DNA-directed RNA polymerase subunit alpha × 2 (Q9Z9H6) DNA-directed RNA polymerase subunit beta × 1 (Q8RQE9) DNA-directed RNA polymerase subunit omega × 1 (Q8RQE7) RNA polymerase sigma factor SigA × 1 (Q5SKW1) ;DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*AP*GP*AP*G)-3') ; × 1 DNA (27-MER) × 1 MAGNESIUM ION × 5 ZINC ION × 2 CYTIDINE-5'-MONOPHOSPHATE × 1 CYTIDINE-5'-TRIPHOSPHATE × 1 ADENOSINE-5'-TRIPHOSPHATE × 1 water × 6 与全部聚合物一致
2 蛋白–DNA 异源复合物 蛋白 6 DNA 2 DNA-directed RNA polymerase subunit alpha × 2 (Q9Z9H6) DNA-directed RNA polymerase subunit beta × 1 (Q8RQE9) DNA-directed RNA polymerase subunit omega × 1 (Q8RQE7) RNA polymerase sigma factor SigA × 1 (Q5SKW1) ;DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*AP*GP*AP*G)-3') ; × 1 DNA (27-MER) × 1 MAGNESIUM ION × 6 ZINC ION × 2 CYTIDINE-5'-MONOPHOSPHATE × 1 CYTIDINE-5'-TRIPHOSPHATE × 1 ADENOSINE-5'-TRIPHOSPHATE × 1 water × 6 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 RPOC_THET8
Isoform
PDB实体 3
链与序列区间 作者链 D; PDB构建体 1–1524; UniProt 1–1524 作者链 N; PDB构建体 1–1524; UniProt 1–1524

DNA-directed RNA polymerase subunit omega

物种未注明

UniProt Q8RQE7

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–DNA 异源复合物 蛋白 6 DNA 2 DNA-directed RNA polymerase subunit alpha × 2 (Q9Z9H6) DNA-directed RNA polymerase subunit beta × 1 (Q8RQE9) ;DNA-directed RNA polymerase subunit beta' ; × 1 (Q8RQE8) RNA polymerase sigma factor SigA × 1 (Q5SKW1) ;DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*AP*GP*AP*G)-3') ; × 1 DNA (27-MER) × 1 MAGNESIUM ION × 5 ZINC ION × 2 CYTIDINE-5'-MONOPHOSPHATE × 1 CYTIDINE-5'-TRIPHOSPHATE × 1 ADENOSINE-5'-TRIPHOSPHATE × 1 water × 6 与全部聚合物一致
2 蛋白–DNA 异源复合物 蛋白 6 DNA 2 DNA-directed RNA polymerase subunit alpha × 2 (Q9Z9H6) DNA-directed RNA polymerase subunit beta × 1 (Q8RQE9) ;DNA-directed RNA polymerase subunit beta' ; × 1 (Q8RQE8) RNA polymerase sigma factor SigA × 1 (Q5SKW1) ;DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*AP*GP*AP*G)-3') ; × 1 DNA (27-MER) × 1 MAGNESIUM ION × 6 ZINC ION × 2 CYTIDINE-5'-MONOPHOSPHATE × 1 CYTIDINE-5'-TRIPHOSPHATE × 1 ADENOSINE-5'-TRIPHOSPHATE × 1 water × 6 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 RPOZ_THET8
Isoform
PDB实体 4
链与序列区间 作者链 E; PDB构建体 1–99; UniProt 1–99 作者链 O; PDB构建体 1–99; UniProt 1–99

RNA polymerase sigma factor SigA

Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)

UniProt Q5SKW1

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–DNA 异源复合物 蛋白 6 DNA 2 DNA-directed RNA polymerase subunit alpha × 2 (Q9Z9H6) DNA-directed RNA polymerase subunit beta × 1 (Q8RQE9) ;DNA-directed RNA polymerase subunit beta' ; × 1 (Q8RQE8) DNA-directed RNA polymerase subunit omega × 1 (Q8RQE7) ;DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*AP*GP*AP*G)-3') ; × 1 DNA (27-MER) × 1 MAGNESIUM ION × 5 ZINC ION × 2 CYTIDINE-5'-MONOPHOSPHATE × 1 CYTIDINE-5'-TRIPHOSPHATE × 1 ADENOSINE-5'-TRIPHOSPHATE × 1 water × 6 与全部聚合物一致
2 蛋白–DNA 异源复合物 蛋白 6 DNA 2 DNA-directed RNA polymerase subunit alpha × 2 (Q9Z9H6) DNA-directed RNA polymerase subunit beta × 1 (Q8RQE9) ;DNA-directed RNA polymerase subunit beta' ; × 1 (Q8RQE8) DNA-directed RNA polymerase subunit omega × 1 (Q8RQE7) ;DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*AP*GP*AP*G)-3') ; × 1 DNA (27-MER) × 1 MAGNESIUM ION × 6 ZINC ION × 2 CYTIDINE-5'-MONOPHOSPHATE × 1 CYTIDINE-5'-TRIPHOSPHATE × 1 ADENOSINE-5'-TRIPHOSPHATE × 1 water × 6 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 Q5SKW1_THET8
Isoform
PDB实体 5
链与序列区间 作者链 F; PDB构建体 21–443; UniProt 1–423 作者链 P; PDB构建体 21–443; UniProt 1–423

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

2. 结构基本信息 2. Structure Basics

条目编号 entry_id5d4c
沉积日期 deposition_date2015-08-07
结构标题 titleCrystal structure of Thermus thermophilus product complex for transcription initiation with ATP and CTP
关键词 keywords;RNA polymerase, transcription initiation, bacterial, NCIN, non-canonical initiating nucleotide, primer-dependent initiation, DNA, Single-Stranded, DNA-Directed RNA Polymerases, Gene Expression Regulation, Promoter Regions, Genetic, Protein Conformation, Sigma Factor, Thermus thermophilus, TRANSCRIPTION, transcription-dna complex ;; transcription/dna
实验方法 methodX-RAY DIFFRACTION

3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

5d4c__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

5d4c__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

5d4c__assembly_1__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)52.09 Å
Rg(电子密度)52.92 Å
总 Rg52.89 Å
原子数28425
残基数3526
排除体积505510 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 5d4c__assembly_1__model_1 octameric (8) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
2 1 5d4c__assembly_2__model_1 octameric (8) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载

4. 晶体学与实验 4. Crystallography & Experiment

5. 实体与聚合物信息 Entities & Polymers (13)

6. 折叠分类 (SCOP + CATH) 27 domains

CATH v4.4 (27 domains)

结构域编号 domain_id5d4cA01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology1360 — Gyrase A; domain 2
同源超家族 H-superfamily homologous superfamily10 — RNA polymerase, RBP11-like subunit
结构域编号 domain_id5d4cA02
类 Class class2 — Mainly Beta
架构 Architecture architecture170 — Beta Complex
拓扑 Topology topology120 — RNA Polymerase Alpha Subunit; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily12 — DNA-directed RNA polymerase, insert domain
结构域编号 domain_id5d4cB01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology1360 — Gyrase A; domain 2
同源超家族 H-superfamily homologous superfamily10 — RNA polymerase, RBP11-like subunit
结构域编号 domain_id5d4cB02
类 Class class2 — Mainly Beta
架构 Architecture architecture170 — Beta Complex
拓扑 Topology topology120 — RNA Polymerase Alpha Subunit; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily12 — DNA-directed RNA polymerase, insert domain
结构域编号 domain_id5d4cC01
类 Class class2 — Mainly Beta
架构 Architecture architecture40 — Beta Barrel
拓扑 Topology topology270 — Dna-directed Rna Polymerase Ii 140kd Polypeptide; Chain: B; Domain 6
同源超家族 H-superfamily homologous superfamily10 — DNA-directed RNA polymerase, subunit 2, domain 6
结构域编号 domain_id5d4cC03
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology1110 — Dna-directed Rna Polymerase Ii 140kd Polypeptide; Chain: B; domain 3
同源超家族 H-superfamily homologous superfamily10 — RNA polymerase Rpb2, domain 2
结构域编号 domain_id5d4cC04
类 Class class2 — Mainly Beta
架构 Architecture architecture30 — Roll
拓扑 Topology topology150 — Rna Polymerase Beta Subunit; Chain: C, domain 4
同源超家族 H-superfamily homologous superfamily10 — DNA-directed RNA polymerase, beta subunit, external 1 domain
结构域编号 domain_id5d4cC05
类 Class class2 — Mainly Beta
架构 Architecture architecture40 — Beta Barrel
拓扑 Topology topology50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain
结构域编号 domain_id5d4cC06
类 Class class2 — Mainly Beta
架构 Architecture architecture40 — Beta Barrel
拓扑 Topology topology50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily150 — RNA polymerase II, Rpb2 subunit, wall domain
结构域编号 domain_id5d4cD01
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology274 — Enzyme I; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily100 — RNA polymerase Rpb1, domain 3
结构域编号 domain_id5d4cD02
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology132 — Topoisomerase I; Chain A, domain 4
同源超家族 H-superfamily homologous superfamily30 — RNA polymerase Rpb1 funnel domain
结构域编号 domain_id5d4cE00
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology940 — Eukaryotic RPB6 RNA polymerase subunit
同源超家族 H-superfamily homologous superfamily10 — RNA polymerase subunit, RPB6/omega
结构域编号 domain_id5d4cF02
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology10 — Arc Repressor Mutant, subunit A
同源超家族 H-superfamily homologous superfamily10 — Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
结构域编号 domain_id5d4cK01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology1360 — Gyrase A; domain 2
同源超家族 H-superfamily homologous superfamily10 — RNA polymerase, RBP11-like subunit
结构域编号 domain_id5d4cK02
类 Class class2 — Mainly Beta
架构 Architecture architecture170 — Beta Complex
拓扑 Topology topology120 — RNA Polymerase Alpha Subunit; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily12 — DNA-directed RNA polymerase, insert domain
结构域编号 domain_id5d4cL01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology1360 — Gyrase A; domain 2
同源超家族 H-superfamily homologous superfamily10 — RNA polymerase, RBP11-like subunit
结构域编号 domain_id5d4cL02
类 Class class2 — Mainly Beta
架构 Architecture architecture170 — Beta Complex
拓扑 Topology topology120 — RNA Polymerase Alpha Subunit; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily12 — DNA-directed RNA polymerase, insert domain
结构域编号 domain_id5d4cM01
类 Class class2 — Mainly Beta
架构 Architecture architecture40 — Beta Barrel
拓扑 Topology topology270 — Dna-directed Rna Polymerase Ii 140kd Polypeptide; Chain: B; Domain 6
同源超家族 H-superfamily homologous superfamily10 — DNA-directed RNA polymerase, subunit 2, domain 6
结构域编号 domain_id5d4cM03
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology1110 — Dna-directed Rna Polymerase Ii 140kd Polypeptide; Chain: B; domain 3
同源超家族 H-superfamily homologous superfamily10 — RNA polymerase Rpb2, domain 2
结构域编号 domain_id5d4cM04
类 Class class2 — Mainly Beta
架构 Architecture architecture30 — Roll
拓扑 Topology topology150 — Rna Polymerase Beta Subunit; Chain: C, domain 4
同源超家族 H-superfamily homologous superfamily10 — DNA-directed RNA polymerase, beta subunit, external 1 domain
结构域编号 domain_id5d4cM05
类 Class class2 — Mainly Beta
架构 Architecture architecture40 — Beta Barrel
拓扑 Topology topology50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily100 — RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain
结构域编号 domain_id5d4cM06
类 Class class2 — Mainly Beta
架构 Architecture architecture40 — Beta Barrel
拓扑 Topology topology50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
同源超家族 H-superfamily homologous superfamily150 — RNA polymerase II, Rpb2 subunit, wall domain
结构域编号 domain_id5d4cN01
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology274 — Enzyme I; Chain A, domain 2
同源超家族 H-superfamily homologous superfamily100 — RNA polymerase Rpb1, domain 3
结构域编号 domain_id5d4cN02
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology132 — Topoisomerase I; Chain A, domain 4
同源超家族 H-superfamily homologous superfamily30 — RNA polymerase Rpb1 funnel domain
结构域编号 domain_id5d4cO00
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology940 — Eukaryotic RPB6 RNA polymerase subunit
同源超家族 H-superfamily homologous superfamily10 — RNA polymerase subunit, RPB6/omega
结构域编号 domain_id5d4cP02
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology10 — Arc Repressor Mutant, subunit A
同源超家族 H-superfamily homologous superfamily10 — Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
结构域编号 domain_id5d4cP03
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology10 — Arc Repressor Mutant, subunit A
同源超家族 H-superfamily homologous superfamily10 — Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

7. 引用文献 (1)