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5f0q

Crystal structure of C-terminal domain of the human DNA primase large subunit with bound DNA template/RNA primer

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

DNA primase large subunit

Homo sapiens

UniProt P49643

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Other combination Monomer Protein 1 DNA 1 RNA 1 ;RNA (5'-R(P*GP*GP*CP*GP*GP*C)-3') ; × 1 ;DNA (5'-D(*GP*CP*CP*GP*CP*CP*AP*AP*CP*AP*TP*A)-3') ; × 1 IRON/SULFUR CLUSTER × 1 MAGNESIUM ION × 1 water × 3 Consistent with all polymers
2 Other combination Monomer Protein 1 DNA 1 RNA 1 ;RNA (5'-R(P*GP*GP*CP*GP*GP*C)-3') ; × 1 ;DNA (5'-D(*GP*CP*CP*GP*CP*CP*AP*AP*CP*AP*TP*A)-3') ; × 1 IRON/SULFUR CLUSTER × 1 MAGNESIUM ION × 1 water × 3 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer
3q36 3q36 4bpu 4bpu 4bpw 4bpw

6 assemblies

Homodimer
3l9q 5dqo 5dqo 5i7m 6dhw 6dhw

6 assemblies

Homotetramer
3l9q

1 assemblies

Other homooligomers

None

Heteromeric or nucleic-acid complex
4bpx 4bpx 4rr2 4rr2 5exr 5exr 5f0q 5f0q 5f0s 5f0s 7opl 7u5c

20 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name PRI2_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–191； UniProt 266–456 Author chain B； PDBConstruct 1–191； UniProt 266–456

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id5f0q
Deposition date deposition_date2015-11-28
Structure title titleCrystal structure of C-terminal domain of the human DNA primase large subunit with bound DNA template/RNA primer
Keywords keywords;Tranferase-DNA-RNA complex, DNA primase, large subunit, iron-sulfur cluster, RNA, DNA, primer, template, triphosphate, initiation site ;; Tranferase/DNA/RNA
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

5f0q__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

5f0q__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

5f0q__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）19.48 Å
Rg (electron density)18.38 Å
Total Rg19.19 Å
Atom count1916
Residues204
Excluded volume32796 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 5f0q__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 5f0q__assembly_2__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (6)

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7. Citations (1)