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5k8w

Crystal structure of mouse CARM1 in complex with inhibitor U2

Method: X-RAY DIFFRACTION Dmax: 128.9 Å Quality: GOOD
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Histone-arginine methyltransferase CARM1

Mus musculus

UniProt Q9WVG6

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein homooligomer Homooligomer Protein × 4 PDB declaration: tetrameric（4） Consistent with protein copy count Chain A； UniProt 130–487 Chain B； UniProt 130–487 Chain C； UniProt 130–487 Chain D； UniProt 130–487 Not recorded GJV 9-(7-{[amino(iminio)methyl]amino}-5,6,7-trideoxy-beta-D-ribo-heptofuranosyl)-9H-purin-6-amine × 4 DXE 1,2-DIMETHOXYETHANE × 6 EDO 1,2-ETHANEDIOL × 9 PG4 TETRAETHYLENE GLYCOL × 1 PEG DI(HYDROXYETHYL)ETHER × 2 X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；Tris-HCl pH 8.0 100 mM, PEG 2000 MME 15 % Resolution 2.10 Å R-free 0.240

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 5K8W Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
2V74 Crystal structure of coactivator-associated arginine methyltransferase 1 (CARM1), in complex with S-adenosyl-homocysteine Deposited 2007-07-26 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain B 147–490（344 aa） Fragment：CATALYTIC DOMAIN, RESIDUES 147-490
Chain D 147–490（344 aa） Fragment：CATALYTIC DOMAIN, RESIDUES 147-490
Not recorded SAH S-ADENOSYL-L-HOMOCYSTEINE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；1.6M DI-AMMONIUM HYDROGENPHOSPHATE, 100MM HEPES PH 7.5.
Resolution 2.70 Å R-free 0.273
2V74 Crystal structure of coactivator-associated arginine methyltransferase 1 (CARM1), in complex with S-adenosyl-homocysteine Deposited 2007-07-26 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain F 147–490（344 aa） Fragment：CATALYTIC DOMAIN, RESIDUES 147-490
Chain H 147–490（344 aa） Fragment：CATALYTIC DOMAIN, RESIDUES 147-490
Not recorded SAH S-ADENOSYL-L-HOMOCYSTEINE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；1.6M DI-AMMONIUM HYDROGENPHOSPHATE, 100MM HEPES PH 7.5.
Resolution 2.70 Å R-free 0.273
2V7E Crystal structure of coactivator-associated arginine methyltransferase 1 (CARM1), unliganded Deposited 2007-07-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 147–490（344 aa） Fragment：CATALYTIC DOMAIN, RESIDUES 147-490
Chain B 147–490（344 aa） Fragment：CATALYTIC DOMAIN, RESIDUES 147-490
Not recorded HG MERCURY (II) ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.5；1.6M DI-AMMONIUM HYDROGENPHOSPHATE, 100MM HEPES PH 7.5
Resolution 2.70 Å R-free 0.276
5IH3 Crystal structure of mouse CARM1 in complex with SAH at 1.8 Angstroms resolution Deposited 2016-02-29 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 130–487（358 aa） Fragment：UNP residues 130-487
Chain B 130–487（358 aa） Fragment：UNP residues 130-487
Chain C 130–487（358 aa） Fragment：UNP residues 130-487
Chain D 130–487（358 aa） Fragment：UNP residues 130-487
Not recorded SAH S-ADENOSYL-L-HOMOCYSTEINE × 4 EDO 1,2-ETHANEDIOL × 11 PEG DI(HYDROXYETHYL)ETHER × 6 PGE TRIETHYLENE GLYCOL × 1 PE8 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL × 1 DXE 1,2-DIMETHOXYETHANE × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；297 K；Tris-HCl pH 8.0 100 mM, PEG 2000 MME 19%, NaCl 167 mM
Resolution 1.77 Å R-free 0.191
5IS6 Crystal structure of mouse CARM1 in complex with Sinefungin at 2.0 Angstroms resolution Deposited 2016-03-15 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 130–487（358 aa）
Chain B 130–487（358 aa）
Chain C 130–487（358 aa）
Chain D 130–487（358 aa）
Not recorded PG4 TETRAETHYLENE GLYCOL × 3 EDO 1,2-ETHANEDIOL × 8 PEG DI(HYDROXYETHYL)ETHER × 3 DXE 1,2-DIMETHOXYETHANE × 6 SFG SINEFUNGIN × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；297 K；Tris-HCl pH 8.0 100 mM PEG 2000 MME 28 % NaCl 100 mM
Resolution 2.01 Å R-free 0.177
5IS7 Crystal structure of mouse CARM1 in complex with decarboxylated SAH Deposited 2016-03-15 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 130–487（358 aa）
Chain B 130–487（358 aa）
Chain C 130–487（358 aa）
Chain D 130–487（358 aa）
Not recorded EDO 1,2-ETHANEDIOL × 5 PEG DI(HYDROXYETHYL)ETHER × 2 DSH 5'-S-(3-aminopropyl)-5'-thioadenosine × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；297 K；Tris-HCl pH 8.0 100 mM PEG 2000 MME 25% NaCl 167 mM
Resolution 2.29 Å R-free 0.247
5IS8 Crystal structure of mouse CARM1 in complex with inhibitor SA0271 Deposited 2016-03-15 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 130–507（378 aa）
Chain B 130–507（378 aa）
Chain C 130–507（378 aa）
Chain D 130–507（378 aa）
Not recorded 6D1 5'-{[(3S)-3-amino-3-carboxypropyl](2-chloroethyl)amino}-5'-deoxyadenosine × 3 EDO 1,2-ETHANEDIOL × 3 SAH S-ADENOSYL-L-HOMOCYSTEINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；290 K；BTP pH 7.5 100 mM, PEG 3350 15%
Resolution 2.71 Å R-free 0.242
5IS9 Crystal structure of mouse CARM1 in complex with inhibitor SA0375 Deposited 2016-03-15 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 130–487（358 aa）
Chain B 130–487（358 aa）
Chain C 130–487（358 aa）
Chain D 130–487（358 aa）
Not recorded 6D3 (2S)-2-amino-4-[(3-{4-[(2S)-2-amino-2-carboxyethyl]-1H-1,2,3-triazol-1-yl}propyl){[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}amino]butanoic acid (non-preferred name) × 4 EDO 1,2-ETHANEDIOL × 16 PEG DI(HYDROXYETHYL)ETHER × 4 DXE 1,2-DIMETHOXYETHANE × 2 PG4 TETRAETHYLENE GLYCOL × 1 M2M 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；297 K；Tris-HCl pH 8.0 100 mM PEG 2000 MME 13 % NaCl 100 mM
Resolution 2.40 Å R-free 0.206
5ISA Crystal structure of mouse CARM1 in complex with inhibitor SA0401 Deposited 2016-03-15 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 130–490（361 aa）
Chain B 130–490（361 aa）
Chain C 130–490（361 aa）
Chain D 130–490（361 aa）
Not recorded 6D5 (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-(3-azidopropyl)amino]-2-azanyl-butanoic acid × 4 EDO 1,2-ETHANEDIOL × 8 DXE 1,2-DIMETHOXYETHANE × 3 PEG DI(HYDROXYETHYL)ETHER × 1 M2M 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE × 1 PG4 TETRAETHYLENE GLYCOL × 1 NA SODIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；290 K；MIB pH 7.0 100 mM PEG 1500 17.5 % NaCl 100 mM
Resolution 2.40 Å R-free 0.204
5ISB Crystal structure of mouse CARM1 in complex with inhibitor SA0435 Deposited 2016-03-15 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 130–487（358 aa）
Chain B 130–487（358 aa）
Chain C 130–487（358 aa）
Chain D 130–487（358 aa）
Not recorded 6CX 5'-{[(3S)-3-amino-3-carboxypropyl][(1H-imidazol-4-yl)methyl]amino}-5'-deoxyadenosine × 4 EDO 1,2-ETHANEDIOL × 16 PEG DI(HYDROXYETHYL)ETHER × 7 M2M 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE × 1 PG4 TETRAETHYLENE GLYCOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；297 K；Tris-HCl pH 8.0 100 mM PEG 2000 MME 19% NaCl 133 mM
Resolution 2.00 Å R-free 0.190
5ISC Crystal structure of mouse CARM1 in complex with inhibitor SA0491 Deposited 2016-03-15 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 130–487（358 aa）
Chain B 130–487（358 aa）
Chain C 130–487（358 aa）
Chain D 130–487（358 aa）
Not recorded SAO 5'-S-[(3S)-3-azaniumyl-3-carboxypropyl]-5'-thioadenosine × 2 EDO 1,2-ETHANEDIOL × 6 6D0 5'-{[(3S)-3-amino-3-carboxypropyl](3-bromo-2-oxopropyl)amino}-5'-deoxyadenosine × 2 DXE 1,2-DIMETHOXYETHANE × 2 M2M 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；290 K；Tris-HCl pH 8.0 100 mM PEG 2000 MME 19 %
Resolution 2.60 Å R-free 0.239
5ISD Crystal structure of mouse CARM1 in complex with inhibitor SA0592 Deposited 2016-03-15 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 130–487（358 aa）
Chain B 130–487（358 aa）
Chain C 130–487（358 aa）
Chain D 130–487（358 aa）
Not recorded EDO 1,2-ETHANEDIOL × 9 PEG DI(HYDROXYETHYL)ETHER × 3 M2M 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE × 1 SAO 5'-S-[(3S)-3-azaniumyl-3-carboxypropyl]-5'-thioadenosine × 3 6CZ 5'-{[(3S)-3-amino-3-carboxypropyl](3-ethoxy-2,3-dioxopropyl)amino}-5'-deoxyadenosine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；290 K；Tris-HCl pH 8.0 100 mM PEG 2000 MME 19 % NaCl 133 mM
Resolution 2.60 Å R-free 0.226
5ISE Crystal structure of mouse CARM1 in complex with inhibitor SA0649 Deposited 2016-03-15 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 130–487（358 aa）
Chain B 130–487（358 aa）
Not recorded 6D2 5'-{[(3S)-3-amino-3-carboxypropyl](3-carbamimidamidopropyl)amino}-5'-deoxyadenosine × 4 EDO 1,2-ETHANEDIOL × 4 PGE TRIETHYLENE GLYCOL × 2 DXE 1,2-DIMETHOXYETHANE × 4 PEG DI(HYDROXYETHYL)ETHER × 4 PE8 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；297 K；Tris-HCl pH 8.0 100 mM PEG 2000 MME 15 % NaCl 133 mM
Resolution 2.10 Å R-free 0.200
5ISE Crystal structure of mouse CARM1 in complex with inhibitor SA0649 Deposited 2016-03-15 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain C 130–487（358 aa）
Chain D 130–487（358 aa）
Not recorded 6D2 5'-{[(3S)-3-amino-3-carboxypropyl](3-carbamimidamidopropyl)amino}-5'-deoxyadenosine × 4 EDO 1,2-ETHANEDIOL × 4 DXE 1,2-DIMETHOXYETHANE × 4 PEG DI(HYDROXYETHYL)ETHER × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；297 K；Tris-HCl pH 8.0 100 mM PEG 2000 MME 15 % NaCl 133 mM
Resolution 2.10 Å R-free 0.200
5ISF Crystal structure of mouse CARM1 in complex with inhibitor SA0705 Deposited 2016-03-15 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 130–487（358 aa）
Chain B 130–487（358 aa）
Chain C 130–487（358 aa）
Chain D 130–487（358 aa）
Not recorded 6D4 5'-{[(3S)-3-amino-3-carboxypropyl][2-(triazan-1-yl)ethyl]amino}-5'-deoxyadenosine × 3 EDO 1,2-ETHANEDIOL × 7 PEG DI(HYDROXYETHYL)ETHER × 1 PG4 TETRAETHYLENE GLYCOL × 3 M2M 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE × 2 DXE 1,2-DIMETHOXYETHANE × 4 SAO 5'-S-[(3S)-3-azaniumyl-3-carboxypropyl]-5'-thioadenosine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；297 K；Tris-HCl pH 8.0 100 mM PEG 2000 MME 10 % NaCl 167 mM
Resolution 2.22 Å R-free 0.201
5ISG Crystal structure of mouse CARM1 in complex with inhibitor SA0707 Deposited 2016-03-15 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 130–487（358 aa）
Chain B 130–487（358 aa）
Chain C 130–487（358 aa）
Chain D 130–487（358 aa）
Not recorded DXE 1,2-DIMETHOXYETHANE × 3 EDO 1,2-ETHANEDIOL × 18 PG6 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE × 1 PEG DI(HYDROXYETHYL)ETHER × 2 6D6 5'-{[(3S)-3-amino-3-carboxypropyl](3-aminopropyl)amino}-5'-deoxyadenosine × 4 M2M 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；297 K；Tris-HCl pH 8.0 100 mM PEG 2000 MME 22% NaCl 200 mM
Resolution 2.42 Å R-free 0.207
5ISH Crystal structure of mouse CARM1 in complex with inhibitor SA0765 Deposited 2016-03-15 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 130–487（358 aa）
Chain B 130–487（358 aa）
Chain C 130–487（358 aa）
Chain D 130–487（358 aa）
Not recorded 765 5'-{1-[(3S)-3-amino-3-carboxypropyl]aziridin-1-ium-1-yl}-5'-deoxyadenosine × 4 EDO 1,2-ETHANEDIOL × 8 PEG DI(HYDROXYETHYL)ETHER × 4 DXE 1,2-DIMETHOXYETHANE × 6 M2M 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE × 1 PG4 TETRAETHYLENE GLYCOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；297 K；Tris-HCl pH 8.0 100 mM PEG 2000 MME 17 % NaCl 67 mM
Resolution 2.15 Å R-free 0.198
5ISI Crystal structure of mouse CARM1 in complex with inhibitor SA0920 (5'-amino-5'-deoxyadenosine) Deposited 2016-03-15 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 130–487（358 aa）
Chain B 130–487（358 aa）
Chain C 130–487（358 aa）
Chain D 130–487（358 aa）
Not recorded 5N5 5'-amino-5'-deoxyadenosine × 4 EDO 1,2-ETHANEDIOL × 6 DXE 1,2-DIMETHOXYETHANE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；297 K；Tris-HCl pH 8.0 100 mM PEG 2000 MME 16% NaCl 67 mM
Resolution 2.74 Å R-free 0.214
5K8V Crystal Structure of Mus musculus Protein Arginine Methyltransferase 4 (CARM1 130-487) with CP1 Deposited 2016-05-31 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 130–487（358 aa）
Chain B 130–487（358 aa）
Chain C 130–487（358 aa）
Chain D 130–487（358 aa）
Not recorded 6RE [[2-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]ethylamino]-azanyl-methylidene]azanium × 4 DXE 1,2-DIMETHOXYETHANE × 1 EDO 1,2-ETHANEDIOL × 10 PEG DI(HYDROXYETHYL)ETHER × 2 PG6 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；Tris-HCl pH 8.0 100 mM, PEG 2000 MME 15 %, NaCl 100 mM
Resolution 2.25 Å R-free 0.235
5K8X Crystal structure of mouse CARM1 in complex with inhibitor U3 Deposited 2016-05-31 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 130–487（358 aa）
Chain B 130–487（358 aa）
Chain C 130–487（358 aa）
Chain D 130–487（358 aa）
Not recorded 6ZH [[[(~{E})-3-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]prop-2-enyl]amino]-azanyl-methylidene]azanium × 4 EDO 1,2-ETHANEDIOL × 14 PEG DI(HYDROXYETHYL)ETHER × 5 PG4 TETRAETHYLENE GLYCOL × 1 PE8 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL × 1 DXE 1,2-DIMETHOXYETHANE × 6 M2M 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；Tris-HCl pH 8.0 100 mM, PEG 2000 MME 15 %, NaCl 100 mM
Resolution 1.99 Å R-free 0.211
5LGP Crystal structure of mouse CARM1 in complex with ligand P1C3s Deposited 2016-07-08 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 130–487（358 aa）
Chain B 130–487（358 aa）
Chain C 130–487（358 aa）
Chain D 130–487（358 aa）
Not recorded EDO 1,2-ETHANEDIOL × 5 8ZB (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-propyl-oxolane-3,4-diol × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；100 mM Tris-HCl pH 8.5 16% PEG 3350 200 mM A.S.
Resolution 2.04 Å R-free 0.219
5LGQ Crystal structure of mouse CARM1 in complex with ligand P2C3s Deposited 2016-07-08 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 130–487（358 aa）
Chain B 130–487（358 aa）
Chain C 130–487（358 aa）
Chain D 130–487（358 aa）
Not recorded EDO 1,2-ETHANEDIOL × 7 PEG DI(HYDROXYETHYL)ETHER × 4 DXE 1,2-DIMETHOXYETHANE × 1 PG6 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE × 1 SO4 SULFATE ION × 1 8ZB (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-propyl-oxolane-3,4-diol × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；100 mM Tris-HCl pH 8.5 14% PEG 3350 200 mM A.S.
Resolution 2.11 Å R-free 0.236
5LGR Crystal structure of mouse CARM1 in complex with ligand P1C3u Deposited 2016-07-08 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 130–487（358 aa）
Chain B 130–487（358 aa）
Chain C 130–487（358 aa）
Chain D 130–487（358 aa）
Not recorded SO4 SULFATE ION × 1 EDO 1,2-ETHANEDIOL × 6 DXE 1,2-DIMETHOXYETHANE × 1 PG6 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE × 1 PEG DI(HYDROXYETHYL)ETHER × 1 QVR (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[(~{E})-prop-1-enyl]oxolane-3,4-diol × 4 LPD L-PROLINAMIDE × 4 ACE ACETYL GROUP × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；Tris-HCl pH 8.5 100 mM PEG 3350 14 % Ammonium Sulfate 200 mM
Resolution 2.00 Å R-free 0.234
5LGS Crystal structure of mouse CARM1 in complex with ligand P2C3u Deposited 2016-07-08 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 130–487（358 aa）
Chain B 130–487（358 aa）
Chain C 130–487（358 aa）
Chain D 130–487（358 aa）
Not recorded SO4 SULFATE ION × 1 DXE 1,2-DIMETHOXYETHANE × 3 PEG DI(HYDROXYETHYL)ETHER × 1 PG4 TETRAETHYLENE GLYCOL × 1 EDO 1,2-ETHANEDIOL × 3 QVR (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[(~{E})-prop-1-enyl]oxolane-3,4-diol × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；Tris-HCl pH 8.5 100 mM PEG 3350 20 % A.S. 200 mM
Resolution 2.10 Å R-free 0.215
5LKJ Crystal structure of mouse CARM1 in complex with ligand SA684 Deposited 2016-07-22 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 130–497（368 aa）
Chain B 130–497（368 aa）
Chain C 130–497（368 aa）
Chain D 130–497（368 aa）
Not recorded 6YB (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-(2-carbamimidamidoethyl)amino]-2-azanyl-butanoic acid × 4 EDO 1,2-ETHANEDIOL × 8 DXE 1,2-DIMETHOXYETHANE × 5 PEG DI(HYDROXYETHYL)ETHER × 3 P33 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；297 K；100 mM BTP pH 7.5 30% PEG 1500
Resolution 2.60 Å R-free 0.220
5LV2 Crystal structure of mouse CARM1 in complex with inhibitor LH1246 Deposited 2016-09-12 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 130–487（358 aa）
Chain B 130–487（358 aa）
Chain C 130–487（358 aa）
Chain D 130–487（358 aa）
Not recorded SAO 5'-S-[(3S)-3-azaniumyl-3-carboxypropyl]-5'-thioadenosine × 2 EDO 1,2-ETHANEDIOL × 5 LHB 5-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylamino]methyl]-4-azanyl-1-(methoxymethyl)pyrimidin-2-one × 2 PG4 TETRAETHYLENE GLYCOL × 2 M2M 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE × 1 DXE 1,2-DIMETHOXYETHANE × 1 PEG DI(HYDROXYETHYL)ETHER × 1 NA SODIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；Tris-HCl pH 8.0 100 mM PEG 2000 MME 17 % NaCl 100 mM
Resolution 2.29 Å R-free 0.238
5LV2 Crystal structure of mouse CARM1 in complex with inhibitor LH1246 Deposited 2016-09-12 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain E 130–487（358 aa）
Chain F 130–487（358 aa）
Chain G 130–487（358 aa）
Chain H 130–487（358 aa）
Not recorded SAO 5'-S-[(3S)-3-azaniumyl-3-carboxypropyl]-5'-thioadenosine × 2 EDO 1,2-ETHANEDIOL × 8 LHB 5-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylamino]methyl]-4-azanyl-1-(methoxymethyl)pyrimidin-2-one × 2 PG4 TETRAETHYLENE GLYCOL × 2 M2M 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE × 1 NA SODIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；Tris-HCl pH 8.0 100 mM PEG 2000 MME 17 % NaCl 100 mM
Resolution 2.29 Å R-free 0.238
5LV3 Crystal structure of mouse CARM1 in complex with ligand LH1561Br Deposited 2016-09-12 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 130–487（358 aa）
Chain B 130–487（358 aa）
Chain C 130–487（358 aa）
Chain D 130–487（358 aa）
Not recorded SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 LHF 5-[[2-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]ethylamino]methyl]-4-azanyl-1-[2-(4-bromanylphenoxy)ethyl]pyrimidin-2-one × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；297 K；Tris-HCl pH 8.0 100 mM PEG 2000 MME 15% NaCl 100 mM
Resolution 1.80 Å R-free 0.203
5NTC Crystal structure of mouse CARM1 in complex with inhibitor SA0678 Deposited 2017-04-27 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 130–497（368 aa）
Chain B 130–497（368 aa）
Chain C 130–497（368 aa）
Chain D 130–497（368 aa）
Not recorded EDO 1,2-ETHANEDIOL × 13 PEG DI(HYDROXYETHYL)ETHER × 2 DXE 1,2-DIMETHOXYETHANE × 2 M2M 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE × 1 B3P 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 3 6L7 [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-(2-azaniumylethyl)-[(3~{S})-3-azaniumyl-4-oxidanyl-4-oxidanylidene-butyl]azanium × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；297 K；BTP pH 7.5 100 mM, PEG 2000 MME 25 %, NaCl 50 mM
Resolution 2.25 Å R-free 0.216
5TBH Crystal structure of mouse CARM1 in complex with inhibitor LH1236 Deposited 2016-09-12 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 130–487（358 aa）
Chain B 130–487（358 aa）
Chain C 130–487（358 aa）
Chain D 130–487（358 aa）
Not recorded M2M 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE × 1 EDO 1,2-ETHANEDIOL × 17 PG4 TETRAETHYLENE GLYCOL × 1 SAO 5'-S-[(3S)-3-azaniumyl-3-carboxypropyl]-5'-thioadenosine × 2 78K (2~{R})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[[4-azanyl-1-(methoxymethyl)-2-oxidanylidene-pyrimidin-5-yl]methyl]amino]-2-azanyl-butanoic acid × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；Tris-HCl pH 8.0 100 mM PEG 2000 MME 19% NaCl 100 mM
Resolution 2.34 Å R-free 0.230
5TBI Crystal structure of mouse CARM1 in complex with inhibitor LH1427 Deposited 2016-09-12 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 130–487（358 aa） Fragment：UNP residues 130-487
Chain B 130–487（358 aa） Fragment：UNP residues 130-487
Chain C 130–487（358 aa） Fragment：UNP residues 130-487
Chain D 130–487（358 aa） Fragment：UNP residues 130-487
Not recorded EDO 1,2-ETHANEDIOL × 17 SAO 5'-S-[(3S)-3-azaniumyl-3-carboxypropyl]-5'-thioadenosine × 2 PE8 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL × 1 78V 4-[2-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylamino]ethylamino]-1-(methoxymethyl)pyrimidin-2-one × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；Tris-HCl pH 8.0 100 mM PEG 2000 MME 21% NaCl 100 mM
Resolution 2.29 Å R-free 0.228
5TBJ Crystal structure of mouse CARM1 in complex with inhibitor LH1452 Deposited 2016-09-12 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 130–487（358 aa）
Chain B 130–487（358 aa）
Chain C 130–487（358 aa）
Chain D 130–487（358 aa）
Not recorded LHD 2-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]ethyl-[[4-azanyl-1-(methoxymethyl)-2-oxidanylidene-pyrimidin-5-yl]methyl]azanium × 4 PEG DI(HYDROXYETHYL)ETHER × 4 EDO 1,2-ETHANEDIOL × 11 DXE 1,2-DIMETHOXYETHANE × 1 PG6 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；Tris-HCl pH 8.0 100 mM PEG 2000 MME 19% NaCl 100 mM
Resolution 2.32 Å R-free 0.237
7OKP Crystal structure of mouse CARM1 in complex with histone H3_13-22 K18 acetylated Deposited 2021-05-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 130–497（368 aa）
Chain B 130–497（368 aa）
Not recorded MLI MALONATE ION × 2 QVR (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[(~{E})-prop-1-enyl]oxolane-3,4-diol × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；1M sodium malonate, 0.1M MES pH7.0, 0.2M sodium chloride
Resolution 2.20 Å R-free 0.254
7OKP Crystal structure of mouse CARM1 in complex with histone H3_13-22 K18 acetylated Deposited 2021-05-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain C 130–497（368 aa）
Chain D 130–497（368 aa）
Not recorded MLI MALONATE ION × 8 QVR (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[(~{E})-prop-1-enyl]oxolane-3,4-diol × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；1M sodium malonate, 0.1M MES pH7.0, 0.2M sodium chloride
Resolution 2.20 Å R-free 0.254
7OS4 Crystal structure of mouse CARM1 in complex with histone H3_13-31 K18 Deposited 2021-06-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 130–497（368 aa）
Chain B 130–497（368 aa）
Not recorded QVR (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[(~{E})-prop-1-enyl]oxolane-3,4-diol × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；293 K；1.2M Sodium malonate 0.1M MES pH 5.5 0.2M NaCl
Resolution 2.54 Å R-free 0.255
7OS4 Crystal structure of mouse CARM1 in complex with histone H3_13-31 K18 Deposited 2021-06-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain C 130–497（368 aa）
Chain D 130–497（368 aa）
Not recorded QVR (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[(~{E})-prop-1-enyl]oxolane-3,4-diol × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；293 K；1.2M Sodium malonate 0.1M MES pH 5.5 0.2M NaCl
Resolution 2.54 Å R-free 0.255
7PPQ CARM1 in complex with EML736 Deposited 2021-09-14 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 130–487（358 aa）
Chain B 130–487（358 aa）
Chain C 130–487（358 aa）
Chain D 130–487（358 aa）
Not recorded LSK methyl 6-[5-[[~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl]carbamimidoyl]amino]pentylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate × 4 EDO 1,2-ETHANEDIOL × 7 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；15% PEG 2000, 0.1M sodium chloride, 0.1M tris-HCl
Resolution 2.10 Å R-free 0.228
7PPY CARM1 in complex with EML709 Deposited 2021-09-15 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 130–487（358 aa）
Chain B 130–487（358 aa）
Chain C 130–487（358 aa）
Chain D 130–487（358 aa）
Not recorded 7ZH methyl 6-[4-[[~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl]carbamimidoyl]amino]butylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate × 4 EDO 1,2-ETHANEDIOL × 12 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；12% PEG 2000, 100mM NaCl, 100mM TrisHCl pH8
Resolution 2.42 Å R-free 0.235
7PU8 CARM1 in complex with EML980 Deposited 2021-09-28 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 130–487（358 aa）
Chain B 130–487（358 aa）
Chain C 130–487（358 aa）
Chain D 130–487（358 aa）
Not recorded 4R7 methyl 6-[4-[[N-[2-[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]ethyl]carbamimidoyl]amino]butylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate × 4 EDO 1,2-ETHANEDIOL × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；15% PEG 2000, 0.1M Sodium Chloride, 0.1M Tris HCl
Resolution 2.19 Å R-free 0.229
7PUC CARM1 in complex with EML981 Deposited 2021-09-29 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 130–487（358 aa）
Chain B 130–487（358 aa）
Chain C 130–487（358 aa）
Chain D 130–487（358 aa）
Not recorded 85U methyl 6-[4-[[~{N}-[(~{E})-3-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]prop-2-enyl]carbamimidoyl]amino]butylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate × 4 EDO 1,2-ETHANEDIOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；15% PEG 3350, 200mM AMMONIUM SULFATE, 100mM TRIS HCL pH8.5
Resolution 2.19 Å R-free 0.231
7PUQ CARM1 in complex with EML982 Deposited 2021-09-30 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 130–486（357 aa）
Chain B 130–486（357 aa）
Chain C 130–486（357 aa）
Chain D 130–486（357 aa）
Not recorded 867 methyl 6-[4-[[~{N}-[3-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]propyl]carbamimidoyl]amino]butylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate × 4 EDO 1,2-ETHANEDIOL × 7 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；12% PEG 3350, 0.1 M NaCl, 0.1 M TrisHCl pH8.5
Resolution 2.09 Å R-free 0.217
7PV6 CARM1 in complex with EML734 Deposited 2021-10-01 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 130–497（368 aa）
Chain B 130–497（368 aa）
Not recorded LRZ methyl 6-[3-[[~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl]carbamimidoyl]amino]propylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate × 4 EDO 1,2-ETHANEDIOL × 18 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；20 mM Tris pH 7.5, 50 mM NaCl, 1 mM TCEP
Resolution 2.40 Å R-free 0.237
7PV6 CARM1 in complex with EML734 Deposited 2021-10-01 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain C 130–497（368 aa）
Chain D 130–497（368 aa）
Not recorded LRZ methyl 6-[3-[[~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl]carbamimidoyl]amino]propylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate × 4 EDO 1,2-ETHANEDIOL × 6 PG4 TETRAETHYLENE GLYCOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；20 mM Tris pH 7.5, 50 mM NaCl, 1 mM TCEP
Resolution 2.40 Å R-free 0.237
7QPH Crystal structure of mouse CARM1 in complex with histone H3_22-31 K27 acetylated Deposited 2022-01-04 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 130–487（358 aa）
Chain B 130–487（358 aa）
Chain C 130–487（358 aa）
Chain D 130–487（358 aa）
Not recorded EDO 1,2-ETHANEDIOL × 1 QVR (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[(~{E})-prop-1-enyl]oxolane-3,4-diol × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；16% PEG 3350, 0.2M ammonium sulfate, 0.1M Tris HCl pH8.5
Resolution 1.90 Å R-free 0.210
7QRD Crystal structure of mouse CARM1 in complex with histone H3_10-25 Deposited 2022-01-11 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain A 130–507（378 aa）
Chain B 130–507（378 aa）
Chain C 130–507（378 aa）
Chain D 130–507（378 aa）
Not recorded EDO 1,2-ETHANEDIOL × 4 MLI MALONATE ION × 2 SAH S-ADENOSYL-L-HOMOCYSTEINE × 2 QVR (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[(~{E})-prop-1-enyl]oxolane-3,4-diol × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；20 mM Tris-HCl pH 7.5 50 mM NaCl 1 mM TCEP
Resolution 2.00 Å R-free 0.254
9I0A CARM1 in complex with arg-aDMA analog Deposited 2025-01-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 130–487（358 aa）
Chain B 130–487（358 aa）
Not recorded A1IZI (phenylmethyl) (2S)-5-[[N-[3-[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]propyl]-N-methyl-carbamimidoyl]amino]-2-(phenylmethoxycarbonylamino)pentanoate × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；10% PEG3350, 100 mM tris pH7.5, 0.1M NaCl
Resolution 2.22 Å R-free 0.237
9I0A CARM1 in complex with arg-aDMA analog Deposited 2025-01-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain C 130–487（358 aa）
Chain D 130–487（358 aa）
Not recorded A1IZI (phenylmethyl) (2S)-5-[[N-[3-[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]propyl]-N-methyl-carbamimidoyl]amino]-2-(phenylmethoxycarbonylamino)pentanoate × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；10% PEG3350, 100 mM tris pH7.5, 0.1M NaCl
Resolution 2.22 Å R-free 0.237
9I1T CARM1 in complex with arg-MMA analog Deposited 2025-01-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 130–487（358 aa）
Chain B 130–487（358 aa）
Not recorded A1IZ2 (phenylmethyl) (2S)-5-[[N-[3-[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]propyl]carbamimidoyl]amino]-2-(phenylmethoxycarbonylamino)pentanoate × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；9% PEG3350, 100mM Tris HCl pH7.5, 0.2M ammonium sulfate
Resolution 2.39 Å R-free 0.238
9I1T CARM1 in complex with arg-MMA analog Deposited 2025-01-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain C 130–487（358 aa）
Chain D 130–487（358 aa）
Not recorded A1IZ2 (phenylmethyl) (2S)-5-[[N-[3-[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]propyl]carbamimidoyl]amino]-2-(phenylmethoxycarbonylamino)pentanoate × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；9% PEG3350, 100mM Tris HCl pH7.5, 0.2M ammonium sulfate
Resolution 2.39 Å R-free 0.238
9I9U CARM1 in complex with arg-sDMA analog Deposited 2025-02-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 130–497（368 aa）
Chain B 130–497（368 aa）
Not recorded A1I1H (phenylmethyl) (2S)-5-[(Z)-[[3-[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]propylamino]-(methylamino)methylidene]amino]-2-(phenylmethoxycarbonylamino)pentanoate × 2 CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；12% PEG6000, 100 mM hepes pH7
Resolution 2.20 Å R-free 0.245
9I9U CARM1 in complex with arg-sDMA analog Deposited 2025-02-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain C 130–497（368 aa）
Chain D 130–497（368 aa）
Not recorded A1I1H (phenylmethyl) (2S)-5-[(Z)-[[3-[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]propylamino]-(methylamino)methylidene]amino]-2-(phenylmethoxycarbonylamino)pentanoate × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；12% PEG6000, 100 mM hepes pH7
Resolution 2.20 Å R-free 0.245

42 other PDB entries and 51 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name CARM1_MOUSE
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 4–361； UniProt 130–487 Author chain B； PDBConstruct 4–361； UniProt 130–487 Author chain C； PDBConstruct 4–361； UniProt 130–487 Author chain D； PDBConstruct 4–361； UniProt 130–487

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

SAXS scattering curve SAXS Profile

SAXS profile for 5k8w

P(r) Distance Distribution P(r) Distribution

P(r) distribution for 5k8w
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2. Structure Basics 2. Structure Basics

Entry ID entry_id5k8w
Deposition date deposition_date2016-05-31
Structure title titleCrystal structure of mouse CARM1 in complex with inhibitor U2
Keywords keywords;PROTEIN ARGININE METHYLTRANSFERASE, CATALYTIC DOMAIN, CHROMATIN REGULATOR, MRNA PROCESSING, MRNA SPLICING, NUCLEUS, S-ADENOSYL-L-METHIONINE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE ;; TRANSFERASE
Experimental Method methodX-RAY DIFFRACTION
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3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier39.95 Å
Radius of gyration Rg (electron density) rg_electron39.63 Å
Forward intensity I(0) i0355417000.00
Molecular weight molecular_weight158960.0 kDa
Excluded volume excluded_volume200590 ų
Envelope volume envelope_volume252670 ų
Hydration-shell volume shell_volume53286 ų
Envelope diameter envelope_diameter130.0 Å
Shell Rg shell_rg45.43 Å
Envelope Rg envelope_rg38.86 Å
Shape Rg shape_rg39.59 Å
Total Rg total_rg40.08 Å
Total atoms total_atoms22265
Residues n_residues1373
Spherical-harmonic order n_harmonics20
q range q_range— – 0.5000 Å−1
Data points n_points101
Shell type shell_typedirectional
Solvent electron density solvent_density0.3340 e/ų
Shell contrast contrast_shell0.0300 e/ų
CRYSOL version crysol_version4.1.3
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4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax128.9 Å
Rg (real space) rg_real39.93 Å
Rg uncertainty (real space) rg_real_error0.93 Å
I(0) (real space) i0_real3.5540e+08
I(0) uncertainty (real space) i0_real_error5.8780e+06
Rg (reciprocal space) rg_reciprocal39.95 Å
I(0) (reciprocal space) i0_reciprocal355400000.0000
Solution quality estimate total_estimate0.8311
Solution quality rating solution_quality GOOD a GOOD solution
P(r) peaks n_peaks1
Primary peak position r_peak_primary45.1 Å
Skewness Skewness skewness0.236
Kurtosis Kurtosis kurtosis-0.656
Angular range angular_range— – 0.2000 Å−1
Current regularization parameter α current_alpha0.0000
Highest regularization parameter α highest_alpha46720000.0000
Real-space data points n_real_points41
GNOM version gnom_version4.1.3
Quality Criteria quality_criteria AN1: 0.000; Oscil: 0.938; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.985; Smooth: 0.000
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5. Crystallography and Experiment 5. Crystallography & Experiment

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6. Entities and Polymers Entities & Polymers (7)

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7. Fold Classification (SCOP + CATH) 8 domains

CATH v4.4 (8 domains)

Domain ID domain_id5k8wA01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily150 — Vaccinia Virus protein VP39
Domain ID domain_id5k8wA02
Class class2 — Mainly Beta
Architecture architecture70 — Distorted Sandwich
Topology topology160 — Hnrnp arginine n-methyltransferase1
Homologous superfamily homologous superfamily11 — Hnrnp arginine n-methyltransferase1
Domain ID domain_id5k8wB01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily150 — Vaccinia Virus protein VP39
Domain ID domain_id5k8wB02
Class class2 — Mainly Beta
Architecture architecture70 — Distorted Sandwich
Topology topology160 — Hnrnp arginine n-methyltransferase1
Homologous superfamily homologous superfamily11 — Hnrnp arginine n-methyltransferase1
Domain ID domain_id5k8wC01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily150 — Vaccinia Virus protein VP39
Domain ID domain_id5k8wC02
Class class2 — Mainly Beta
Architecture architecture70 — Distorted Sandwich
Topology topology160 — Hnrnp arginine n-methyltransferase1
Homologous superfamily homologous superfamily11 — Hnrnp arginine n-methyltransferase1
Domain ID domain_id5k8wD01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily150 — Vaccinia Virus protein VP39
Domain ID domain_id5k8wD02
Class class2 — Mainly Beta
Architecture architecture70 — Distorted Sandwich
Topology topology160 — Hnrnp arginine n-methyltransferase1
Homologous superfamily homologous superfamily11 — Hnrnp arginine n-methyltransferase1
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8. Citations (1)

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9. Files and Curves (10)