5lxs

Tubulin-KS-1-199-32 complex

Method: X-RAY DIFFRACTION
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

Tubulin alpha-1B chain

物种未注明

UniProt P81947

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 6 Tubulin beta-2B chain × 2 (Q6B856) Stathmin-4 × 1 (P63043) Tubulin tyrosine ligase × 1 (E1BQ43) GUANOSINE-5'-TRIPHOSPHATE × 2 MAGNESIUM ION × 5 CALCIUM ION × 4 GUANOSINE-5'-DIPHOSPHATE × 2 ;[(3~{Z},5~{S},6~{S},7~{S},8~{R},9~{S},11~{Z},13~{S},14~{S},15~{S},16~{Z},18~{S})-19-[(2~{S},3~{R},4~{S},5~{R})-3,5-dimethyl-4-oxidanyl-6-oxidanylidene-oxan-2-yl]-5,7,9,11,13,15-hexamethyl-8,14,18-tris(oxidanyl)nonadeca-1,3,11,16-tetraen-6-yl] ~{N}-[3-[(3-azidophenyl)carbonylamino]propyl]carbamate ; × 2 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER × 1 water × 6 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 TBA1B_BOVIN
Isoform —
PDB实体 1
链与序列区间 作者链 A; PDB构建体 1–451; UniProt 1–451 作者链 C; PDB构建体 1–451; UniProt 1–451

Tubulin beta-2B chain

物种未注明

UniProt Q6B856

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 6 Tubulin alpha-1B chain × 2 (P81947) Stathmin-4 × 1 (P63043) Tubulin tyrosine ligase × 1 (E1BQ43) GUANOSINE-5'-TRIPHOSPHATE × 2 MAGNESIUM ION × 5 CALCIUM ION × 4 GUANOSINE-5'-DIPHOSPHATE × 2 ;[(3~{Z},5~{S},6~{S},7~{S},8~{R},9~{S},11~{Z},13~{S},14~{S},15~{S},16~{Z},18~{S})-19-[(2~{S},3~{R},4~{S},5~{R})-3,5-dimethyl-4-oxidanyl-6-oxidanylidene-oxan-2-yl]-5,7,9,11,13,15-hexamethyl-8,14,18-tris(oxidanyl)nonadeca-1,3,11,16-tetraen-6-yl] ~{N}-[3-[(3-azidophenyl)carbonylamino]propyl]carbamate ; × 2 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER × 1 water × 6 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 TBB2B_BOVIN
Isoform —
PDB实体 2
链与序列区间 作者链 B; PDB构建体 1–445; UniProt 1–445 作者链 D; PDB构建体 1–445; UniProt 1–445

Stathmin-4

Rattus norvegicus

UniProt P63043

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 6 Tubulin alpha-1B chain × 2 (P81947) Tubulin beta-2B chain × 2 (Q6B856) Tubulin tyrosine ligase × 1 (E1BQ43) GUANOSINE-5'-TRIPHOSPHATE × 2 MAGNESIUM ION × 5 CALCIUM ION × 4 GUANOSINE-5'-DIPHOSPHATE × 2 ;[(3~{Z},5~{S},6~{S},7~{S},8~{R},9~{S},11~{Z},13~{S},14~{S},15~{S},16~{Z},18~{S})-19-[(2~{S},3~{R},4~{S},5~{R})-3,5-dimethyl-4-oxidanyl-6-oxidanylidene-oxan-2-yl]-5,7,9,11,13,15-hexamethyl-8,14,18-tris(oxidanyl)nonadeca-1,3,11,16-tetraen-6-yl] ~{N}-[3-[(3-azidophenyl)carbonylamino]propyl]carbamate ; × 2 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER × 1 water × 6 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 STMN4_RAT
Isoform —
PDB实体 3
链与序列区间 作者链 E; PDB构建体 3–143; UniProt 49–189

Tubulin tyrosine ligase

Gallus gallus

UniProt E1BQ43

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 6 Tubulin alpha-1B chain × 2 (P81947) Tubulin beta-2B chain × 2 (Q6B856) Stathmin-4 × 1 (P63043) GUANOSINE-5'-TRIPHOSPHATE × 2 MAGNESIUM ION × 5 CALCIUM ION × 4 GUANOSINE-5'-DIPHOSPHATE × 2 ;[(3~{Z},5~{S},6~{S},7~{S},8~{R},9~{S},11~{Z},13~{S},14~{S},15~{S},16~{Z},18~{S})-19-[(2~{S},3~{R},4~{S},5~{R})-3,5-dimethyl-4-oxidanyl-6-oxidanylidene-oxan-2-yl]-5,7,9,11,13,15-hexamethyl-8,14,18-tris(oxidanyl)nonadeca-1,3,11,16-tetraen-6-yl] ~{N}-[3-[(3-azidophenyl)carbonylamino]propyl]carbamate ; × 2 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER × 1 water × 6 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 E1BQ43_CHICK
Isoform —
PDB实体 4
链与序列区间 作者链 F; PDB构建体 1–378; UniProt 1–378

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id5lxs
沉积日期 deposition_date2016-09-22
结构标题 titleTubulin-KS-1-199-32 complex
关键词 keywordsCELL CYCLE, TUBULIN FOLD, CYTOSKELETON, MICROTUBULE, DISCODERMOLIDE; CELL CYCLE
实验方法 methodX-RAY DIFFRACTION
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

5lxs__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

5lxs__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

5lxs__assembly_1__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)56.25 Å
Rg(电子密度)57.15 Å
总 Rg56.93 Å
原子数17715
残基数2201
排除体积313560 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 5lxs__assembly_1__model_1 hexameric (6) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (12)

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6. 折叠分类 (SCOP + CATH) 28 domains

SCOP 2.08 (12 domains)

结构域编号 domain_idd5lxsa1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.32 — Tubulin nucleotide-binding domain-like
超家族 Superfamily superfamilyc.32.1 — Tubulin nucleotide-binding domain-like
家族 Family familyc.32.1.1 — Tubulin, GTPase domain
结构域编号 domain_idd5lxsa2
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.79 — Bacillus chorismate mutase-like
超家族 Superfamily superfamilyd.79.2 — Tubulin C-terminal domain-like
家族 Family familyd.79.2.1 — Tubulin, C-terminal domain
结构域编号 domain_idd5lxsb1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.32 — Tubulin nucleotide-binding domain-like
超家族 Superfamily superfamilyc.32.1 — Tubulin nucleotide-binding domain-like
家族 Family familyc.32.1.1 — Tubulin, GTPase domain
结构域编号 domain_idd5lxsb2
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.79 — Bacillus chorismate mutase-like
超家族 Superfamily superfamilyd.79.2 — Tubulin C-terminal domain-like
家族 Family familyd.79.2.1 — Tubulin, C-terminal domain
结构域编号 domain_idd5lxsc1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.32 — Tubulin nucleotide-binding domain-like
超家族 Superfamily superfamilyc.32.1 — Tubulin nucleotide-binding domain-like
家族 Family familyc.32.1.1 — Tubulin, GTPase domain
结构域编号 domain_idd5lxsc2
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.79 — Bacillus chorismate mutase-like
超家族 Superfamily superfamilyd.79.2 — Tubulin C-terminal domain-like
家族 Family familyd.79.2.1 — Tubulin, C-terminal domain
结构域编号 domain_idd5lxsd1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.32 — Tubulin nucleotide-binding domain-like
超家族 Superfamily superfamilyc.32.1 — Tubulin nucleotide-binding domain-like
家族 Family familyc.32.1.1 — Tubulin, GTPase domain
结构域编号 domain_idd5lxsd2
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.79 — Bacillus chorismate mutase-like
超家族 Superfamily superfamilyd.79.2 — Tubulin C-terminal domain-like
家族 Family familyd.79.2.1 — Tubulin, C-terminal domain
结构域编号 domain_idd5lxse_
类 Class classa — All alpha proteins
折叠类型 Fold folda.137 — Non-globular all-alpha subunits of globular proteins
超家族 Superfamily superfamilya.137.10 — Stathmin
家族 Family familya.137.10.1 — Stathmin
结构域编号 domain_idd5lxsf1
类 Class classc — Alpha and beta proteins (a/b)
折叠类型 Fold foldc.30 — PreATP-grasp domain
超家族 Superfamily superfamilyc.30.1 — PreATP-grasp domain
家族 Family familyc.30.1.9 — Tubulin tyrosine ligase (TTL) N-terminal domain-like
结构域编号 domain_idd5lxsf2
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.142 — ATP-grasp
超家族 Superfamily superfamilyd.142.1 — Glutathione synthetase ATP-binding domain-like
家族 Family familyd.142.1.10 — Tubulin tyrosine ligase (TTL) C-terminal domain-like
结构域编号 domain_idd5lxsf3
类 Class classl — Artifacts
折叠类型 Fold foldl.1 — Tags
超家族 Superfamily superfamilyl.1.1 — Tags
家族 Family familyl.1.1.1 — Tags

CATH v4.4 (16 domains)

结构域编号 domain_id5lxsA01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily1440 — Tubulin/FtsZ, GTPase domain
结构域编号 domain_id5lxsA02
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology1330 — 60s Ribosomal Protein L30; Chain: A;
同源超家族 H-superfamily homologous superfamily20 — Tubulin/FtsZ, C-terminal domain
结构域编号 domain_id5lxsA03
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology287 — Helix Hairpins
同源超家族 H-superfamily homologous superfamily600 — Helix hairpin bin
结构域编号 domain_id5lxsB01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily1440 — Tubulin/FtsZ, GTPase domain
结构域编号 domain_id5lxsB02
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology1330 — 60s Ribosomal Protein L30; Chain: A;
同源超家族 H-superfamily homologous superfamily20 — Tubulin/FtsZ, C-terminal domain
结构域编号 domain_id5lxsB03
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology287 — Helix Hairpins
同源超家族 H-superfamily homologous superfamily600 — Helix hairpin bin
结构域编号 domain_id5lxsC01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily1440 — Tubulin/FtsZ, GTPase domain
结构域编号 domain_id5lxsC02
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology1330 — 60s Ribosomal Protein L30; Chain: A;
同源超家族 H-superfamily homologous superfamily20 — Tubulin/FtsZ, C-terminal domain
结构域编号 domain_id5lxsC03
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology287 — Helix Hairpins
同源超家族 H-superfamily homologous superfamily600 — Helix hairpin bin
结构域编号 domain_id5lxsD01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily1440 — Tubulin/FtsZ, GTPase domain
结构域编号 domain_id5lxsD02
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology1330 — 60s Ribosomal Protein L30; Chain: A;
同源超家族 H-superfamily homologous superfamily20 — Tubulin/FtsZ, C-terminal domain
结构域编号 domain_id5lxsD03
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology287 — Helix Hairpins
同源超家族 H-superfamily homologous superfamily600 — Helix hairpin bin
结构域编号 domain_id5lxsE01
类 Class class6 — Special
架构 Architecture architecture10 — Helix non-globular
拓扑 Topology topology280 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
同源超家族 H-superfamily homologous superfamily30 —
结构域编号 domain_id5lxsF01
类 Class class3 — Alpha Beta
架构 Architecture architecture40 — 3-Layer(aba) Sandwich
拓扑 Topology topology50 — Rossmann fold
同源超家族 H-superfamily homologous superfamily11480 —
结构域编号 domain_id5lxsF02
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology470 — D-amino Acid Aminotransferase; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily20 — ATP-grasp fold, B domain
结构域编号 domain_id5lxsF03
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology1490 — Dna Ligase; domain 1
同源超家族 H-superfamily homologous superfamily20 — ATP-grasp fold, A domain
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7. 引用文献 (1)