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5vyk

Crystal structure of the BRS domain of BRAF in complex with the CC-SAM domain of KSR1

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Chimera protein of BRS domain of BRAF and CC-SAM domain of KSR1,Serine/threonine-protein kinase B-raf

Homo sapiens

UniProt P15056

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Homooligomer Protein 2 GLYCEROL × 2 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2fb8 2fb8 2l05 3c4c 3c4c 3d4q 3d4q 3idp 3idp 3ii5 3ii5 3ppj

104 assemblies; showing the first 12

Homodimer
1uwh 1uwj 3ii5 3ny5 3ny5 3ny5 3q96 4dbn 4e26 4ehe 4ehg 4fc0

43 assemblies; showing the first 12

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
4mne 4mne 5vyk 6nyb 6pp9 6q0j 6q0k 6q0t 6u2g 6u2h 6uan 6v2w

44 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name BRAF_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 158–232； UniProt 36–110 Author chain C； PDBConstruct 158–232； UniProt 36–110

Chimera protein of BRS domain of BRAF and CC-SAM domain of KSR1,Serine/threonine-protein kinase B-raf

Homo sapiens

UniProt Q8IVT5

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Homooligomer Protein 2 GLYCEROL × 2 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
5vyk 7juw 7jux 7juy 7juz 7jv0 7jv1 9axh

8 assemblies

View Construct and Data Evidence
UniProt name KSR1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 4–149； UniProt 27–172 Author chain C； PDBConstruct 4–149； UniProt 27–172

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id5vyk
Deposition date deposition_date2017-05-25
Structure title titleCrystal structure of the BRS domain of BRAF in complex with the CC-SAM domain of KSR1
Keywords keywordsBRAF, KSR1, BRS, CC-SAM, Complex, Kinase, Pseudokinase, Signaling., SIGNALING PROTEIN; SIGNALING PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

5vyk__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

5vyk__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

5vyk__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）22.26 Å
Rg (electron density)21.17 Å
Total Rg22.03 Å
Atom count3050
Residues405
Excluded volume54381 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 5vyk__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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7. Citations (1)