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5wbh

Structure of the FRB domain of mTOR bound to a substrate recruitment peptide of S6K1

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Serine/threonine-protein kinase mTOR

Homo sapiens

UniProt P42345

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 water × 1 Consistent with protein count
2 Protein monomer Monomer Protein 1 water × 1 Consistent with protein count
3 Protein monomer Monomer Protein 1 water × 1 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 Ribosomal protein S6 kinase beta-1 × 1 （P23443） water × 2 Consistent with protein count
5 Protein monomer Monomer Protein 1 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1aue 1aue 2gaq 2npu 3jbz 5wbh 5wbh 5wbh 5wbh

9 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1fap 1nsg 2fap 2rse 3fap 4drh 4drh 4dri 4drj 4fap 4jsn 4jsn

76 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name MTOR_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 3–99； UniProt 2018–2114 Author chain B； PDBConstruct 3–99； UniProt 2018–2114 Author chain C； PDBConstruct 3–99； UniProt 2018–2114 Author chain D； PDBConstruct 3–99； UniProt 2018–2114 Author chain E； PDBConstruct 3–99； UniProt 2018–2114

Ribosomal protein S6 kinase beta-1

Homo sapiens

UniProt P23443

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
4 Protein heterocomplex Heteromer Protein 2 Serine/threonine-protein kinase mTOR × 1 （P42345） water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
3a61 3a62 3we4 3wf5 3wf6 3wf7 3wf8 3wf9 4rlo 4rlo 4rlp 7n91

15 assemblies; showing the first 12

Homodimer
3a60 3wf8 3wf9 4rlo 4rlp

5 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
5wbh 5wbk

2 assemblies

View Construct and Data Evidence
UniProt name KS6B1_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain W； PDBConstruct 1–26； UniProt 412–437

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id5wbh
Deposition date deposition_date2017-06-29
Structure title titleStructure of the FRB domain of mTOR bound to a substrate recruitment peptide of S6K1
Keywords keywordsTRANSFERASE; TRANSFERASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

5wbh__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

5wbh__assembly_1__model_1 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

5wbh__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）14.27 Å
Rg (electron density)13.00 Å
Total Rg14.38 Å
Atom count1532
Residues92
Excluded volume13842 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 5wbh__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 5wbh__assembly_2__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 5wbh__assembly_3__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 5wbh__assembly_4__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
5 1 5wbh__assembly_5__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 11 domains

SCOP 2.08 (6 domains)

Domain ID domain_idd5wbha_
Class classa — All alpha proteins
Fold Fold folda.24 — Four-helical up-and-down bundle
Superfamily Superfamily superfamilya.24.7 — FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
Family Family familya.24.7.1 — FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
Domain ID domain_idd5wbhb_
Class classa — All alpha proteins
Fold Fold folda.24 — Four-helical up-and-down bundle
Superfamily Superfamily superfamilya.24.7 — FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
Family Family familya.24.7.1 — FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
Domain ID domain_idd5wbhc_
Class classa — All alpha proteins
Fold Fold folda.24 — Four-helical up-and-down bundle
Superfamily Superfamily superfamilya.24.7 — FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
Family Family familya.24.7.1 — FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
Domain ID domain_idd5wbhd_
Class classa — All alpha proteins
Fold Fold folda.24 — Four-helical up-and-down bundle
Superfamily Superfamily superfamilya.24.7 — FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
Family Family familya.24.7.1 — FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
Domain ID domain_idd5wbhe1
Class classa — All alpha proteins
Fold Fold folda.24 — Four-helical up-and-down bundle
Superfamily Superfamily superfamilya.24.7 — FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
Family Family familya.24.7.1 — FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
Domain ID domain_idd5wbhe2
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags

CATH v4.4 (5 domains)

Domain ID domain_id5wbhA00
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily150 — FKBP12-rapamycin binding domain
Domain ID domain_id5wbhB00
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily150 — FKBP12-rapamycin binding domain
Domain ID domain_id5wbhC00
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily150 — FKBP12-rapamycin binding domain
Domain ID domain_id5wbhD00
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily150 — FKBP12-rapamycin binding domain
Domain ID domain_id5wbhE00
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily150 — FKBP12-rapamycin binding domain
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7. Citations (1)