← Back to search
5wp6

Cryo-EM structure of a human TRPM4 channel in complex with calcium and decavanadate

Method: ELECTRON MICROSCOPY
▼

1. Protein Identity and Related Structures Protein Identity & Related Structures

Transient receptor potential cation channel subfamily M member 4

Homo sapiens

UniProt Q8TD43

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 4 DECAVANADATE × 8 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
9b8x 9b8z 9b91 9y2c 9z24 9z26

6 assemblies

Homodimer

None

Homotetramer
30kw 30kz 30la 30ld 5wp6 6bqr 6bqv 8rcr 8rcu 8rd9 9b8w 9b8y

32 assemblies; showing the first 12

Other homooligomers

None

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name TRPM4_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–1214； UniProt 1–1214 Author chain B； PDBConstruct 1–1214； UniProt 1–1214 Author chain C； PDBConstruct 1–1214； UniProt 1–1214 Author chain D； PDBConstruct 1–1214； UniProt 1–1214

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

▼

2. Structure Basics 2. Structure Basics

Entry ID entry_id5wp6
Deposition date deposition_date2017-08-03
Structure title titleCryo-EM structure of a human TRPM4 channel in complex with calcium and decavanadate
Keywords keywordsIon channel, MEMBRANE PROTEIN; MEMBRANE PROTEIN
Experimental Method methodELECTRON MICROSCOPY
▼

3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

5wp6__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

5wp6__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

5wp6__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）54.35 Å
Rg (electron density)53.82 Å
Total Rg53.79 Å
Atom count29036
Residues3908
Excluded volume519480 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 5wp6__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
▶

4. Crystallography and Experiment 4. Crystallography & Experiment

▶

5. Entities and Polymers Entities & Polymers (2)

▼

6. Fold Classification (SCOP + CATH) 3 domains

SCOP 2.08 (3 domains)

Domain ID domain_idd5wp6b1
Class classf — Membrane and cell surface proteins and peptides
Fold Fold foldf.14 — Gated ion channels
Superfamily Superfamily superfamilyf.14.1 — Voltage-gated ion channels
Family Family familyf.14.1.4 — TRPM-like (melastatin-like transient receptor potential) channels
Domain ID domain_idd5wp6b2
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.211 — beta-hairpin-alpha-hairpin repeat
Superfamily Superfamily superfamilyd.211.1 — Ankyrin repeat
Family Family familyd.211.1.1 — Ankyrin repeat
Domain ID domain_idd5wp6b3
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.129 — MCP/YpsA-like
Superfamily Superfamily superfamilyc.129.1 — MCP/YpsA-like
Family Family familyc.129.1.3 — SMF/DprA-LOG (SLOG) domain from TPRM channels
▶

7. Citations (1)