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9z26

Cryo-EM structure of human TRPM4 channel in complex with calcium and NBA at 37 degrees Celsius (monomeric TMD-focused map with best-resolved NBA density)

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Transient receptor potential cation channel subfamily M member 4

Homo sapiens

UniProt Q8TD43

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 CALCIUM ION × 1 4-chloranyl-2-(2-naphthalen-1-yloxyethanoylamino)benzoic acid × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
9b8x 9b8z 9b91 9y2c 9z24 9z26

6 assemblies

Homodimer

None

Homotetramer
30kw 30kz 30la 30ld 5wp6 6bqr 6bqv 8rcr 8rcu 8rd9 9b8w 9b8y

32 assemblies; showing the first 12

Other homooligomers

None

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name TRPM4_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–1214； UniProt 1–1214

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id9z26
Deposition date deposition_date2025-11-04
Structure title titleCryo-EM structure of human TRPM4 channel in complex with calcium and NBA at 37 degrees Celsius (monomeric TMD-focused map with best-resolved NBA density)
Keywords keywordsion channel, TRP channel, MEMBRANE PROTEIN; MEMBRANE PROTEIN
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

9z26__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

9z26__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

9z26__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）28.98 Å
Rg (electron density)28.19 Å
Total Rg28.74 Å
Atom count2945
Residues364
Excluded volume53652 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 9z26__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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7. Citations (1)