Transient receptor potential cation channel subfamily M member 4
Homo sapiens
State in the Current Structure
| Assembly | Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Associated Components | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|
| 1 | Protein monomer Monomer Protein × 1 PDB declaration: monomeric（1） Consistent with protein copy count | Chain A； UniProt 1–1214 | Not recorded | CA CALCIUM ION × 2 ATP ADENOSINE-5'-TRIPHOSPHATE × 1 | ELECTRON MICROSCOPY cryo-EM buffer：pH 8 cryo-EM vitrification conditions：Cryogen ETHANE | Resolution 3.30 Å |
Other States of the Same Protein in the Database
Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.
| Other PDB | Difference from Current Entry 9B91 | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 30KW Human Trpm4 at 8 degrees Celsius Deposited 2026-05-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–1214（1214 aa）
Chain B
1–1214（1214 aa）
Chain C
1–1214（1214 aa）
Chain D
1–1214（1214 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions | Resolution 3.10 Å |
| 30KZ Human trpm4 in complex with PBA at 8 degrees Celsius Deposited 2026-05-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–1214（1214 aa）
Chain B
1–1214（1214 aa）
Chain C
1–1214（1214 aa）
Chain D
1–1214（1214 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions | Resolution 3.40 Å |
| 30LA Human Trpm4 with calcium at 37 degrees celsius Deposited 2026-05-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–1214（1214 aa）
Chain B
1–1214（1214 aa）
Chain C
1–1214（1214 aa）
Chain D
1–1214（1214 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions | Resolution 3.00 Å |
| 30LD Human Trpm4 with calcium and PBA at 37 degrees celsius Deposited 2026-05-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–1214（1214 aa）
Chain B
1–1214（1214 aa）
Chain C
1–1214（1214 aa）
Chain D
1–1214（1214 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions | Resolution 3.00 Å |
| 5WP6 Cryo-EM structure of a human TRPM4 channel in complex with calcium and decavanadate Deposited 2017-08-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–1214（1214 aa）
Chain B
1–1214（1214 aa）
Chain C
1–1214（1214 aa）
Chain D
1–1214（1214 aa）
|
Not recorded | DVT DECAVANADATE × 8 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.80 Å |
| 6BQR Human TRPM4 ion channel in lipid nanodiscs in a calcium-free state Deposited 2017-11-28 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
75–1168（1094 aa）
Chain B
75–1168（1094 aa）
Chain C
75–1168（1094 aa）
Chain D
75–1168（1094 aa）
|
Not recorded | Y01 CHOLESTEROL HEMISUCCINATE × 12 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.20 Å |
| 6BQV Human TRPM4 ion channel in lipid nanodiscs in a calcium-bound state Deposited 2017-11-28 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–1214（1213 aa）
Chain B
2–1214（1213 aa）
Chain C
2–1214（1213 aa）
Chain D
2–1214（1213 aa）
|
Not recorded | CA CALCIUM ION × 4 Y01 CHOLESTEROL HEMISUCCINATE × 12 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.10 Å |
| 8RCR human TRPM4 in SMA apo Deposited 2023-12-07 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
421–1168（748 aa）
Chain B
421–1168（748 aa）
Chain C
421–1168（748 aa）
Chain D
421–1168（748 aa）
|
Not recorded | CLR CHOLESTEROL × 12 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.60 Å |
| 8RCU human TRPM4 in SMA IBA Deposited 2023-12-07 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
421–1168（748 aa）
Chain B
421–1168（748 aa）
Chain C
421–1168（748 aa）
Chain D
421–1168（748 aa）
|
Not recorded | A1HZ5 4-chloranyl-2-[2-(3-iodanylphenoxy)ethanoylamino]benzoic acid × 4 CLR CHOLESTEROL × 8 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.50 Å |
| 8RD9 human TRPM4 in SMA NBA Deposited 2023-12-07 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
420–1168（749 aa）
Chain C
420–1168（749 aa）
Chain D
420–1168（749 aa）
Chain E
420–1168（749 aa）
|
Not recorded | A1H0C 4-chloranyl-2-(2-naphthalen-1-yloxyethanoylamino)benzoic acid × 4 CLR CHOLESTEROL × 8 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.30 Å |
| 9B8W Cryo-EM structure of the human TRPM4 in complex with calcium at 37 degrees Celsius Deposited 2024-04-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–1214（1214 aa）
Chain B
1–1214（1214 aa）
Chain C
1–1214（1214 aa）
Chain D
1–1214（1214 aa）
|
Not recorded | CA CALCIUM ION × 8 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.10 Å |
| 9B8X Cryo-EM structure of the human TRPM4 channel subunit in complex with calcium 37 degrees Celsius Deposited 2024-04-01 | Different ligand/ion Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1–1214（1214 aa）
|
Not recorded | CA CALCIUM ION × 2 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.00 Å |
| 9B8Y Cryo-EM structure of the human TRPM4 channel in complex with calcium and decavanadate at 37 degrees Celsius Deposited 2024-04-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–1214（1214 aa）
Chain B
1–1214（1214 aa）
Chain C
1–1214（1214 aa）
Chain D
1–1214（1214 aa）
|
Not recorded | CA CALCIUM ION × 8 DVT DECAVANADATE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.20 Å |
| 9B8Z Cryo-EM structure of the human TRPM4 channel subunit in complex with calcium and decavanadate at 37 degrees Celsius Deposited 2024-04-01 | Different ligand/ion Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1–1214（1214 aa）
|
Not recorded | CA CALCIUM ION × 2 DVT DECAVANADATE × 1 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.40 Å |
| 9B90 Cryo-EM structure of the human TRPM4 channel in complex with calcium and ATP at 37 degrees Celsius Deposited 2024-04-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–1214（1214 aa）
Chain B
1–1214（1214 aa）
Chain C
1–1214（1214 aa）
Chain D
1–1214（1214 aa）
|
Not recorded | CA CALCIUM ION × 8 ATP ADENOSINE-5'-TRIPHOSPHATE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.40 Å |
| 9B92 Cryo-EM structure of the human TRPM4 in complex with calcium at 18 degrees Celsius Deposited 2024-04-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–1214（1214 aa）
Chain B
1–1214（1214 aa）
Chain C
1–1214（1214 aa）
Chain D
1–1214（1214 aa）
|
Not recorded | CA CALCIUM ION × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.50 Å |
| 9B93 Cryo-EM structure of the human TRPM4 channel in the presence of EDTA at 37 degrees Celsius Deposited 2024-04-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–1214（1214 aa）
Chain B
1–1214（1214 aa）
Chain C
1–1214（1214 aa）
Chain D
1–1214（1214 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.10 Å |
| 9B94 Cryo-EM structure of the E396A mutant of human TRPM4 in complex with calcium at 37 degrees Celsius Deposited 2024-04-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–1214（1214 aa）
Chain B
1–1214（1214 aa）
Chain C
1–1214（1214 aa）
Chain D
1–1214（1214 aa）
|
Mutation：E396A Mutation：E396A Mutation：E396A Mutation：E396A | CA CALCIUM ION × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.10 Å |
| 9I3R Human TRPM4 ion channel in MAASTY copolymer lipid nanodisc in a calcium-bound state Deposited 2025-01-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–1214（1213 aa）
Chain B
2–1214（1213 aa）
Chain C
2–1214（1213 aa）
Chain D
2–1214（1213 aa）
|
Not recorded | CLR CHOLESTEROL × 12 CA CALCIUM ION × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.46 Å |
| 9MRT Cryo-EM structure of the human TRPM4 channel in a calcium and PI(4,5)P2 bound open state Deposited 2025-01-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–1214（1214 aa）
Chain B
1–1214（1214 aa）
Chain C
1–1214（1214 aa）
Chain D
1–1214（1214 aa）
|
Not recorded | PT5 [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate × 4 CA CALCIUM ION × 8 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.44 Å |
| 9MT8 Cryo-EM structure of the human TRPM4 channel in a calcium bound putative desensitized state Deposited 2025-01-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–1214（1214 aa）
Chain B
1–1214（1214 aa）
Chain C
1–1214（1214 aa）
Chain D
1–1214（1214 aa）
|
Not recorded | CA CALCIUM ION × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.19 Å |
| 9MTA Cryo-EM structure of the human TRPM4 channel in an apo closed state Deposited 2025-01-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–1214（1214 aa）
Chain B
1–1214（1214 aa）
Chain C
1–1214（1214 aa）
Chain D
1–1214（1214 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.78 Å |
| 9MTC Cryo-EM structure of the human TRPM4 channel in a ATP bound inhibited state Deposited 2025-01-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–1214（1214 aa）
Chain B
1–1214（1214 aa）
Chain C
1–1214（1214 aa）
Chain D
1–1214（1214 aa）
|
Not recorded | ATP ADENOSINE-5'-TRIPHOSPHATE × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.63 Å |
| 9SMK Human TRPM4 ion channel in MSP2N2 lipid nanodisc in a calcium-bound state Deposited 2025-09-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–1214（1213 aa）
Chain B
2–1214（1213 aa）
Chain C
2–1214（1213 aa）
Chain D
2–1214（1213 aa）
|
Not recorded | CA CALCIUM ION × 4 Y01 CHOLESTEROL HEMISUCCINATE × 12 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.80 Å |
| 9Y2A Cryo-EM structure of the human TRPM4 channel in complex with calcium and DAB at 37 degrees Celsius Deposited 2025-08-31 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–1214（1214 aa）
Chain B
1–1214（1214 aa）
Chain C
1–1214（1214 aa）
Chain D
1–1214（1214 aa）
|
Not recorded | CA CALCIUM ION × 8 A1CR0 4,4'-[(pyridin-2-yl)methylene]diphenol × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.30 Å |
| 9Y2B Cryo-EM structure of the human TRPM4 channel in complex with EGTA and DAB at 37 degrees Celsius Deposited 2025-08-31 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–1214（1214 aa）
Chain B
1–1214（1214 aa）
Chain C
1–1214（1214 aa）
Chain D
1–1214（1214 aa）
|
Not recorded | A1CR0 4,4'-[(pyridin-2-yl)methylene]diphenol × 4 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.20 Å |
| 9Y2C Cryo-EM structure of the human TRPM4 channel subunit in complex with calcium and DAB at 37 degrees Celsius Deposited 2025-08-31 | Different ligand/ion Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1–1214（1214 aa）
|
Not recorded | CA CALCIUM ION × 2 A1CR0 4,4'-[(pyridin-2-yl)methylene]diphenol × 1 |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.40 Å |
| 9Z1W Cryo-EM structure of human TRPM4 channel in complex with calcium and TPPO at 37 degrees Celsius (consensus) Deposited 2025-11-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–1214（1214 aa）
Chain B
1–1214（1214 aa）
Chain C
1–1214（1214 aa）
Chain D
1–1214（1214 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions | Resolution 2.86 Å |
| 9Z1Z Cryo-EM structure of human TRPM4 channel in complex with calcium and TPPO at 18 degrees Celsius (consensus) Deposited 2025-11-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–1214（1214 aa）
Chain B
1–1214（1214 aa）
Chain C
1–1214（1214 aa）
Chain D
1–1214（1214 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions | Resolution 2.63 Å |
| 9Z20 Cryo-EM structure of human TRPM4 channel in complex with EGTA and TPPO at 37 degrees Celsius (consensus) Deposited 2025-11-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–1214（1214 aa）
Chain B
1–1214（1214 aa）
Chain C
1–1214（1214 aa）
Chain D
1–1214（1214 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions | Resolution 2.51 Å |
| 9Z21 Cryo-EM structure of human TRPM4 channel in complex with calcium and NC1 at 37 degrees Celsius (consensus) Deposited 2025-11-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–1214（1214 aa）
Chain B
1–1214（1214 aa）
Chain C
1–1214（1214 aa）
Chain D
1–1214（1214 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions | Resolution 2.83 Å |
| 9Z22 Cryo-EM structure of human TRPM4 channel in complex with EGTA and NC1 at 37 degrees Celsius (consensus) Deposited 2025-11-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–1214（1214 aa）
Chain B
1–1214（1214 aa）
Chain C
1–1214（1214 aa）
Chain D
1–1214（1214 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions | Resolution 2.58 Å |
| 9Z23 Cryo-EM structure of human TRPM4 channel in complex with calcium and CBA at 37 degrees Celsius (consensus) Deposited 2025-11-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–1214（1214 aa）
Chain B
1–1214（1214 aa）
Chain C
1–1214（1214 aa）
Chain D
1–1214（1214 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions | Resolution 2.59 Å |
| 9Z24 Cryo-EM structure of human TRPM4 channel in complex with calcium and CBA at 37 degrees Celsius (monomeric TMD-focused map with best-resolved CBA density) Deposited 2025-11-04 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1–1214（1214 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions | Resolution 3.10 Å |
| 9Z25 Cryo-EM structure of human TRPM4 channel in complex with calcium and NBA at 37 degrees Celsius (consensus) Deposited 2025-11-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–1214（1214 aa）
Chain B
1–1214（1214 aa）
Chain C
1–1214（1214 aa）
Chain D
1–1214（1214 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions | Resolution 2.64 Å |
| 9Z26 Cryo-EM structure of human TRPM4 channel in complex with calcium and NBA at 37 degrees Celsius (monomeric TMD-focused map with best-resolved NBA density) Deposited 2025-11-04 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1–1214（1214 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions | Resolution 2.90 Å |
| 9Z27 Cryo-EM structure of human TRPM4 channel in complex with calcium and CBA and DVT at 37 degrees Celsius (consensus) Deposited 2025-11-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
1–1214（1214 aa）
Chain B
1–1214（1214 aa）
Chain C
1–1214（1214 aa）
Chain D
1–1214（1214 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions | Resolution 2.76 Å |
37 other PDB entries and 37 assemblies. Open the comparison page and filter oligomeric states
View Construct and Data Evidence
| UniProt name | TRPM4_HUMAN |
| Isoform | — |
| PDB entities | 1 |
| Chains and sequence ranges | Author chain A； PDBConstruct 1–1214； UniProt 1–1214 |
