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5wqd

Crystal structure of TRF2 TRFH in complex with an NBS1 peptide

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Telomeric repeat-binding factor 2

Homo sapiens

UniProt Q15554

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Nibrin × 1 （O60934） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 Nibrin × 1 （O60934） Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 Nibrin × 1 （O60934） Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 Nibrin × 1 （O60934） Consistent with protein count
5 Protein heterocomplex Heteromer Protein 2 Nibrin × 1 （O60934） Consistent with protein count
6 Protein heterocomplex Heteromer Protein 2 Nibrin × 1 （O60934） Consistent with protein count
7 Protein heterocomplex Heteromer Protein 2 Nibrin × 1 （O60934） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1vf9 1xg1

2 assemblies

Homodimer
1h6p

1 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1vfc 1w0u 3bu8 3bu8 3bu8 3bu8 3bua 3bua 3bua 3bua 3bua 3k6g

32 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name TERF2_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–204； UniProt 84–287 Author chain B； PDBConstruct 1–204； UniProt 84–287 Author chain C； PDBConstruct 1–204； UniProt 84–287 Author chain D； PDBConstruct 1–204； UniProt 84–287 Author chain E； PDBConstruct 1–204； UniProt 84–287 Author chain F； PDBConstruct 1–204； UniProt 84–287 Author chain G； PDBConstruct 1–204； UniProt 84–287

Nibrin

OrganismNot specified

UniProt O60934

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Telomeric repeat-binding factor 2 × 1 （Q15554） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 Telomeric repeat-binding factor 2 × 1 （Q15554） Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 Telomeric repeat-binding factor 2 × 1 （Q15554） Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 Telomeric repeat-binding factor 2 × 1 （Q15554） Consistent with protein count
5 Protein heterocomplex Heteromer Protein 2 Telomeric repeat-binding factor 2 × 1 （Q15554） Consistent with protein count
6 Protein heterocomplex Heteromer Protein 2 Telomeric repeat-binding factor 2 × 1 （Q15554） Consistent with protein count
7 Protein heterocomplex Heteromer Protein 2 Telomeric repeat-binding factor 2 × 1 （Q15554） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
5wqd 5wqd 5wqd 5wqd 5wqd 5wqd 5wqd 7sid 8bah 9q9i 9q9j 9q9m

13 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name NBN_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain H； PDBConstruct 1–16； UniProt 423–438 Author chain I； PDBConstruct 1–16； UniProt 423–438 Author chain J； PDBConstruct 1–16； UniProt 423–438 Author chain K； PDBConstruct 1–16； UniProt 423–438 Author chain L； PDBConstruct 1–16； UniProt 423–438 Author chain M； PDBConstruct 1–16； UniProt 423–438 Author chain N； PDBConstruct 1–16； UniProt 423–438

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id5wqd
Deposition date deposition_date2016-11-26
Structure title titleCrystal structure of TRF2 TRFH in complex with an NBS1 peptide
Keywords keywordsTelomere, shelterin complex, DNA damage response, CELL CYCLE; CELL CYCLE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

5wqd__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

5wqd__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

5wqd__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）19.45 Å
Rg (electron density)18.72 Å
Total Rg19.66 Å
Atom count1705
Residues214
Excluded volume30620 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 5wqd__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 5wqd__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 5wqd__assembly_3__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 5wqd__assembly_4__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
5 1 5wqd__assembly_5__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
6 1 5wqd__assembly_6__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
7 1 5wqd__assembly_7__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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6. Fold Classification (SCOP + CATH) 7 domains

CATH v4.4 (7 domains)

Domain ID domain_id5wqdA00
Class class1 — Mainly Alpha
Architecture architecture25 — Alpha Horseshoe
Topology topology40 — Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homologous superfamily homologous superfamily210 — Telomere repeat-binding factor, dimerisation domain
Domain ID domain_id5wqdB00
Class class1 — Mainly Alpha
Architecture architecture25 — Alpha Horseshoe
Topology topology40 — Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homologous superfamily homologous superfamily210 — Telomere repeat-binding factor, dimerisation domain
Domain ID domain_id5wqdC00
Class class1 — Mainly Alpha
Architecture architecture25 — Alpha Horseshoe
Topology topology40 — Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homologous superfamily homologous superfamily210 — Telomere repeat-binding factor, dimerisation domain
Domain ID domain_id5wqdD00
Class class1 — Mainly Alpha
Architecture architecture25 — Alpha Horseshoe
Topology topology40 — Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homologous superfamily homologous superfamily210 — Telomere repeat-binding factor, dimerisation domain
Domain ID domain_id5wqdE00
Class class1 — Mainly Alpha
Architecture architecture25 — Alpha Horseshoe
Topology topology40 — Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homologous superfamily homologous superfamily210 — Telomere repeat-binding factor, dimerisation domain
Domain ID domain_id5wqdF00
Class class1 — Mainly Alpha
Architecture architecture25 — Alpha Horseshoe
Topology topology40 — Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homologous superfamily homologous superfamily210 — Telomere repeat-binding factor, dimerisation domain
Domain ID domain_id5wqdG00
Class class1 — Mainly Alpha
Architecture architecture25 — Alpha Horseshoe
Topology topology40 — Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homologous superfamily homologous superfamily210 — Telomere repeat-binding factor, dimerisation domain
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7. Citations (1)