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6bys

Structures of the PKA RI alpha holoenzyme with the FLHCC driver J-PKAc alpha or native PRKAc alpha

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

cAMP-dependent protein kinase catalytic subunit alpha

Homo sapiens

UniProt P17612

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 cAMP-dependent protein kinase type I-alpha regulatory subunit × 2 （P00514） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 4 cAMP-dependent protein kinase type I-alpha regulatory subunit × 2 （P00514） Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 cAMP-dependent protein kinase type I-alpha regulatory subunit × 1 （P00514） Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 cAMP-dependent protein kinase type I-alpha regulatory subunit × 1 （P00514） Consistent with protein count
5 Protein heterocomplex Heteromer Protein 2 cAMP-dependent protein kinase type I-alpha regulatory subunit × 1 （P00514） Consistent with protein count
6 Protein heterocomplex Heteromer Protein 2 cAMP-dependent protein kinase type I-alpha regulatory subunit × 1 （P00514） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
3agl 3agl 4ae6 4ae6 4ae9 4ae9 6c0u 7y1g 7y1g 8x5l 8x5l

11 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2gu8 3agm 3ama 3amb 3l9l 3l9l 3l9m 3l9m 3l9n 3mvj 3mvj 3mvj

68 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name KAPCA_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–350； UniProt 2–351 Author chain C； PDBConstruct 1–350； UniProt 2–351 Author chain E； PDBConstruct 1–350； UniProt 2–351 Author chain G； PDBConstruct 1–350； UniProt 2–351

cAMP-dependent protein kinase type I-alpha regulatory subunit

Bos taurus

UniProt P00514

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 cAMP-dependent protein kinase catalytic subunit alpha × 2 （P17612） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 4 cAMP-dependent protein kinase catalytic subunit alpha × 2 （P17612） Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 cAMP-dependent protein kinase catalytic subunit alpha × 1 （P17612） Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 cAMP-dependent protein kinase catalytic subunit alpha × 1 （P17612） Consistent with protein count
5 Protein heterocomplex Heteromer Protein 2 cAMP-dependent protein kinase catalytic subunit alpha × 1 （P17612） Consistent with protein count
6 Protein heterocomplex Heteromer Protein 2 cAMP-dependent protein kinase catalytic subunit alpha × 1 （P17612） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1ne4 1ne6 1rgs 1rl3 1rl3 3iia 3plq 3pna 3pna 4jv4 4mx3 4mx3

20 assemblies; showing the first 12

Homodimer
2ezw 3im3 4mx3

3 assemblies

Homotetramer
3pna

1 assemblies

Other homooligomers

None

Heteromeric or nucleic-acid complex
2qcs 3fhi 3im4 3pvb 4x6r 5hvz 5jr7 5jr7 6byr 6byr 6byr 6bys

23 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name KAP0_BOVIN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–379； UniProt 2–380 Author chain D； PDBConstruct 1–379； UniProt 2–380 Author chain F； PDBConstruct 1–379； UniProt 2–380 Author chain H； PDBConstruct 1–379； UniProt 2–380

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6bys
Deposition date deposition_date2017-12-21
Structure title titleStructures of the PKA RI alpha holoenzyme with the FLHCC driver J-PKAc alpha or native PRKAc alpha
Keywords keywordsSIGNALING PROTEIN; SIGNALING PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6bys__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6bys__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6bys__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）39.04 Å
Rg (electron density)38.65 Å
Total Rg39.00 Å
Atom count10168
Residues1246
Excluded volume181530 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6bys__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 6bys__assembly_2__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 6bys__assembly_3__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 6bys__assembly_4__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
5 1 6bys__assembly_5__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
6 1 6bys__assembly_6__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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7. Citations (1)