← Back to search
6e5u

Crystal structure of the mRNA export receptor NXF1/NXT1 in complex with influenza virus NS1 protein

Method: X-RAY DIFFRACTION
▼

1. Protein Identity and Related Structures Protein Identity & Related Structures

Nuclear RNA export factor 1

Homo sapiens

UniProt Q9UBU9

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 8 NTF2-related export protein 1 × 2 （Q9UKK6） Non-structural protein 1 × 2 （I7CAR2） Non-structural protein 1 × 2 （I7CAR2） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 8 NTF2-related export protein 1 × 2 （Q9UKK6） Non-structural protein 1 × 2 （I7CAR2） Non-structural protein 1 × 2 （I7CAR2） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1ft8 1ft8 1ft8 1ft8 1ft8 1go5 1koh 1koh 1koh 1koh 1koo 1koo

19 assemblies; showing the first 12

Homodimer
1fo1

1 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1jkg 1jn5 1jn5 1oai 2z5k 3rw6 3rw6 4wyk 6e5u 6e5u 9i8a

11 assemblies

View Construct and Data Evidence
UniProt name NXF1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 5–508； UniProt 116–619 Author chain C； PDBConstruct 5–508； UniProt 116–619 Author chain E； PDBConstruct 5–508； UniProt 116–619 Author chain G； PDBConstruct 5–508； UniProt 116–619

NTF2-related export protein 1

Homo sapiens

UniProt Q9UKK6

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 8 Nuclear RNA export factor 1 × 2 （Q9UBU9） Non-structural protein 1 × 2 （I7CAR2） Non-structural protein 1 × 2 （I7CAR2） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 8 Nuclear RNA export factor 1 × 2 （Q9UBU9） Non-structural protein 1 × 2 （I7CAR2） Non-structural protein 1 × 2 （I7CAR2） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1jkg 1jn5 1jn5 4wyk 6e5u 6e5u 9i8a

7 assemblies

View Construct and Data Evidence
UniProt name NXT1_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–140； UniProt 1–140 Author chain D； PDBConstruct 1–140； UniProt 1–140 Author chain F； PDBConstruct 1–140； UniProt 1–140 Author chain H； PDBConstruct 1–140； UniProt 1–140

Non-structural protein 1

Influenza A virus

UniProt I7CAR2

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 8 Nuclear RNA export factor 1 × 2 （Q9UBU9） NTF2-related export protein 1 × 2 （Q9UKK6） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 8 Nuclear RNA export factor 1 × 2 （Q9UBU9） NTF2-related export protein 1 × 2 （Q9UKK6） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
6e5u 6e5u

2 assemblies

View Construct and Data Evidence
UniProt name I7CAR2_9INFA
Isoform —
PDB entities 3, 4
Chains and sequence ranges Author chain J； PDBConstruct 6–77； UniProt 1–72 Author chain K； PDBConstruct 6–77； UniProt 1–72 Author chain L； PDBConstruct 6–77； UniProt 1–72 Author chain M； PDBConstruct 6–77； UniProt 1–72 Author chain U； PDBConstruct 1–153； UniProt 73–230 Author chain V； PDBConstruct 1–153； UniProt 73–230 Author chain X； PDBConstruct 1–153； UniProt 73–230 Author chain Y； PDBConstruct 1–153； UniProt 73–230

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

▼

2. Structure Basics 2. Structure Basics

Entry ID entry_id6e5u
Deposition date deposition_date2018-07-23
Structure title titleCrystal structure of the mRNA export receptor NXF1/NXT1 in complex with influenza virus NS1 protein
Keywords keywordsmRNA nuclear export, RNA BINDING PROTEIN; RNA BINDING PROTEIN
Experimental Method methodX-RAY DIFFRACTION
▼

3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6e5u__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6e5u__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6e5u__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）47.98 Å
Rg (electron density)48.19 Å
Total Rg48.37 Å
Atom count10217
Residues1288
Excluded volume182000 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6e5u__assembly_1__model_1 octameric （8） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 6e5u__assembly_2__model_1 octameric （8） Success 4.1.3-1-20251215 (887e7ef) View Download
▶

4. Crystallography and Experiment 4. Crystallography & Experiment

▶

5. Entities and Polymers Entities & Polymers (4)

▼

6. Fold Classification (SCOP + CATH) 18 domains

CATH v4.4 (18 domains)

Domain ID domain_id6e5uA01
Class class3 — Alpha Beta
Architecture architecture80 — Alpha-Beta Horseshoe
Topology topology10 — Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Homologous superfamily homologous superfamily10 — Ribonuclease Inhibitor
Domain ID domain_id6e5uA02
Class class3 — Alpha Beta
Architecture architecture10 — Roll
Topology topology450 — Nuclear Transport Factor 2; Chain: A,
Homologous superfamily homologous superfamily50 —
Domain ID domain_id6e5uB00
Class class3 — Alpha Beta
Architecture architecture10 — Roll
Topology topology450 — Nuclear Transport Factor 2; Chain: A,
Homologous superfamily homologous superfamily50 —
Domain ID domain_id6e5uC01
Class class3 — Alpha Beta
Architecture architecture80 — Alpha-Beta Horseshoe
Topology topology10 — Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Homologous superfamily homologous superfamily10 — Ribonuclease Inhibitor
Domain ID domain_id6e5uC02
Class class3 — Alpha Beta
Architecture architecture10 — Roll
Topology topology450 — Nuclear Transport Factor 2; Chain: A,
Homologous superfamily homologous superfamily50 —
Domain ID domain_id6e5uD00
Class class3 — Alpha Beta
Architecture architecture10 — Roll
Topology topology450 — Nuclear Transport Factor 2; Chain: A,
Homologous superfamily homologous superfamily50 —
Domain ID domain_id6e5uE01
Class class3 — Alpha Beta
Architecture architecture80 — Alpha-Beta Horseshoe
Topology topology10 — Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Homologous superfamily homologous superfamily10 — Ribonuclease Inhibitor
Domain ID domain_id6e5uE02
Class class3 — Alpha Beta
Architecture architecture10 — Roll
Topology topology450 — Nuclear Transport Factor 2; Chain: A,
Homologous superfamily homologous superfamily50 —
Domain ID domain_id6e5uF00
Class class3 — Alpha Beta
Architecture architecture10 — Roll
Topology topology450 — Nuclear Transport Factor 2; Chain: A,
Homologous superfamily homologous superfamily50 —
Domain ID domain_id6e5uG01
Class class3 — Alpha Beta
Architecture architecture80 — Alpha-Beta Horseshoe
Topology topology10 — Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Homologous superfamily homologous superfamily10 — Ribonuclease Inhibitor
Domain ID domain_id6e5uG02
Class class3 — Alpha Beta
Architecture architecture10 — Roll
Topology topology450 — Nuclear Transport Factor 2; Chain: A,
Homologous superfamily homologous superfamily50 —
Domain ID domain_id6e5uH00
Class class3 — Alpha Beta
Architecture architecture10 — Roll
Topology topology450 — Nuclear Transport Factor 2; Chain: A,
Homologous superfamily homologous superfamily50 —
Domain ID domain_id6e5uK00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology287 — Helix Hairpins
Homologous superfamily homologous superfamily10 — S15/NS1, RNA-binding
Domain ID domain_id6e5uM00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology287 — Helix Hairpins
Homologous superfamily homologous superfamily10 — S15/NS1, RNA-binding
Domain ID domain_id6e5uU00
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology420 — Nucleotidyltransferase; domain 5
Homologous superfamily homologous superfamily330 — Influenza virus non-structural protein, effector domain
Domain ID domain_id6e5uV00
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology420 — Nucleotidyltransferase; domain 5
Homologous superfamily homologous superfamily330 — Influenza virus non-structural protein, effector domain
Domain ID domain_id6e5uX00
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology420 — Nucleotidyltransferase; domain 5
Homologous superfamily homologous superfamily330 — Influenza virus non-structural protein, effector domain
Domain ID domain_id6e5uY00
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology420 — Nucleotidyltransferase; domain 5
Homologous superfamily homologous superfamily330 — Influenza virus non-structural protein, effector domain
▶

7. Citations (1)