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6f0e

Structure of yeast Sec14p with a picolinamide compound

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

SEC14 cytosolic factor

Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

UniProt P24280

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 ~{N}-(1,3-benzodioxol-5-ylmethyl)-5-bromanyl-3-fluoranyl-pyridine-2-carboxamide × 1 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
6f0e 7zg9 7zg9 7zga 7zgb 7zgc 7zgd 9efp 9efp 9yv3

10 assemblies

Homodimer
1aua

1 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex

None

View Construct and Data Evidence
UniProt name SEC14_YEAST
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 9–312； UniProt 1–304

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6f0e
Deposition date deposition_date2017-11-20
Structure title titleStructure of yeast Sec14p with a picolinamide compound
Keywords keywords;Sec14p, lipid transfer protein, chemogenomics, target identification, functional variomics, co-crystal, antifungal, benzamide, picolinamide, lipid binding protein ;; LIPID BINDING PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6f0e__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6f0e__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6f0e__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）20.05 Å
Rg (electron density)19.13 Å
Total Rg20.04 Å
Atom count2396
Residues300
Excluded volume42537 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6f0e__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 4 domains

SCOP 2.08 (2 domains)

Domain ID domain_idd6f0ea1
Class classa — All alpha proteins
Fold Fold folda.5 — RuvA C-terminal domain-like
Superfamily Superfamily superfamilya.5.3 — CRAL/TRIO N-terminal domain
Family Family familya.5.3.0 — automated matches
Domain ID domain_idd6f0ea2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.13 — SpoIIaa-like
Superfamily Superfamily superfamilyc.13.1 — CRAL/TRIO domain
Family Family familyc.13.1.1 — CRAL/TRIO domain

CATH v4.4 (2 domains)

Domain ID domain_id6f0eA01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology8 — Helicase, Ruva Protein; domain 3
Homologous superfamily homologous superfamily20 — N-terminal domain of phosphatidylinositol transfer protein sec14p
Domain ID domain_id6f0eA02
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology525 — Phosphatidylinositol Transfer Protein Sec14p
Homologous superfamily homologous superfamily10 — CRAL-TRIO lipid binding domain
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7. Citations (1)