6hyx

THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT Y197F-P250C

Method: X-RAY DIFFRACTION Dmax: 124.8 Å Quality: REASONABLE

1. 蛋白身份与相关结构 Protein Identity & Related Structures

Proton-gated ion channel

Gloeobacter violaceus PCC 7421

UniProt Q7NDN8

当前结构中的状态

Assembly 聚集状态 构建体 突变与修饰 配体、离子与共同组分 实验方法与环境 结构质量
1 蛋白同源多聚体 同源多聚体 蛋白 × 5 PDB 声明:pentameric(5) 与蛋白拷贝数一致 链 A; UniProt 43–359 链 B; UniProt 43–359 链 C; UniProt 43–359 链 D; UniProt 43–359 链 E; UniProt 43–359 片段:UNP RESIDUES 44-359 突变:YES CL CHLORIDE ION × 5 NA SODIUM ION × 7 LMT DODECYL-BETA-D-MALTOSIDE × 1 X-RAY DIFFRACTION X-ray结晶条件:EVAPORATION;pH 4;293 K;PH 4, VAPOR DIFFUSION, TEMPERATURE 293K.12-14.5% PEG4K; 15% GLycerol; 400 mM NaSCN; 3% DMSO; 100mM NaAcetate pH 4 分辨率 3.00 Å R-free 0.224

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly, “相对当前条目”直接指出证据层面的不同;没有差异标签表示当前已读取字段一致。

共 129 个其他 PDB 条目、135 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据
UniProt名称 GLIC_GLOVI
Isoform
PDB实体 1
链与序列区间 作者链 A; PDB构建体 1–317; UniProt 43–359 作者链 B; PDB构建体 1–317; UniProt 43–359 作者链 C; PDB构建体 1–317; UniProt 43–359 作者链 D; PDB构建体 1–317; UniProt 43–359 作者链 E; PDB构建体 1–317; UniProt 43–359

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

SAXS 散射曲线 SAXS Profile

SAXS profile for 6hyx

P(r) 距离分布 P(r) Distribution

P(r) distribution for 6hyx
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2. 结构基本信息 2. Structure Basics

条目编号 entry_id6hyx
沉积日期 deposition_date2018-10-22
结构标题 titleTHE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT Y197F-P250C
关键词 keywordsPENTAMERIC TRANSMEMBRANE CHANNEL, ION CHANNEL., MEMBRANE PROTEIN; MEMBRANE PROTEIN
实验方法 methodX-RAY DIFFRACTION

3. SAXS 参数 (CRYSOL 理论计算) 3. SAXS Parameters (CRYSOL)

回转半径 Rg (Guinier) rg_guinier38.28
回转半径 Rg (电子) rg_electron37.50
零角强度 I(0) i0398717000.00
分子量 molecular_weight177930.0 kDa
排除体积 excluded_volume228700 ų
包络体积 envelope_volume290630 ų
水化壳体积 shell_volume63697 ų
包络直径 envelope_diameter130.8
壳层 Rg shell_rg44.74
包络 Rg envelope_rg37.07
形状 Rg shape_rg37.48
总 Rg total_rg38.02
总原子数 total_atoms12609
残基数 n_residues1555
球谐函数阶数 n_harmonics20
q 范围 q_range— – 0.5000 −1
数据点数 n_points101
壳层类型 shell_typedirectional
溶剂电子密度 solvent_density0.3340 e/ų
壳层衬度 contrast_shell0.0300 e/ų
CRYSOL 版本 crysol_version4.1.3

4. P(r) 距离分布 (GNOM 反演) 4. P(r) Analysis (GNOM)

最大尺寸 Dmax dmax124.8
Rg (实空间) rg_real39.11
Rg 误差 (实空间) rg_real_error0.34
I(0) (实空间) i0_real3.9410e+08
I(0) 误差 (实空间) i0_real_error4.3420e+06
Rg (倒空间) rg_reciprocal38.25
I(0) (倒空间) i0_reciprocal398700000.0000
解质量估计 total_estimate0.7042
解质量评级 solution_quality REASONABLE a REASONABLE solution
P(r) 峰数 n_peaks1
主峰位置 r_peak_primary45.6
偏度 Skewness skewness0.410
峰度 Kurtosis kurtosis-0.162
角度范围 angular_range— – 0.2050 −1
当前正则化参数 α current_alpha2.3820
最高正则化参数 α highest_alpha71850000.0000
实空间数据点数 n_real_points42
GNOM 版本 gnom_version4.1.3
质量判据 quality_criteria AN1: 0.000; Oscil: 0.873; Stabil: 0.921; Sysdev: 0.000; Positv: 1.000; Valcen: 0.997; Smooth: 0.801

5. 晶体学与实验 5. Crystallography & Experiment

6. 实体与聚合物信息 Entities & Polymers (5)

7. 折叠分类 (SCOP + CATH) 10 domains

CATH v4.4 (10 domains)

结构域编号 domain_id6hyxA01
类 Class class2 — Mainly Beta
架构 Architecture architecture70 — Distorted Sandwich
拓扑 Topology topology170 — Acetylcholine Binding Protein; Chain: A,
同源超家族 H-superfamily homologous superfamily10 — Neurotransmitter-gated ion-channel ligand-binding domain
结构域编号 domain_id6hyxA02
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
同源超家族 H-superfamily homologous superfamily390 — Neurotransmitter-gated ion-channel transmembrane domain
结构域编号 domain_id6hyxB01
类 Class class2 — Mainly Beta
架构 Architecture architecture70 — Distorted Sandwich
拓扑 Topology topology170 — Acetylcholine Binding Protein; Chain: A,
同源超家族 H-superfamily homologous superfamily10 — Neurotransmitter-gated ion-channel ligand-binding domain
结构域编号 domain_id6hyxB02
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
同源超家族 H-superfamily homologous superfamily390 — Neurotransmitter-gated ion-channel transmembrane domain
结构域编号 domain_id6hyxC01
类 Class class2 — Mainly Beta
架构 Architecture architecture70 — Distorted Sandwich
拓扑 Topology topology170 — Acetylcholine Binding Protein; Chain: A,
同源超家族 H-superfamily homologous superfamily10 — Neurotransmitter-gated ion-channel ligand-binding domain
结构域编号 domain_id6hyxC02
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
同源超家族 H-superfamily homologous superfamily390 — Neurotransmitter-gated ion-channel transmembrane domain
结构域编号 domain_id6hyxD01
类 Class class2 — Mainly Beta
架构 Architecture architecture70 — Distorted Sandwich
拓扑 Topology topology170 — Acetylcholine Binding Protein; Chain: A,
同源超家族 H-superfamily homologous superfamily10 — Neurotransmitter-gated ion-channel ligand-binding domain
结构域编号 domain_id6hyxD02
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
同源超家族 H-superfamily homologous superfamily390 — Neurotransmitter-gated ion-channel transmembrane domain
结构域编号 domain_id6hyxE01
类 Class class2 — Mainly Beta
架构 Architecture architecture70 — Distorted Sandwich
拓扑 Topology topology170 — Acetylcholine Binding Protein; Chain: A,
同源超家族 H-superfamily homologous superfamily10 — Neurotransmitter-gated ion-channel ligand-binding domain
结构域编号 domain_id6hyxE02
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
同源超家族 H-superfamily homologous superfamily390 — Neurotransmitter-gated ion-channel transmembrane domain

8. 引用文献 (1)

9. 文件与曲线 (10)