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6l89

Human PPARgamma ligand binding domain complexed with Butyrolactone 1

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Peroxisome proliferator-activated receptor gamma

Homo sapiens

UniProt P37231

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 2 methyl (2R)-3-(4-hydroxyphenyl)-2-[[3-(3-methylbut-2-enyl)-4-oxidanyl-phenyl]methyl]-4-oxidanyl-5-oxidanylidene-furan-2-carboxylate × 2 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1i7i 1i7i 2f4b 2f4b 2om9 2om9 2om9 2om9 2prg 2qmv 2vsr 2vsr

158 assemblies; showing the first 12

Homodimer
1knu 1nyx 1prg 1zeo 2ath 2g0g 2i4j 2i4p 2i4z 2p4y 2pob 2q59

201 assemblies; showing the first 12

Homotetramer
2hwq 2hwr 4em9 4prg 9mah

5 assemblies

Other homooligomers

None

Heteromeric or nucleic-acid complex
1fm6 1fm6 1fm9 1k74 1rdt 1zgy 2fvj 2gtk 2prg 3b1m 3cs8 3cwd

137 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name PPARG_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 5–287； UniProt 223–505 Author chain B； PDBConstruct 5–287； UniProt 223–505

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6l89
Deposition date deposition_date2019-11-05
Structure title titleHuman PPARgamma ligand binding domain complexed with Butyrolactone 1
Keywords keywordsNuclear receptor Ligand binding domain Butyrolactone 1 Partial agonist, TRANSCRIPTION; TRANSCRIPTION
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6l89__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6l89__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6l89__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）27.08 Å
Rg (electron density)25.93 Å
Total Rg26.93 Å
Atom count4177
Residues514
Excluded volume75850 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6l89__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (2 domains)

Domain ID domain_idd6l89a_
Class classa — All alpha proteins
Fold Fold folda.123 — Nuclear receptor ligand-binding domain
Superfamily Superfamily superfamilya.123.1 — Nuclear receptor ligand-binding domain
Family Family familya.123.1.1 — Nuclear receptor ligand-binding domain
Domain ID domain_idd6l89b_
Class classa — All alpha proteins
Fold Fold folda.123 — Nuclear receptor ligand-binding domain
Superfamily Superfamily superfamilya.123.1 — Nuclear receptor ligand-binding domain
Family Family familya.123.1.1 — Nuclear receptor ligand-binding domain
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7. Citations (1)