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1k74

The 2.3 Angstrom resolution crystal structure of the heterodimer of the human PPARgamma and RXRalpha ligand binding domains respectively bound with GW409544 and 9-cis retinoic acid and co-activator peptides.

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Retinoic acid receptor RXR-alpha

Homo sapiens

UniProt P19793

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 Peroxisome proliferator activated receptor gamma × 1 （P37231） steroid receptor coactivator × 2 （O43792） (9cis)-retinoic acid × 1 2-(1-METHYL-3-OXO-3-PHENYL-PROPYLAMINO)-3-{4-[2-(5-METHYL-2-PHENYL-OXAZOL-4-YL)-ETHOXY]-PHENYL}-PROPIONIC ACID × 1 water × 4 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1rxr

1 assemblies

Homodimer
1fby 5tbp 5tbp 6hn6

4 assemblies

Homotetramer
1g1u 1g5y 4n5g 4n8r 5tbp 5zqu 6jno 7cfo

8 assemblies

Other homooligomers

None

Heteromeric or nucleic-acid complex
1by4 1by4 1dsz 1fm6 1fm6 1fm9 1k74 1mv9 1mvc 1mzn 1mzn 1r0n

126 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name RXRA_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–238； UniProt 225–462

Peroxisome proliferator activated receptor gamma

Homo sapiens

UniProt P37231

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 Retinoic acid receptor RXR-alpha × 1 （P19793） steroid receptor coactivator × 2 （O43792） (9cis)-retinoic acid × 1 2-(1-METHYL-3-OXO-3-PHENYL-PROPYLAMINO)-3-{4-[2-(5-METHYL-2-PHENYL-OXAZOL-4-YL)-ETHOXY]-PHENYL}-PROPIONIC ACID × 1 water × 4 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1i7i 1i7i 2f4b 2f4b 2om9 2om9 2om9 2om9 2prg 2qmv 2vsr 2vsr

158 assemblies; showing the first 12

Homodimer
1knu 1nyx 1prg 1zeo 2ath 2g0g 2i4j 2i4p 2i4z 2p4y 2pob 2q59

201 assemblies; showing the first 12

Homotetramer
2hwq 2hwr 4em9 4prg 9mah

5 assemblies

Other homooligomers

None

Heteromeric or nucleic-acid complex
1fm6 1fm6 1fm9 1k74 1rdt 1zgy 2fvj 2gtk 2prg 3b1m 3cs8 3cwd

137 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name PPARG_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain D； PDBConstruct 12–283； UniProt 234–505

steroid receptor coactivator

OrganismNot specified

UniProt O43792

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 Retinoic acid receptor RXR-alpha × 1 （P19793） Peroxisome proliferator activated receptor gamma × 1 （P37231） (9cis)-retinoic acid × 1 2-(1-METHYL-3-OXO-3-PHENYL-PROPYLAMINO)-3-{4-[2-(5-METHYL-2-PHENYL-OXAZOL-4-YL)-ETHOXY]-PHENYL}-PROPIONIC ACID × 1 water × 4 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1k74 1k7l 1k7l 1k7l 1k7l 2prg

6 assemblies

View Construct and Data Evidence
UniProt name O43792_TOBAC
Isoform —
PDB entities 3
Chains and sequence ranges Author chain B； PDBConstruct 1–25； UniProt 675–701 Author chain E； PDBConstruct 1–25； UniProt 675–701

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1k74
Deposition date deposition_date2001-10-18
Structure title titleThe 2.3 Angstrom resolution crystal structure of the heterodimer of the human PPARgamma and RXRalpha ligand binding domains respectively bound with GW409544 and 9-cis retinoic acid and co-activator peptides.
Keywords keywords;The heterodimer of the nuclear receptor ligand binding domains of RXRalpha and PPARgamma bound respectively with 9-cis retinoic acid and GW409544 and coactivator peptides, TRANSCRIPTION ;; TRANSCRIPTION
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1k74__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1k74__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1k74__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）25.12 Å
Rg (electron density)23.68 Å
Total Rg24.56 Å
Atom count4197
Residues530
Excluded volume75561 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1k74__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (6)

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6. Fold Classification (SCOP + CATH) 4 domains

SCOP 2.08 (2 domains)

Domain ID domain_idd1k74a_
Class classa — All alpha proteins
Fold Fold folda.123 — Nuclear receptor ligand-binding domain
Superfamily Superfamily superfamilya.123.1 — Nuclear receptor ligand-binding domain
Family Family familya.123.1.1 — Nuclear receptor ligand-binding domain
Domain ID domain_idd1k74d_
Class classa — All alpha proteins
Fold Fold folda.123 — Nuclear receptor ligand-binding domain
Superfamily Superfamily superfamilya.123.1 — Nuclear receptor ligand-binding domain
Family Family familya.123.1.1 — Nuclear receptor ligand-binding domain

CATH v4.4 (2 domains)

Domain ID domain_id1k74A00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology565 — Retinoid X Receptor
Homologous superfamily homologous superfamily10 — Retinoid X Receptor
Domain ID domain_id1k74D00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology565 — Retinoid X Receptor
Homologous superfamily homologous superfamily10 — Retinoid X Receptor
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7. Citations (1)