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6pbx

Single particle cryo-EM structure of the voltage-gated K+ channel Eag1 3-13 deletion mutant bound to calmodulin (conformation 2)

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Potassium voltage-gated channel subfamily H member 1

Rattus norvegicus

UniProt Q63472

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 8 Calmodulin-1 × 4 （P0DP23） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
5k7l 5k7l 5k7l 6pbx 6pby 8eow 8ep0 8ep1

8 assemblies

View Construct and Data Evidence
UniProt name KCNH1_RAT
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 3–762； UniProt 14–773 Author chain A； PDBConstruct 763–837； UniProt 888–962 Author chain C； PDBConstruct 3–762； UniProt 14–773 Author chain C； PDBConstruct 763–837； UniProt 888–962 Author chain E； PDBConstruct 3–762； UniProt 14–773 Author chain E； PDBConstruct 763–837； UniProt 888–962 Author chain G； PDBConstruct 3–762； UniProt 14–773 Author chain G； PDBConstruct 763–837； UniProt 888–962

Calmodulin-1

Homo sapiens

UniProt P0DP23

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 8 Potassium voltage-gated channel subfamily H member 1 × 4 （Q63472） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2kug 6dah 6dah 6dah 6dah 6eeb 6gdk 6gdl 6m7h 6o5g 6os4 6y94

22 assemblies; showing the first 12

Homodimer
6eeb 6os4 7t2q

3 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
12dk 22rj 3evv 3o77 3o78 3o78 3o78 5oeo 5v02 5v7x 5wbx 5wbx

255 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name CALM1_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–149； UniProt 1–149 Author chain D； PDBConstruct 1–149； UniProt 1–149 Author chain F； PDBConstruct 1–149； UniProt 1–149 Author chain H； PDBConstruct 1–149； UniProt 1–149

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6pbx
Deposition date deposition_date2019-06-14
Structure title titleSingle particle cryo-EM structure of the voltage-gated K+ channel Eag1 3-13 deletion mutant bound to calmodulin (conformation 2)
Keywords keywordsVoltage-gated potassium channel, ion channel, calmodulin, TRANSPORT PROTEIN-CALCIUM BINDING PROTEIN complex; TRANSPORT PROTEIN/CALCIUM BINDING PROTEIN
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6pbx__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6pbx__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6pbx__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）53.39 Å
Rg (electron density)52.57 Å
Total Rg52.29 Å
Atom count23028
Residues3152
Excluded volume408940 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6pbx__assembly_1__model_1 octameric （8） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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6. Fold Classification (SCOP + CATH) 8 domains

CATH v4.4 (8 domains)

Domain ID domain_id6pbxA01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily10 — Jelly Rolls
Domain ID domain_id6pbxB01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology238 — Recoverin; domain 1
Homologous superfamily homologous superfamily10 — EF-hand
Domain ID domain_id6pbxC01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily10 — Jelly Rolls
Domain ID domain_id6pbxD01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology238 — Recoverin; domain 1
Homologous superfamily homologous superfamily10 — EF-hand
Domain ID domain_id6pbxE01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily10 — Jelly Rolls
Domain ID domain_id6pbxF01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology238 — Recoverin; domain 1
Homologous superfamily homologous superfamily10 — EF-hand
Domain ID domain_id6pbxG01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology120 — Jelly Rolls
Homologous superfamily homologous superfamily10 — Jelly Rolls
Domain ID domain_id6pbxH01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology238 — Recoverin; domain 1
Homologous superfamily homologous superfamily10 — EF-hand
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7. Citations (1)