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5v02

A positive allosteric modulator binding pocket in SK2 ion channels is shared by Riluzole and CyPPA

Method: X-RAY DIFFRACTION Dmax: 84.4 Å Quality: GOOD
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Small conductance calcium-activated potassium channel protein 2

Homo sapiens

UniProt Q9H2S1

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 2 PDB declaration: dimeric（2） Consistent with protein copy count Chain B； UniProt 395–486 Fragment：UNP residues 395-486 Calmodulin-1 × 1 （P0DP23） SO4 SULFATE ION × 2 657 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine × 1 GOL GLYCEROL × 1 CA CALCIUM ION × 2 X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；295 K；ammonia sulfate Resolution 1.78 Å R-free 0.215

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 5V02 Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
5V03 A positive allosteric modulator binding pocket in SK2 ion channels is shared by Riluzole and CyPPA Deposited 2017-02-28 Different ligand/ion Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 395–486（92 aa） Fragment：UNP residues 395-486
Not recorded SO4 SULFATE ION × 1 658 N-(4-chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)pyrimidin-4-amine × 1 CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；295 K；ammonia sulfate
Resolution 1.58 Å R-free 0.220
5WBX Structural insights into the potency of SK/IK channel positive modulators Deposited 2017-06-29 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 395–486（92 aa）
Mutation：N407A SO4 SULFATE ION × 4 GOL GLYCEROL × 2 CA CALCIUM ION × 2 AJY (3Z)-6-bromo-3-(hydroxyimino)-5-methyl-1,3-dihydro-2H-indol-2-one × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.8；293.15 K；0.1 M Sodium itrate tribasic dihydrate 0.5 M Ammonium sulfate 1.5 M Lithium sulfate monohydrate
Resolution 1.90 Å R-free 0.243
5WBX Structural insights into the potency of SK/IK channel positive modulators Deposited 2017-06-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 395–486（92 aa）
Mutation：N407A SO4 SULFATE ION × 8 GOL GLYCEROL × 4 CA CALCIUM ION × 4 AJY (3Z)-6-bromo-3-(hydroxyimino)-5-methyl-1,3-dihydro-2H-indol-2-one × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.8；293.15 K；0.1 M Sodium itrate tribasic dihydrate 0.5 M Ammonium sulfate 1.5 M Lithium sulfate monohydrate
Resolution 1.90 Å R-free 0.243
5WC5 Structural insights into the potency of SK/IK channel positive modulators Deposited 2017-06-29 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 395–486（92 aa）
Mutation：N407A SO4 SULFATE ION × 6 GOL GLYCEROL × 1 CA CALCIUM ION × 2 AJV 7-fluoro-3-(hydroxyamino)-2H-indol-2-one × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.8；293.15 K；0.1 M Sodium citrate tribasic dihydrate 0.5 M Ammonium sulfate 1.5 M Litium sulfate monohydrate
Resolution 2.30 Å R-free 0.250
5WC5 Structural insights into the potency of SK/IK channel positive modulators Deposited 2017-06-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain B 395–486（92 aa）
Mutation：N407A SO4 SULFATE ION × 12 GOL GLYCEROL × 2 CA CALCIUM ION × 4 AJV 7-fluoro-3-(hydroxyamino)-2H-indol-2-one × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.8；293.15 K；0.1 M Sodium citrate tribasic dihydrate 0.5 M Ammonium sulfate 1.5 M Litium sulfate monohydrate
Resolution 2.30 Å R-free 0.250
6ALE A V-to-F substitution in SK2 channels causes Ca2+ hypersensitivity and improves locomotion in a C. elegans ALS model Deposited 2017-08-07 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 394–486（93 aa） Fragment：calmodulin binding domain (UNP residues 394-486)
Not recorded SO4 SULFATE ION × 4 1KP (3E)-6,7-dichloro-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-one × 1 GOL GLYCEROL × 1 CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.6；293.15 K；0.1 M Sodium Citrate Tribasic dehydrate 0.6 M Ammonium sulfate 1.4 M Lithium sulfate monohydrate
Resolution 2.50 Å R-free 0.255
9O48 Cryo-EM structure of the human SK2-4 chimera/calmodulin channel complex in the Ca2+ bound state Deposited 2025-04-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 8 PDB declaration: octameric
Chain A 124–412（289 aa） Fragment：SK4 residues 1-15 + SK2 residues 124-412 + SK4 residues 306-428
Chain B 124–412（289 aa） Fragment：SK4 residues 1-15 + SK2 residues 124-412 + SK4 residues 306-428
Chain C 124–412（289 aa） Fragment：SK4 residues 1-15 + SK2 residues 124-412 + SK4 residues 306-428
Chain D 124–412（289 aa） Fragment：SK4 residues 1-15 + SK2 residues 124-412 + SK4 residues 306-428
Not recorded K POTASSIUM ION × 2 CA CALCIUM ION × 16 ELECTRON MICROSCOPY
cryo-EM buffer pH 8；20 mM Tris pH 8, 150 mM KCl, 2 mM CaCl2, 0.005% GDN, 0.0005% CHS
cryo-EM vitrification conditions Cryogen ETHANE；5 uL of sample was applied to grids at 4 degree temperature with 100% humidity. After 30 seconds, grids were blotted for 5 seconds with blot force 25 and plunged into liquid ethane.
Resolution 3.10 Å
9O51 Cryo-EM structure of the human SK2-4 chimera/calmodulin channel complex in the Ca2+ free state Deposited 2025-04-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 8 PDB declaration: octameric
Chain A 124–412（289 aa） Fragment：SK4 residues 1-15 + SK2 residues 124-412 + SK4 residues 306-428
Chain B 124–412（289 aa） Fragment：SK4 residues 1-15 + SK2 residues 124-412 + SK4 residues 306-428
Chain C 124–412（289 aa） Fragment：SK4 residues 1-15 + SK2 residues 124-412 + SK4 residues 306-428
Chain D 124–412（289 aa） Fragment：SK4 residues 1-15 + SK2 residues 124-412 + SK4 residues 306-428
Not recorded K POTASSIUM ION × 2 CA CALCIUM ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8；20 mM Tris pH 8, 150 mM KCl, 5 mM EGTA, 0.005% GDN, 0.0005% CHS
cryo-EM vitrification conditions Cryogen ETHANE；5 uL of sample was applied to grids at 4 degree temperature with 100% humidity. After 30 seconds, grids were blotted for 5 seconds with blot force 25 and plunged into liquid ethane.
Resolution 3.40 Å
9O52 Cryo-EM structure of the human SK2-4 chimera/calmodulin channel complex bound to the bee toxin apamin Deposited 2025-04-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 9 PDB declaration: nonameric
Chain A 124–412（289 aa） Fragment：SK4 residues 1-15 + SK2 residues 124-412 + SK4 residues 306-428
Chain B 124–412（289 aa） Fragment：SK4 residues 1-15 + SK2 residues 124-412 + SK4 residues 306-428
Chain C 124–412（289 aa） Fragment：SK4 residues 1-15 + SK2 residues 124-412 + SK4 residues 306-428
Chain D 124–412（289 aa） Fragment：SK4 residues 1-15 + SK2 residues 124-412 + SK4 residues 306-428
Not recorded K POTASSIUM ION × 4 CA CALCIUM ION × 16 ELECTRON MICROSCOPY
cryo-EM buffer pH 8；20 mM Tris pH 8, 150 mM KCl, 2 mM CaCl2, 0.005% GDN, 0.0005% CHS
cryo-EM vitrification conditions Cryogen ETHANE；5 uL of sample was applied to grids at 4 degree temperature with 100% humidity. After 30 seconds, grids were blotted for 5 seconds with blot force 25 and plunged into liquid ethane.
Resolution 3.18 Å
9O53 Cryo-EM structure of the human SK2-4 chimera/calmodulin channel complex bound to a small molecule inhibitor Deposited 2025-04-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 8 PDB declaration: octameric
Chain A 124–412（289 aa） Fragment：SK4 residues 1-15 + SK2 residues 124-412 + SK4 residues 306-428
Chain B 124–412（289 aa） Fragment：SK4 residues 1-15 + SK2 residues 124-412 + SK4 residues 306-428
Chain C 124–412（289 aa） Fragment：SK4 residues 1-15 + SK2 residues 124-412 + SK4 residues 306-428
Chain D 124–412（289 aa） Fragment：SK4 residues 1-15 + SK2 residues 124-412 + SK4 residues 306-428
Not recorded A1B8D N-(2,1,3-benzoxadiazol-4-yl)-3-(4-methoxybenzene-1-sulfonamido)benzamide × 4 K POTASSIUM ION × 4 CA CALCIUM ION × 16 ELECTRON MICROSCOPY
cryo-EM buffer pH 8；20 mM Tris pH 8, 150 mM KCl, 2 mM CaCl2, 0.005% GDN, 0.0005% CHS
cryo-EM vitrification conditions Cryogen ETHANE；5 uL of sample was applied to grids at 4 degree temperature with 100% humidity. After 30 seconds, grids were blotted for 5 seconds with blot force 25 and plunged into liquid ethane.
Resolution 3.30 Å
9O5O Cryo-EM structure of the human SK2-4 chimera/calmodulin channel complex bound to a small molecule activator Deposited 2025-04-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 8 PDB declaration: octameric
Chain A 124–412（289 aa） Fragment：SK4 residues 1-15 + SK2 residues 124-412 + SK4 residues 306-428
Chain B 124–412（289 aa） Fragment：SK4 residues 1-15 + SK2 residues 124-412 + SK4 residues 306-428
Chain C 124–412（289 aa） Fragment：SK4 residues 1-15 + SK2 residues 124-412 + SK4 residues 306-428
Chain D 124–412（289 aa） Fragment：SK4 residues 1-15 + SK2 residues 124-412 + SK4 residues 306-428
Not recorded A1B8G N-(2,1,3-benzoxadiazol-4-yl)-4-(trifluoromethyl)benzamide × 4 K POTASSIUM ION × 2 CA CALCIUM ION × 16 ELECTRON MICROSCOPY
cryo-EM buffer pH 8；20 mM Tris pH 8, 150 mM KCl, 2 mM CaCl2, 0.005% GDN, 0.0005% CHS
cryo-EM vitrification conditions Cryogen ETHANE；5 uL of sample was applied to grids at 4 degree temperature with 100% humidity. After 30 seconds, grids were blotted for 5 seconds with blot force 25 and plunged into liquid ethane.
Resolution 3.10 Å
9VU9 channel D complex with 4 Deposited 2025-07-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric
Chain A 1–579（579 aa）
Chain B 1–579（579 aa）
Chain C 1–579（579 aa）
Chain D 1–579（579 aa）
Not recorded A1ETX (3~{S})-3-(1~{H}-benzimidazol-2-ylamino)-~{N}-(cyanomethyl)-~{N}-methyl-3-[3-(trifluoromethyl)phenyl]propanamide × 1 K POTASSIUM ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.34 Å
9VUA channel A complex with 1 Deposited 2025-07-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 1–579（579 aa）
Chain B 1–579（579 aa）
Chain C 1–579（579 aa）
Chain D 1–579（579 aa）
Not recorded K POTASSIUM ION × 4 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.23 Å
9VUB channel C complex with 3 Deposited 2025-07-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 1–579（579 aa）
Chain B 1–579（579 aa）
Chain C 1–579（579 aa）
Chain D 1–579（579 aa）
Not recorded POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 32 CLR CHOLESTEROL × 8 CA CALCIUM ION × 12 A1B92 Rimtuzalcap × 4 K POTASSIUM ION × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.35 Å
9VUC channel B complex with 2 Deposited 2025-07-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric
Chain A 1–579（579 aa）
Chain B 1–579（579 aa）
Chain C 1–579（579 aa）
Chain D 1–579（579 aa）
Not recorded K POTASSIUM ION × 4 Y7Z UCL1684 × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.96 Å
9ZRQ Cryo-EM structure of KCa2.2/calmodulin channel in complex with SKA31. Deposited 2025-12-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 117–477（361 aa）
Chain B 117–477（361 aa）
Chain C 117–477（361 aa）
Chain D 117–477（361 aa）
Not recorded K POTASSIUM ION × 4 A1C3Q naphtho[1,2-d][1,3]thiazol-2-amine × 4 CA CALCIUM ION × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.77 Å
9ZRR Cryo-EM structure of KCa2.2/calmodulin channel in complex with SKA111. Deposited 2025-12-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain A 117–477（361 aa）
Chain B 117–477（361 aa）
Chain C 117–477（361 aa）
Chain D 117–477（361 aa）
Not recorded K POTASSIUM ION × 2 A1C3U 5-methylnaphtho[1,2-d][1,3]thiazol-2-amine × 4 CA CALCIUM ION × 12 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.31 Å

15 other PDB entries and 17 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name KCNN2_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain B； PDBConstruct 3–94； UniProt 395–486

Calmodulin-1

Homo sapiens

UniProt P0DP23

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein heterocomplex Heteromer Protein × 2 PDB declaration: dimeric（2） Consistent with protein copy count Chain R； UniProt 1–149 Not recorded Small conductance calcium-activated potassium channel protein 2 × 1 （Q9H2S1） SO4 SULFATE ION × 2 657 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine × 1 GOL GLYCEROL × 1 CA CALCIUM ION × 2 X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；295 K；ammonia sulfate Resolution 1.78 Å R-free 0.215

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 5V02 Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
12DK structure of human KCNQ1-CaM-PIP2 intermediate state Deposited 2026-03-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain B 1–149（149 aa）
Chain D 1–149（149 aa）
Chain F 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded PT5 [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate × 4 CA CALCIUM ION × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.47 Å
22RJ Human KCNQ3-CaM in apo state Deposited 2026-01-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Chain G 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 2.82 Å
2KUG Halothane binds to druggable sites in calcium-calmodulin: Solution Structure of halothane-CaM N-terminal domain Deposited 2010-02-17 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2–149（148 aa）
Not recorded CA CALCIUM ION × 2 HLT 2-BROMO-2-CHLORO-1,1,1-TRIFLUOROETHANE × 1 SOLUTION NMR
NMR measurement conditions pH 7.2；298 K；Ionic strength (raw mmCIF value) 0.1；Pressure ambient
NMR sample composition 2 mM [U-99% 13C; U-99% 15N] CALMODULIN, 20 mM CALCIUM ION, 20 mM N-{[2-({[1-(4-CARBOXYBUTANOYL)AMINO]-2-PHENYLETHYL}-HYDROXYPHOSPHINYL)OXY]ACETYL}-2-PHENYLETHYLAMINE, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 2 mM [U-99% 15N] CALMODULIN, 20 mM CALCIUM ION, 20 mM N-{[2-({[1-(4-CARBOXYBUTANOYL)AMINO]-2-PHENYLETHYL}-HYDROXYPHOSPHINYL)OXY]ACETYL}-2-PHENYLETHYLAMINE, 95% H2O/5% D2O | 95% H2O/5% D2O
Resolution not provided
3EVV Crystal Structure of Calcium bound dimeric GCAMP2 (#2) Deposited 2008-10-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 5–149（145 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CA CALCIUM ION × 8 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.60 Å R-free 0.270
3O77 The structure of Ca2+ Sensor (Case-16) Deposited 2010-07-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric
Chain A 3–149（147 aa）
Mutation：POINT MUTATIONS Non-standard monomer：Yes (specific site not provided by mmCIF) CA CALCIUM ION × 2 SO4 SULFATE ION × 2 CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.4；293 K；Reservoir: 50mM Imidazol, 1.9M Na2malonate pH 6.4; Protein stock solution: 50mM Tris HCl (pH 7.4), 150mM NaCl, 10mM dithiothreitol, protein 4.1mg/ml; Drop ratio reservoir/protein = 1/3, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.35 Å R-free 0.274
3O78 The structure of Ca2+ Sensor (Case-12) Deposited 2010-07-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric
Chain A 3–149（147 aa）
Mutation：POINT MUTATIONS Non-standard monomer：Yes (specific site not provided by mmCIF) CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；293 K；Reservoir: 100mM Tris HCL (pH 5.5), 100mM (NH4)2SO4, 21% PEG 3350; Protein stock: 7.6 mg/ml Protein, 50mM Tris HCl (pH 7.4), 150mM NaCl; Seed stock solution: 20mM CaCl2, 20% PEG 3350, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.60 Å R-free 0.316
3O78 The structure of Ca2+ Sensor (Case-12) Deposited 2010-07-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric
Chain B 3–149（147 aa）
Mutation：POINT MUTATIONS Non-standard monomer：Yes (specific site not provided by mmCIF) CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；293 K；Reservoir: 100mM Tris HCL (pH 5.5), 100mM (NH4)2SO4, 21% PEG 3350; Protein stock: 7.6 mg/ml Protein, 50mM Tris HCl (pH 7.4), 150mM NaCl; Seed stock solution: 20mM CaCl2, 20% PEG 3350, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.60 Å R-free 0.316
3O78 The structure of Ca2+ Sensor (Case-12) Deposited 2010-07-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 3–149（147 aa）
Chain B 3–149（147 aa）
Mutation：POINT MUTATIONS Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：POINT MUTATIONS Non-standard monomer：Yes (specific site not provided by mmCIF) CA CALCIUM ION × 8 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；293 K；Reservoir: 100mM Tris HCL (pH 5.5), 100mM (NH4)2SO4, 21% PEG 3350; Protein stock: 7.6 mg/ml Protein, 50mM Tris HCl (pH 7.4), 150mM NaCl; Seed stock solution: 20mM CaCl2, 20% PEG 3350, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.60 Å R-free 0.316
5OEO Solution structure of the complex of TRPV5(655-725) with a Calmodulin E32Q/E68Q double mutant Deposited 2017-07-09 Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1–149（149 aa）
Mutation：E32Q, E68Q CA CALCIUM ION × 2 SOLUTION NMR
NMR measurement conditions pH 7.4；308 K；Ionic strength (raw mmCIF value) 84；Pressure 1
NMR sample composition 220 uM 13C/15N Calmodulin, 220 uM hTRPV5(655-725), 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 380 uM [U-99% 15N] Calmodulin, 380 uM [U-99% 13C; U-99% 15N] hTRPV5(655-725), 95% H2O/5% D2O | 95% H2O/5% D2O
Resolution not provided
5V7X Crystal Structure of Myosin 1b residues 1-728 with bound sulfate and Calmodulin Deposited 2017-03-20 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1–149（149 aa）
Not recorded SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277 K；10% PEG 3350, 100 mM LiOOCCH3, 100 mM HEPES, pH 7.0, 20 mM Mg2SO4
Resolution 3.14 Å R-free 0.202
5WBX Structural insights into the potency of SK/IK channel positive modulators Deposited 2017-06-29 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain R 5–148（144 aa）
Not recorded SO4 SULFATE ION × 4 GOL GLYCEROL × 2 CA CALCIUM ION × 2 AJY (3Z)-6-bromo-3-(hydroxyimino)-5-methyl-1,3-dihydro-2H-indol-2-one × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.8；293.15 K；0.1 M Sodium itrate tribasic dihydrate 0.5 M Ammonium sulfate 1.5 M Lithium sulfate monohydrate
Resolution 1.90 Å R-free 0.243
5WBX Structural insights into the potency of SK/IK channel positive modulators Deposited 2017-06-29 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain R 5–148（144 aa）
Not recorded SO4 SULFATE ION × 8 GOL GLYCEROL × 4 CA CALCIUM ION × 4 AJY (3Z)-6-bromo-3-(hydroxyimino)-5-methyl-1,3-dihydro-2H-indol-2-one × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.8；293.15 K；0.1 M Sodium itrate tribasic dihydrate 0.5 M Ammonium sulfate 1.5 M Lithium sulfate monohydrate
Resolution 1.90 Å R-free 0.243
5WC5 Structural insights into the potency of SK/IK channel positive modulators Deposited 2017-06-29 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain R 5–148（144 aa）
Not recorded SO4 SULFATE ION × 6 GOL GLYCEROL × 1 CA CALCIUM ION × 2 AJV 7-fluoro-3-(hydroxyamino)-2H-indol-2-one × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.8；293.15 K；0.1 M Sodium citrate tribasic dihydrate 0.5 M Ammonium sulfate 1.5 M Litium sulfate monohydrate
Resolution 2.30 Å R-free 0.250
5WC5 Structural insights into the potency of SK/IK channel positive modulators Deposited 2017-06-29 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain R 5–148（144 aa）
Not recorded SO4 SULFATE ION × 12 GOL GLYCEROL × 2 CA CALCIUM ION × 4 AJV 7-fluoro-3-(hydroxyamino)-2H-indol-2-one × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.8；293.15 K；0.1 M Sodium citrate tribasic dihydrate 0.5 M Ammonium sulfate 1.5 M Litium sulfate monohydrate
Resolution 2.30 Å R-free 0.250
6B8L Crystal Structure of the Apo/CaM:Kv7.4 (KCNQ4) AB Domain Complex Deposited 2017-10-09 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1–149（149 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；2M ammonium sulfate, 0.1M BisTris pH 6.5
Resolution 2.30 Å R-free 0.246
6B8L Crystal Structure of the Apo/CaM:Kv7.4 (KCNQ4) AB Domain Complex Deposited 2017-10-09 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 1–149（149 aa）
Not recorded SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；2M ammonium sulfate, 0.1M BisTris pH 6.5
Resolution 2.30 Å R-free 0.246
6B8L Crystal Structure of the Apo/CaM:Kv7.4 (KCNQ4) AB Domain Complex Deposited 2017-10-09 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain F 1–149（149 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；2M ammonium sulfate, 0.1M BisTris pH 6.5
Resolution 2.30 Å R-free 0.246
6B8L Crystal Structure of the Apo/CaM:Kv7.4 (KCNQ4) AB Domain Complex Deposited 2017-10-09 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain H 1–149（149 aa）
Not recorded SO4 SULFATE ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；2M ammonium sulfate, 0.1M BisTris pH 6.5
Resolution 2.30 Å R-free 0.246
6B8M Crystal Structure of the Ca2+/CaM:Kv7.4 (KCNQ4) AB Domain Complex, 1 mM CaCl2 soak Deposited 2017-10-09 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1–149（149 aa）
Not recorded CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；2M ammonium sulfate, 0.1M BisTris pH 6.5, 1mM CaCl2
Resolution 2.30 Å R-free 0.262
6B8M Crystal Structure of the Ca2+/CaM:Kv7.4 (KCNQ4) AB Domain Complex, 1 mM CaCl2 soak Deposited 2017-10-09 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 1–149（149 aa）
Not recorded CA CALCIUM ION × 1 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；2M ammonium sulfate, 0.1M BisTris pH 6.5, 1mM CaCl2
Resolution 2.30 Å R-free 0.262
6B8M Crystal Structure of the Ca2+/CaM:Kv7.4 (KCNQ4) AB Domain Complex, 1 mM CaCl2 soak Deposited 2017-10-09 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain F 1–149（149 aa）
Not recorded CA CALCIUM ION × 2 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；2M ammonium sulfate, 0.1M BisTris pH 6.5, 1mM CaCl2
Resolution 2.30 Å R-free 0.262
6B8M Crystal Structure of the Ca2+/CaM:Kv7.4 (KCNQ4) AB Domain Complex, 1 mM CaCl2 soak Deposited 2017-10-09 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain H 1–149（149 aa）
Not recorded CA CALCIUM ION × 2 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；2M ammonium sulfate, 0.1M BisTris pH 6.5, 1mM CaCl2
Resolution 2.30 Å R-free 0.262
6B8N Crystal Structure of the Ca2+/CaM:Kv7.4 (KCNQ4) AB Domain Complex, 10 uM CaCl2 soak Deposited 2017-10-09 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1–149（149 aa）
Not recorded CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；2M ammonium sulfate, 0.1M BisTris pH 6.5, 0.01mM CaCl2
Resolution 2.20 Å R-free 0.264
6B8N Crystal Structure of the Ca2+/CaM:Kv7.4 (KCNQ4) AB Domain Complex, 10 uM CaCl2 soak Deposited 2017-10-09 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 1–149（149 aa）
Not recorded CA CALCIUM ION × 1 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；2M ammonium sulfate, 0.1M BisTris pH 6.5, 0.01mM CaCl2
Resolution 2.20 Å R-free 0.264
6B8N Crystal Structure of the Ca2+/CaM:Kv7.4 (KCNQ4) AB Domain Complex, 10 uM CaCl2 soak Deposited 2017-10-09 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain F 1–149（149 aa）
Not recorded CA CALCIUM ION × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；2M ammonium sulfate, 0.1M BisTris pH 6.5, 0.01mM CaCl2
Resolution 2.20 Å R-free 0.264
6B8N Crystal Structure of the Ca2+/CaM:Kv7.4 (KCNQ4) AB Domain Complex, 10 uM CaCl2 soak Deposited 2017-10-09 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain H 1–149（149 aa）
Not recorded CA CALCIUM ION × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；2M ammonium sulfate, 0.1M BisTris pH 6.5, 0.01mM CaCl2
Resolution 2.20 Å R-free 0.264
6B8P Crystal Structure of the Mg2+/CaM:Kv7.4 (KCNQ4) AB domain complex Deposited 2017-10-09 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1–149（149 aa）
Not recorded MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；2M ammonium sulfate, 0.1M BisTris pH 6.5, 1mM MgCl2
Resolution 2.20 Å R-free 0.240
6B8P Crystal Structure of the Mg2+/CaM:Kv7.4 (KCNQ4) AB domain complex Deposited 2017-10-09 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 1–149（149 aa）
Not recorded MG MAGNESIUM ION × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；2M ammonium sulfate, 0.1M BisTris pH 6.5, 1mM MgCl2
Resolution 2.20 Å R-free 0.240
6B8P Crystal Structure of the Mg2+/CaM:Kv7.4 (KCNQ4) AB domain complex Deposited 2017-10-09 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain F 1–149（149 aa）
Not recorded MG MAGNESIUM ION × 1 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；2M ammonium sulfate, 0.1M BisTris pH 6.5, 1mM MgCl2
Resolution 2.20 Å R-free 0.240
6B8P Crystal Structure of the Mg2+/CaM:Kv7.4 (KCNQ4) AB domain complex Deposited 2017-10-09 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain H 1–149（149 aa）
Not recorded MG MAGNESIUM ION × 1 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；2M ammonium sulfate, 0.1M BisTris pH 6.5, 1mM MgCl2
Resolution 2.20 Å R-free 0.240
6B8Q Crystal Structure of the Mg2+/CaM:Kv7.5 (KCNQ5) AB domain complex Deposited 2017-10-09 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1–149（149 aa）
Not recorded MG MAGNESIUM ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；0.2M magnesium formate, 20% PEG 3350
Resolution 2.60 Å R-free 0.270
6B8Q Crystal Structure of the Mg2+/CaM:Kv7.5 (KCNQ5) AB domain complex Deposited 2017-10-09 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 1–149（149 aa）
Not recorded MG MAGNESIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；0.2M magnesium formate, 20% PEG 3350
Resolution 2.60 Å R-free 0.270
6B8Q Crystal Structure of the Mg2+/CaM:Kv7.5 (KCNQ5) AB domain complex Deposited 2017-10-09 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain F 1–149（149 aa）
Not recorded MG MAGNESIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；0.2M magnesium formate, 20% PEG 3350
Resolution 2.60 Å R-free 0.270
6B8Q Crystal Structure of the Mg2+/CaM:Kv7.5 (KCNQ5) AB domain complex Deposited 2017-10-09 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain H 1–149（149 aa）
Not recorded MG MAGNESIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；0.2M magnesium formate, 20% PEG 3350
Resolution 2.60 Å R-free 0.270
6BUT Solution structure of full-length apo mammalian calmodulin bound to the IQ motif of the human voltage-gated sodium channel NaV1.2 Deposited 2017-12-11 Different construct Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 2–149（148 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.5；298 K；Ionic strength (raw mmCIF value) 100；Pressure 1
NMR measurement conditions pH 6.5；298 K；Ionic strength (raw mmCIF value) 100；Pressure 1
NMR sample composition 0.950 mM U-99% C13, U-99% N15 Calmodulin, 0.950 mM U-99% C13, U-99% N15 voltage-gated sodium channel NaV1.2 IQ motif, 0.1 mM U-98% 2H EDTA, 100 mM KCl, 10 mM [U-99% 2H] imidazole, 0.01 % w/v sodium azide, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 0.95 mM U-99% C13, U-99% N15 Calmodulin, 0.95 mM U-99% C13, U-99% N15 voltage-gated sodium channel NaV1.2 IQ motif, 0.1 mM U-98% 2H EDTA, 100 mM potassium chloride, 10 mM [U-99% 2H] imidazole, 0.01 % w/v sodium azide, 100% D2O | 100% D2O
Resolution not provided
6CNM Cryo-EM structure of the human SK4/calmodulin channel complex Deposited 2018-03-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Chain G 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded K POTASSIUM ION × 5 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 4 LMT DODECYL-BETA-D-MALTOSIDE × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
6CNN Cryo-EM structure of the human SK4/calmodulin channel complex in the Ca2+ bound state I Deposited 2018-03-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Chain G 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded K POTASSIUM ION × 4 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 4 LMT DODECYL-BETA-D-MALTOSIDE × 8 CA CALCIUM ION × 12 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.50 Å
6CNO Cryo-EM structure of the human SK4/calmodulin channel complex in the Ca2+ bound state II Deposited 2018-03-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Chain G 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded CA CALCIUM ION × 12 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.70 Å
6DAD 1.65 Angstrom crystal structure of the N97I Ca/CaM:CaV1.2 IQ domain complex Deposited 2018-05-01 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 2–149（148 aa）
Mutation：N97I CA CALCIUM ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；2.1 M sodium malonate, 0.1 M HEPES, pH 7.5
Resolution 1.65 Å R-free 0.208
6DAD 1.65 Angstrom crystal structure of the N97I Ca/CaM:CaV1.2 IQ domain complex Deposited 2018-05-01 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 2–149（148 aa）
Mutation：N97I CA CALCIUM ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；2.1 M sodium malonate, 0.1 M HEPES, pH 7.5
Resolution 1.65 Å R-free 0.208
6DAE 2.0 Angstrom crystal structure of the D95V Ca/CaM:CaV1.2 IQ domain complex Deposited 2018-05-01 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 2–149（148 aa）
Mutation：D95V CA CALCIUM ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 10.3；277 K；1 M lithium chloride, 30% PEG6000, 0.1M Bicine, pH 10.3
Resolution 2.00 Å R-free 0.226
6DAE 2.0 Angstrom crystal structure of the D95V Ca/CaM:CaV1.2 IQ domain complex Deposited 2018-05-01 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 2–149（148 aa）
Mutation：D95V CA CALCIUM ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 10.3；277 K；1 M lithium chloride, 30% PEG6000, 0.1M Bicine, pH 10.3
Resolution 2.00 Å R-free 0.226
6DAF 2.4 Angstrom crystal structure of the F141L Ca/CaM:CaV1.2 IQ domain complex Deposited 2018-05-01 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 2–149（148 aa）
Mutation：F141L CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；0.5 M potassium nitrate, 20% PEG3350
Resolution 2.40 Å R-free 0.243
6DAF 2.4 Angstrom crystal structure of the F141L Ca/CaM:CaV1.2 IQ domain complex Deposited 2018-05-01 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 2–149（148 aa）
Mutation：F141L CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；0.5 M potassium nitrate, 20% PEG3350
Resolution 2.40 Å R-free 0.243
6DAH 2.5 Angstrom crystal structure of the N97S CaM mutant Deposited 2018-05-01 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1–149（149 aa）
Mutation：N97S CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；20% PEG3350, 0.1 M Bis-Tris, pH 6.5
Resolution 2.50 Å R-free 0.279
6DAH 2.5 Angstrom crystal structure of the N97S CaM mutant Deposited 2018-05-01 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 1–149（149 aa）
Mutation：N97S CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；20% PEG3350, 0.1 M Bis-Tris, pH 6.5
Resolution 2.50 Å R-free 0.279
6DAH 2.5 Angstrom crystal structure of the N97S CaM mutant Deposited 2018-05-01 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain C 1–149（149 aa）
Mutation：N97S CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；20% PEG3350, 0.1 M Bis-Tris, pH 6.5
Resolution 2.50 Å R-free 0.279
6DAH 2.5 Angstrom crystal structure of the N97S CaM mutant Deposited 2018-05-01 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain D 1–149（149 aa）
Mutation：N97S CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；20% PEG3350, 0.1 M Bis-Tris, pH 6.5
Resolution 2.50 Å R-free 0.279
6E2F Cryo-EM structure of human TRPV6 in complex with Calmodulin Deposited 2018-07-11 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric
Chain E 1–149（149 aa）
Not recorded CA CALCIUM ION × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.90 Å
6E2G Cryo-EM structure of rat TRPV6 in complex with Calmodulin Deposited 2018-07-11 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric
Chain E 1–149（149 aa）
Not recorded CA CALCIUM ION × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.60 Å
6EEB Calmodulin in complex with malbrancheamide Deposited 2018-08-13 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1–149（149 aa）
Not recorded J6P (5aS,12aS,13aS)-8,9-dichloro-12,12-dimethyl-2,3,11,12,12a,13-hexahydro-1H,5H,6H-5a,13a-(epiminomethano)indolizino[7,6-b]carbazol-14-one × 1 CA CALCIUM ION × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.1 M Tris pH 8.5, 0.2 M MgCl2, 20% (w/v) PEG 8000
Resolution 1.96 Å R-free 0.263
6EEB Calmodulin in complex with malbrancheamide Deposited 2018-08-13 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 1–149（149 aa）
Not recorded J6P (5aS,12aS,13aS)-8,9-dichloro-12,12-dimethyl-2,3,11,12,12a,13-hexahydro-1H,5H,6H-5a,13a-(epiminomethano)indolizino[7,6-b]carbazol-14-one × 2 CA CALCIUM ION × 8 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.1 M Tris pH 8.5, 0.2 M MgCl2, 20% (w/v) PEG 8000
Resolution 1.96 Å R-free 0.263
6FEG Solution Structure of CaM/Kv7.2-hAB Complex Deposited 2018-01-02 Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1–149（149 aa）
Not recorded CA CALCIUM ION × 2 SOLUTION NMR
NMR measurement conditions pH 6；303 K；Ionic strength (raw mmCIF value) 120；Pressure 1
NMR sample composition 1 mM [U-100% 13C; U-100% 15N; U-50% 2H] Kv7.2-hAB, 1 mM [U-100% 13C; U-100% 15N; U-50% 2H] Calmodulin, 120 mM potassium chloride, 20 mM MES, 2 uM sodium azide, 200 uM [U-2H] DSS, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 500 uM [U-100% 13C; U-100% 15N] Kv7.2-hAB, 500 uM Calmodulin, 120 mM potassium chloride, 20 mM MES, 2 uM sodium azide, 200 uM [U-2H] DSS, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 500 uM Kv7.2-hAB, 500 uM [U-100% 13C; U-100% 15N] Calmodulin, 120 mM potassium chloride, 20 mM MES, 2 uM sodium azide, 200 uM [U-2H] DSS, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 250 uM [U-100% 15N] Kv7.2-hAB, 250 uM [U-100% 15N] Calmodulin, 120 mM potassium chloride, 20 mM MES, 2 uM sodium azide, 200 uM [U-2H] DSS, 95% H2O/5% D2O | 95% H2O/5% D2O
Resolution not provided
6FEH Solution Structure of CaM/Kv7.2-hAB Complex Deposited 2018-01-02 Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 1–149（149 aa）
Not recorded CA CALCIUM ION × 4 SOLUTION NMR
NMR measurement conditions pH 6；303 K；Ionic strength (raw mmCIF value) 120；Pressure 1
NMR sample composition 1 mM [U-100% 13C; U-100% 15N; U-50% 2H] Kv7.2-hAB, 1 mM [U-100% 13C; U-100% 15N; U-50% 2H] Calmodulin, 120 mM potassium chloride, 20 mM MES, 5 mM CaCl2, 2 uM sodium azide, 200 uM [U-2H] DSS, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 500 uM [U-100% 13C; U-100% 15N] Kv7.2-hAB, 500 uM Calmodulin, 120 mM potassium chloride, 20 mM MES, 5 mM CaCl2, 2 uM sodium azide, 200 uM [U-2H] DSS, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 250 uM [U-100% 15N] Kv7.2-hAB, 250 uM [U-100% 15N] Calmodulin, 120 mM potassium chloride, 20 mM MES, 5 mM CaCl2, 2 uM sodium azide, 200 uM [U-2H] DSS, 95% H2O/5% D2O | 95% H2O/5% D2O
Resolution not provided
6GDK Calcium bound form of human calmodulin mutant F141L Deposited 2018-04-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2–149（148 aa）
Mutation：F141L CA CALCIUM ION × 4 SOLUTION NMR
NMR measurement conditions pH 6.45；298.1 K；Ionic strength (raw mmCIF value) 24；Pressure 1
NMR sample composition 0.53 mM [U-13C; U-15N] Calmodulin mutant F141L, 10 mM NA calcium chloride, 10 mM NA potassium chloride, 2 mM NA HEPES, 2 mM NA sodium azide, 0.1 mM NA TSP-d4, 95% H2O/5% D2O | 95% H2O/5% D2O
Resolution not provided
6GDL Calmodulin mutant - F141L apo-form Unstructured C-domain Deposited 2018-04-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2–149（148 aa）
Mutation：F141L No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.55；298.1 K；Ionic strength (raw mmCIF value) 24；Pressure 1
NMR sample composition 580 uM [U-99% 13C; U-99% 15N] Calmodulin, 2 mM HEPES, 10 mM potassium chloride, 10 mM EDTA, 2 mM sodium azide, 95% H2O/5% D2O | 95% H2O/5% D2O
Resolution not provided
6HCS Crystal structure of CaM-peptide complex containing AzF at position 108 Deposited 2018-08-16 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1–149（149 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5；293 K；PEG 6000, lithium chloride, sodium chloride
Resolution 2.00 Å R-free 0.294
6HCS Crystal structure of CaM-peptide complex containing AzF at position 108 Deposited 2018-08-16 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 1–149（149 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5；293 K；PEG 6000, lithium chloride, sodium chloride
Resolution 2.00 Å R-free 0.294
6HCS Crystal structure of CaM-peptide complex containing AzF at position 108 Deposited 2018-08-16 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain E 1–149（149 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5；293 K；PEG 6000, lithium chloride, sodium chloride
Resolution 2.00 Å R-free 0.294
6HCS Crystal structure of CaM-peptide complex containing AzF at position 108 Deposited 2018-08-16 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain G 1–149（149 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5；293 K；PEG 6000, lithium chloride, sodium chloride
Resolution 2.00 Å R-free 0.294
6HR1 Crystal structure of the YFPnano fusion protein Deposited 2018-09-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2–149（148 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) TLA L(+)-TARTARIC ACID × 1 CA CALCIUM ION × 4 EDO 1,2-ETHANEDIOL × 2 GOL GLYCEROL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.8；293 K；24% w/v PEG 3350 0.2 M di-Ammonium tartrate 10% v/v Glycerol
Resolution 1.90 Å R-free 0.214
6HR1 Crystal structure of the YFPnano fusion protein Deposited 2018-09-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric
Chain B 2–149（148 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CA CALCIUM ION × 4 EDO 1,2-ETHANEDIOL × 7 GOL GLYCEROL × 2 NA SODIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.8；293 K；24% w/v PEG 3350 0.2 M di-Ammonium tartrate 10% v/v Glycerol
Resolution 1.90 Å R-free 0.214
6JI8 Structure of RyR2 (F/apoCaM dataset) Deposited 2019-02-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain C 1–149（149 aa）
Chain F 1–149（149 aa）
Chain I 1–149（149 aa）
Chain L 1–149（149 aa）
Not recorded ZN ZINC ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.60 Å
6JII Structure of RyR2 (F/A/C/L-Ca2+/apo-CaM-M dataset) Deposited 2019-02-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain C 1–149（149 aa）
Chain F 1–149（149 aa）
Chain I 1–149（149 aa）
Chain L 1–149（149 aa）
Mutation：E32A,E68A,E105A,E141A Mutation：E32A,E68A,E105A,E141A Mutation：E32A,E68A,E105A,E141A Mutation：E32A,E68A,E105A,E141A ZN ZINC ION × 4 CA CALCIUM ION × 4 CFF CAFFEINE × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.20 Å
6JIU Structure of RyR2 (F/A/C/L-Ca2+/Ca2+CaM dataset) Deposited 2019-02-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain C 1–149（149 aa）
Chain F 1–149（149 aa）
Chain I 1–149（149 aa）
Chain L 1–149（149 aa）
Not recorded ZN ZINC ION × 4 CA CALCIUM ION × 12 ATP ADENOSINE-5'-TRIPHOSPHATE × 4 CFF CAFFEINE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.20 Å
6JIY Structure of RyR2 (F/A/C/H-Ca2+/Ca2+CaM dataset) Deposited 2019-02-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain C 1–149（149 aa）
Chain F 1–149（149 aa）
Chain I 1–149（149 aa）
Chain L 1–149（149 aa）
Not recorded ZN ZINC ION × 4 CA CALCIUM ION × 20 ATP ADENOSINE-5'-TRIPHOSPHATE × 4 CFF CAFFEINE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.90 Å
6JRS Structure of RyR2 (*F/A/C/L-Ca2+/Ca2+-CaM dataset) Deposited 2019-04-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain C 1–149（149 aa）
Chain F 1–149（149 aa）
Chain I 1–149（149 aa）
Chain L 1–149（149 aa）
Not recorded ZN ZINC ION × 4 CA CALCIUM ION × 12 ATP ADENOSINE-5'-TRIPHOSPHATE × 4 CFF CAFFEINE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.70 Å
6JV2 Structure of RyR2 (P/L-Ca2+/Ca2+-CaM dataset) Deposited 2019-04-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain B 1–149（149 aa）
Chain D 1–149（149 aa）
Chain F 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded ZN ZINC ION × 4 CA CALCIUM ION × 20 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.40 Å
6K4K Crystal structure of SidJ-CaM binary complex at 2.71 A Deposited 2019-05-24 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 1–149（149 aa）
Not recorded CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；299 K；20% PEG 3350, 0.2M NaI
Resolution 2.71 Å R-free 0.243
6K4K Crystal structure of SidJ-CaM binary complex at 2.71 A Deposited 2019-05-24 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 1–149（149 aa）
Not recorded CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；299 K；20% PEG 3350, 0.2M NaI
Resolution 2.71 Å R-free 0.243
6K4L Crystal structure of Se-labelled SidJ complex with CaM at 2.95 A Deposited 2019-05-24 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 1–149（149 aa）
Not recorded CL CHLORIDE ION × 2 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；299 K；25% PEG 3350, 0.2M NaI
Resolution 2.95 Å R-free 0.269
6K4L Crystal structure of Se-labelled SidJ complex with CaM at 2.95 A Deposited 2019-05-24 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 1–149（149 aa）
Not recorded CL CHLORIDE ION × 2 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；299 K；25% PEG 3350, 0.2M NaI
Resolution 2.95 Å R-free 0.269
6K4R Crystal structure of SidJ-CaM-AMP ternary complex at 3.11 A Deposited 2019-05-26 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 1–149（149 aa）
Not recorded AMP ADENOSINE MONOPHOSPHATE × 1 CL CHLORIDE ION × 2 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；299 K；25% PEG 3350, 0.2M NaI, 0.1M HEPES 7.5
Resolution 3.11 Å R-free 0.279
6K4R Crystal structure of SidJ-CaM-AMP ternary complex at 3.11 A Deposited 2019-05-26 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 1–149（149 aa）
Not recorded AMP ADENOSINE MONOPHOSPHATE × 1 CL CHLORIDE ION × 2 PG4 TETRAETHYLENE GLYCOL × 2 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；299 K；25% PEG 3350, 0.2M NaI, 0.1M HEPES 7.5
Resolution 3.11 Å R-free 0.279
6M2W Structure of RyR1 (Ca2+/Caffeine/ATP/CaM1234/CHL) Deposited 2020-03-01 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain C 1–149（149 aa）
Chain F 1–149（149 aa）
Chain I 1–149（149 aa）
Chain L 1–149（149 aa）
Mutation：E32A, E68A, E105A, E141A Mutation：E32A, E68A, E105A, E141A Mutation：E32A, E68A, E105A, E141A Mutation：E32A, E68A, E105A, E141A CFF CAFFEINE × 4 CA CALCIUM ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 4 ZN ZINC ION × 4 F0U 5-bromanyl-N-[4-chloranyl-2-methyl-6-(methylcarbamoyl)phenyl]-2-(3-chloranylpyridin-2-yl)pyrazole-3-carboxamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.80 Å
6M7H Structure of calmodulin with KN93 Deposited 2018-08-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2–148（147 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) KN9 N-[2-[[[3-(4'-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4'-methoxybenzenesulfonamide × 3 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；289 K；bis tris ph 6.5, peg 3350
Resolution 1.60 Å R-free 0.267
6MUD Voltage-gated sodium channel NaV1.5 C-terminal domain in complex with Ca2+/Calmodulin Deposited 2018-10-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1–149（149 aa）
Not recorded CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 9.5；277 K；5-15 % (w/v) PEG 4000, 0.1 M Tris, pH 9.5, 0.1 M MgCl2, and 5 % (v/v) isopropanol
Resolution 2.69 Å R-free 0.269
6MUE Voltage-gated sodium channel NaV1.4 IQ domain in complex with Ca2+/Calmodulin Deposited 2018-10-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1–149（149 aa）
Not recorded CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；277 K；0.1 M MES pH 6.0 and 55 % (v/v) isopropanol
Resolution 1.90 Å R-free 0.260
6N5W Crystal structure of the Ca2+/CaM complex with independent peptides of Kv7.4 (KCNQ4) A & B domains Deposited 2018-11-22 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain C 1–149（149 aa）
Not recorded CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；295 K；1.3 M sodium citrate, 0.1 M HEPES pH 7.0
Resolution 2.15 Å R-free 0.274
6O5G Calmodulin in complex with isomalbrancheamide D Deposited 2019-03-02 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1–149（149 aa）
Not recorded LMJ (5aS,12aS,13aS)-9-bromo-8-chloro-12,12-dimethyl-2,3,11,12,12a,13-hexahydro-1H,5H,6H-5a,13a-(epiminomethano)indolizino[7 ,6-b]carbazol-14-one × 1 CA CALCIUM ION × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；0.1 M Tris pH 8.5, 0.2 M MgCl2, 20% PEG 8000
Resolution 1.89 Å R-free 0.226
6OS4 Calmodulin in complex with farnesyl cysteine methyl ester Deposited 2019-05-01 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2–149（148 aa）
Not recorded CA CALCIUM ION × 4 5U0 s-farnesyl-l-cysteine methyl ester × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.7；293 K；0.2mM sodium acetate, 0.1mM cacodylate, 28% PEG 8000
Resolution 2.05 Å R-free 0.225
6OS4 Calmodulin in complex with farnesyl cysteine methyl ester Deposited 2019-05-01 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 2–149（148 aa）
Not recorded CA CALCIUM ION × 8 5U0 s-farnesyl-l-cysteine methyl ester × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.7；293 K；0.2mM sodium acetate, 0.1mM cacodylate, 28% PEG 8000
Resolution 2.05 Å R-free 0.225
6PAW Crystal structure of DAPK2 S308A Calcium/Calmodulin complex Deposited 2019-06-12 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 1–149（149 aa）
Not recorded CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；292.15 K；0.1 M Bis-Tris-HCl, pH 6.5, 0.6 M sodium chloride, 14.3% PEG3350
Resolution 2.95 Å R-free 0.288
6PAW Crystal structure of DAPK2 S308A Calcium/Calmodulin complex Deposited 2019-06-12 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 1–149（149 aa）
Not recorded CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；292.15 K；0.1 M Bis-Tris-HCl, pH 6.5, 0.6 M sodium chloride, 14.3% PEG3350
Resolution 2.95 Å R-free 0.288
6PAW Crystal structure of DAPK2 S308A Calcium/Calmodulin complex Deposited 2019-06-12 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain H 1–149（149 aa）
Not recorded CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；292.15 K；0.1 M Bis-Tris-HCl, pH 6.5, 0.6 M sodium chloride, 14.3% PEG3350
Resolution 2.95 Å R-free 0.288
6PAW Crystal structure of DAPK2 S308A Calcium/Calmodulin complex Deposited 2019-06-12 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain G 1–149（149 aa）
Not recorded CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；292.15 K；0.1 M Bis-Tris-HCl, pH 6.5, 0.6 M sodium chloride, 14.3% PEG3350
Resolution 2.95 Å R-free 0.288
6PBX Single particle cryo-EM structure of the voltage-gated K+ channel Eag1 3-13 deletion mutant bound to calmodulin (conformation 2) Deposited 2019-06-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain B 1–149（149 aa）
Chain D 1–149（149 aa）
Chain F 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.00 Å
6PBY Single particle cryo-EM structure of the voltage-gated K+ channel Eag1 3-13 deletion mutant bound to calmodulin (conformation 1) Deposited 2019-06-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain B 1–149（149 aa）
Chain D 1–149（149 aa）
Chain F 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.67 Å
6U39 2.4 Angstrom crystal structure of the D129G Ca-CaM:CaV1.2 IQ domain complex Deposited 2019-08-21 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 2–149（148 aa）
Mutation：D129G CA CALCIUM ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；ammonium sulfate
Resolution 2.40 Å R-free 0.283
6U39 2.4 Angstrom crystal structure of the D129G Ca-CaM:CaV1.2 IQ domain complex Deposited 2019-08-21 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 10 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain S 2–149（148 aa）
Mutation：D129G CA CALCIUM ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；ammonium sulfate
Resolution 2.40 Å R-free 0.283
6U39 2.4 Angstrom crystal structure of the D129G Ca-CaM:CaV1.2 IQ domain complex Deposited 2019-08-21 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 2–149（148 aa）
Mutation：D129G CA CALCIUM ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；ammonium sulfate
Resolution 2.40 Å R-free 0.283
6U39 2.4 Angstrom crystal structure of the D129G Ca-CaM:CaV1.2 IQ domain complex Deposited 2019-08-21 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain E 2–149（148 aa）
Mutation：D129G CA CALCIUM ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；ammonium sulfate
Resolution 2.40 Å R-free 0.283
6U39 2.4 Angstrom crystal structure of the D129G Ca-CaM:CaV1.2 IQ domain complex Deposited 2019-08-21 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain G 2–149（148 aa）
Mutation：D129G CA CALCIUM ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；ammonium sulfate
Resolution 2.40 Å R-free 0.283
6U39 2.4 Angstrom crystal structure of the D129G Ca-CaM:CaV1.2 IQ domain complex Deposited 2019-08-21 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 5 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain I 2–149（148 aa）
Mutation：D129G CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；ammonium sulfate
Resolution 2.40 Å R-free 0.283
6U39 2.4 Angstrom crystal structure of the D129G Ca-CaM:CaV1.2 IQ domain complex Deposited 2019-08-21 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 6 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain K 2–149（148 aa）
Mutation：D129G CA CALCIUM ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；ammonium sulfate
Resolution 2.40 Å R-free 0.283
6U39 2.4 Angstrom crystal structure of the D129G Ca-CaM:CaV1.2 IQ domain complex Deposited 2019-08-21 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 7 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain M 2–149（148 aa）
Mutation：D129G CA CALCIUM ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；ammonium sulfate
Resolution 2.40 Å R-free 0.283
6U39 2.4 Angstrom crystal structure of the D129G Ca-CaM:CaV1.2 IQ domain complex Deposited 2019-08-21 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 8 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain O 2–149（148 aa）
Mutation：D129G CA CALCIUM ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；ammonium sulfate
Resolution 2.40 Å R-free 0.283
6U39 2.4 Angstrom crystal structure of the D129G Ca-CaM:CaV1.2 IQ domain complex Deposited 2019-08-21 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 9 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain Q 2–149（148 aa）
Mutation：D129G CA CALCIUM ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；ammonium sulfate
Resolution 2.40 Å R-free 0.283
6U3A 1.65 Angstrom crystal structure of the N97S Ca-CaM:CaV1.2 IQ domain complex Deposited 2019-08-21 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 2–149（148 aa）
Mutation：N97S CA CALCIUM ION × 3 NA SODIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277 K；DL-malic acid
Resolution 1.65 Å R-free 0.209
6U3A 1.65 Angstrom crystal structure of the N97S Ca-CaM:CaV1.2 IQ domain complex Deposited 2019-08-21 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 2–149（148 aa）
Mutation：N97S CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277 K；DL-malic acid
Resolution 1.65 Å R-free 0.209
6U3B 1.7 Angstrom crystal structure of the Q135P Ca-CaM:CaV1.2 IQ domain complex Deposited 2019-08-21 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 2–149（148 aa）
Mutation：Q135P CA CALCIUM ION × 5 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；PEG 550 MME, sodium acetate
Resolution 1.70 Å R-free 0.200
6U3D 1.75 Angstrom crystal structure of the N53I Ca-CaM:CaV1.2 IQ domain complex Deposited 2019-08-21 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 2–149（148 aa）
Mutation：N53I CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；PEG 3350, citric acid
Resolution 1.75 Å R-free 0.201
6U3D 1.75 Angstrom crystal structure of the N53I Ca-CaM:CaV1.2 IQ domain complex Deposited 2019-08-21 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 2–149（148 aa）
Mutation：N53I CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；PEG 3350, citric acid
Resolution 1.75 Å R-free 0.201
6UZZ structure of human KCNQ1-CaM complex Deposited 2019-11-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain B 1–149（149 aa）
Chain D 1–149（149 aa）
Chain F 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded CA CALCIUM ION × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
6V00 structure of human KCNQ1-KCNE3-CaM complex Deposited 2019-11-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 12 PDB declaration: dodecameric
Chain B 1–149（149 aa）
Chain E 1–149（149 aa）
Chain H 1–149（149 aa）
Chain K 1–149（149 aa）
Not recorded CA CALCIUM ION × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
6V01 structure of human KCNQ1-KCNE3-CaM complex with PIP2 Deposited 2019-11-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain B 1–149（149 aa）
Chain E 1–149（149 aa）
Chain H 1–149（149 aa）
Chain K 1–149（149 aa）
Not recorded CA CALCIUM ION × 8 PT5 [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.90 Å
6X32 Wt pig RyR1 in complex with apoCaM, EGTA condition (class 1 and 2, closed) Deposited 2020-05-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain C 3–148（146 aa）
Chain F 3–148（146 aa）
Chain I 3–148（146 aa）
Chain L 3–148（146 aa）
Not recorded ZN ZINC ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.80 Å
6X33 Wt pig RyR1 in complex with apoCaM, EGTA condition (class 3, open) Deposited 2020-05-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain C 1–148（148 aa）
Chain F 1–148（148 aa）
Chain I 1–148（148 aa）
Chain L 1–148（148 aa）
Not recorded ZN ZINC ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.20 Å
6X35 Pig R615C RyR1 in complex with CaM, EGTA (class 1, open) Deposited 2020-05-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain C 1–148（148 aa）
Chain F 1–148（148 aa）
Chain I 1–148（148 aa）
Chain L 1–148（148 aa）
Not recorded ZN ZINC ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.20 Å
6X36 Pig R615C RyR1 in complex with CaM, EGTA (class 3, closed) Deposited 2020-05-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain C 1–148（148 aa）
Chain F 1–148（148 aa）
Chain I 1–148（148 aa）
Chain L 1–148（148 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.70 Å
6XXX 1.25 Angstrom crystal structure of Ca/CaM A102V:RyR2 peptide complex Deposited 2020-01-28 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain AAA 1–149（149 aa）
Not recorded CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M Sodium acetate trihydrate pH 4.0, 25% w/v Polyethylene glycol 1,500
Resolution 1.25 Å R-free 0.189
6XY3 2.0 Angstrom crystal structure of Ca/CaM N53I:RyR2 peptide complex Deposited 2020-01-29 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain AAA 1–149（149 aa）
Not recorded CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M Sodium acetate trihydrate pH 4.5, 10% w/v Polyethylene glycol 10,000
Resolution 2.00 Å R-free 0.260
6XYR Structure of the T4Lnano fusion protein Deposited 2020-01-31 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2–149（148 aa）
Not recorded CA CALCIUM ION × 5 GOL GLYCEROL × 5 CL CHLORIDE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；8% PEG 8000, 200 mM LiCl2, 100 mM Tris pH 8.0, 15% Glycerol
Resolution 2.08 Å R-free 0.236
6Y4P Calmodulin N53I variant bound to cardiac ryanodine receptor (RyR2) calmodulin binding domain Deposited 2020-02-21 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1–149（149 aa）
Mutation：N53I CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298.15 K；0.1 M Sodium Acetate pH 4.70 and 23 % PEG 550 MME
Resolution 2.13 Å R-free 0.246
6Y94 Ca2+-bound Calmodulin mutant N53I Deposited 2020-03-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2–149（148 aa）
Mutation：N53I CA CALCIUM ION × 4 SOLUTION NMR
NMR measurement conditions pH 6.57；298.1 K；Ionic strength (raw mmCIF value) 182；Pressure 1
NMR measurement conditions pH 6.57；298.1 K；Ionic strength (raw mmCIF value) 42；Pressure 1
NMR measurement conditions pH 6.57；298.1 K；Ionic strength (raw mmCIF value) 42；Pressure 1
NMR sample composition 0.56 mM [U-99% 13C; U-99% 15N] Calmodulin N53I, 2 mM HEPES, 100 mM potassium chloride, 10 mM calcium chloride, 50 mM sodium acetate, 2 mM sodium azide, 0.05 mM TSP, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 1.0 mM [U-99% 15N] Calmodulin N53I, 2 mM HEPES, 10 mM potassium chloride, 10 mM calcium chloride, 2 mM sodium azide, 0.05 mM TSP, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 1.0 mM [U-99% 13C; U-99% 15N] Calmodulin, 2 mM HEPES, 10 mM potassium chloride, 10 mM calcium chloride, 2 mM sodium azide, 0.05 mM TSP, 95% H2O/5% D2O | 95% H2O/5% D2O
Resolution not provided
6Y95 Ca2+-free Calmodulin mutant N53I Deposited 2020-03-06 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2–149（148 aa）
Mutation：N53I No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.3；298.1 K；Ionic strength (raw mmCIF value) 105；Pressure 1
NMR measurement conditions pH 6.56；298.1 K；Ionic strength (raw mmCIF value) 42；Pressure 1
NMR measurement conditions pH 6.53；298.1 K；Ionic strength (raw mmCIF value) 42；Pressure 1
NMR sample composition 1.9 mM [U-99% 13C; U-99% 15N] Calmodulin N53I, 20 mM HEPES, 100 mM potassium chloride, 1 mM EDTA, 2 mM sodium azide, 0.05 mM TSP, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 1.2 mM [U-99% 15N] Calmodulin N53I, 2 mM HEPES, 10 mM potassium chloride, 10 mM EDTA, 2 mM sodium azide, 0.05 mM TSP, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 1.2 mM [U-99% 13C; U-99% 15N] Calmodulin, 2 mM HEPES, 10 mM potassium chloride, 10 mM EDTA, 2 mM sodium azide, 0.05 mM TSP, 95% H2O/5% D2O | 95% H2O/5% D2O
Resolution not provided
6YNS CaM-P458 complex (crystal form 2) Deposited 2020-04-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain A 2–149（148 aa）
Chain C 2–149（148 aa）
Not recorded CA CALCIUM ION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；300 K；0.2M of MgCl2 0.1M HEPES-HCl pH 7.5 25% (w/v) PEG3350
Resolution 3.94 Å R-free 0.284
6YNS CaM-P458 complex (crystal form 2) Deposited 2020-04-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain B 2–149（148 aa）
Chain K 2–149（148 aa）
Not recorded CA CALCIUM ION × 8 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；300 K；0.2M of MgCl2 0.1M HEPES-HCl pH 7.5 25% (w/v) PEG3350
Resolution 3.94 Å R-free 0.284
6YNS CaM-P458 complex (crystal form 2) Deposited 2020-04-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain D 2–149（148 aa）
Chain E 2–149（148 aa）
Not recorded CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；300 K；0.2M of MgCl2 0.1M HEPES-HCl pH 7.5 25% (w/v) PEG3350
Resolution 3.94 Å R-free 0.284
6YNS CaM-P458 complex (crystal form 2) Deposited 2020-04-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain F 2–149（148 aa）
Chain G 2–149（148 aa）
Not recorded CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；300 K；0.2M of MgCl2 0.1M HEPES-HCl pH 7.5 25% (w/v) PEG3350
Resolution 3.94 Å R-free 0.284
6YNS CaM-P458 complex (crystal form 2) Deposited 2020-04-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 5 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain H 2–149（148 aa）
Chain I 2–149（148 aa）
Not recorded CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；300 K；0.2M of MgCl2 0.1M HEPES-HCl pH 7.5 25% (w/v) PEG3350
Resolution 3.94 Å R-free 0.284
6YNS CaM-P458 complex (crystal form 2) Deposited 2020-04-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 6 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain J 2–149（148 aa）
Chain L 2–149（148 aa）
Not recorded CA CALCIUM ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；300 K；0.2M of MgCl2 0.1M HEPES-HCl pH 7.5 25% (w/v) PEG3350
Resolution 3.94 Å R-free 0.284
6YNU CaM-P458 complex (crystal form 1) Deposited 2020-04-14 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 2–149（148 aa）
Not recorded CA CALCIUM ION × 5 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；300 K；0.3 M Ammonium sulfate 30% (w/v) PEG 4000
Resolution 3.12 Å R-free 0.291
6YNU CaM-P458 complex (crystal form 1) Deposited 2020-04-14 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 2–149（148 aa）
Not recorded CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；300 K；0.3 M Ammonium sulfate 30% (w/v) PEG 4000
Resolution 3.12 Å R-free 0.291
6ZBI Ternary complex of Calmodulin bound to 2 molecules of NHE1 Deposited 2020-06-08 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 2–149（148 aa）
Not recorded CA CALCIUM ION × 4 SOLUTION NMR
NMR measurement conditions pH 7.5；310 K；Ionic strength (raw mmCIF value) 120；Pressure 1
NMR sample composition 0.5 mM [U-99% 13C; U-99% 15N] Calmodulin, 1.15 mM Sodium/Hydrogen exchanger 1 (NHE1, SLC9A1), 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 1 mM [U-99% 13C; U-99% 15N] Sodium/Hydrogen exchanger 1 (NHE1, SLC9A1), 0.5 mM Calmodulin, 95% H2O/5% D2O | 95% H2O/5% D2O
Resolution not provided
7BF1 Ca2+-Calmodulin in complex with peptide from brain-type creatine kinase in extended 1:2 binding mode Deposited 2020-12-31 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain AAA 1–149（149 aa）
Not recorded CA CALCIUM ION × 4 ACE ACETYL GROUP × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；25% PEG 1500, 0.1 M SPG buffer pH 4-5. CaM-CKBpeptide ratios of 1:4
Resolution 1.24 Å R-free 0.186
7BF2 Ca2+-Calmodulin in complex with human muscle form creatine kinase peptide in extended 1:2 binding mode Deposited 2020-12-31 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain AAA 1–149（149 aa）
Not recorded CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.5；293 K；25% PEG 1500, 0.1 M SPG buffer pH 4-5. CaM-CKBpeptide ratios of 1:4
Resolution 1.43 Å R-free 0.228
7KL5 Structure of Calmodulin Bound to the Cardiac Ryanodine Receptor (RyR2) at Residues: Phe4246 to Val4271 Deposited 2020-10-29 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1–149（149 aa）
Not recorded CA CALCIUM ION × 5 EDO 1,2-ETHANEDIOL × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；0.2M sodium acetate, 0.1M Tris pH 8.5, 30%(w/v) PEG 4000
Resolution 1.65 Å R-free 0.245
7L8V NMR Structure of half-calcified calmodulin mutant (CaMEF12) bound to the IQ-motif of CaV1.2 Deposited 2021-01-01 Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1–149（149 aa）
Mutation：D21A, D23A, D25A, E32Q, D57A, D59A, N61A, E68Q CA CALCIUM ION × 2 SOLUTION NMR
NMR measurement conditions pH 7.4；303 K；Ionic strength (raw mmCIF value) 0.1；Pressure 1
NMR sample composition 0.5 mM [U-95% 15N] calmodulin, 0.75 mM IQ-motif, 10 mM TRIS, 2 mM CALCIUM ION, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 0.5 mM [U-13C; U-15N] calmodulin, 0.75 mM IQ-motif, 10 mM TRIS, 2 mM CALCIUM ION, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
7PSZ Crystal structure of CaM in complex with CDZ (form 1) Deposited 2021-09-24 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2–149（148 aa）
Not recorded 85H 1-[bis(4-chlorophenyl)methyl]-3-[(2~{R})-2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole × 1 SO4 SULFATE ION × 1 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；292 K；30 %w/v PEG 8K and 0.2 M (NH4)2SO4
Resolution 1.90 Å R-free 0.251
7PU9 Crystal structure of CaM in complex with CDZ (form 2) Deposited 2021-09-28 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2–149（148 aa）
Not recorded 85H 1-[bis(4-chlorophenyl)methyl]-3-[(2~{R})-2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole × 2 CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；292 K；0.2 M CaCl2, 0.1 M Tris pH 8.5 and 25 %w/v PEG 4K
Resolution 2.28 Å R-free 0.266
7SHQ Structure of a functional construct of eukaryotic elongation factor 2 kinase in complex with calmodulin. Deposited 2021-10-11 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 2–149（148 aa）
Not recorded ZN ZINC ION × 1 MG MAGNESIUM ION × 5 CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions MICROBATCH；pH 6.9；298.15 K；Cocktail solution: Peg3350: 24% MgCl2: 300 mM BisTris pH 6.9: 100 mM Protein Solution: 11 mg/mL CaM-eEF2Kp1/1 Tris pH 7.5: 20 mM NaCl: 0.1 M CaCl2: 3mM TCEP: 1mM MgCl2: 1.5 mM AMPPNP: 1.0 mM Crystallization conditions: 1/1 Protein/Cocktail under Paraffin Oil in a Greiner 72-Well microbatch plate
Resolution 2.34 Å R-free 0.252
7SX3 Human NALCN-FAM155A-UNC79-UNC80 channelosome with CaM bound, conformation 1/2 Deposited 2021-11-22 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric
Chain C 1–149（149 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 PEV (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE × 4 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 Y01 CHOLESTEROL HEMISUCCINATE × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；3.5 sec blotting
Resolution 3.10 Å
7SX4 Human NALCN-FAM155A-UNC79-UNC80 channelosome with CaM bound, conformation 2/2 Deposited 2021-11-22 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric
Chain C 1–149（149 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 PEV (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE × 1 PGV (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 1 Y01 CHOLESTEROL HEMISUCCINATE × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；3.5 sec blotting
Resolution 3.50 Å
7T2Q PEGylated Calmodulin-1 (K148U) Deposited 2021-12-06 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2–149（148 aa）
Not recorded CA CALCIUM ION × 4 MG MAGNESIUM ION × 2 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.2 M Magnesium chloride hexahydrate, 0.1 M Tris pH 8.5, 20% w/v PEG 8000
Resolution 1.95 Å R-free 0.258
7T2Q PEGylated Calmodulin-1 (K148U) Deposited 2021-12-06 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 2–149（148 aa）
Not recorded CA CALCIUM ION × 8 MG MAGNESIUM ION × 4 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293 K；0.2 M Magnesium chloride hexahydrate, 0.1 M Tris pH 8.5, 20% w/v PEG 8000
Resolution 1.95 Å R-free 0.258
7TCI Structure of Xenopus KCNQ1-CaM in complex with ML277 Deposited 2021-12-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain B 1–149（149 aa）
Chain D 1–149（149 aa）
Chain F 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded I0S (2R)-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylbenzene-1-sulfonyl)piperidine-2-carboxamide × 4 CA CALCIUM ION × 12 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.90 Å
7TCP Structure of Xenopus KCNQ1-CaM Deposited 2021-12-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain B 1–149（149 aa）
Chain D 1–149（149 aa）
Chain F 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded CA CALCIUM ION × 12 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.84 Å
7TZC A drug and ATP binding site in type 1 ryanodine receptor Deposited 2022-02-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain C 1–149（149 aa）
Chain D 1–149（149 aa）
Chain E 1–149（149 aa）
Chain K 1–149（149 aa）
Not recorded CA CALCIUM ION × 20 ATP ADENOSINE-5'-TRIPHOSPHATE × 8 ZN ZINC ION × 4 CFF CAFFEINE × 4 KVR 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid × 4 L9R (2S)-3-(octadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.45 Å
7U9T Structure of PKA phosphorylated human RyR2 in the closed state in the presence of Calmodulin Deposited 2022-03-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain I 1–149（149 aa）
Chain J 1–149（149 aa）
Chain K 1–149（149 aa）
Chain L 1–149（149 aa）
Not recorded ZN ZINC ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；Xanthine was made fresh to avoid aggregation. Xanthine stock solution was 10 mM in NaOH 0.5 N.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.68 Å
7UA3 Structure of PKA phosphorylated human RyR2-R2474S in the closed state in the presence of Calmodulin Deposited 2022-03-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain I 1–149（149 aa）
Chain J 1–149（149 aa）
Chain K 1–149（149 aa）
Chain L 1–149（149 aa）
Not recorded ZN ZINC ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；Xanthine was made fresh to avoid aggregation. Xanthine stock solution was 10 mM in NaOH 0.5 N.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.97 Å
7UA4 Structure of PKA phosphorylated human RyR2-R2474S in the open state in the presence of Calmodulin Deposited 2022-03-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain I 1–149（149 aa）
Chain J 1–149（149 aa）
Chain K 1–149（149 aa）
Chain L 1–149（149 aa）
Not recorded ZN ZINC ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 8 CA CALCIUM ION × 4 XAN XANTHINE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；Xanthine was made fresh to avoid aggregation. Xanthine stock solution was 10 mM in NaOH 0.5 N.
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.93 Å
7VMB Crystal structure of IQSEC1-IQ motif, Sec7PH tandem in complex with calmodulin Deposited 2021-10-08 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain C 1–149（149 aa）
Not recorded GOL GLYCEROL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；289.15 K；0.1M HEPES pH 7.5, 4% w/v Polyethylene glycol 8000
Resolution 2.00 Å R-free 0.252
7VUO Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation F141L Deposited 2021-11-03 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 2–149（148 aa）
Mutation：F141L CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；291 K；0.1M Tris8.5 25% w/v Polyethylene glycol 3,350 0.2M Trimethylamine N-oxide dihydrate
Resolution 2.68 Å R-free 0.274
7VVD Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation Q135P Deposited 2021-11-05 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 1–149（149 aa）
Mutation：Q135P CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；291 K；25% PEG 1500, 0.1M MMT pH 8.0
Resolution 3.13 Å R-free 0.274
7VVD Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation Q135P Deposited 2021-11-05 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain E 1–149（149 aa）
Mutation：Q135P CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8；291 K；25% PEG 1500, 0.1M MMT pH 8.0
Resolution 3.13 Å R-free 0.274
7VVH Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation E140G Deposited 2021-11-06 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 1–149（149 aa） Fragment：E141G
Not recorded CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 9；291 K；25% PEG 1500, 0.1M MMT pH 9.0
Resolution 2.30 Å R-free 0.272
7WJI Architecture of the human NALCN channelosome Deposited 2022-01-06 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 5 PDB declaration: pentameric
Chain E 1–149（149 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.50 Å
7WR3 Crystal structure of MBP-fused OspC3 in complex with calmodulin Deposited 2022-01-26 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 1–149（149 aa）
Not recorded SO4 SULFATE ION × 2 NCA NICOTINAMIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；20% PEG3350, 0.1 M Tris pH 8.2-8.4, 0.2 M Lithium Sulfate, 0.7% 1-Butanol
Resolution 1.87 Å R-free 0.228
7WR3 Crystal structure of MBP-fused OspC3 in complex with calmodulin Deposited 2022-01-26 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 1–149（149 aa）
Not recorded SO4 SULFATE ION × 2 NCA NICOTINAMIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；20% PEG3350, 0.1 M Tris pH 8.2-8.4, 0.2 M Lithium Sulfate, 0.7% 1-Butanol
Resolution 1.87 Å R-free 0.228
7WR4 Crystal structure of OspC3-calmodulin-caspase-4 complex Deposited 2022-01-26 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain B 1–149（149 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；25% PEG3350, 0.1 M HEPES pH 7.4, 0.2 M Ammonium sulfate, 0.3 M NDSB-195
Resolution 2.75 Å R-free 0.270
7WR5 Crystal structure of OspC3-calmodulin-caspase-4 complex binding with 2'-aF-NAD+ Deposited 2022-01-26 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain B 1–149（149 aa）
Not recorded 5ZV [[(2~{R},3~{R},4~{S},5~{R})-5-(3-aminocarbonylpyridin-1-yl)-4-fluoranyl-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；20% PEG3350, 0.2 M Potassium acetate
Resolution 3.10 Å R-free 0.272
7WZS Crystal structure of Chromobacterium violaceum effector CopC in complex with host calmodulin and caspase-7 Deposited 2022-02-19 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain C 1–149（149 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；291 K；100 mM Bis-Tris propane pH 7.5, 1.5 M lithium sulfate
Resolution 3.60 Å R-free 0.314
7XN4 Cryo-EM structure of CopC-CaM-caspase-3 with NAD+ Deposited 2022-04-28 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain D 1–149（149 aa）
Not recorded NAD NICOTINAMIDE-ADENINE-DINUCLEOTIDE × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.35 Å
7XN5 Cryo-EM structure of CopC-CaM-caspase-3 with ADPR Deposited 2022-04-28 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain D 1–149（149 aa）
Not recorded NCA NICOTINAMIDE × 1 APR ADENOSINE-5-DIPHOSPHORIBOSE × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.18 Å
7XN6 Cryo-EM structure of CopC-CaM-caspase-3 with ADPR-deacylization Deposited 2022-04-28 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain D 1–149（149 aa）
Not recorded NCA NICOTINAMIDE × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.45 Å
7ZRP 2.65 Angstrom crystal structure of Ca/CaM:CaMKIIdelta peptide complex Deposited 2022-05-04 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 2–149（148 aa）
Not recorded CA CALCIUM ION × 4 PG4 TETRAETHYLENE GLYCOL × 2 IMD IMIDAZOLE × 1 ZN ZINC ION × 5 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；292 K；200 mM Zinc acetate, 100 mM Imidazole pH8.0, 18% PEG3000
Resolution 2.65 Å R-free 0.272
7ZRP 2.65 Angstrom crystal structure of Ca/CaM:CaMKIIdelta peptide complex Deposited 2022-05-04 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 2–149（148 aa）
Not recorded CA CALCIUM ION × 4 IMD IMIDAZOLE × 1 ZN ZINC ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；292 K；200 mM Zinc acetate, 100 mM Imidazole pH8.0, 18% PEG3000
Resolution 2.65 Å R-free 0.272
7ZRQ 1.68 Angstrom crystal structure of Ca/CaM-E140G:CaMKIIdelta peptide complex Deposited 2022-05-04 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 2–149（148 aa）
Mutation：E140G CA CALCIUM ION × 4 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；292 K；0.1 M Na+-HEPES, 0.1 M MOPS (acid), pH 7.5, 0.03 M magnesium chloride hexahydrate, 0.03 M calcium chloride dihydrate, 12.5% v/v MPD; 12.5% PEG 1000; 12.5% w/v PEG 3350
Resolution 1.68 Å R-free 0.244
8AHS Crystal structure of human Ca2+/Calmodulin in complex with melittin Deposited 2022-07-22 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1–149（149 aa）
Not recorded CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.4；293 K；0.2M NaCl, 22w/v% PEG3350, 0.1M Bis-Tris, pH 5.4
Resolution 2.48 Å R-free 0.270
8B6Q X-ray structure of the haloalkane dehalogenase HaloTag7 with an insertion of Calmodulin-M13 fusion at position 154-156 that mimic the structure of CaProLa, an calcium gated protein labeling technology Deposited 2022-09-27 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric
Chain A 3–148（146 aa）
Not recorded CL CHLORIDE ION × 1 CA CALCIUM ION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；293 K；0.1 M MES pH 6.0, 0.2 M calcium acetate, 18% (m/v) PEG 8000
Resolution 2.60 Å R-free 0.318
8BFG Solution structure of human apo/Calmodulin G113R (G114R) Deposited 2022-10-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2–149（148 aa）
Mutation：G113R No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.64；298.1 K；Ionic strength (raw mmCIF value) 128；Pressure 1
NMR sample composition 1.2 mM aa 81-148: U-13C,15N Calmodulin G113R, 5 mM EDTA, 100 mM potassium chloride, 2 mM NaN3, 20 mM HEPES, 0.1 mM TSP-d4, 95% H2O/5% D2O | 95% H2O/5% D2O
Resolution not provided
8DGH NMR Structure of calmodulin bound to C-terminal site in the beta-subunit of cyclic nucleotide-gated channel Deposited 2022-06-23 Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1–149（149 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7；308 K；Ionic strength (raw mmCIF value) 1；Pressure 1
NMR sample composition 0.4 mM [U-100% 13C; U-100% 15N] Calmodulin, 1.2 mM Cyclic nucleotide-gated cation channel beta-1, 20 mM [U-100% 2H] TRIS, 1 mM Calcium chloride, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 0.4 mM [U-100% 13C; U-100% 15N] Calmodulin, 1.2 mM Cyclic nucleotide-gated cation channel beta-1, 20 mM [U-100% 2H] TRIS, 1 mM Calcium chloride, 100% D2O | 100% D2O
Resolution not provided
8DGK NMR structure of calmodulin bound to N-terminal site in the beta-subunit of cyclic nucleotide-gated channel Deposited 2022-06-23 Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1–149（149 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7；308 K；Ionic strength (raw mmCIF value) 1；Pressure 1
NMR sample composition 0.5 mM [U-100% 13C; U-100% 15N] Calmodulin, 0.85 mM Cyclic nucleotide-gated cation channel beta-1, 20 mM [U-100% 2H] TRIS, 1 mM Calcium chloride, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 0.5 mM [U-100% 13C; U-100% 15N] Calmodulin, 0.85 mM Cyclic nucleotide-gated cation channel beta-1, 20 mM [U-100% 2H] TRIS, 1 mM Calcium chloride, 100% D2O | 100% D2O
NMR sample composition 0.5 mM [U-10% 13C; U-100% 15N] Calmodulin, 0.85 mM Cyclic nucleotide-gated cation channel beta-1, 20 mM [U-100% 2H] TRIS, 1 mM Calcium chloride, 100% D2O | 100% D2O
Resolution not provided
8DUJ Global map in C1 of RyR1 particles in complex with ImperaCalcin Deposited 2022-07-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric
Chain C 1–149（149 aa）
Chain F 1–149（149 aa）
Chain I 1–149（149 aa）
Chain L 1–149（149 aa）
Mutation：E32A, E68A, E105A, E141A Mutation：E32A, E68A, E105A, E141A Mutation：E32A, E68A, E105A, E141A Mutation：E32A, E68A, E105A, E141A CFF CAFFEINE × 4 CA CALCIUM ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 4 ZN ZINC ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.70 Å
8DVE RyR1 in presence of IpCa-T26E phosphomimetic and activating ligands Deposited 2022-07-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain C 1–149（149 aa）
Chain F 1–149（149 aa）
Chain I 1–149（149 aa）
Chain L 1–149（149 aa）
Mutation：E32A, E68A, E105A, E141A Mutation：E32A, E68A, E105A, E141A Mutation：E32A, E68A, E105A, E141A Mutation：E32A, E68A, E105A, E141A CFF CAFFEINE × 4 CA CALCIUM ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 4 ZN ZINC ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.84 Å
8EOW Eag Kv channel with voltage sensor in the up conformation Deposited 2022-10-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain E 7–148（142 aa）
Chain F 7–148（142 aa）
Chain G 7–148（142 aa）
Chain H 7–148（142 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.90 Å
8EP0 Eag Kv channel with voltage sensor in the intermediate conformation Deposited 2022-10-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain E 7–148（142 aa）
Chain F 7–148（142 aa）
Chain G 7–148（142 aa）
Chain H 7–148（142 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.90 Å
8EP1 Eag Kv channel with voltage sensor in the down conformation Deposited 2022-10-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain E 7–148（142 aa）
Chain F 7–148（142 aa）
Chain G 7–148（142 aa）
Chain H 7–148（142 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 5.40 Å
8FNY Nucleotide-bound structure of a functional construct of eukaryotic elongation factor 2 kinase. Deposited 2022-12-28 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 2–149（148 aa）
Not recorded ATP ADENOSINE-5'-TRIPHOSPHATE × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 1 ZN ZINC ION × 1 CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.5；293 K；100 mM Bis-trispropane, 100 mM NaF, 20.5 % w/v PEG-3350 (2protein/1solution)
Resolution 2.22 Å R-free 0.229
8FNY Nucleotide-bound structure of a functional construct of eukaryotic elongation factor 2 kinase. Deposited 2022-12-28 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 2–149（148 aa）
Not recorded ATP ADENOSINE-5'-TRIPHOSPHATE × 1 ADP ADENOSINE-5'-DIPHOSPHATE × 1 ZN ZINC ION × 1 CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.5；293 K；100 mM Bis-trispropane, 100 mM NaF, 20.5 % w/v PEG-3350 (2protein/1solution)
Resolution 2.22 Å R-free 0.229
8FO6 Nucleotide-free structure of a functional construct of eukaryotic elongation factor 2 kinase. Deposited 2022-12-29 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 2–149（148 aa）
Not recorded ZN ZINC ION × 1 CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 5.9；293 K；100 mM Bis-trispropane, 200 mM NaF, 17.6% PEG-3350 (2protein 1solution)
Resolution 2.55 Å R-free 0.231
8GM4 Functional construct of the Eukaryotic elongation factor 2 kinase bound to an ATP-competitive inhibitor Deposited 2023-03-24 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 2–149（148 aa）
Not recorded ADP ADENOSINE-5'-DIPHOSPHATE × 1 EKI 7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide × 1 ZN ZINC ION × 1 CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 6.2；295.15 K；Cocktail:16.55% PEG-3350, 200 mM NaF, 100 mM BisTris-Propane Protein sol: 10.3 mg/mL 20 mM Tris pH 7.5, 100 mM NaCl, 3 mM CaCl2, 1mM TCEP, 0.3 mM ADP, 0.3 m Inhibitor , 0.7 % DMSO 2protein/1cocktail (0.2 ul total)
Resolution 2.12 Å R-free 0.238
8GM5 Functional construct of the Eukaryotic elongation factor 2 kinase bound to Calmodulin, ADP and to the A-484954 inhibitor and showing two conformations for the 498-520 loop Deposited 2023-03-24 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 2–149（148 aa）
Not recorded ADP ADENOSINE-5'-DIPHOSPHATE × 1 EKI 7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide × 1 ZN ZINC ION × 1 CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 6.5；295.15 K；Cocktail:16.55% PEG-3350, 0.2 M NaF, 100 mM BisTris-Propane Protein solution: 10.3 mg/mL 20 mM Tris pH 7.5, 100 mM NaCl, 3 mM CaCl2, 1mM TCEP, 1.5 m Inhibitor , 3.1 % DMSO 2protein/1cocktail (0.2 ul total)
Resolution 2.12 Å R-free 0.225
8IJK human KCNQ2-CaM-Ebio1 complex in the presence of PIP2 Deposited 2023-02-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Chain G 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded 7PN N-(1,2-dihydroacenaphthylen-5-yl)-4-fluoranyl-benzamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
8J00 Human KCNQ2-CaM in complex with CBD Deposited 2023-04-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Chain G 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded P0T cannabidiol × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
8J01 Human KCNQ2-CaM in complex with CBD and PIP2 Deposited 2023-04-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain C 1–149（149 aa）
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded P0T cannabidiol × 8 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
8J02 Human KCNQ2(F104A)-CaM-PIP2-CBD complex in state II Deposited 2023-04-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain C 1–149（149 aa）
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded P0T cannabidiol × 4 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.50 Å
8J03 Human KCNQ2(F104A)-CaM-PIP2-CBD complex in state I Deposited 2023-04-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Chain H 1–149（149 aa）
Chain J 1–149（149 aa）
Not recorded P0T cannabidiol × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å
8J04 Human KCNQ2-CaM-HN37 complex in the presence of PIP2 Deposited 2023-04-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain C 1–149（149 aa）
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded 9MF methyl N-[4-[(4-fluorophenyl)methyl-prop-2-ynyl-amino]-2,6-dimethyl-phenyl]carbamate × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å
8J05 Human KCNQ2-CaM complex in the presence of PIP2 Deposited 2023-04-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain C 1–149（149 aa）
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å
8J07 96nm repeat of human respiratory doublet microtubule and associated axonemal complexes Deposited 2023-04-09 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 974 PDB declaration: 974-meric
Chain W 1–149（149 aa）
Not recorded GTP GUANOSINE-5'-TRIPHOSPHATE × 285 MG MAGNESIUM ION × 285 GDP GUANOSINE-5'-DIPHOSPHATE × 289 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.3
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.10 Å
8JFK PhK holoenzyme in inactive state, muscle isoform Deposited 2023-05-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric
Chain D 1–149（149 aa）
Chain H 1–149（149 aa）
Chain L 1–149（149 aa）
Chain P 1–149（149 aa）
Not recorded FAR FARNESYL × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 6.8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.90 Å
8ODZ Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 1). Deposited 2023-03-10 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 4 PDB declaration: tetrameric
Chain D 5–149（145 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；HEPES-buffered saline (HBS) with added calcium chloride: 25 mM HEPES, pH 7.4, 150 mM NaCl, 5 mM CaCl
cryo-EM vitrification conditions Cryogen ETHANE；Leica EM GP2, 5 s. blotting time.
Resolution 3.60 Å
8OE0 Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 2). Deposited 2023-03-10 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 4 PDB declaration: tetrameric
Chain D 5–149（145 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；HEPES-buffered saline (HBS) with added calcium chloride: 25 mM HEPES, pH 7.4, 150 mM NaCl, 5 mM CaCl
cryo-EM vitrification conditions Cryogen ETHANE；Leica EM GP2, 5 s. blotting time.
Resolution 4.60 Å
8OE4 Cryo-EM structure of a pre-dimerized human IL-23 complete extracellular signaling complex. Deposited 2023-03-10 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 4 PDB declaration: tetrameric
Chain C 5–149（145 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；HEPES-buffered saline (HBS) with added calcium chloride: 25 mM HEPES, pH 7.4, 150 mM NaCl, 5 mM CaCl
cryo-EM vitrification conditions Cryogen ETHANE；Leica EM GP2, 4.5 s. blotting time.
Resolution 3.60 Å
8PB1 Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 1), obtained after local refinement. Deposited 2023-06-08 Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 4 PDB declaration: tetrameric
Chain D 5–149（145 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；HEPES-buffered saline (HBS) with added calcium chloride: 25 mM HEPES, pH 7.4, 150 mM NaCl, 5 mM CaCl
cryo-EM vitrification conditions Cryogen ETHANE；Leica EM GP2, 5 s. blotting time.
Resolution 3.50 Å
8SIK KCNQ1 with voltage sensor in the up conformation Deposited 2023-04-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain B 1–149（149 aa）
Chain D 1–149（149 aa）
Chain F 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded CA CALCIUM ION × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.90 Å
8SIM KCNQ1 with voltage sensor in the intermediate conformation Deposited 2023-04-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain B 1–149（149 aa）
Chain D 1–149（149 aa）
Chain F 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded CA CALCIUM ION × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 6.20 Å
8SIN KCNQ1 with voltage sensor in the down conformation Deposited 2023-04-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain B 1–149（149 aa）
Chain D 1–149（149 aa）
Chain F 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 6.80 Å
8UXL Structure of PKA phosphorylated human RyR2-R420W in the primed state in the presence of calcium and calmodulin Deposited 2023-11-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain I 1–149（149 aa）
Chain J 1–149（149 aa）
Chain K 1–149（149 aa）
Chain L 1–149（149 aa）
Not recorded ZN ZINC ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 8 CA CALCIUM ION × 20 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；0.020 mM Calmodulin was added to the final sample
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.12 Å
8UXM Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium and calmodulin Deposited 2023-11-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain I 1–149（149 aa）
Chain J 1–149（149 aa）
Chain K 1–149（149 aa）
Chain L 1–149（149 aa）
Not recorded CA CALCIUM ION × 20 ZN ZINC ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；0.020 mM Calmodulin was added to the final sample
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.56 Å
8W4U human KCNQ2-CaM in complex with PIP2 and HN37 Deposited 2023-08-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain C 1–149（149 aa）
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded 9MF methyl N-[4-[(4-fluorophenyl)methyl-prop-2-ynyl-amino]-2,6-dimethyl-phenyl]carbamate × 4 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
8X43 human KCNQ2-CaM-Ebio1-S1 complex in the presence of PIP2 Deposited 2023-11-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain B 1–149（149 aa）
Chain D 1–149（149 aa）
Chain F 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded 7Q0 N-(4-azanyl-1,2-dihydroacenaphthylen-5-yl)-4-fluoranyl-benzamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.00 Å
8XJI Structure of chimeric RyR complex with flubendiamide Deposited 2023-12-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain I 1–148（148 aa）
Chain J 1–148（148 aa）
Chain K 1–148（148 aa）
Chain L 1–148（148 aa）
Mutation：E32A, E68A, E105A, E141A Mutation：E32A, E68A, E105A, E141A Mutation：E32A, E68A, E105A, E141A Mutation：E32A, E68A, E105A, E141A A1LVX Flubendiamide × 4 ZN ZINC ION × 4 CA CALCIUM ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 4 CFF CAFFEINE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.91 Å
8XKH Structure of chimeric RyR Complex with tetraniliprole Deposited 2023-12-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain I 1–149（149 aa）
Chain J 1–149（149 aa）
Chain K 1–149（149 aa）
Chain L 1–149（149 aa）
Mutation：E32A, E68A, E105A, E141A Mutation：E32A, E68A, E105A, E141A Mutation：E32A, E68A, E105A, E141A Mutation：E32A, E68A, E105A, E141A ZN ZINC ION × 4 CA CALCIUM ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 4 CFF CAFFEINE × 4 A1LV1 tetraniliprole × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.87 Å
8XLF Structure of chimeric RyR Deposited 2023-12-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain I 1–148（148 aa）
Chain J 1–148（148 aa）
Chain K 1–148（148 aa）
Chain L 1–148（148 aa）
Mutation：E32A, E68A, E105A, E141A Mutation：E32A, E68A, E105A, E141A Mutation：E32A, E68A, E105A, E141A Mutation：E32A, E68A, E105A, E141A CA CALCIUM ION × 4 ZN ZINC ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 4 CFF CAFFEINE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.62 Å
8XLH Structure of chimeric RyR-I4657M/G4819E Deposited 2023-12-26 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain I 1–149（149 aa）
Chain J 1–149（149 aa）
Chain K 1–149（149 aa）
Chain L 1–149（149 aa）
Mutation：E32A, E68A, E105A, E141A Mutation：E32A, E68A, E105A, E141A Mutation：E32A, E68A, E105A, E141A Mutation：E32A, E68A, E105A, E141A ZN ZINC ION × 4 CA CALCIUM ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 4 CFF CAFFEINE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.62 Å
8XO1 Human KCNQ2-CaM in complex with QO-83 Deposited 2023-12-31 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Chain G 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded A1LWZ ~{N}-[2-azanyl-3-fluoranyl-4-[[4-(trifluoromethyl)phenyl]methylamino]phenyl]-3-cyclopentyl-propanamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.80 Å
8XYA hPhK alpha-beta-gamma-delta subcomplex in inactive state Deposited 2024-01-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain D 1–149（149 aa）
Not recorded FAR FARNESYL × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 6.8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å
8XYB hPhK gamma-delta subcomplex in inactive state Deposited 2024-01-19 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain D 1–149（149 aa）
Not recorded FAR FARNESYL × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 6.8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
8Y40 Structure of chimeric RyR-I4657M/G4819E complex with chlorantraniliprole Deposited 2024-01-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: 12-meric
Chain I 1–149（149 aa）
Chain J 1–149（149 aa）
Chain K 1–149（149 aa）
Chain L 1–149（149 aa）
Mutation：E32A, E68A, E105A, E141A Mutation：E32A, E68A, E105A, E141A Mutation：E32A, E68A, E105A, E141A Mutation：E32A, E68A, E105A, E141A F0U 5-bromanyl-N-[4-chloranyl-2-methyl-6-(methylcarbamoyl)phenyl]-2-(3-chloranylpyridin-2-yl)pyrazole-3-carboxamide × 4 ZN ZINC ION × 4 CA CALCIUM ION × 4 ATP ADENOSINE-5'-TRIPHOSPHATE × 4 CFF CAFFEINE × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.58 Å
9CUI Structure of human full-length ancestral TRPV6 channel in Calmodulin-bound state Deposited 2024-07-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric
Chain E 1–149（149 aa）
Not recorded Y01 CHOLESTEROL HEMISUCCINATE × 8 CLR CHOLESTEROL × 4 PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 43 CA CALCIUM ION × 7 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.42 Å
9CUK Structure of human full-length derived TRPV6 channel in Calmodulin-bound state Deposited 2024-07-26 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric
Chain E 1–149（149 aa）
Not recorded Y01 CHOLESTEROL HEMISUCCINATE × 8 CLR CHOLESTEROL × 4 PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 43 CA CALCIUM ION × 7 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.26 Å
9D9Z Structure of human UBR4-KCMF1-CaM E3 ligase complex (Silencing Factor of the Integrated stress response, SiFI) Deposited 2024-08-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain C 1–149（149 aa）
Chain D 1–149（149 aa）
Not recorded ZN ZINC ION × 20 CA CALCIUM ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
9E17 Structure of RyR1 in the primed state in the presence of caffeine (reprocessed/reanalyzed from EMPIAR-10997, 7TZC, EMD-26205) Deposited 2024-10-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: 12-meric
Chain C 1–149（149 aa）
Chain D 1–149（149 aa）
Chain E 1–149（149 aa）
Chain K 1–149（149 aa）
Not recorded CA CALCIUM ION × 20 ATP ADENOSINE-5'-TRIPHOSPHATE × 8 ZN ZINC ION × 4 CFF CAFFEINE × 4 KVR 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid × 4 L9R (2S)-3-(octadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.45 Å
9EL6 Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation F90L Deposited 2024-12-04 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 1–149（149 aa）
Not recorded CA CALCIUM ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293.15 K；0.1M PCTP (pH8.0), 25% (w/v) PEG 1500
Resolution 2.25 Å R-free 0.301
9EL6 Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation F90L Deposited 2024-12-04 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain E 1–149（149 aa）
Not recorded CA CALCIUM ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293.15 K；0.1M PCTP (pH8.0), 25% (w/v) PEG 1500
Resolution 2.25 Å R-free 0.301
9HXW Cryo-EM structure of the human UBR4/KCMF1/CALM1 complex (composite map) Deposited 2025-01-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Not recorded ZN ZINC ION × 20 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9IXZ human KCNQ2-CaM-Ebio3 Complex in the Presence of PIP2 Deposited 2024-07-29 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Chain G 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded A1L3D ~{N}-[7-[bis(fluoranyl)methoxy]-1-prop-2-ynyl-indazol-3-yl]-2-propyl-pentanamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.20 Å
9J38 human KCNQ5-CaM in apo state Deposited 2024-08-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Chain G 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.40 Å
9JQI Crystal structure of calmodulin in complex with KN93 (1:1 complex) Deposited 2024-09-27 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1–149（149 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CA CALCIUM ION × 4 KN9 N-[2-[[[3-(4'-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4'-methoxybenzenesulfonamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；277 K；sodium acetate, sodium cacodylate, PEG 8000
Resolution 2.10 Å R-free 0.288
9JQI Crystal structure of calmodulin in complex with KN93 (1:1 complex) Deposited 2024-09-27 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 1–149（149 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CA CALCIUM ION × 4 KN9 N-[2-[[[3-(4'-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4'-methoxybenzenesulfonamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；277 K；sodium acetate, sodium cacodylate, PEG 8000
Resolution 2.10 Å R-free 0.288
9JQI Crystal structure of calmodulin in complex with KN93 (1:1 complex) Deposited 2024-09-27 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain C 1–149（149 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) CA CALCIUM ION × 4 KN9 N-[2-[[[3-(4'-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4'-methoxybenzenesulfonamide × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；277 K；sodium acetate, sodium cacodylate, PEG 8000
Resolution 2.10 Å R-free 0.288
9K8W Crystal structure of the calcium indicator GCaMP6s-BrUS in calcium-bound state Deposited 2024-10-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2–149（148 aa）
Mutation：A314P/N373D/D391Y/T392R/S394T/R403G Non-standard monomer：Yes (specific site not provided by mmCIF) CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；288 K；0.2 M Ammonium tartrate dibasic, pH 7.0, 20% PEG 3350
Resolution 2.65 Å R-free 0.236
9K8X Crystal structure of the calcium indicator GCaMP6s-BrUS-145 in calcium-bounded state Deposited 2024-10-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2–149（148 aa）
Mutation：A313P/N372D/D390Y/T391R/S393T/R402G Non-standard monomer：Yes (specific site not provided by mmCIF) EDO 1,2-ETHANEDIOL × 6 CA CALCIUM ION × 4 NA SODIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；288 K；0.2M Sodium thiocyanate, pH 6.9, 20% PEG 3350
Resolution 2.05 Å R-free 0.251
9KUI Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation F142L Deposited 2024-12-04 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 1–149（149 aa）
Mutation：F142L CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298.15 K；0.1M Tris (pH8.5), 0.2 M Trimethylamine N-oxide dihydrate, 25% (w/v) PEG 3350
Resolution 2.68 Å R-free 0.275
9KUO Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation Q136P Deposited 2024-12-04 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 1–149（149 aa）
Mutation：Q136P CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298.15 K；0.1M MMT (pH8.0), 25% (w/v) PEG 1500
Resolution 3.13 Å R-free 0.277
9KUO Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation Q136P Deposited 2024-12-04 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain E 1–149（149 aa）
Mutation：Q136P CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298.15 K；0.1M MMT (pH8.0), 25% (w/v) PEG 1500
Resolution 3.13 Å R-free 0.277
9KUU Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation D130G Deposited 2024-12-04 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 1–149（149 aa）
Mutation：D130G CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298.15 K；0.1 M Tris (pH 8.5), 0.2 M Sodium acetate trihydrate, 30% (w/v) PEG4000
Resolution 2.50 Å R-free 0.262
9KUU Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation D130G Deposited 2024-12-04 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain E 1–149（149 aa）
Mutation：D130G CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298.15 K；0.1 M Tris (pH 8.5), 0.2 M Sodium acetate trihydrate, 30% (w/v) PEG4000
Resolution 2.50 Å R-free 0.262
9KUZ Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation D134H Deposited 2024-12-04 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 1–149（149 aa）
Mutation：D134H CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298.15 K；0.1 M Hepes (pH 7.5), 25% (w/v) PEGMME2000
Resolution 2.07 Å R-free 0.268
9KUZ Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation D134H Deposited 2024-12-04 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain F 1–149（149 aa）
Mutation：D134H CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298.15 K；0.1 M Hepes (pH 7.5), 25% (w/v) PEGMME2000
Resolution 2.07 Å R-free 0.268
9KV1 Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation E141G Deposited 2024-12-04 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 1–149（149 aa）
Mutation：E141G CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298.15 K；0.1M MMT (pH9.0), 25% (w/v) PEG 1500
Resolution 2.30 Å R-free 0.292
9KV9 Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation E141G-Ca Deposited 2024-12-04 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 1–149（149 aa）
Mutation：E141G CA CALCIUM ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298.15 K；0.1M MMT (pH9.0), 25% (w/v) PEG 1500
Resolution 2.05 Å R-free 0.279
9KVB Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin Deposited 2024-12-04 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 1–149（149 aa）
Not recorded CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298.15 K；0.2 M NH4CH3COO (PH8.5), 27% (w/v) PEG3350
Resolution 2.77 Å R-free 0.342
9KVO Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation D132E Deposited 2024-12-05 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 1–149（149 aa）
Mutation：D132E CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298.15 K；0.1M Tris (pH8.5), 0.2M Sodium acetate trihydrate, 32% PEG4000
Resolution 3.14 Å R-free 0.345
9KVO Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation D132E Deposited 2024-12-05 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 1–149（149 aa）
Mutation：D132E CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298.15 K；0.1M Tris (pH8.5), 0.2M Sodium acetate trihydrate, 32% PEG4000
Resolution 3.14 Å R-free 0.345
9MVW Crystal structure of S101F calmodulin - CaM:RM20 analog complex Deposited 2025-01-16 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1–149（149 aa）
Mutation：S101F CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.6；295 K；0.1M Sodium Acetate pH 4.6, 25%(w/v) PEG 4000, 20mM CaCl2
Resolution 1.58 Å R-free 0.237
9MXD Human E104A calmodulin:MLCK RM20 complex Deposited 2025-01-19 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1–149（149 aa）
Mutation：E104A CA CALCIUM ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.6；293 K；0.1M Sodium Acetate pH 4.6, 25%(w/v) PEG 4000, 20mM CaCl2
Resolution 1.17 Å R-free 0.178
9MY3 Structure of Xenopus KCNQ1-CaM in GDN Deposited 2025-01-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain B 1–149（149 aa）
Chain D 1–149（149 aa）
Chain F 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.46 Å
9MY4 Structure of Xenopus KCNQ1(E150R/R221E)-CaM with the VSD in the intermediate state Deposited 2025-01-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain B 1–149（149 aa）
Chain D 1–149（149 aa）
Chain F 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.2
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.53 Å
9NVN Structure of Nanchung-Inactive-Calmodulin in apo state Deposited 2025-03-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric
Chain E 1–74（74 aa）
Chain F 1–74（74 aa）
Not recorded 6OU [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate × 12 LBN 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine × 6 CA CALCIUM ION × 6 D39 (2~{S})-2-azanyl-3-[[(2~{R})-3-hexadecanoyloxy-2-[(~{Z})-octadec-9-enoyl]oxy-propoxy]-oxidanyl-phosphoryl]oxy-propanoic acid × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.89 Å
9NVO Structure of Nanchung-Inactive-Calmodulin in complex with Nicotinamide Deposited 2025-03-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric
Chain E 1–74（74 aa）
Chain F 1–74（74 aa）
Not recorded 6OU [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate × 14 LBN 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine × 6 NCA NICOTINAMIDE × 2 CA CALCIUM ION × 6 D39 (2~{S})-2-azanyl-3-[[(2~{R})-3-hexadecanoyloxy-2-[(~{Z})-octadec-9-enoyl]oxy-propoxy]-oxidanyl-phosphoryl]oxy-propanoic acid × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.49 Å
9NVP Structure of Nanchung-Inactive-Calmodulin in complex with Nicotinamide, EDTA Deposited 2025-03-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Not recorded 6OU [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate × 14 LBN 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine × 6 NCA NICOTINAMIDE × 2 D39 (2~{S})-2-azanyl-3-[[(2~{R})-3-hexadecanoyloxy-2-[(~{Z})-octadec-9-enoyl]oxy-propoxy]-oxidanyl-phosphoryl]oxy-propanoic acid × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.85 Å
9NVQ Structure of Nanchung-Inactive-Calmodulin in complex with Afidopyropen and calcium Deposited 2025-03-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric
Chain E 1–74（74 aa）
Chain F 1–74（74 aa）
Not recorded 6OU [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate × 12 LBN 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine × 6 A1B32 Afidopyropen × 2 CA CALCIUM ION × 6 D39 (2~{S})-2-azanyl-3-[[(2~{R})-3-hexadecanoyloxy-2-[(~{Z})-octadec-9-enoyl]oxy-propoxy]-oxidanyl-phosphoryl]oxy-propanoic acid × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.01 Å
9NVR Structure of Nanchung-Inactive-Calmodulin in complex with Afidopyropen, EDTA Deposited 2025-03-21 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Not recorded 6OU [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate × 8 LBN 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine × 2 A1B32 Afidopyropen × 2 D39 (2~{S})-2-azanyl-3-[[(2~{R})-3-hexadecanoyloxy-2-[(~{Z})-octadec-9-enoyl]oxy-propoxy]-oxidanyl-phosphoryl]oxy-propanoic acid × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.13 Å
9NWE E3 ligase UBR4-KCMF1-calmodulin complex Deposited 2025-03-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain C 1–149（149 aa）
Chain D 1–149（149 aa）
Not recorded ZN ZINC ION × 6 CA CALCIUM ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.20 Å
9O48 Cryo-EM structure of the human SK2-4 chimera/calmodulin channel complex in the Ca2+ bound state Deposited 2025-04-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 8 PDB declaration: octameric
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Chain G 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded K POTASSIUM ION × 2 CA CALCIUM ION × 16 ELECTRON MICROSCOPY
cryo-EM buffer pH 8；20 mM Tris pH 8, 150 mM KCl, 2 mM CaCl2, 0.005% GDN, 0.0005% CHS
cryo-EM vitrification conditions Cryogen ETHANE；5 uL of sample was applied to grids at 4 degree temperature with 100% humidity. After 30 seconds, grids were blotted for 5 seconds with blot force 25 and plunged into liquid ethane.
Resolution 3.10 Å
9O51 Cryo-EM structure of the human SK2-4 chimera/calmodulin channel complex in the Ca2+ free state Deposited 2025-04-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 8 PDB declaration: octameric
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Chain G 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded K POTASSIUM ION × 2 CA CALCIUM ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8；20 mM Tris pH 8, 150 mM KCl, 5 mM EGTA, 0.005% GDN, 0.0005% CHS
cryo-EM vitrification conditions Cryogen ETHANE；5 uL of sample was applied to grids at 4 degree temperature with 100% humidity. After 30 seconds, grids were blotted for 5 seconds with blot force 25 and plunged into liquid ethane.
Resolution 3.40 Å
9O52 Cryo-EM structure of the human SK2-4 chimera/calmodulin channel complex bound to the bee toxin apamin Deposited 2025-04-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 9 PDB declaration: nonameric
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Chain G 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded K POTASSIUM ION × 4 CA CALCIUM ION × 16 ELECTRON MICROSCOPY
cryo-EM buffer pH 8；20 mM Tris pH 8, 150 mM KCl, 2 mM CaCl2, 0.005% GDN, 0.0005% CHS
cryo-EM vitrification conditions Cryogen ETHANE；5 uL of sample was applied to grids at 4 degree temperature with 100% humidity. After 30 seconds, grids were blotted for 5 seconds with blot force 25 and plunged into liquid ethane.
Resolution 3.18 Å
9O53 Cryo-EM structure of the human SK2-4 chimera/calmodulin channel complex bound to a small molecule inhibitor Deposited 2025-04-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 8 PDB declaration: octameric
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Chain G 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded A1B8D N-(2,1,3-benzoxadiazol-4-yl)-3-(4-methoxybenzene-1-sulfonamido)benzamide × 4 K POTASSIUM ION × 4 CA CALCIUM ION × 16 ELECTRON MICROSCOPY
cryo-EM buffer pH 8；20 mM Tris pH 8, 150 mM KCl, 2 mM CaCl2, 0.005% GDN, 0.0005% CHS
cryo-EM vitrification conditions Cryogen ETHANE；5 uL of sample was applied to grids at 4 degree temperature with 100% humidity. After 30 seconds, grids were blotted for 5 seconds with blot force 25 and plunged into liquid ethane.
Resolution 3.30 Å
9O5O Cryo-EM structure of the human SK2-4 chimera/calmodulin channel complex bound to a small molecule activator Deposited 2025-04-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Heteromer；Protein × 8 PDB declaration: octameric
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Chain G 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded A1B8G N-(2,1,3-benzoxadiazol-4-yl)-4-(trifluoromethyl)benzamide × 4 K POTASSIUM ION × 2 CA CALCIUM ION × 16 ELECTRON MICROSCOPY
cryo-EM buffer pH 8；20 mM Tris pH 8, 150 mM KCl, 2 mM CaCl2, 0.005% GDN, 0.0005% CHS
cryo-EM vitrification conditions Cryogen ETHANE；5 uL of sample was applied to grids at 4 degree temperature with 100% humidity. After 30 seconds, grids were blotted for 5 seconds with blot force 25 and plunged into liquid ethane.
Resolution 3.10 Å
9OCW A constitutively active construct of eukaryotic elongation factor 2 kinase Deposited 2025-04-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric
Chain A 78–149（72 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) ADP ADENOSINE-5'-DIPHOSPHATE × 2 ZN ZINC ION × 1 CA CALCIUM ION × 2 MG MAGNESIUM ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；298.15 K；2 ul of protein were mixed with 1 ul of a 18.8% PEG3350 (Hampton Research) and 314 mM magnesium acetate (pH not adjusted) solution in a 24 wells plate at room temperature
Resolution 2.27 Å R-free 0.257
9PCQ Phosphorylation of a Conserved Aspartate at the Eukaryotic Elongation Factor 2 Kinase Catalytic Site Deposited 2025-06-28 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B00A 3–149（147 aa）
Not recorded ADP ADENOSINE-5'-DIPHOSPHATE × 2 MN MANGANESE (II) ION × 2 ZN ZINC ION × 1 CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.5；298.15 K；Protein was mixed 1/1 with 100 mM BisTrisPropane, 80 mM NaF, 20% w/v PEG3350
Resolution 2.30 Å R-free 0.243
9PQH NMR Structure of Ca2+/Calmodulin bound to the GluN1 C0 domain of the NMDA receptor Deposited 2025-07-22 Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1–149（149 aa）
Not recorded CA CALCIUM ION × 4 SOLUTION NMR
NMR measurement conditions pH 7；308 K；Ionic strength (raw mmCIF value) 1；Pressure 1
NMR sample composition 0.4 mM [U-99% 13C; U-99% 15N] Calmodulin, 1.0 mM GluN1 C0, 1 mM Calcium chloride, 20 mM [U-99% 2H] TRIS, 93 % H2O, 7 % [U-2H] D2O, 93% H2O/7% D2O | 93% H2O/7% D2O
NMR sample composition 0.4 mM [U-99% 13C; U-99% 15N] Calmodulin, 1.0 mM GluN1 C0, 1 mM Calcium chloride, 20 mM [U-99% 2H] TRIS, 100 % [U-2H] D2O, 100% D2O | 100% D2O
Resolution not provided
9PQI NMR Structure of Ca2+/Calmodulin bound to the GluN2A C0 domain of the NMDA receptor Deposited 2025-07-22 Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1–149（149 aa）
Not recorded CA CALCIUM ION × 2 SOLUTION NMR
NMR measurement conditions pH 7；308 K；Ionic strength (raw mmCIF value) 1；Pressure 1
NMR sample composition 400 uM [U-100% 13C; U-100% 15N] Calmodulin, 1 mM GluN2, 1 mM Calcium chloride, 20 mM [U-99% 2H] TRIS, 93 % H2O, 7 % [U-2H] D2O, 93% H2O/7% D2O | 93% H2O/7% D2O
NMR sample composition 400 uM [U-100% 13C; U-100% 15N] Calmodulin, 1 mM GluN2, 1 mM Calcium chloride, 20 mM [U-99% 2H] TRIS, 100 % [U-2H] D2O, 100% D2O | 100% D2O
Resolution not provided
9QWS Cryo-EM structure of the human UBR4/KCMF1/CALM1 complex (C-term dimer interface focused refinement) Deposited 2025-04-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Not recorded ZN ZINC ION × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9QWU Cryo-EM structure of the human UBR4/KCMF1/CALM1 complex (CALM1 focused refinement) Deposited 2025-04-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Not recorded ZN ZINC ION × 2 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9QX0 Cryo-EM structure of the human UBR4/KCMF1/CALM1 complex (C-term focused refinement) Deposited 2025-04-15 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric
Chain F 1–149（149 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
9U7F structure of human KCNQ1-KCNE1-CaM complex Deposited 2025-03-24 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain B 1–149（149 aa）
Chain E 1–149（149 aa）
Chain H 1–149（149 aa）
Chain K 1–149（149 aa）
Not recorded PT5 [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate × 4 K POTASSIUM ION × 4 CA CALCIUM ION × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.90 Å
9UC8 structure of human KCNQ1-KCNE1-CaM complex with PIP2 Deposited 2025-04-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain B 1–149（149 aa）
Chain E 1–149（149 aa）
Chain H 1–149（149 aa）
Chain K 1–149（149 aa）
Not recorded PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 8 K POTASSIUM ION × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.36 Å
9UJ4 Structure of human KCNQ1-CaM complex Deposited 2025-04-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain B 1–149（149 aa）
Chain D 1–149（149 aa）
Chain F 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded K POTASSIUM ION × 4 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 4 CA CALCIUM ION × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.59 Å
9UPG Cryo-EM structure of human olfactory CNGA2/A4/B1 in CaM-bound closed state Deposited 2025-04-28 Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric
Chain H 1–149（149 aa）
Not recorded CA CALCIUM ION × 6 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.87 Å
9VEC structure of human KCNQ1-KCNE1-CaM complex Deposited 2025-06-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: 12-meric
Chain B 1–149（149 aa）
Chain E 1–149（149 aa）
Chain H 1–149（149 aa）
Chain K 1–149（149 aa）
Not recorded CA CALCIUM ION × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å
9VEI structure of human KCNQ1-KCNE1-CaM complex with PIP2 Deposited 2025-06-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: 12-meric
Chain B 1–149（149 aa）
Chain E 1–149（149 aa）
Chain H 1–149（149 aa）
Chain K 1–149（149 aa）
Not recorded PT5 [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate × 8 CA CALCIUM ION × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.90 Å
9VEN structure of human KCNQ1-CaM-PIP2 complex with bent conformation Deposited 2025-06-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain B 1–149（149 aa）
Chain D 1–149（149 aa）
Chain F 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded CA CALCIUM ION × 8 PT5 [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.80 Å
9VEO structure of human KCNQ1-CaM-PIP2 complex with straight conformation Deposited 2025-06-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain B 1–149（149 aa）
Chain D 1–149（149 aa）
Chain F 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded PT5 [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate × 8 CA CALCIUM ION × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.70 Å
9VU9 channel D complex with 4 Deposited 2025-07-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Chain G 1–149（149 aa）
Not recorded A1ETX (3~{S})-3-(1~{H}-benzimidazol-2-ylamino)-~{N}-(cyanomethyl)-~{N}-methyl-3-[3-(trifluoromethyl)phenyl]propanamide × 1 K POTASSIUM ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.34 Å
9VUA channel A complex with 1 Deposited 2025-07-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Chain G 1–149（149 aa）
Not recorded K POTASSIUM ION × 4 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.23 Å
9VUB channel C complex with 3 Deposited 2025-07-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Chain G 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 32 CLR CHOLESTEROL × 8 CA CALCIUM ION × 12 A1B92 Rimtuzalcap × 4 K POTASSIUM ION × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.35 Å
9VUC channel B complex with 2 Deposited 2025-07-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Chain G 1–149（149 aa）
Not recorded K POTASSIUM ION × 4 Y7Z UCL1684 × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.96 Å
9WD8 structure of human KCNQ1-KCNE3-CaM complex with two PIP2 Deposited 2025-08-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric
Chain B 1–149（149 aa）
Chain E 1–149（149 aa）
Chain H 1–149（149 aa）
Chain K 1–149（149 aa）
Not recorded CA CALCIUM ION × 8 A1BBG (2R)-3-{[(S)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl di[(9Z)-octadec-9-enoate] × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.90 Å
9X5J Cryo-EM structure of the human KCNQ2/3 heteromer channel Deposited 2025-10-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain E 6–148（143 aa）
Chain F 6–148（143 aa）
Chain G 6–148（143 aa）
Chain H 6–148（143 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 3.05 Å
9X65 Cryo-EM structure of the human KCNQ2/3 heteromer channel in the XEN1101-bound open state Deposited 2025-10-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Chain G 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded A1EY8 Azetukalner × 4 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 K POTASSIUM ION × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.19 Å
9XB9 Human KCNQ2-CaM in complex with QO-58 and PIP2 Deposited 2025-10-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Chain G 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 A1LVR QO-58 × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9XED Human KCNQ2-CaM in complex with QO-83 and PIP2 Deposited 2025-10-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Chain G 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 A1LWZ ~{N}-[2-azanyl-3-fluoranyl-4-[[4-(trifluoromethyl)phenyl]methylamino]phenyl]-3-cyclopentyl-propanamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
9Y5Q Cryo EM structure of KCa3.1_R355K_I/calmodulin channel in complex with rimtuzalcap Deposited 2025-09-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain E 3–148（146 aa）
Chain F 3–148（146 aa）
Chain G 3–148（146 aa）
Chain H 3–148（146 aa）
Not recorded K POTASSIUM ION × 1 A1B92 Rimtuzalcap × 4 CA CALCIUM ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.73 Å
9YDZ Cryo EM structure of KCa3.1_R355K_II/calmodulin channel in complex with rimtuzalcap Deposited 2025-09-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain E 82–148（67 aa） Fragment：residues 82-148
Chain F 82–148（67 aa） Fragment：residues 82-148
Chain G 82–148（67 aa） Fragment：residues 82-148
Chain H 82–148（67 aa） Fragment：residues 82-148
Not recorded K POTASSIUM ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.40 Å
9YG4 VPS13A/Nt-CaM Deposited 2025-09-27 Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 1–149（149 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 3.38 Å
9YQP Cryo-EM structure of the VPS13C N-terminal region in complex with Calmodulin Deposited 2025-10-15 Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1–149（149 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 4.10 Å
9YRM CryoEM Structure of VPS13 protein, 1-1390 from C. thermophilum, in complex with calmodulin Deposited 2025-10-16 Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1–149（149 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 3.75 Å
9YRP Full-length human VPS13C in complex with calmodulin from the CryoEM composite map Deposited 2025-10-16 Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1–149（149 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY mmCIF provides none of the parsed conditions Resolution 4.13 Å
9ZPO Cryo-EM structure of KCa3.1_I/calmodulin channel in complex with SKA31. Deposited 2025-12-16 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain E 3–148（146 aa）
Chain F 3–148（146 aa）
Chain G 3–148（146 aa）
Chain H 3–148（146 aa）
Not recorded A1C3Q naphtho[1,2-d][1,3]thiazol-2-amine × 4 CA CALCIUM ION × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.67 Å
9ZPT Cryo-EM structure of KCa3.1_II/calmodulin channel in complex with SKA31. Deposited 2025-12-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain E 82–148（67 aa） Fragment：residues 82-148
Chain F 82–148（67 aa） Fragment：residues 82-148
Chain G 82–148（67 aa） Fragment：residues 82-148
Chain H 82–148（67 aa） Fragment：residues 82-148
Not recorded K POTASSIUM ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.39 Å
9ZRK Cryo-EM structure of KCa3.1_I/calmodulin channel in complex with SKA111. Deposited 2025-12-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain E 3–148（146 aa）
Chain F 3–148（146 aa）
Chain G 3–148（146 aa）
Chain H 3–148（146 aa）
Not recorded A1C3U 5-methylnaphtho[1,2-d][1,3]thiazol-2-amine × 4 K POTASSIUM ION × 4 CA CALCIUM ION × 16 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.99 Å
9ZRL Cryo-EM structure of KCa3.1_II/calmodulin channel in complex with SKA111. Deposited 2025-12-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain E 82–148（67 aa） Fragment：residues 82-148
Chain F 82–148（67 aa） Fragment：residues 82-148
Chain G 82–148（67 aa） Fragment：residues 82-148
Chain H 82–148（67 aa） Fragment：residues 82-148
Not recorded K POTASSIUM ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.38 Å
9ZRQ Cryo-EM structure of KCa2.2/calmodulin channel in complex with SKA31. Deposited 2025-12-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain E 3–148（146 aa）
Chain F 3–148（146 aa）
Chain G 3–148（146 aa）
Chain H 3–148（146 aa）
Not recorded K POTASSIUM ION × 4 A1C3Q naphtho[1,2-d][1,3]thiazol-2-amine × 4 CA CALCIUM ION × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.77 Å
9ZRR Cryo-EM structure of KCa2.2/calmodulin channel in complex with SKA111. Deposited 2025-12-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric
Chain E 3–146（144 aa）
Chain F 3–146（144 aa）
Chain G 3–146（144 aa）
Chain H 3–146（144 aa）
Not recorded K POTASSIUM ION × 2 A1C3U 5-methylnaphtho[1,2-d][1,3]thiazol-2-amine × 4 CA CALCIUM ION × 12 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.31 Å

213 other PDB entries and 279 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name CALM1_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain R； PDBConstruct 1–149； UniProt 1–149

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

SAXS scattering curve SAXS Profile

SAXS profile for 5v02

P(r) Distance Distribution P(r) Distribution

P(r) distribution for 5v02
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2. Structure Basics 2. Structure Basics

Entry ID entry_id5v02
Deposition date deposition_date2017-02-28
Structure title titleA positive allosteric modulator binding pocket in SK2 ion channels is shared by Riluzole and CyPPA
Keywords keywordscalcium-activated ion channels, activator, calmodulin, TRANSPORT PROTEIN-Metal Binding protein complex; TRANSPORT PROTEIN/Metal Binding protein
Experimental Method methodX-RAY DIFFRACTION
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3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier25.55 Å
Radius of gyration Rg (electron density) rg_electron25.23 Å
Forward intensity I(0) i014231800.00
Molecular weight molecular_weight27255.0 kDa
Excluded volume excluded_volume33589 ų
Envelope volume envelope_volume46860 ų
Hydration-shell volume shell_volume17091 ų
Envelope diameter envelope_diameter88.4 Å
Shell Rg shell_rg29.14 Å
Envelope Rg envelope_rg25.11 Å
Shape Rg shape_rg25.23 Å
Total Rg total_rg25.73 Å
Total atoms total_atoms1906
Residues n_residues233
Spherical-harmonic order n_harmonics20
q range q_range— – 0.5000 Å−1
Data points n_points101
Shell type shell_typedirectional
Solvent electron density solvent_density0.3340 e/ų
Shell contrast contrast_shell0.0300 e/ų
CRYSOL version crysol_version4.1.3
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4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax84.4 Å
Rg (real space) rg_real25.65 Å
Rg uncertainty (real space) rg_real_error0.54 Å
I(0) (real space) i0_real1.4230e+07
I(0) uncertainty (real space) i0_real_error2.0530e+05
Rg (reciprocal space) rg_reciprocal25.62 Å
I(0) (reciprocal space) i0_reciprocal14230000.0000
Solution quality estimate total_estimate0.8830
Solution quality rating solution_quality GOOD a GOOD solution
P(r) peaks n_peaks1
Primary peak position r_peak_primary21.8 Å
Skewness Skewness skewness0.290
Kurtosis Kurtosis kurtosis-0.667
Angular range angular_range— – 0.3100 Å−1
Current regularization parameter α current_alpha0.0000
Highest regularization parameter α highest_alpha1051000.0000
Real-space data points n_real_points63
GNOM version gnom_version4.1.3
Quality Criteria quality_criteria AN1: 0.000; Oscil: 0.898; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.794; Smooth: 0.986
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5. Crystallography and Experiment 5. Crystallography & Experiment

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6. Entities and Polymers Entities & Polymers (7)

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7. Fold Classification (SCOP + CATH) 6 domains

SCOP 2.08 (4 domains)

Domain ID domain_idd5v02b1
Class classf — Membrane and cell surface proteins and peptides
Fold Fold foldf.15 — Small-conductance potassium channel
Superfamily Superfamily superfamilyf.15.1 — Small-conductance potassium channel
Family Family familyf.15.1.1 — Small-conductance potassium channel
Domain ID domain_idd5v02b2
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags
Domain ID domain_idd5v02b3
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags
Domain ID domain_idd5v02r_
Class classa — All alpha proteins
Fold Fold folda.39 — EF Hand-like
Superfamily Superfamily superfamilya.39.1 — EF-hand
Family Family familya.39.1.5 — Calmodulin-like

CATH v4.4 (2 domains)

Domain ID domain_id5v02B00
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology287 — Helix Hairpins
Homologous superfamily homologous superfamily70 —
Domain ID domain_id5v02R01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology238 — Recoverin; domain 1
Homologous superfamily homologous superfamily10 — EF-hand
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8. Citations (1)

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9. Files and Curves (10)