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9y5q

Cryo EM structure of KCa3.1_R355K_I/calmodulin channel in complex with rimtuzalcap

Method: ELECTRON MICROSCOPY D_max: 134.6 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9y5q
deposition_date	2025-09-05
title	Cryo EM structure of KCa3.1_R355K_I/calmodulin channel in complex with rimtuzalcap
keywords	Ion channel, Intermediate conductance calcium-activated potassium channel, Calmodulin binding protein, TRANSPORT PROTEIN; TRANSPORT PROTEIN
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	44.08 Å
rg_electron	43.30 Å
i0	1340600000.00
molecular_weight	199810.0 kDa
excluded_volume	193010 Å³
envelope_volume	433620 Å³
shell_volume	82372 Å³
envelope_diameter	134.2 Å
shell_rg	50.32 Å
envelope_rg	41.43 Å
shape_rg	43.29 Å
total_rg	43.57 Å
total_atoms	15135
n_residues	2024
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	134.6 Å
rg_real	43.73 Å
rg_real_error	0.74 Å
i0_real	1.3410e+09
i0_real_error	1.9730e+07
rg_reciprocal	44.07 Å
i0_reciprocal	1341000000.0000
total_estimate	0.8908
solution_quality	GOOD a GOOD solution
n_peaks	1
r_peak_primary	59.8 Å
skewness	0.005
kurtosis	-0.505
angular_range	— – 0.1800 Å⁻¹
current_alpha	0.0000
highest_alpha	93820000.0000
n_real_points	37
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.897; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.953; Smooth: 0.931

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4. Crystallography & Experiment

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5. Entities & Polymer Info (5)

Entity 1 polymer

description	Intermediate conductance calcium-activated potassium channel protein 4
formula_weight	42570.6 kDa
mutation	R355K
src_method	man
entity_count	4

Polymer

type	polypeptide(L)
strand_id	A,B,C,D
atom_count	15135

LGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFLVKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPAPVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYRSIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDTLWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHNFMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVKLKHRKLREQVNSMVDISKMHMILYDLQQNLS

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 2 polymer

description	Calmodulin-1
formula_weight	16521.1 kDa
src_method	man
entity_count	4

Polymer

type	polypeptide(L)
strand_id	E,F,G,H

DQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTA

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 3 non-polymer

description	POTASSIUM ION
formula_weight	39.1 kDa
src_method	syn
entity_count	1

Entity 4 non-polymer

description	Rimtuzalcap
formula_weight	378.4 kDa
src_method	syn
entity_count	4

Entity 5 non-polymer

description	CALCIUM ION
formula_weight	40.1 kDa
src_method	syn
entity_count	4

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6. Citations (1)

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length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	4.730 Å
resolution_low	— Å
r_factor	—
r_work	—
r_free	—

resolution	4.73 Å
resolution_method	—
num_particles	77867

fit	/app/data/saxs_computation/y5/9y5q/9y5q.fit
pddf	/app/data/pr_computation/y5/9y5q/9y5q.pr.out
profile	/app/data/saxs_computation/y5/9y5q/9y5q.dat

Cryo EM structure of KCa3.1_R355K_I/calmodulin channel in complex with rimtuzalcap

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

EM 3D

5. Entities & Polymer Info (5)

Entity 1 polymer

Polymer

Source

Entity 2 polymer

Polymer

Source

Entity 3 non-polymer

Entity 4 non-polymer

Entity 5 non-polymer

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)