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9ven

structure of human KCNQ1-CaM-PIP2 complex with bent conformation

Method: ELECTRON MICROSCOPY D_max: 124.1 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9ven
deposition_date	2025-06-09
title	structure of human KCNQ1-CaM-PIP2 complex with bent conformation
keywords	potassium channel complex, membrane protein; MEMBRANE PROTEIN
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	41.36 Å
rg_electron	40.59 Å
i0	615424000.00
molecular_weight	211930.0 kDa
excluded_volume	268520 Å³
envelope_volume	389370 Å³
shell_volume	76768 Å³
envelope_diameter	126.4 Å
shell_rg	49.28 Å
envelope_rg	39.43 Å
shape_rg	40.59 Å
total_rg	41.07 Å
total_atoms	14936
n_residues	1984
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	124.1 Å
rg_real	41.07 Å
rg_real_error	0.72 Å
i0_real	6.1540e+08
i0_real_error	1.0400e+07
rg_reciprocal	41.35 Å
i0_reciprocal	615600000.0000
total_estimate	0.8961
solution_quality	GOOD a GOOD solution
n_peaks	1
r_peak_primary	52.2 Å
skewness	0.004
kurtosis	-0.541
angular_range	— – 0.1900 Å⁻¹
current_alpha	0.0000
highest_alpha	47150000.0000
n_real_points	39
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.925; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.958; Smooth: 0.911

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4. Crystallography & Experiment

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5. Entities & Polymer Info (4)

Entity 1 polymer

description	Calmodulin-1
formula_weight	16852.5 kDa
src_method	man
entity_count	4

Polymer

type	polypeptide(L)
strand_id	B,D,F,H
atom_count	14936

MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 2 polymer

description	Potassium voltage-gated channel subfamily KQT member 1
formula_weight	62086.3 kDa
src_method	man
entity_count	4

Polymer

type	polypeptide(L)
strand_id	A,C,G,E

MASDLGPRPPVSLDPRVSIYSTRRPVLARTHVQGRVYNFLERPTGWKCFVYHFAVFLIVLVCLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQTAWRCYAAENPDSSTWKIYIRKAPRSHTLLSPSPKPKKSVVVKKKKFKLDKDNGVTPGEKMLTVPHITCDPPEERRLDHFSVDGYDSSVRKSPTLLEVSMPHFMRTNSFAEDLDLEGETLLTPITHISQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFISVSEKSKDRGSNTIGARLNRVEDKVTQLDQRLALITDMLHQLLSLH

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 3 non-polymer

description	CALCIUM ION
formula_weight	40.1 kDa
src_method	syn
entity_count	8

Entity 4 non-polymer

description	;[(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate ;
formula_weight	1047.1 kDa
src_method	syn
entity_count	4

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6. Citations (1)

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length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	3.80 Å
resolution_method	—
num_particles	93105

fit	/app/data/saxs_computation/ve/9ven/9ven.fit
pddf	/app/data/pr_computation/ve/9ven/9ven.pr.out
profile	/app/data/saxs_computation/ve/9ven/9ven.dat

structure of human KCNQ1-CaM-PIP2 complex with bent conformation

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

EM 3D

5. Entities & Polymer Info (4)

Entity 1 polymer

Polymer

Source

Entity 2 polymer

Polymer

Source

Entity 3 non-polymer

Entity 4 non-polymer

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)