6qkl

Mechanism of eIF6 release from the nascent 60S ribosomal subunit

Method: ELECTRON MICROSCOPY

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1. Protein Identity and Related Structures Protein Identity & Related Structures

60S ribosomal protein L3

OrganismNot specified

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 10 RNA 1	26S RIBOSOMAL RNA × 1 60S ribosomal protein L9 × 1 （Q54XI5） 60S ribosomal protein L23 × 1 （Q54G86） 60S ribosomal protein L10 × 1 （Q54J69） 60S ribosomal protein L24 × 1 （Q54VN6） Ubiquitin-60S ribosomal protein L40 × 1 （P14794） Eukaryotic translation initiation factor 6 × 1 （Q551M2） Ribosome maturation protein SBDS × 1 （Q9Y3A5） 60S acidic ribosomal protein P0 × 1 （P22685） 60S ribosomal protein L12 × 1 （Q54J50）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RL3_DICDI
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain A； PDBConstruct 1–398； UniProt 1–398

60S ribosomal protein L9

OrganismNot specified

UniProt Q54XI5

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 10 RNA 1	26S RIBOSOMAL RNA × 1 60S ribosomal protein L3 × 1 （P34113） 60S ribosomal protein L23 × 1 （Q54G86） 60S ribosomal protein L10 × 1 （Q54J69） 60S ribosomal protein L24 × 1 （Q54VN6） Ubiquitin-60S ribosomal protein L40 × 1 （P14794） Eukaryotic translation initiation factor 6 × 1 （Q551M2） Ribosome maturation protein SBDS × 1 （Q9Y3A5） 60S acidic ribosomal protein P0 × 1 （P22685） 60S ribosomal protein L12 × 1 （Q54J50）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RL9_DICDI
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain B； PDBConstruct 1–188； UniProt 1–188

60S ribosomal protein L23

OrganismNot specified

UniProt Q54G86

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 10 RNA 1	26S RIBOSOMAL RNA × 1 60S ribosomal protein L3 × 1 （P34113） 60S ribosomal protein L9 × 1 （Q54XI5） 60S ribosomal protein L10 × 1 （Q54J69） 60S ribosomal protein L24 × 1 （Q54VN6） Ubiquitin-60S ribosomal protein L40 × 1 （P14794） Eukaryotic translation initiation factor 6 × 1 （Q551M2） Ribosome maturation protein SBDS × 1 （Q9Y3A5） 60S acidic ribosomal protein P0 × 1 （P22685） 60S ribosomal protein L12 × 1 （Q54J50）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RL23_DICDI
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain E； PDBConstruct 1–136； UniProt 1–136

60S ribosomal protein L10

OrganismNot specified

UniProt Q54J69

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 10 RNA 1	26S RIBOSOMAL RNA × 1 60S ribosomal protein L3 × 1 （P34113） 60S ribosomal protein L9 × 1 （Q54XI5） 60S ribosomal protein L23 × 1 （Q54G86） 60S ribosomal protein L24 × 1 （Q54VN6） Ubiquitin-60S ribosomal protein L40 × 1 （P14794） Eukaryotic translation initiation factor 6 × 1 （Q551M2） Ribosome maturation protein SBDS × 1 （Q9Y3A5） 60S acidic ribosomal protein P0 × 1 （P22685） 60S ribosomal protein L12 × 1 （Q54J50）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RL10_DICDI
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain F； PDBConstruct 1–217； UniProt 1–217

60S ribosomal protein L24

OrganismNot specified

UniProt Q54VN6

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 10 RNA 1	26S RIBOSOMAL RNA × 1 60S ribosomal protein L3 × 1 （P34113） 60S ribosomal protein L9 × 1 （Q54XI5） 60S ribosomal protein L23 × 1 （Q54G86） 60S ribosomal protein L10 × 1 （Q54J69） Ubiquitin-60S ribosomal protein L40 × 1 （P14794） Eukaryotic translation initiation factor 6 × 1 （Q551M2） Ribosome maturation protein SBDS × 1 （Q9Y3A5） 60S acidic ribosomal protein P0 × 1 （P22685） 60S ribosomal protein L12 × 1 （Q54J50）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RL24_DICDI
Isoform	—
PDB entities	6
Chains and sequence ranges	Author chain G； PDBConstruct 1–69； UniProt 1–69

Ubiquitin-60S ribosomal protein L40

OrganismNot specified

UniProt P14794

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 10 RNA 1	26S RIBOSOMAL RNA × 1 60S ribosomal protein L3 × 1 （P34113） 60S ribosomal protein L9 × 1 （Q54XI5） 60S ribosomal protein L23 × 1 （Q54G86） 60S ribosomal protein L10 × 1 （Q54J69） 60S ribosomal protein L24 × 1 （Q54VN6） Eukaryotic translation initiation factor 6 × 1 （Q551M2） Ribosome maturation protein SBDS × 1 （Q9Y3A5） 60S acidic ribosomal protein P0 × 1 （P22685） 60S ribosomal protein L12 × 1 （Q54J50）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RL40_DICDI
Isoform	—
PDB entities	7
Chains and sequence ranges	Author chain H； PDBConstruct 1–52； UniProt 77–128

Eukaryotic translation initiation factor 6

OrganismNot specified

UniProt Q551M2

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 10 RNA 1	26S RIBOSOMAL RNA × 1 60S ribosomal protein L3 × 1 （P34113） 60S ribosomal protein L9 × 1 （Q54XI5） 60S ribosomal protein L23 × 1 （Q54G86） 60S ribosomal protein L10 × 1 （Q54J69） 60S ribosomal protein L24 × 1 （Q54VN6） Ubiquitin-60S ribosomal protein L40 × 1 （P14794） Ribosome maturation protein SBDS × 1 （Q9Y3A5） 60S acidic ribosomal protein P0 × 1 （P22685） 60S ribosomal protein L12 × 1 （Q54J50）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	IF6_DICDI
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain I； PDBConstruct 1–224； UniProt 1–224

Ribosome maturation protein SBDS

Homo sapiens

UniProt Q9Y3A5

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 10 RNA 1	26S RIBOSOMAL RNA × 1 60S ribosomal protein L3 × 1 （P34113） 60S ribosomal protein L9 × 1 （Q54XI5） 60S ribosomal protein L23 × 1 （Q54G86） 60S ribosomal protein L10 × 1 （Q54J69） 60S ribosomal protein L24 × 1 （Q54VN6） Ubiquitin-60S ribosomal protein L40 × 1 （P14794） Eukaryotic translation initiation factor 6 × 1 （Q551M2） 60S acidic ribosomal protein P0 × 1 （P22685） 60S ribosomal protein L12 × 1 （Q54J50）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	SBDS_HUMAN
Isoform	—
PDB entities	9
Chains and sequence ranges	Author chain J； PDBConstruct 1–250； UniProt 1–250

60S acidic ribosomal protein P0

OrganismNot specified

UniProt P22685

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 10 RNA 1	26S RIBOSOMAL RNA × 1 60S ribosomal protein L3 × 1 （P34113） 60S ribosomal protein L9 × 1 （Q54XI5） 60S ribosomal protein L23 × 1 （Q54G86） 60S ribosomal protein L10 × 1 （Q54J69） 60S ribosomal protein L24 × 1 （Q54VN6） Ubiquitin-60S ribosomal protein L40 × 1 （P14794） Eukaryotic translation initiation factor 6 × 1 （Q551M2） Ribosome maturation protein SBDS × 1 （Q9Y3A5） 60S ribosomal protein L12 × 1 （Q54J50）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RLA0_DICDI
Isoform	—
PDB entities	10
Chains and sequence ranges	Author chain C； PDBConstruct 1–205； UniProt 1–205

60S ribosomal protein L12

OrganismNot specified

UniProt Q54J50

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 10 RNA 1	26S RIBOSOMAL RNA × 1 60S ribosomal protein L3 × 1 （P34113） 60S ribosomal protein L9 × 1 （Q54XI5） 60S ribosomal protein L23 × 1 （Q54G86） 60S ribosomal protein L10 × 1 （Q54J69） 60S ribosomal protein L24 × 1 （Q54VN6） Ubiquitin-60S ribosomal protein L40 × 1 （P14794） Eukaryotic translation initiation factor 6 × 1 （Q551M2） Ribosome maturation protein SBDS × 1 （Q9Y3A5） 60S acidic ribosomal protein P0 × 1 （P22685）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RL12_DICDI
Isoform	—
PDB entities	11
Chains and sequence ranges	Author chain D； PDBConstruct 1–166； UniProt 1–166

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	6qkl
Deposition date deposition_date	2019-01-29
Structure title title	Mechanism of eIF6 release from the nascent 60S ribosomal subunit
Keywords keywords	60S subunit, eIF6, SBDS, uL16, RIBOSOME; RIBOSOME
Experimental Method method	ELECTRON MICROSCOPY

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6qkl__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6qkl__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

6qkl__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	58.53 Å
Rg (electron density)	59.04 Å
Total Rg	59.08 Å
Atom count	39284
Residues	3024
Excluded volume	612070 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`6qkl__assembly_1__model_1`	undecameric （11）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (11)

Entity 1 Entity 1 polymer

Description description	26S RIBOSOMAL RNA
Molecular weight formula_weight	1205997.8 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polyribonucleotide
Chain IDs strand_id	N
Atom count atom_count	39284

UCCGCCUCACCUUUGUAAGAUUACCCGCUGAACUUAAGCAUAUCAGUAAGCGGAGGAAAAGAAACUAACUAGGAUUCCGUCAGUAACGGCGAGUGAAGACGGAAUAGCCCAAGGUUCAAACCUGGAUCUCUUCGAGGUUAGGUGAUGUGACCUAUGGACUGAUGGAGCCCGCUGUUGUGACUGCUAAUUCCGUUUGGAAUUUCGAGUCGUAGAAGGUGAUAACCCUGUUCGCAGUAUCACAACAGUUGGACUUUGCCAUUAGCUCCACGAGUAGGAAUGUCUGAAAUUGCAUUCUGAAUGGGUGAUAAGAUUCAUCCAAGGCUAAAUAUAUGUUAGGAGAUCGAUAGCAUACAAGUACCGUGAGGGAAAGGUGAAAAGAACUUUGAAAAAAGGUUUAAAAGUAUUUGACACCGUUUAUGUGGAAGCGUUUACUUGGACCCCGAUUAAUGACGUCGGUUUAGCUCUAAUUCUUAGGUGGCCAAAGUAGAGUGUUACGUGCUGAUCAAAAGGUAACGGACAUUUGAUUCAUUGGUUAUCGACGAGGAAGGUACUCUAAAUCGGCCAGUUACUAACGGGUGAGAUCUGAUGUUUAUAAAAUGGGGGAUGAGGCUUAUCGGCUUGCUGGUGGCUCGCUCUCAAUAAUGGAUAUUGGGUUUCAUCAAGAGUGCAAAAUGGUGGCAAUUCACUAUUAGUGGUUAUUAAUUUUGUUUGCGUGGCUUGGCCUUGUCUACAGGUUAUCUUCGGAUGGCUUGUAGCUUUGUUGAACGCGUGGGCUUAAUGUUGUGAUUCUAGUAGCGUUACCAUAUCGUUAGAGUGGGUUCAAUAAAUGUCCCGUCUUGAAACACGGAUCAAGGAGGCCGUUUUGUGUGCGAGUGUAAGAGUAAUUAAAACUCUGACGCGUAUUGAAAGAAAGAAUACUCCAAAAGAUCGUAACUACGGUUACCUUCUGUAAGGAGUGCCCGAAUCAUGAGAACUCUGUUUCGAAAGGAUUUGCGGUUGAGCACCUAGAAUGGGACCCGAAAGGUUGUGAACUAUGCCUGAGGAAGGCGAAGUCAGGGGAAACUCUGAUGGAGGCUUGUCGCAAUGCUGACGUGCAAAUCGCUUGUCUAACUUGGGUAUAGGGGCGAAAGACUAAUCGAACAACCUAGUAGCUGGUUCCUUCCGAAGUUUCCCUCAGGAUAGCUGGAGCAGUAUUCUAGUUCCAUCUUGUAAAGACAAUGAUUAGCAGUUUCGGGGGCGUAAUGCUCUCAGCUGAUUCUCAAACUCUGAACGGGUGGGUAUCAUUUUAAUUCACUUAAUUGGAUUUUAAAAUUAAAUUGCACAUGUGCAAUGAAAAAUAGGAGCUCUUAGUGGGCCAUUUUUGGUAAGCAGAACUGGCGAUGUGGGUUGAACCAAAUAUUGGGAUAAGACGUCUAACAUUCACUAAUAGAUACCACAAAAGGUGUUAGUUCAUUAAGACAGCAGGACGGUGGCCAUGGAAGUCGGUAUCCGCUAAGGAGUGUGUAACAACUCACCUGCCAAAUGGACUAGCCCUGAAAAUGGAUGACGCUAGCAGUGGAUGGUCGAUGCCCAAUCGUUAAAAGAAGUGAUAAUACUUUUAACGUGUAGGAAGGCGUGAAGGUAACGUAGAAGCUUGAAUGUGAAUUCGAGUGGAGUUGUCUUUAGUGCAGAUCUUGAUGGUAGUAGCAAAUAUUCAAAAGAAUUUACUUUGAAGGCCGAAGUGGGGAAGGGUUCCAUAACAAUGGAAUUCACUUAUGGGUGAGUCGAUCCUAAGGUUUGGGUUAACUCUCUCUAAUAAGGUUACUAGGUCAUUGGAUCGAAAGUGAAGGUGGCUUUAACACUAGUGACUUUAUAGGCCGAAAGGGAAGCGGGUUAAAAUUCCUGCACCAUCGAAUGGGAUAUUAGGGUAACCGAUCGUAAUCCGGGACAUCAAUUGGCGGUCGAGGAAGAGUUAUCUUUUCUUGUUAACAUUGUCUUGGGGUCCUCCGAAUCAGGUCAACUGGAGACGAGGAUUCAUCGCACAAUGGAAGAGCACAGUCCUUUGGAUUGGGUCUCGCAUCCGCUAAAUGGUCCUUGAAAACCGGAUUAUGGUAUUUAAUCCUAUUUGGUGUUCGUACCAAUAACCACAUCAGGUCUCCAAGGUGAAUAGCCUCUGGUCAAAUGUAUUAAUGUAGAUAAGGGAAGUCGGCAAAACCGAUCUGUAACUUCGGGAUAAGGAUUGGCUCUAAAGGCUGGUGGAGUGGACAUAUUGGAGUUUGCUAUUUGUUUUUUACUUUUAGGAUGGGCAACUGUUUUGAAGGUUUAAGAUGGGUGGUAAUUCUUUCCAAUGUGAGGGCUUGCUCGUUCUGCUUUACGAUUAACAGCUAAUUUAGAACUGUGACGAUCACCGGGAAUCCAACUGUUUAAUUAAAACAAAGCAUUGCGAUAAGCUUAAAAGCUUUUGACGCAAUGUGAUUUCUGCCCAGUGCUCUGAAUGUCAAAGUGAAGAGAUUCAACCUAGCACGGGUAAACGGCGGGAGUAACUAUGACUCUCUUAAGGUAGCCAAAUGCCUCGUCAUCUAAUUAGUGACGCGCAUGAAUGGAUCAAUGAGAUUCCCACUGUCCCUAACUACUAUACAGCGAAACCACUGCAAGGGGAACGGGCCUUGCAAAAACAGCGGGGAAAGAAGACCCUGUUGAGCUUGACUCUAGUCUGAUAUUGCAUAGUGACCUAAAAGGUGUAGAAUAGGUGGGAGGGGCAACCCGACGGUGAAAUACCACCCCUUUUGGCGUUACUUUGCUAACUUGGAAUAACAGUACCUCAUAAUUCAUUUUAUGAUGGUUUUGGUGAAUAAGCGGAUCAACCACGGGUGAAAUCUGUGCAAAUUGGGCAACUGAUUUGUAUAGCAAAGUAGUCCCUCUGGUCCCGUAUUAUGUCGACCAAGAACAGUUUCAGGUGGGGAGUUUGGCUGGGGCGGCACAUUUGUUAAAAGAUAACGCAAGUGUCCAAAGGCAGGCUCAGUGAGAACAGAAAUCUCACGUAGAGUAAAAGGGCAAAAGCCUGCUUGAUUCUGAUUUUCAGUACUAAUCGGAACUGGGAAACCAGGGCCUAUCGAUCCUUUAUGUGCUUAAAUCUUAACCCUAGAGGUGUCAGAAAAGUUACCACAGGGAUAACUGGCUUGUGGCAGCCAAGCGCUCAUAGCGACGCUGCUUUUUGAUCCUUCGAUGUCGGCUCUUCUUAUCAUUGUGAAGCAGAAUUCACAAAGUGUUGGAUUGUUCACCCACUAACAAGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUGUUGUCAAUUGUUUGCGUAAUAGUAGCAUGAUUUAGUACGAGAGGAACUGUCAUGCCGGAUCACUGGUCUGUAGGUUUAUUUGACAAAAUAGUGACCUGCCGCUACCAUCCGUUGGAUAAUGGCUGAACGCCUCUAAGUCAGAAUCCAUUCUAGAAACGCAAACCAAAUGCUUUAGAGUGUGAAUGUUGUAGGUAACAUUAGGUUGUUGGUGGGGGACCACUUUCAACUUUAAACCAUAUGAUUAAUCGCUGUUACACUGCAGUUUCCUUCCGGUUAUUGUGGUGGGUGGCUAAAUUCUAAUUUAUAUCCUCGUUCCGCUCAACUCUUCGAUUGUAGACGACUAUCAAAUGAACUAGGUGCUGUAAGCUUCCGAGUAGCGUUCAGUUACGAGGGGUUGAGGCUUUUCCAUUAGUUCUUU

Entity 2 Entity 2 polymer

Description description	60S ribosomal protein L3
Molecular weight formula_weight	45158.8 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A

MSHRKFEAPRHGNLGFRPRKRAARHQGKVKSFPKDDRTQKVHLTAFMGYKAGMTHVVRDLEKPGSKMHKKEIVEAVTIIECPPMYIVGLVGYVETAQGLKTYKTVWAQHLSDNFRRRLYKNWYKSKSKKAFTKYVKQYETEEGKKSIEASLQAIKKRCSVVRVIAHTQVHKLKLTQKKAHVLEIQVNGGSIVEKVNFAVANFEKTVNVTGVFAENELIDVIGVTKGKGFNGVIKRWGVRKLPRKTHKGLRKVACIGAWHPSRVSTTVPRAGQLGYHHRVERNKKIYRIGQAQPEDGKQISTGKTEFDLTEKTINPMGGFAHYGMVKHEFLMLKGCVAGPRKRALTLRKSITTQTGRAALEKITLKFIDTSSKFGHGLHQTAEDKTKYFGVKKSRSTKA

Entity 3 Entity 3 polymer

Description description	60S ribosomal protein L9
Molecular weight formula_weight	21250.7 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B

MKVINSSRKVQIPENVTVDVKGRSVKVTGPRGTLSKSFDHASVDINLVGKKELTVDLWFGNRKQIACIKTITSIIENMITGVTKGYEYKMRFVYAHFPINVAVTDGGRVVEIRNFFGEKIVRRIELLDGITCYRNEKAKDEIVLTGNSLELLSQSCATIQLRSAIKYKDVRKFLDGIYVSERNVLESN

Entity 4 Entity 4 polymer

Description description	60S ribosomal protein L23
Molecular weight formula_weight	14567.1 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	E

MSKAQAVGSNYRVSLGLPVGAVMNSADNSGAKNLYVIAVKGIKGRLNRLPSAGVGDMVMATVKKGKPELRKKVCTGLVVRQRKHWKRKDGVYIYFEDNAGVMCNPKGEVKGNILGPVAKECSDLWPKVATNAGTIV

Entity 5 Entity 5 polymer

Description description	60S ribosomal protein L10
Molecular weight formula_weight	24591.8 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	F

MGRRPARCYRYCKNKPYIKSRYCRGVPDAKIRIFDLGRKKASTDEFPLCVHLISLEKEQLSSEAIEAGRISCNKYISKTGGKDSFHMRVRVHPWHVLRINKMLSCAGADRLQTGMRGAFGKPMGTVARVNIGQIIFSIRTRDNMLANVVEALRRSSYKFPGRQKIVVSKKWGFTAYNREAYQKLKADGRLMNDGANVKVITNHGTLAQYAKDIAAAN

Entity 6 Entity 6 polymer

Description description	60S ribosomal protein L24
Molecular weight formula_weight	8334.8 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	G

MKTSLCNYSEFKIYPARGMKFVRGDSKVFHFINTKVESLFFRKINPRDIRWSMVYRRIYKNTTTDVSAK

Entity 7 Entity 7 polymer

Description description	Ubiquitin-60S ribosomal protein L40
Molecular weight formula_weight	6170.7 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	H

IEPSLVILARKYKCDKMICRKCYARLHPRAVNCRKKKCGHSNNLRPKKKLLK

Entity 8 Entity 8 polymer

Description description	Eukaryotic translation initiation factor 6
Molecular weight formula_weight	24107.3 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	I

MATRLQYENSCDVGVFLKLTNKYCLVGQCGSKQFLHTVENRLADHIPVVETSIAGTRIVGRLSAGNKNGLLLPNTCTDQELQQIRNSLPDDVVVQRIEEKFSALGNCIATNDYVALVHPDIDRETEEIIADVLGVEVFRQTVSGNVLVGTYCALTNQGALVHPMTSIADQDELSSLLQVPLVAGTVNRGNECVAAGCVVNDWTAIVGADTTATEISVIESIFAL

Entity 9 Entity 9 polymer

Description description	Ribosome maturation protein SBDS
Molecular weight formula_weight	28813.6 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	J

MSIFTPTNQIRLTNVAVVRMKRAGKRFEIACYKNKVVGWRSGVEKDLDEVLQTHSVFVNVSKGQVAKKEDLISAFGTDDQTEICKQILTKGEVQVSDKERHTQLEQMFRDIATIVADKCVNPETKRPYTVILIERAMKDIHYSVKTNKSTKQQALEVIKQLKEKMKIERAHMRLRFILPVNEGKKLKEKLKPLIKVIESEDYGQQLEIVCLIDPGCFREIDELIKKETKGKGSLEVLNLKDVEEGDEKFE

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Escherichia coli

Entity 10 Entity 10 polymer

Description description	60S acidic ribosomal protein P0
Molecular weight formula_weight	22434.2 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	C

MSGAGSKRKNVFIEKATKLFTTYDKMIVAEADFVGSSQLQKIRKSIRGIGAVLMGKKTMIRKVIRDLADSKPELDALNTYLKQNTCIIFCKDNIAEVKRVINTQRVGAPAKAGVFAPNDVIIPAGPTGMEPTQTSFLQDLKIATKINRGQIDIVNEVHIIKTGQKVGASEATLLQKLNIKPFTYGLEPKIIYDAGACYSPSISEE

Entity 11 Entity 11 polymer

Description description	60S ribosomal protein L12
Molecular weight formula_weight	17811.0 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	D

MPPKVDPSEKVEVFLRVCGGEAGAMSTLAPKLGPLGVSPKKVGDDIAKATQPWKGMKVSVKLTIQNRIAVPEVLPSASALVIKALKEPPRDRKKEKNIKHNGNIPLEEICKIAKTMRFKSLAVDFKGSVLEILGTAHSVGCKVNGKSPRDIQAGIQSGEIEVVEPK

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6. Fold Classification (SCOP + CATH) 11 domains

CATH v4.4 (11 domains)

Domain ID domain_id	6qklA01
Class class	4 — Few Secondary Structures
Architecture architecture	10 — Irregular
Topology topology	960 — Ribosomal protein L3; domain 3
Homologous superfamily homologous superfamily	10 — Ribosomal protein L3, domain 3

Domain ID domain_id	6qklA02
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	30 — Elongation Factor Tu (Ef-tu); domain 3
Homologous superfamily homologous superfamily	10 — Translation factors

Domain ID domain_id	6qklA03
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	1430 — Ribosomal Protein L3; Chain: B; domain 2,
Homologous superfamily homologous superfamily	10 —

Domain ID domain_id	6qklB01
Class class	3 — Alpha Beta
Architecture architecture	90 — Alpha-Beta Complex
Topology topology	930 — Outer Surface Protein A; domain 3
Homologous superfamily homologous superfamily	12 — Ribosomal protein L6

Domain ID domain_id	6qklB02
Class class	3 — Alpha Beta
Architecture architecture	90 — Alpha-Beta Complex
Topology topology	930 — Outer Surface Protein A; domain 3
Homologous superfamily homologous superfamily	12 — Ribosomal protein L6

Domain ID domain_id	6qklE00
Class class	2 — Mainly Beta
Architecture architecture	40 — Beta Barrel
Topology topology	150 — Ribosomal Protein L14
Homologous superfamily homologous superfamily	20 — Ribosomal protein L14/L23

Domain ID domain_id	6qklF01
Class class	3 — Alpha Beta
Architecture architecture	90 — Alpha-Beta Complex
Topology topology	1170 — Aldehyde Oxidoreductase; domain 3
Homologous superfamily homologous superfamily	10 — Ribosomal protein L16/L10

Domain ID domain_id	6qklF02
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	60 — Wheat Germ Agglutinin (Isolectin 2); domain 1
Homologous superfamily homologous superfamily	300 —

Domain ID domain_id	6qklG00
Class class	2 — Mainly Beta
Architecture architecture	30 — Roll
Topology topology	170 — Ribosomal Protein L24e; Chain: T;
Homologous superfamily homologous superfamily	20 — Ribosomal protein L24

Domain ID domain_id	6qklH00
Class class	4 — Few Secondary Structures
Architecture architecture	10 — Irregular
Topology topology	1060 — ZNF265 like
Homologous superfamily homologous superfamily	50 —

Domain ID domain_id	6qklI00
Class class	3 — Alpha Beta
Architecture architecture	75 — 5-stranded Propeller
Topology topology	10 — L-arginine/glycine Amidinotransferase; Chain A
Homologous superfamily homologous superfamily	10 — L-arginine/glycine Amidinotransferase; Chain A

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Unit-cell length a length_a	1.000 Å
Unit-cell length b length_b	1.000 Å
Unit-cell length c length_c	1.000 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	1

Space group space_group	P 1
Space-group number int_tables_number	1
Crystal system crystal_system	triclinic

Resolution resolution	3.30 Å
Resolution测定Method resolution_method	—
颗粒数 num_particles	43063

Mechanism of eIF6 release from the nascent 60S ribosomal subunit

1. Protein Identity and Related Structures Protein Identity & Related Structures

60S ribosomal protein L3

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

60S ribosomal protein L9

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

60S ribosomal protein L23

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

60S ribosomal protein L10

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

60S ribosomal protein L24

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Ubiquitin-60S ribosomal protein L40

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Eukaryotic translation initiation factor 6

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Ribosome maturation protein SBDS

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

60S acidic ribosomal protein P0

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

60S ribosomal protein L12

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer