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6qzr

14-3-3 sigma in complex with FOXO1 pT24 peptide

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

14-3-3 protein sigma

Homo sapiens

UniProt P31947

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 Forkhead box protein O1 × 2 （Q12778） 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 GLYCEROL × 2 water × 3 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 4 Forkhead box protein O1 × 2 （Q12778） 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 GLYCEROL × 2 water × 3 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 4 Forkhead box protein O1 × 2 （Q12778） 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 GLYCEROL × 2 water × 4 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 4 Forkhead box protein O1 × 2 （Q12778） 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 GLYCEROL × 1 water × 4 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer
1yz5 3t0l 3t0m 3u9x 4dhm 4dhn 4dho 4dhp 4dhq 4dhr 4dhs 4dht

21 assemblies; showing the first 12

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1ywt 1ywt 3iqj 3iqu 3iqv 3lw1 3mhr 3o8i 3p1n 3p1o 3p1p 3p1q

523 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name 1433S_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 6–253； UniProt 1–248 Author chain B； PDBConstruct 6–253； UniProt 1–248 Author chain C； PDBConstruct 6–253； UniProt 1–248 Author chain D； PDBConstruct 6–253； UniProt 1–248 Author chain E； PDBConstruct 6–253； UniProt 1–248 Author chain F； PDBConstruct 6–253； UniProt 1–248 Author chain G； PDBConstruct 6–253； UniProt 1–248 Author chain H； PDBConstruct 6–253； UniProt 1–248

Forkhead box protein O1

OrganismNot specified

UniProt Q12778

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 14-3-3 protein sigma × 2 （P31947） 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 GLYCEROL × 2 water × 3 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 4 14-3-3 protein sigma × 2 （P31947） 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 GLYCEROL × 2 water × 3 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 4 14-3-3 protein sigma × 2 （P31947） 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 GLYCEROL × 2 water × 4 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 4 14-3-3 protein sigma × 2 （P31947） 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 GLYCEROL × 1 water × 4 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
6qvw

1 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
3co6 3co7 3co7 3coa 3coa 4lg0 5dui 6lbi 6lbi 6lbi 6qzr 6qzr

16 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name FOXO1_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain J； PDBConstruct 1–11； UniProt 19–29 Author chain M； PDBConstruct 1–11； UniProt 19–29 Author chain N； PDBConstruct 1–11； UniProt 19–29 Author chain O； PDBConstruct 1–11； UniProt 19–29 Author chain P； PDBConstruct 1–11； UniProt 19–29 Author chain R； PDBConstruct 1–11； UniProt 19–29 Author chain T； PDBConstruct 1–11； UniProt 19–29 Author chain U； PDBConstruct 1–11； UniProt 19–29

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6qzr
Deposition date deposition_date2019-03-12
Structure title title14-3-3 sigma in complex with FOXO1 pT24 peptide
Keywords keywordsprotein binding, 14-3-3, FOXO1, PEPTIDE BINDING PROTEIN; PEPTIDE BINDING PROTEIN
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6qzr__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6qzr__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6qzr__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）27.41 Å
Rg (electron density)26.49 Å
Total Rg27.23 Å
Atom count3624
Residues466
Excluded volume64175 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6qzr__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 6qzr__assembly_2__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 6qzr__assembly_3__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 6qzr__assembly_4__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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6. Fold Classification (SCOP + CATH) 8 domains

CATH v4.4 (8 domains)

Domain ID domain_id6qzrA00
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology190 — Delta-Endotoxin; domain 1
Homologous superfamily homologous superfamily20 — 14-3-3 domain
Domain ID domain_id6qzrB00
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology190 — Delta-Endotoxin; domain 1
Homologous superfamily homologous superfamily20 — 14-3-3 domain
Domain ID domain_id6qzrC00
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology190 — Delta-Endotoxin; domain 1
Homologous superfamily homologous superfamily20 — 14-3-3 domain
Domain ID domain_id6qzrD00
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology190 — Delta-Endotoxin; domain 1
Homologous superfamily homologous superfamily20 — 14-3-3 domain
Domain ID domain_id6qzrE00
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology190 — Delta-Endotoxin; domain 1
Homologous superfamily homologous superfamily20 — 14-3-3 domain
Domain ID domain_id6qzrF00
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology190 — Delta-Endotoxin; domain 1
Homologous superfamily homologous superfamily20 — 14-3-3 domain
Domain ID domain_id6qzrG00
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology190 — Delta-Endotoxin; domain 1
Homologous superfamily homologous superfamily20 — 14-3-3 domain
Domain ID domain_id6qzrH00
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology190 — Delta-Endotoxin; domain 1
Homologous superfamily homologous superfamily20 — 14-3-3 domain
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7. Citations (1)