6s66

Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor

Method: X-RAY DIFFRACTION D_max: 75.7 Å Quality: GOOD

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1. Protein Identity and Related Structures Protein Identity & Related Structures

Transcriptional enhancer factor TEF-4

Homo sapiens

State in the Current Structure

Assembly	Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Associated Components	Method and Experimental Conditions	Structure Quality
1	Protein monomer Monomer Protein × 1 PDB declaration: monomeric（1） Consistent with protein copy count	Chain A； UniProt 217–447	Not recorded	MYR MYRISTIC ACID × 1	X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate	Resolution 2.20 Å R-free 0.262
2	Protein monomer Monomer Protein × 1 PDB declaration: monomeric（1） Consistent with protein copy count	Chain B； UniProt 217–447	Not recorded	MYR MYRISTIC ACID × 1 KWW 1-(2-azanylethyl)-3-(3,4-dichlorophenyl)-~{N}-(phenylmethyl)pyrazole-4-carboxamide × 1	X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate	Resolution 2.20 Å R-free 0.262

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB	Difference from Current Entry 6S66	Assembly / Oligomeric State	Construct	Mutations and Modifications	Ligands, Ions and Non-polymers	Method and Experimental Conditions	Structure Quality
3L15 Human Tead2 transcriptional factor Deposited 2009-12-10	Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 217–447（231 aa） Fragment：C-terminal residues 217-447	Non-standard monomer：Yes (specific site not provided by mmCIF)	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.4；293 K；0.1 M Tris, 2.5 M Sodium Formate, 100 mM NaCl, 2 mM MgCl2, 1 mM TCEP, 5% (w/v) Glycerol;, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 293K	Resolution 2.00 Å R-free 0.244
3L15 Human Tead2 transcriptional factor Deposited 2009-12-10	Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 217–447（231 aa） Fragment：C-terminal residues 217-447	Non-standard monomer：Yes (specific site not provided by mmCIF)	GOL GLYCEROL × 3	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.4；293 K；0.1 M Tris, 2.5 M Sodium Formate, 100 mM NaCl, 2 mM MgCl2, 1 mM TCEP, 5% (w/v) Glycerol;, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 293K	Resolution 2.00 Å R-free 0.244
5DQ8 Crystal structure of human transcription factor TEAD2 in complex with flufenamic acid Deposited 2015-09-14	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 217–447（231 aa） Fragment：residues 217-447	Not recorded	FLF 2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.2；293 K；0.1 M HEPES pH 7.2, 2.4 M sodium formate	Resolution 2.31 Å R-free 0.232
5DQ8 Crystal structure of human transcription factor TEAD2 in complex with flufenamic acid Deposited 2015-09-14	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 217–447（231 aa） Fragment：residues 217-447	Not recorded	FLF 2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID × 2	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.2；293 K；0.1 M HEPES pH 7.2, 2.4 M sodium formate	Resolution 2.31 Å R-free 0.232
5DQE Crystal structure of human transcription factor TEAD2 in complex with bromo-fenamic acid Deposited 2015-09-14	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 217–447（231 aa） Fragment：residues 217-447	Not recorded	5E4 2-[(3-bromophenyl)amino]benzoic acid × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.2；293 K；0.1 M HEPES pH 7.2 and 2.4 M sodium formate.	Resolution 2.18 Å R-free 0.227
5DQE Crystal structure of human transcription factor TEAD2 in complex with bromo-fenamic acid Deposited 2015-09-14	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 217–447（231 aa） Fragment：residues 217-447	Not recorded	5E4 2-[(3-bromophenyl)amino]benzoic acid × 2	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.2；293 K；0.1 M HEPES pH 7.2 and 2.4 M sodium formate.	Resolution 2.18 Å R-free 0.227
5EMV Crystal structure of the palmitoylated human TEAD2 transcription factor Deposited 2015-11-06	Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 218–446（229 aa） Fragment：YAP binding domain, unp residues 219-435	Non-standard monomer：Yes (specific site not provided by mmCIF)	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.3；292 K；1.7-2.1 M Sodium Formate	Resolution 2.00 Å R-free 0.231
5EMV Crystal structure of the palmitoylated human TEAD2 transcription factor Deposited 2015-11-06	Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 218–446（229 aa） Fragment：YAP binding domain, unp residues 219-435	Non-standard monomer：Yes (specific site not provided by mmCIF)	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.3；292 K；1.7-2.1 M Sodium Formate	Resolution 2.00 Å R-free 0.231
5HGU Crystal structure of human transcription factor TEAD2 in complex with palmitate Deposited 2016-01-08	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 217–447（231 aa） Fragment：residues 217-447	Not recorded	PLM PALMITIC ACID × 1	X-RAY DIFFRACTION X-ray crystallization conditions EVAPORATION；pH 7.2；293 K；0.1 M HEPES pH 7.2, 2.4 M sodium formate	Resolution 2.05 Å R-free 0.222
5HGU Crystal structure of human transcription factor TEAD2 in complex with palmitate Deposited 2016-01-08	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 217–447（231 aa） Fragment：residues 217-447	Not recorded	PLM PALMITIC ACID × 1	X-RAY DIFFRACTION X-ray crystallization conditions EVAPORATION；pH 7.2；293 K；0.1 M HEPES pH 7.2, 2.4 M sodium formate	Resolution 2.05 Å R-free 0.222
6CDY Crystal structure of TEAD complexed with its inhibitor Deposited 2018-02-09	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 217–447（231 aa）	Not recorded	EY1 2-[(4H-1,2,4-triazol-3-yl)sulfanyl]-N-{4-[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]decan-1-yl]phenyl}acetamide × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.2；293 K；0.1 M Hepes, pH 7.2, 2.4 M sodium formate.	Resolution 2.32 Å R-free 0.255
6CDY Crystal structure of TEAD complexed with its inhibitor Deposited 2018-02-09	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 217–447（231 aa）	Not recorded	EY1 2-[(4H-1,2,4-triazol-3-yl)sulfanyl]-N-{4-[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]decan-1-yl]phenyl}acetamide × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.2；293 K；0.1 M Hepes, pH 7.2, 2.4 M sodium formate.	Resolution 2.32 Å R-free 0.255
6E5G Crystal structure of human TEAD2-Yap binding domain covalently bound to an allosteric regulator Deposited 2018-07-20	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 220–450（231 aa）	Not recorded	HUY 1-(2-{[3-(trifluoromethyl)phenyl]amino}phenyl)ethan-1-one × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；294 K；2.4-2.8 M sodium formate, HEPES, pH 7.2- 7.4	Resolution 2.43 Å R-free 0.268
6E5G Crystal structure of human TEAD2-Yap binding domain covalently bound to an allosteric regulator Deposited 2018-07-20	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 220–450（231 aa）	Not recorded	HUY 1-(2-{[3-(trifluoromethyl)phenyl]amino}phenyl)ethan-1-one × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；294 K；2.4-2.8 M sodium formate, HEPES, pH 7.2- 7.4	Resolution 2.43 Å R-free 0.268
6S60 Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor Deposited 2019-07-02	Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 217–447（231 aa）	Not recorded	MYR MYRISTIC ACID × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate	Resolution 2.00 Å R-free 0.228
6S60 Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor Deposited 2019-07-02	Different ligand/ion Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 217–447（231 aa）	Not recorded	MYR MYRISTIC ACID × 1 KX8 4-[3-(3,4-dichlorophenyl)-4-[(phenylmethyl)carbamoyl]pyrazol-1-yl]butanoic acid × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate	Resolution 2.00 Å R-free 0.228
6S64 Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor Deposited 2019-07-02	Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 217–447（231 aa）	Not recorded	MYR MYRISTIC ACID × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate	Resolution 2.22 Å R-free 0.259
6S64 Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor Deposited 2019-07-02	Different ligand/ion Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 217–447（231 aa）	Not recorded	PLM PALMITIC ACID × 1 KXE 3-[3-(3,4-dichlorophenyl)-4-[(phenylmethyl)carbamoyl]pyrazol-1-yl]propanoic acid × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate	Resolution 2.22 Å R-free 0.259
6S69 Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor Deposited 2019-07-02	Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 217–447（231 aa）	Not recorded	MYR MYRISTIC ACID × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate	Resolution 2.15 Å R-free 0.255
6S69 Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor Deposited 2019-07-02	Different ligand/ion Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 217–447（231 aa）	Not recorded	MYR MYRISTIC ACID × 1 KX5 3-[3-(3,4-dichlorophenyl)-4-(2-phenylethylcarbamoyl)pyrazol-1-yl]propanoic acid × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate	Resolution 2.15 Å R-free 0.255
6S6J Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor Deposited 2019-07-03	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric	Chain A 217–447（231 aa） Chain B 217–447（231 aa）	Not recorded	MYR MYRISTIC ACID × 2 KXH ethyl 1-(4-azanylbutyl)-3-(3,4-dichlorophenyl)pyrazole-4-carboxylate × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate	Resolution 2.10 Å R-free 0.231
6UYB Crystal structure of TEAD2 bound to Compound 1 Deposited 2019-11-12	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 221–451（231 aa）	Not recorded	GOL GLYCEROL × 1 QSJ (3R,4R)-1-{3-[(E)-2-(4-chlorophenyl)ethenyl]-4-methoxy-5-methylphenyl}-3,4-dihydroxypyrrolidin-2-one × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；292 K；200 mM potassium/sodium tartrate pH 6.5 20% PEG 3350	Resolution 1.54 Å R-free 0.232
6UYB Crystal structure of TEAD2 bound to Compound 1 Deposited 2019-11-12	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 221–451（231 aa）	Not recorded	QSJ (3R,4R)-1-{3-[(E)-2-(4-chlorophenyl)ethenyl]-4-methoxy-5-methylphenyl}-3,4-dihydroxypyrrolidin-2-one × 1 TRS 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；292 K；200 mM potassium/sodium tartrate pH 6.5 20% PEG 3350	Resolution 1.54 Å R-free 0.232
6UYC Crystal structure of TEAD2 bound to Compound 2 Deposited 2019-11-12	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 221–451（231 aa）	Not recorded	QLV N-{5-[(E)-2-(4,4-difluorocyclohexyl)ethenyl]-6-methoxypyridin-3-yl}methanesulfonamide × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；292 K；200 mM potassium/sodium tartrate pH 6.5 20% PEG 3350	Resolution 1.66 Å R-free 0.216
6UYC Crystal structure of TEAD2 bound to Compound 2 Deposited 2019-11-12	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 221–451（231 aa）	Not recorded	QLV N-{5-[(E)-2-(4,4-difluorocyclohexyl)ethenyl]-6-methoxypyridin-3-yl}methanesulfonamide × 1 TRS 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；292 K；200 mM potassium/sodium tartrate pH 6.5 20% PEG 3350	Resolution 1.66 Å R-free 0.216
6VAH Crystal structure of human TEAD2 transcription factor in complex with Flufenamic acid derivative Deposited 2019-12-17	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 217–447（231 aa）	Not recorded	QZ1 2-fluoro-6-[(3-hexylphenyl)amino]benzoic acid × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；3.5M Na Formate, and 0.1M Bis-Tris Propane pH7.0	Resolution 2.11 Å R-free 0.242
6VAH Crystal structure of human TEAD2 transcription factor in complex with Flufenamic acid derivative Deposited 2019-12-17	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 217–447（231 aa）	Not recorded	QZ1 2-fluoro-6-[(3-hexylphenyl)amino]benzoic acid × 1 UNX UNKNOWN LIGAND × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；3.5M Na Formate, and 0.1M Bis-Tris Propane pH7.0	Resolution 2.11 Å R-free 0.242
7OYJ Crystal structure of hTEAD2 in complex with fragment at the interface 2 Deposited 2021-06-24	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 217–447（231 aa）	Not recorded	PLM PALMITIC ACID × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate	Resolution 1.91 Å R-free 0.222
7OYJ Crystal structure of hTEAD2 in complex with fragment at the interface 2 Deposited 2021-06-24	Different ligand/ion Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 217–447（231 aa）	Not recorded	PLM PALMITIC ACID × 1 3DI 3-(1~{H}-pyrazol-5-yl)aniline × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate	Resolution 1.91 Å R-free 0.222
7T2J Crystal Structure of TEAD2 in a covalent complex with TED-642 Deposited 2021-12-05	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 217–447（231 aa）	Not recorded	E8Y 4-[3-(trifluoromethyl)anilino]-1,3-dihydro-2H-isoindole-2-carbonitrile × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；Sodium Formate 1.8 - 2.4 M Hepes pH 7.2 - 7.4	Resolution 2.70 Å R-free 0.279
7T2J Crystal Structure of TEAD2 in a covalent complex with TED-642 Deposited 2021-12-05	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 217–447（231 aa）	Not recorded	E8Y 4-[3-(trifluoromethyl)anilino]-1,3-dihydro-2H-isoindole-2-carbonitrile × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；Sodium Formate 1.8 - 2.4 M Hepes pH 7.2 - 7.4	Resolution 2.70 Å R-free 0.279
7T2K Crystal Structure of TEAD2 in a covalent complex with TED-661 Deposited 2021-12-05	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 217–447（231 aa）	Not recorded	ED0 4-[2-(trifluoromethyl)anilino]-1,3-dihydro-2H-isoindole-2-carbonitrile × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；Sodium Formate 1.8 M - 2.4 M Hepes pH 7.2 - 7.4	Resolution 2.34 Å R-free 0.286
7T2K Crystal Structure of TEAD2 in a covalent complex with TED-661 Deposited 2021-12-05	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 217–447（231 aa）	Not recorded	ED0 4-[2-(trifluoromethyl)anilino]-1,3-dihydro-2H-isoindole-2-carbonitrile × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；Sodium Formate 1.8 M - 2.4 M Hepes pH 7.2 - 7.4	Resolution 2.34 Å R-free 0.286
7T2L Crystal Structure of TEAD2 in a covalent complex with TED-662 Deposited 2021-12-05	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 217–447（231 aa）	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；Sodium Formate 1.8M - 2.4M HEPES, pH 7.2-7.4	Resolution 2.15 Å R-free 0.257
7T2L Crystal Structure of TEAD2 in a covalent complex with TED-662 Deposited 2021-12-05	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 217–447（231 aa）	Not recorded	EFI (3aR,4R,7aS)-4-[3-(trifluoromethyl)anilino]octahydro-2H-isoindole-2-carbonitrile × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；Sodium Formate 1.8M - 2.4M HEPES, pH 7.2-7.4	Resolution 2.15 Å R-free 0.257
7T2M Crystal Structure of TEAD2 in a covalent complex with TED-664 Deposited 2021-12-05	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 217–447（231 aa）	Not recorded	EGK (3aR,4R,7aS)-4-[2-(trifluoromethyl)anilino]octahydro-2H-isoindole-2-carbonitrile × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；Sodium Formate 1.8M - 2.4M HEPES pH 7.2 - 7.4	Resolution 2.81 Å R-free 0.279
7T2M Crystal Structure of TEAD2 in a covalent complex with TED-664 Deposited 2021-12-05	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 217–447（231 aa）	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；Sodium Formate 1.8M - 2.4M HEPES pH 7.2 - 7.4	Resolution 2.81 Å R-free 0.279
7TYP TEAD2 bound to GNE-7883 Deposited 2022-02-14	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 217–447（231 aa）	Not recorded	TRS 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 KUR (8S)-5-(4-cyclohexylphenyl)-3-[3-(fluoromethyl)azetidine-1-carbonyl]-2-(3-methylpyrazin-2-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.2 M Na/K Tartrate, 0.1 M Bis Tris pH 6.5, 35% PEG 3350	Resolution 1.60 Å R-free 0.216
7TYP TEAD2 bound to GNE-7883 Deposited 2022-02-14	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 217–447（231 aa）	Not recorded	KUR (8S)-5-(4-cyclohexylphenyl)-3-[3-(fluoromethyl)azetidine-1-carbonyl]-2-(3-methylpyrazin-2-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.2 M Na/K Tartrate, 0.1 M Bis Tris pH 6.5, 35% PEG 3350	Resolution 1.60 Å R-free 0.216
7TYQ TEAD2 bound to Compound 1 Deposited 2022-02-14	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 217–447（231 aa）	Not recorded	KUI ethyl (8S)-7-oxo-5-[4-(trifluoromethyl)phenyl]-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylate × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.2 M Na/K Tartrate, 0.1 M Bis Tris pH 6.5, 35% PEG 3350	Resolution 1.88 Å R-free 0.247
7TYQ TEAD2 bound to Compound 1 Deposited 2022-02-14	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 217–447（231 aa）	Not recorded	KUI ethyl (8S)-7-oxo-5-[4-(trifluoromethyl)phenyl]-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylate × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.2 M Na/K Tartrate, 0.1 M Bis Tris pH 6.5, 35% PEG 3350	Resolution 1.88 Å R-free 0.247
7TYU TEAD2 bound to Compound 2 Deposited 2022-02-14	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 217–447（231 aa）	Not recorded	KTF (3R)-1-[(8S)-5-(4-cyclohexylphenyl)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonyl]pyrrolidine-3-carbonitrile × 1 TRS 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.2 M Na/K Tartrate, 0.1 M Bis Tris pH 6.5, 35% PEG 3350	Resolution 1.78 Å R-free 0.230
7TYU TEAD2 bound to Compound 2 Deposited 2022-02-14	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 217–447（231 aa）	Not recorded	KTF (3R)-1-[(8S)-5-(4-cyclohexylphenyl)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonyl]pyrrolidine-3-carbonitrile × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.2 M Na/K Tartrate, 0.1 M Bis Tris pH 6.5, 35% PEG 3350	Resolution 1.78 Å R-free 0.230
8CUH Crystal structure of human TEAD2 complexed with its inhibitor TM2. Deposited 2022-05-17	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 217–447（231 aa）	Not recorded	P0I 4-[3-(2-cyclohexylethoxy)benzoyl]-N-phenylpiperazine-1-carboxamide × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.2；293 K；0.1 M Hepes, pH 7.2, 2.4 M sodium formate.	Resolution 2.40 Å R-free 0.235
8CUH Crystal structure of human TEAD2 complexed with its inhibitor TM2. Deposited 2022-05-17	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 217–447（231 aa）	Not recorded	P0I 4-[3-(2-cyclohexylethoxy)benzoyl]-N-phenylpiperazine-1-carboxamide × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.2；293 K；0.1 M Hepes, pH 7.2, 2.4 M sodium formate.	Resolution 2.40 Å R-free 0.235
8E1O Crystal structure of hTEAD2 bound to a methoxypyridine lipid pocket binder Deposited 2022-08-10	Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 217–447（231 aa）	Mutation：UNP residues 217-447	TRS 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 Y2S 5-methoxy-N-({3-[2-(methylamino)-2-oxoethyl]phenyl}methyl)-4-{(E)-2-[trans-4-(trifluoromethyl)cyclohexyl]ethenyl}pyridine-2-carboxamide × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；292 K；200 mM potassium/sodium tartrate, pH 6.5, 20% PEG3350	Resolution 2.25 Å R-free 0.247
8E1O Crystal structure of hTEAD2 bound to a methoxypyridine lipid pocket binder Deposited 2022-08-10	Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 217–447（231 aa）	Mutation：UNP residues 217-447	Y2S 5-methoxy-N-({3-[2-(methylamino)-2-oxoethyl]phenyl}methyl)-4-{(E)-2-[trans-4-(trifluoromethyl)cyclohexyl]ethenyl}pyridine-2-carboxamide × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；292 K；200 mM potassium/sodium tartrate, pH 6.5, 20% PEG3350	Resolution 2.25 Å R-free 0.247
8P29 TEAD2 in complex with an inhibitor Deposited 2023-05-15	Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 217–447（231 aa）	Not recorded	MYR MYRISTIC ACID × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate	Resolution 2.06 Å R-free 0.240
8P29 TEAD2 in complex with an inhibitor Deposited 2023-05-15	Different ligand/ion Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 217–447（231 aa）	Not recorded	GOL GLYCEROL × 1 WJC 5-methyl-2-[(3-phenylmethoxyphenyl)amino]benzoic acid × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate	Resolution 2.06 Å R-free 0.240
8POJ TEAD2 in complex with an inhibitor Deposited 2023-07-05	Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 217–447（231 aa）	Not recorded	MYR MYRISTIC ACID × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate	Resolution 2.45 Å R-free 0.268
8POJ TEAD2 in complex with an inhibitor Deposited 2023-07-05	Different ligand/ion Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 217–447（231 aa）	Not recorded	ZUL 4-fluoranyl-2-[(3-phenylphenyl)amino]benzoic acid × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate	Resolution 2.45 Å R-free 0.268
8POM TEAD2 in complex with an inhibitor Deposited 2023-07-05	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 217–447（231 aa）	Not recorded	ZUP 2-[[3-(2-phenylethoxy)phenyl]amino]pyridine-3-carboxylic acid × 1 GOL GLYCEROL × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate	Resolution 1.95 Å R-free 0.248
8POM TEAD2 in complex with an inhibitor Deposited 2023-07-05	Different ligand/ion Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 217–447（231 aa）	Not recorded	ZUP 2-[[3-(2-phenylethoxy)phenyl]amino]pyridine-3-carboxylic acid × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate	Resolution 1.95 Å R-free 0.248
8PON TEAD2 in complex with an inhibitor Deposited 2023-07-05	Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 217–447（231 aa）	Not recorded	MYR MYRISTIC ACID × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate	Resolution 2.20 Å R-free 0.254
8PON TEAD2 in complex with an inhibitor Deposited 2023-07-05	Different ligand/ion Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 217–447（231 aa）	Not recorded	ZUT 4-fluoranyl-2-[(3-phenylmethoxyphenyl)amino]benzoic acid × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate	Resolution 2.20 Å R-free 0.254
8PUX TEAD2 with a covalent inhibitor Deposited 2023-07-17	Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 217–447（231 aa）	Not recorded	MYR MYRISTIC ACID × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate	Resolution 2.05 Å R-free 0.261
8PUX TEAD2 with a covalent inhibitor Deposited 2023-07-17	Different ligand/ion Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 217–447（231 aa）	Not recorded	B3F ~{N}-[2-[(3-pentoxyphenyl)amino]phenyl]propanamide × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate	Resolution 2.05 Å R-free 0.261
8PUY TEAD2 with a covalent inhibitor Deposited 2023-07-17	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric	Chain A 217–447（231 aa） Chain B 217–447（231 aa）	Not recorded	F3Y ~{N}-[3-[(3-pentoxyphenyl)amino]phenyl]propanamide × 1 MYR MYRISTIC ACID × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate	Resolution 2.20 Å R-free 0.252
8RXL TEAD2 with an inhibitor Deposited 2024-02-07	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 216–447（232 aa）	Not recorded	A1H3Z 4-(5-phenylmethoxy-1~{H}-indol-3-yl)butan-2-one × 1 GOL GLYCEROL × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；2.8M sodium formate	Resolution 2.29 Å R-free 0.271
8RXL TEAD2 with an inhibitor Deposited 2024-02-07	Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 216–447（232 aa）	Not recorded	A1H3Z 4-(5-phenylmethoxy-1~{H}-indol-3-yl)butan-2-one × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；291 K；2.8M sodium formate	Resolution 2.29 Å R-free 0.271
8RXP TEAD2 with an inhibitor Deposited 2024-02-07	Different ligand/ion Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 217–447（231 aa）	Not recorded	A1H3Y 2-(5-phenylmethoxy-1~{H}-indol-3-yl)ethanol × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate	Resolution 2.49 Å R-free 0.274
8RXP TEAD2 with an inhibitor Deposited 2024-02-07	Different ligand/ion Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 217–447（231 aa）	Not recorded	A1H3Y 2-(5-phenylmethoxy-1~{H}-indol-3-yl)ethanol × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate	Resolution 2.49 Å R-free 0.274
8RXQ TEAD2 with an inhibitor Deposited 2024-02-07	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 217–447（231 aa）	Not recorded	A1H3X ethyl (~{E})-3-(5-phenylmethoxy-1~{H}-indol-3-yl)prop-2-enoate × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；288 K；2.8M sodium formate	Resolution 2.63 Å R-free 0.269
8RXQ TEAD2 with an inhibitor Deposited 2024-02-07	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 217–447（231 aa）	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；288 K；2.8M sodium formate	Resolution 2.63 Å R-free 0.269
8RXV TEAD2 with an inhibitor Deposited 2024-02-08	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 217–447（231 aa）	Not recorded	A1H3W ~{N}-[2-(5-phenylmethoxy-1~{H}-indol-3-yl)ethyl]methanesulfonamide × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；288 K；2.8M sodium formate	Resolution 2.05 Å R-free 0.297
8RXV TEAD2 with an inhibitor Deposited 2024-02-08	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 217–447（231 aa）	Not recorded	A1H3W ~{N}-[2-(5-phenylmethoxy-1~{H}-indol-3-yl)ethyl]methanesulfonamide × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；288 K；2.8M sodium formate	Resolution 2.05 Å R-free 0.297
8RYC TEAD2 with an inhibitor Deposited 2024-02-08	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 217–447（231 aa）	Not recorded	A1H32 5-phenylmethoxy-1~{H}-indole × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；288 K；2.8M sodium formate	Resolution 2.09 Å R-free 0.249
8RYC TEAD2 with an inhibitor Deposited 2024-02-08	Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 217–447（231 aa）	Not recorded	MYR MYRISTIC ACID × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；288 K；2.8M sodium formate	Resolution 2.09 Å R-free 0.249
8YGQ Crystal structure of Human TEAD2 in complex with Cobimetinib Deposited 2024-02-26	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric	Chain A 221–446（226 aa） Chain B 221–446（226 aa）	Not recorded	PLM PALMITIC ACID × 1 EUI [3,4-BIS(FLUORANYL)-2-[(2-FLUORANYL-4-IODANYL-PHENYL)AMINO]PHENYL]-[3-OXIDANYL-3-[(2S)-PIPERIDIN-2-YL]AZETIDIN-1-YL]METHANONE × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；0.1 M HEPS pH 7.0, 2.6 M sodium formate	Resolution 2.71 Å R-free 0.257
9NEO TEAD2 YAP binding domain (YBD) Deposited 2025-02-20	Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric	Chain A 217–447（231 aa） Fragment：UNP Residues 217-447 Chain B 217–447（231 aa） Fragment：UNP Residues 217-447	Not recorded	A1BXX (3R)-3-ethenyl-3-(5-{3-[4-(trifluoromethyl)anilino]pyridin-2-yl}-1,3,4-oxadiazol-2-yl)pyrrolidin-2-one × 2	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；3.1M Na Formate, 100mM HEPES pH 7.5	Resolution 3.13 Å R-free 0.316
9Q1M Crystal structure of human TEAD2 Yap binding domain covalently bound to an allosteric regulator Deposited 2025-08-14	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 217–447（231 aa）	Not recorded	IU8 1-{4-[3-(trifluoromethyl)anilino]-2H-isoindol-2-yl}propan-1-one × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；Sodium Formate 1.8 - 2.4 M Hepes pH 7.2 - 7.4	Resolution 2.60 Å R-free 0.261
9Q1M Crystal structure of human TEAD2 Yap binding domain covalently bound to an allosteric regulator Deposited 2025-08-14	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 217–447（231 aa）	Not recorded	IU8 1-{4-[3-(trifluoromethyl)anilino]-2H-isoindol-2-yl}propan-1-one × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；Sodium Formate 1.8 - 2.4 M Hepes pH 7.2 - 7.4	Resolution 2.60 Å R-free 0.261
9Q1N Crystal structure of human TEAD2-Yap binding domain covalently bound to an allosteric regulator Deposited 2025-08-14	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 217–447（231 aa）	Not recorded	EI2 1-{4-[4-(trifluoromethyl)anilino]-1,3-dihydro-2H-isoindol-2-yl}propan-1-one × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；Sodium Formate 1.8M - 2.4M HEPES pH 7.2 - 7.4	Resolution 2.13 Å R-free 0.248
9Q1N Crystal structure of human TEAD2-Yap binding domain covalently bound to an allosteric regulator Deposited 2025-08-14	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 217–447（231 aa）	Not recorded	EI2 1-{4-[4-(trifluoromethyl)anilino]-1,3-dihydro-2H-isoindol-2-yl}propan-1-one × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；Sodium Formate 1.8M - 2.4M HEPES pH 7.2 - 7.4	Resolution 2.13 Å R-free 0.248
9Q1O Crystal structure of human TEAD2-Yap binding domain covalently bound to an allosteric regulator Deposited 2025-08-14	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 217–447（231 aa）	Not recorded	EI6 1-{(3aS,4R,7aR)-4-[4-(trifluoromethyl)anilino]octahydro-2H-isoindol-2-yl}propan-1-one × 1 FMT FORMIC ACID × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；Sodium Formate 1.8M - 2.4M HEPES pH 7.2 - 7.4	Resolution 2.26 Å R-free 0.266
9Q1O Crystal structure of human TEAD2-Yap binding domain covalently bound to an allosteric regulator Deposited 2025-08-14	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 217–447（231 aa）	Not recorded	EI6 1-{(3aS,4R,7aR)-4-[4-(trifluoromethyl)anilino]octahydro-2H-isoindol-2-yl}propan-1-one × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；Sodium Formate 1.8M - 2.4M HEPES pH 7.2 - 7.4	Resolution 2.26 Å R-free 0.266
9YK2 Crystal structure of TEAD2 with non-covalent aryl ether inhibitor. Deposited 2025-10-06	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain A 217–447（231 aa）	Not recorded	A1CXJ (3P)-N-methyl-3-(1-methyl-1H-pyrazol-4-yl)-4-[4-(trifluoromethyl)phenoxy]benzene-1-sulfonamide × 1	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；277 K；21% PEG 3350, 0.15 M NaSO4, 0.1 M Bis-Tris propane (pH 6.5)	Resolution 2.16 Å R-free 0.288
9YK2 Crystal structure of TEAD2 with non-covalent aryl ether inhibitor. Deposited 2025-10-06	Different ligand/ion Different experimental conditions Different structure-quality metrics	Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric	Chain B 217–447（231 aa）	Not recorded	No recorded non-water small molecule	X-RAY DIFFRACTION X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；277 K；21% PEG 3350, 0.15 M NaSO4, 0.1 M Bis-Tris propane (pH 6.5)	Resolution 2.16 Å R-free 0.288

41 other PDB entries and 78 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence

UniProt name	TEAD2_HUMAN
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 2–232； UniProt 217–447 Author chain B； PDBConstruct 2–232； UniProt 217–447

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

SAXS scattering curve SAXS Profile

P(r) Distance Distribution P(r) Distribution

Download Download SAXS (.dat) P(r) (.pr.out) CIF

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	6s66
Deposition date deposition_date	2019-07-02
Structure title title	Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor
Keywords keywords	TEAD2, Inhibitor, TRANSCRIPTION; TRANSCRIPTION
Experimental Method method	X-RAY DIFFRACTION

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3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier	23.63 Å
Radius of gyration Rg (electron density) rg_electron	22.21 Å
Forward intensity I(0) i0	36473400.00
Molecular weight molecular_weight	47457.0 kDa
Excluded volume excluded_volume	59848 Å³
Envelope volume envelope_volume	71554 Å³
Hydration-shell volume shell_volume	26510 Å³
Envelope diameter envelope_diameter	77.0 Å
Shell Rg shell_rg	29.28 Å
Envelope Rg envelope_rg	22.26 Å
Shape Rg shape_rg	22.23 Å
Total Rg total_rg	23.04 Å
Total atoms total_atoms	3348
Residues n_residues	400
Spherical-harmonic order n_harmonics	20
q range q_range	— – 0.5000 Å⁻¹
Data points n_points	101
Shell type shell_type	directional
Solvent electron density solvent_density	0.3340 e/Å³
Shell contrast contrast_shell	0.0300 e/Å³
CRYSOL version crysol_version	4.1.3

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4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax	75.7 Å
Rg (real space) rg_real	23.49 Å
Rg uncertainty (real space) rg_real_error	0.36 Å
I(0) (real space) i0_real	3.6470e+07
I(0) uncertainty (real space) i0_real_error	4.5230e+05
Rg (reciprocal space) rg_reciprocal	23.52 Å
I(0) (reciprocal space) i0_reciprocal	36470000.0000
Solution quality estimate total_estimate	0.8959
Solution quality rating solution_quality	GOOD a GOOD solution
P(r) peaks n_peaks	2
Primary peak position r_peak_primary	29.6 Å
Skewness Skewness skewness	0.157
Kurtosis Kurtosis kurtosis	-0.466
Angular range angular_range	— – 0.3350 Å⁻¹
Current regularization parameter α current_alpha	0.0001
Highest regularization parameter α highest_alpha	6367000.0000
Real-space data points n_real_points	65
GNOM version gnom_version	4.1.3
Quality Criteria quality_criteria	AN1: 0.000; Oscil: 0.883; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.996; Smooth: 0.998

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5. Crystallography and Experiment 5. Crystallography & Experiment

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6. Entities and Polymers Entities & Polymers (4)

Entity 1 Entity 1 polymer

Description description	Transcriptional enhancer factor TEF-4
Molecular weight formula_weight	27489.1 kDa
Source method src_method	man
Copy count entity_count	2

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,B
Atom count atom_count	3429

MAWQARGLGTARLQLVEFSAFVEPPDAVDSYQRHLFVHISQHCPSPGAPPLESVDVRQIYDKFPEKKGGLRELYDRGPPHAFFLVKFWADLNWGPSGEEAGAGGSISSGGFYGVSSQYESLEHMTLTCSSKVCSFGKQVVEKVETERAQLEDGRFVYRLLRSPMCEYLVNFLHKLRQLPERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQHHIYRLVRDVEHHHHHH

来源 Source

来源生物 organism	Homo sapiens
通用名 common_name	Human
NCBI Class编号 ncbi_taxonomy_id	9606
宿主生物 host_organism	Escherichia coli

Entity 2 Entity 2 non-polymer

Description description	MYRISTIC ACID
Molecular weight formula_weight	228.4 kDa
Source method src_method	syn
Copy count entity_count	2

Entity 3 Entity 3 non-polymer

Description description	1-(2-azanylethyl)-3-(3,4-dichlorophenyl)-~{N}-(phenylmethyl)pyrazole-4-carboxamide
Molecular weight formula_weight	389.3 kDa
Source method src_method	syn
Copy count entity_count	1

Entity 4 Entity 4 water

Description description	water
Molecular weight formula_weight	18.0 kDa
Source method src_method	nat
Copy count entity_count	59

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7. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (2 domains)

Domain ID domain_id	d6s66a_
Class class	b — All beta proteins
Fold Fold fold	b.1 — Immunoglobulin-like beta-sandwich
Superfamily Superfamily superfamily	b.1.18 — E set domains
Family Family family	b.1.18.26 — TEAD-like transcription factors, E-set domain

Domain ID domain_id	d6s66b_
Class class	b — All beta proteins
Fold Fold fold	b.1 — Immunoglobulin-like beta-sandwich
Superfamily Superfamily superfamily	b.1.18 — E set domains
Family Family family	b.1.18.26 — TEAD-like transcription factors, E-set domain

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8. Citations (1)

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Unit-cell length a length_a	122.037 Å
Unit-cell length b length_b	61.569 Å
Unit-cell length c length_c	80.021 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	117.38 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	8

Space group space_group	C 1 2 1
Space-group number int_tables_number	5
Crystal system crystal_system	—

Resolution resolution	2.200 Å
Low-resolution limit resolution_low	71.060 Å
R factor r_factor	0.2047
R_work r_work	0.2017
R_free r_free	0.2624

fit	/app/data/saxs_computation/s6/6s66/6s66.fit
pddf	/app/data/pr_computation/s6/6s66/6s66.pr.out
profile	/app/data/saxs_computation/s6/6s66/6s66.dat