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6tdc

PPAR gamma ligand binding domain in complex with MRL-871

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Peroxisome proliferator-activated receptor gamma

Homo sapiens

UniProt P37231

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 4-{1-[2-chloro-6-(trifluoromethyl)benzoyl]-1H-indazol-3-yl}benzoic acid × 1 GLYCEROL × 1 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1i7i 1i7i 2f4b 2f4b 2om9 2om9 2om9 2om9 2prg 2qmv 2vsr 2vsr

158 assemblies; showing the first 12

Homodimer
1knu 1nyx 1prg 1zeo 2ath 2g0g 2i4j 2i4p 2i4z 2p4y 2pob 2q59

201 assemblies; showing the first 12

Homotetramer
2hwq 2hwr 4em9 4prg 9mah

5 assemblies

Other homooligomers

None

Heteromeric or nucleic-acid complex
1fm6 1fm6 1fm9 1k74 1rdt 1zgy 2fvj 2gtk 2prg 3b1m 3cs8 3cwd

137 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name PPARG_HUMAN
Isoform P37231-2
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 22–292； UniProt 207–477

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6tdc
Deposition date deposition_date2019-11-08
Structure title titlePPAR gamma ligand binding domain in complex with MRL-871
Keywords keywordsNuclear Receptor, NR1C3, Transcription Factor, GENE REGULATION; GENE REGULATION
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6tdc__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6tdc__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6tdc__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）21.14 Å
Rg (electron density)20.15 Å
Total Rg21.13 Å
Atom count2116
Residues260
Excluded volume38311 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6tdc__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (2 domains)

Domain ID domain_idd6tdca1
Class classa — All alpha proteins
Fold Fold folda.123 — Nuclear receptor ligand-binding domain
Superfamily Superfamily superfamilya.123.1 — Nuclear receptor ligand-binding domain
Family Family familya.123.1.1 — Nuclear receptor ligand-binding domain
Domain ID domain_idd6tdca2
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags
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7. Citations (1)