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6uon

Molecular basis for tumor infiltrating TCR recognition of hotspot KRAS-G12D mutation

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

HLA class I antigen

Homo sapiens

UniProt C1K0Y1

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 5 TCR-V-alpha-12-02*01 × 1 TCR-V-beta-10-2*01 × 1 Beta-2-microglobulin × 1 （P61769） GLY-ALA-ASP-GLY-VAL-GLY-LYS-SER-ALA-LEU × 1 （P01111） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 5 TCR-V-alpha-12-02*01 × 1 TCR-V-beta-10-2*01 × 1 Beta-2-microglobulin × 1 （P61769） GLY-ALA-ASP-GLY-VAL-GLY-LYS-SER-ALA-LEU × 1 （P01111） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
6jtn 6jtp 6uli 6ulk 6uln 6ulr 6uon 6uon

8 assemblies

View Construct and Data Evidence
UniProt name C1K0Y1_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain A； PDBConstruct 1–274； UniProt 25–298 Author chain D； PDBConstruct 1–274； UniProt 25–298

Beta-2-microglobulin

Homo sapiens

UniProt P61769

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 5 TCR-V-alpha-12-02*01 × 1 TCR-V-beta-10-2*01 × 1 HLA class I antigen × 1 （C1K0Y1） GLY-ALA-ASP-GLY-VAL-GLY-LYS-SER-ALA-LEU × 1 （P01111） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 5 TCR-V-alpha-12-02*01 × 1 TCR-V-beta-10-2*01 × 1 HLA class I antigen × 1 （C1K0Y1） GLY-ALA-ASP-GLY-VAL-GLY-LYS-SER-ALA-LEU × 1 （P01111） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1jnj 1lds 1py4 1py4 1py4 1py4 2d4d 2d4f 2vb5 2xks 2xku 2yxf

61 assemblies; showing the first 12

Homodimer
2x89 2x89 2z9t 3low 4r9h 4r9h 4ra3 4ra3 4rah 6m1b

10 assemblies

Homotetramer
2e8d 2f8o 3tlr 3tm6 3tm6 7afv

6 assemblies

Other homooligomers
3ciq 3ciq 3loz 6gk3 8a7o 8a7p 8a7q 8a7t

8 assemblies

Heteromeric or nucleic-acid complex
1a1m 1a1n 1a1o 1a6z 1a6z 1a9b 1a9b 1a9e 1agb 1agc 1agd 1age

1914 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name B2MG_HUMAN
Isoform —
PDB entities 4
Chains and sequence ranges Author chain B； PDBConstruct 1–99； UniProt 21–119 Author chain E； PDBConstruct 1–99； UniProt 21–119

GLY-ALA-ASP-GLY-VAL-GLY-LYS-SER-ALA-LEU

OrganismNot specified

UniProt P01111

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 5 TCR-V-alpha-12-02*01 × 1 TCR-V-beta-10-2*01 × 1 HLA class I antigen × 1 （C1K0Y1） Beta-2-microglobulin × 1 （P61769） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 5 TCR-V-alpha-12-02*01 × 1 TCR-V-beta-10-2*01 × 1 HLA class I antigen × 1 （C1K0Y1） Beta-2-microglobulin × 1 （P61769） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2n9c 3con 5uhv 6e6h 6wgh 6wgh 6zir 6ziz 6ziz 7f68 8vm2 8vm2

25 assemblies; showing the first 12

Homodimer
5uhv 6zio

2 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
6uli 6ulk 6uln 6ulr 6uon 6uon 7ow3 7ow3 7ow3 7ow3 7ow4 7ow4

36 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name RASN_HUMAN
Isoform —
PDB entities 5
Chains and sequence ranges Author chain C； PDBConstruct 1–10； UniProt 10–19 Author chain F； PDBConstruct 1–10； UniProt 10–19

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6uon
Deposition date deposition_date2019-10-15
Structure title titleMolecular basis for tumor infiltrating TCR recognition of hotspot KRAS-G12D mutation
Keywords keywordsHLA-C Neoantigen KRAS, IMMUNE SYSTEM; IMMUNE SYSTEM
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6uon__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6uon__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6uon__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）37.61 Å
Rg (electron density)37.87 Å
Total Rg37.99 Å
Atom count6569
Residues817
Excluded volume114780 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6uon__assembly_1__model_1 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 6uon__assembly_2__model_1 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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6. Fold Classification (SCOP + CATH) 8 domains

CATH v4.4 (8 domains)

Domain ID domain_id6uonA01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology500 — Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1
Homologous superfamily homologous superfamily10 — MHC class I-like antigen recognition-like
Domain ID domain_id6uonA02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id6uonB00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id6uonD01
Class class3 — Alpha Beta
Architecture architecture30 — 2-Layer Sandwich
Topology topology500 — Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1
Homologous superfamily homologous superfamily10 — MHC class I-like antigen recognition-like
Domain ID domain_id6uonD02
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id6uonE00
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id6uonH01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
Domain ID domain_id6uonJ01
Class class2 — Mainly Beta
Architecture architecture60 — Sandwich
Topology topology40 — Immunoglobulin-like
Homologous superfamily homologous superfamily10 — Immunoglobulins
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7. Citations (1)