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6wvt

Structural basis of alphaE-catenin - F-actin catch bond behavior

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Actin, alpha skeletal muscle

OrganismNot specified

UniProt P68135

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 12 Catenin alpha-1 × 6 （P26231） MAGNESIUM ION × 6 ADENOSINE-5'-DIPHOSPHATE × 6 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1ijj 1ijj 1j6z 1nwk 1qz5 1s22 1wua 2asm 2aso 2asp 2fxu 2gwj

40 assemblies; showing the first 12

Homodimer
1lcu 1rdw 1rfq 1yxq 2a5x 2gwk 2hmp 2q1n 2q1n 2q31 2q31 2q36

14 assemblies; showing the first 12

Homotetramer
8dmx 8ru0 9fjo

3 assemblies

Other homooligomers
2y83 3b5u 3g37 3j8i 3j8j 3j8k 3mfp 4a7n 5mva 5mvy 5onv 5ooc

42 assemblies; showing the first 12

Heteromeric or nucleic-acid complex
1eqy 1esv 1kxp 1lot 1m8q 1ma9 1mvw 1o18 1o19 1o1a 1o1b 1o1c

255 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name ACTS_RABIT
Isoform —
PDB entities 1
Chains and sequence ranges Author chain B； PDBConstruct 1–377； UniProt 1–377 Author chain D； PDBConstruct 1–377； UniProt 1–377 Author chain E； PDBConstruct 1–377； UniProt 1–377 Author chain F； PDBConstruct 1–377； UniProt 1–377 Author chain H； PDBConstruct 1–377； UniProt 1–377 Author chain I； PDBConstruct 1–377； UniProt 1–377

Catenin alpha-1

Mus musculus

UniProt P26231

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 12 Actin, alpha skeletal muscle × 6 （P68135） MAGNESIUM ION × 6 ADENOSINE-5'-DIPHOSPHATE × 6 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer
1dov 1dov 4k1n 6dv1 6o3e

5 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1dow 4e17 4e18 5y04 6wvt 9dva

6 assemblies

View Construct and Data Evidence
UniProt name CTNA1_MOUSE
Isoform —
PDB entities 2
Chains and sequence ranges Author chain K； PDBConstruct 1–236； UniProt 671–906 Author chain L； PDBConstruct 1–236； UniProt 671–906 Author chain N； PDBConstruct 1–236； UniProt 671–906 Author chain O； PDBConstruct 1–236； UniProt 671–906 Author chain Q； PDBConstruct 1–236； UniProt 671–906 Author chain X； PDBConstruct 1–236； UniProt 671–906

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6wvt
Deposition date deposition_date2020-05-06
Structure title titleStructural basis of alphaE-catenin - F-actin catch bond behavior
Keywords keywordsalphaE-catenin, catch bond, adherens junction, CELL ADHESION; CELL ADHESION
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6wvt__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6wvt__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6wvt__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）56.47 Å
Rg (electron density)56.88 Å
Total Rg56.91 Å
Atom count25248
Residues3234
Excluded volume451210 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6wvt__assembly_1__model_1 dodecameric （12） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 6 domains

CATH v4.4 (6 domains)

Domain ID domain_id6wvtK01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily230 — Alpha-catenin/vinculin-like
Domain ID domain_id6wvtL01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily230 — Alpha-catenin/vinculin-like
Domain ID domain_id6wvtN01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily230 — Alpha-catenin/vinculin-like
Domain ID domain_id6wvtO01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily230 — Alpha-catenin/vinculin-like
Domain ID domain_id6wvtQ01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily230 — Alpha-catenin/vinculin-like
Domain ID domain_id6wvtX01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology120 — Four Helix Bundle (Hemerythrin (Met), subunit A)
Homologous superfamily homologous superfamily230 — Alpha-catenin/vinculin-like
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7. Citations (1)