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7acc

human GTP cyclohydrolase I feedback regulatory protein (GFRP)

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

GTP cyclohydrolase 1 feedback regulatory protein

Homo sapiens

UniProt P30047

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 5 POTASSIUM ION × 5 water × 5 Consistent with protein count
2 Protein homooligomer Homooligomer Protein 5 POTASSIUM ION × 5 water × 5 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers
7acc 7acc 7al9 7al9

4 assemblies

Heteromeric or nucleic-acid complex
6z80 6z85 7ala 7alb 7alb 7alc 7alq 7alq

8 assemblies

View Construct and Data Evidence
UniProt name GFRP_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 3–86； UniProt 1–84 Author chain B； PDBConstruct 3–86； UniProt 1–84 Author chain C； PDBConstruct 3–86； UniProt 1–84 Author chain D； PDBConstruct 3–86； UniProt 1–84 Author chain E； PDBConstruct 3–86； UniProt 1–84 Author chain F； PDBConstruct 3–86； UniProt 1–84 Author chain G； PDBConstruct 3–86； UniProt 1–84 Author chain H； PDBConstruct 3–86； UniProt 1–84 Author chain I； PDBConstruct 3–86； UniProt 1–84 Author chain J； PDBConstruct 3–86； UniProt 1–84

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id7acc
Deposition date deposition_date2020-09-10
Structure title titlehuman GTP cyclohydrolase I feedback regulatory protein (GFRP)
Keywords keywords;GTP cyclohydrolase 1 feedback regulatory protein, regulatory protein, L-phenylalanine binding (Phe) synthesis allosteric regulation, PROTEIN BINDING ;; PROTEIN BINDING
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

7acc__assembly_2__model_1

Assembly 2 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

7acc__assembly_2__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

7acc__assembly_2__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）23.10 Å
Rg (electron density)21.76 Å
Total Rg22.49 Å
Atom count3397
Residues420
Excluded volume60874 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 7acc__assembly_1__model_1 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 7acc__assembly_2__model_1 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 14 domains

SCOP 2.08 (14 domains)

Domain ID domain_idd7acca_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.205 — GTP cyclohydrolase I feedback regulatory protein, GFRP
Superfamily Superfamily superfamilyd.205.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
Family Family familyd.205.1.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
Domain ID domain_idd7accb_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.205 — GTP cyclohydrolase I feedback regulatory protein, GFRP
Superfamily Superfamily superfamilyd.205.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
Family Family familyd.205.1.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
Domain ID domain_idd7accc1
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.205 — GTP cyclohydrolase I feedback regulatory protein, GFRP
Superfamily Superfamily superfamilyd.205.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
Family Family familyd.205.1.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
Domain ID domain_idd7accc2
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags
Domain ID domain_idd7accd_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.205 — GTP cyclohydrolase I feedback regulatory protein, GFRP
Superfamily Superfamily superfamilyd.205.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
Family Family familyd.205.1.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
Domain ID domain_idd7acce1
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.205 — GTP cyclohydrolase I feedback regulatory protein, GFRP
Superfamily Superfamily superfamilyd.205.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
Family Family familyd.205.1.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
Domain ID domain_idd7acce2
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags
Domain ID domain_idd7accf_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.205 — GTP cyclohydrolase I feedback regulatory protein, GFRP
Superfamily Superfamily superfamilyd.205.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
Family Family familyd.205.1.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
Domain ID domain_idd7accg1
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.205 — GTP cyclohydrolase I feedback regulatory protein, GFRP
Superfamily Superfamily superfamilyd.205.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
Family Family familyd.205.1.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
Domain ID domain_idd7accg2
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags
Domain ID domain_idd7acch1
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.205 — GTP cyclohydrolase I feedback regulatory protein, GFRP
Superfamily Superfamily superfamilyd.205.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
Family Family familyd.205.1.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
Domain ID domain_idd7acch2
Class classl — Artifacts
Fold Fold foldl.1 — Tags
Superfamily Superfamily superfamilyl.1.1 — Tags
Family Family familyl.1.1.1 — Tags
Domain ID domain_idd7acci_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.205 — GTP cyclohydrolase I feedback regulatory protein, GFRP
Superfamily Superfamily superfamilyd.205.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
Family Family familyd.205.1.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
Domain ID domain_idd7accj_
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.205 — GTP cyclohydrolase I feedback regulatory protein, GFRP
Superfamily Superfamily superfamilyd.205.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
Family Family familyd.205.1.1 — GTP cyclohydrolase I feedback regulatory protein, GFRP
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7. Citations (1)