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7d49

X-ray crystal Structure of E.coli Dihydrofolate Reductase complexed with folate and NADP+ at pH4.5

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Dihydrofolate reductase

Escherichia coli (strain K12)

UniProt P0ABQ4

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 FOLIC ACID × 1 NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 water × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1dre 1drh 1jom 1ra1 1ra2 1ra3 1ra8 1ra9 1rc4 1rf7 1rg7 1rh3

128 assemblies; showing the first 12

Homodimer
1ddr 1dds 1dhi 1dhj 1dra 1drb 1dyh 1dyi 1dyj 1jol 1rb2 1rb3

20 assemblies; showing the first 12

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
3k74 4eig 4eiz 4eiz 4ej1 4ej1 4fhb 4i13 4i1n

9 assemblies

View Construct and Data Evidence
UniProt name DYR_ECOLI
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–159； UniProt 1–159

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id7d49
Deposition date deposition_date2020-09-23
Structure title titleX-ray crystal Structure of E.coli Dihydrofolate Reductase complexed with folate and NADP+ at pH4.5
Keywords keywordsdihydrofolate, reductase, alpha-beta sandiwitch, NADPH, OXIDOREDUCTASE; OXIDOREDUCTASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

7d49__assembly_1__model_36

Assembly 1 · Model 36 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

7d49__assembly_1__model_36 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

7d49__assembly_1__model_36 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）16.62 Å
Rg (electron density)15.22 Å
Total Rg16.28 Å
Atom count1348
Residues159
Excluded volume23573 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 7d49__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 2 7d49__assembly_1__model_2 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 3 7d49__assembly_1__model_3 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 4 7d49__assembly_1__model_4 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 5 7d49__assembly_1__model_5 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 6 7d49__assembly_1__model_6 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 7 7d49__assembly_1__model_7 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 8 7d49__assembly_1__model_8 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 9 7d49__assembly_1__model_9 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 10 7d49__assembly_1__model_10 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 11 7d49__assembly_1__model_11 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 12 7d49__assembly_1__model_12 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 13 7d49__assembly_1__model_13 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 14 7d49__assembly_1__model_14 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 15 7d49__assembly_1__model_15 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 16 7d49__assembly_1__model_16 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 17 7d49__assembly_1__model_17 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 18 7d49__assembly_1__model_18 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 19 7d49__assembly_1__model_19 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 20 7d49__assembly_1__model_20 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 21 7d49__assembly_1__model_21 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 22 7d49__assembly_1__model_22 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 23 7d49__assembly_1__model_23 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 24 7d49__assembly_1__model_24 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 25 7d49__assembly_1__model_25 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 26 7d49__assembly_1__model_26 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 27 7d49__assembly_1__model_27 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 28 7d49__assembly_1__model_28 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 29 7d49__assembly_1__model_29 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 30 7d49__assembly_1__model_30 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 31 7d49__assembly_1__model_31 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 32 7d49__assembly_1__model_32 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 33 7d49__assembly_1__model_33 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 34 7d49__assembly_1__model_34 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 35 7d49__assembly_1__model_35 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 36 7d49__assembly_1__model_36 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 37 7d49__assembly_1__model_37 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 38 7d49__assembly_1__model_38 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 39 7d49__assembly_1__model_39 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 40 7d49__assembly_1__model_40 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 41 7d49__assembly_1__model_41 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 42 7d49__assembly_1__model_42 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 43 7d49__assembly_1__model_43 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 44 7d49__assembly_1__model_44 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 45 7d49__assembly_1__model_45 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 46 7d49__assembly_1__model_46 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 47 7d49__assembly_1__model_47 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 48 7d49__assembly_1__model_48 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 49 7d49__assembly_1__model_49 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 50 7d49__assembly_1__model_50 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 51 7d49__assembly_1__model_51 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 52 7d49__assembly_1__model_52 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 53 7d49__assembly_1__model_53 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 54 7d49__assembly_1__model_54 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 55 7d49__assembly_1__model_55 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 56 7d49__assembly_1__model_56 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 57 7d49__assembly_1__model_57 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 58 7d49__assembly_1__model_58 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 59 7d49__assembly_1__model_59 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 60 7d49__assembly_1__model_60 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 61 7d49__assembly_1__model_61 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 62 7d49__assembly_1__model_62 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 63 7d49__assembly_1__model_63 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 64 7d49__assembly_1__model_64 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 65 7d49__assembly_1__model_65 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 66 7d49__assembly_1__model_66 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 67 7d49__assembly_1__model_67 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 68 7d49__assembly_1__model_68 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 69 7d49__assembly_1__model_69 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 70 7d49__assembly_1__model_70 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 71 7d49__assembly_1__model_71 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 72 7d49__assembly_1__model_72 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 73 7d49__assembly_1__model_73 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 74 7d49__assembly_1__model_74 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 75 7d49__assembly_1__model_75 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 76 7d49__assembly_1__model_76 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 77 7d49__assembly_1__model_77 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 78 7d49__assembly_1__model_78 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 79 7d49__assembly_1__model_79 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
1 80 7d49__assembly_1__model_80 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 1 domains

SCOP 2.08 (1 domains)

Domain ID domain_idd7d49a_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.71 — Dihydrofolate reductase-like
Superfamily Superfamily superfamilyc.71.1 — Dihydrofolate reductase-like
Family Family familyc.71.1.1 — Dihydrofolate reductases
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7. Citations (1)