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7d8t

MITF bHLHLZ complex with M-box DNA

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Microphthalmia-associated transcription factor,Methionyl-tRNA synthetase beta subunit

Aquifex aeolicus VF5

UniProt O66738

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Homooligomer Protein 2 DNA 2 ;DNA (5'-D(P*GP*GP*GP*AP*CP*AP*CP*AP*TP*GP*TP*TP*AP*CP*AP*G)-3') ; × 1 ;DNA (5'-D(*TP*GP*TP*AP*AP*CP*AP*TP*GP*TP*GP*TP*CP*CP*CP*C)-3') ; × 1 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer

None

Homodimer
1pyb 1pyb 8vtz

3 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
7d8r 7d8r 7d8s 7d8s 7d8t 8vu0

6 assemblies

View Construct and Data Evidence
UniProt name O66738_AQUAE
Isoform —
PDB entities 3
Chains and sequence ranges Author chain A； PDBConstruct 92–195； UniProt 8–111 Author chain B； PDBConstruct 92–195； UniProt 8–111

Microphthalmia-associated transcription factor,Methionyl-tRNA synthetase beta subunit

Aquifex aeolicus VF5

UniProt O75030

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Homooligomer Protein 2 DNA 2 ;DNA (5'-D(P*GP*GP*GP*AP*CP*AP*CP*AP*TP*GP*TP*TP*AP*CP*AP*G)-3') ; × 1 ;DNA (5'-D(*TP*GP*TP*AP*AP*CP*AP*TP*GP*TP*GP*TP*CP*CP*CP*C)-3') ; × 1 Consistent with all polymers

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers
9h5f 9h5h 9h7q 9h7r 9h7s 9h7t

6 assemblies

Heteromeric or nucleic-acid complex
4c7n 7d8r 7d8r 7d8s 7d8s 7d8t 8e1d

7 assemblies

View Construct and Data Evidence
UniProt name MITF_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain A； PDBConstruct 2–91； UniProt 306–395 Author chain B； PDBConstruct 2–91； UniProt 306–395

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id7d8t
Deposition date deposition_date2020-10-09
Structure title titleMITF bHLHLZ complex with M-box DNA
Keywords keywordsTRANSCRIPTION FACTOR, TRANSCRIPTION, TRANSCRIPTION-DNA complex; TRANSCRIPTION/DNA
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

7d8t__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

7d8t__assembly_1__model_1 | I(q)

10-2 10-1 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

7d8t__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）34.42 Å
Rg (electron density)34.06 Å
Total Rg34.47 Å
Atom count3599
Residues430
Excluded volume62058 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 7d8t__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 4 domains

CATH v4.4 (4 domains)

Domain ID domain_id7d8tA01
Class class4 — Few Secondary Structures
Architecture architecture10 — Irregular
Topology topology280 — MYOD Basic-Helix-Loop-Helix Domain, subunit B
Homologous superfamily homologous superfamily10 — Helix-loop-helix DNA-binding domain
Domain ID domain_id7d8tA02
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily140 — Nucleic acid-binding proteins
Domain ID domain_id7d8tB01
Class class4 — Few Secondary Structures
Architecture architecture10 — Irregular
Topology topology280 — MYOD Basic-Helix-Loop-Helix Domain, subunit B
Homologous superfamily homologous superfamily10 — Helix-loop-helix DNA-binding domain
Domain ID domain_id7d8tB02
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology50 — OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homologous superfamily homologous superfamily140 — Nucleic acid-binding proteins
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7. Citations (1)