INSULIN (CHAIN A)
Sus scrofa
State in the Current Structure
| Assembly | Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Associated Components | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|
| 1 | Protein heterocomplex Heteromer Protein × 3 PDB declaration: trimeric（3） Consistent with protein copy count | Chain A； UniProt 88–108 Chain B； UniProt 25–54 | Not recorded | GENERAL PROTAMINE CHAIN × 1 CRS M-CRESOL × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed experimental conditions | Resolution 2.00 Å |
| 10 | Protein heterocomplex Heteromer Protein × 4 PDB declaration: tetrameric（4） Consistent with protein copy count | Chain B； UniProt 25–54 Chain D； UniProt 25–54 Chain F； UniProt 25–54 | Not recorded | GENERAL PROTAMINE CHAIN × 1 ZN ZINC ION × 1 UNL UNKNOWN LIGAND × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed experimental conditions | Resolution 2.00 Å |
| 11 | Protein homooligomer Homooligomer Protein × 4 PDB declaration: tetrameric（4） Consistent with protein copy count | Chain C； UniProt 88–108 Chain D； UniProt 25–54 | Not recorded | CRS M-CRESOL × 2 ZN ZINC ION × 2 UNL UNKNOWN LIGAND × 4 | X-RAY DIFFRACTION mmCIF provides none of the parsed experimental conditions | Resolution 2.00 Å |
| 12 | Protein homooligomer Homooligomer Protein × 2 PDB declaration: dimeric（2） Consistent with protein copy count | Chain A； UniProt 88–108 Chain B； UniProt 25–54 | Not recorded | CRS M-CRESOL × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed experimental conditions | Resolution 2.00 Å |
| 2 | Protein homooligomer Homooligomer Protein × 2 PDB declaration: dimeric（2） Consistent with protein copy count | Chain C； UniProt 88–108 Chain D； UniProt 25–54 | Not recorded | CRS M-CRESOL × 1 ZN ZINC ION × 1 UNL UNKNOWN LIGAND × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed experimental conditions | Resolution 2.00 Å |
| 3 | Protein homooligomer Homooligomer Protein × 2 PDB declaration: dimeric（2） Consistent with protein copy count | Chain E； UniProt 88–108 Chain F； UniProt 25–54 | Not recorded | CRS M-CRESOL × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed experimental conditions | Resolution 2.00 Å |
| 4 | Protein heterocomplex Heteromer Protein × 14 PDB declaration: tetradecameric（14） Consistent with protein copy count | Chain A； UniProt 88–108 Chain B； UniProt 25–54 Chain C； UniProt 88–108 Chain D； UniProt 25–54 Chain E； UniProt 88–108 Chain F； UniProt 25–54 | Not recorded | GENERAL PROTAMINE CHAIN × 2 CRS M-CRESOL × 6 ZN ZINC ION × 2 UNL UNKNOWN LIGAND × 4 | X-RAY DIFFRACTION mmCIF provides none of the parsed experimental conditions | Resolution 2.00 Å |
| 5 | Protein heterocomplex Heteromer Protein × 7 PDB declaration: heptameric（7） Consistent with protein copy count | Chain A； UniProt 88–108 Chain B； UniProt 25–54 Chain C； UniProt 88–108 Chain D； UniProt 25–54 Chain E； UniProt 88–108 Chain F； UniProt 25–54 | Not recorded | GENERAL PROTAMINE CHAIN × 1 CRS M-CRESOL × 3 ZN ZINC ION × 1 UNL UNKNOWN LIGAND × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed experimental conditions | Resolution 2.00 Å |
| 6 | Protein heterocomplex Heteromer Protein × 10 PDB declaration: decameric（10） Consistent with protein copy count | Chain C； UniProt 88–108 Chain D； UniProt 25–54 Chain E； UniProt 88–108 Chain F； UniProt 25–54 | Not recorded | GENERAL PROTAMINE CHAIN × 2 CRS M-CRESOL × 4 ZN ZINC ION × 2 UNL UNKNOWN LIGAND × 4 | X-RAY DIFFRACTION mmCIF provides none of the parsed experimental conditions | Resolution 2.00 Å |
| 7 | Protein homooligomer Homooligomer Protein × 4 PDB declaration: tetrameric（4） Consistent with protein copy count | Chain A； UniProt 88–108 Chain B； UniProt 25–54 | Not recorded | CRS M-CRESOL × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed experimental conditions | Resolution 2.00 Å |
| 8 | Protein heterocomplex Heteromer Protein × 8 PDB declaration: octameric（8） Consistent with protein copy count | Chain B； UniProt 25–54 Chain D； UniProt 25–54 Chain F； UniProt 25–54 | Not recorded | GENERAL PROTAMINE CHAIN × 2 ZN ZINC ION × 2 UNL UNKNOWN LIGAND × 4 | X-RAY DIFFRACTION mmCIF provides none of the parsed experimental conditions | Resolution 2.00 Å |
| 9 | Protein homooligomer Homooligomer Protein × 4 PDB declaration: tetrameric（4） Consistent with protein copy count | Chain C； UniProt 88–108 Chain D； UniProt 25–54 Chain E； UniProt 88–108 Chain F； UniProt 25–54 | Not recorded | CRS M-CRESOL × 2 ZN ZINC ION × 1 UNL UNKNOWN LIGAND × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed experimental conditions | Resolution 2.00 Å |
Other States of the Same Protein in the Database
Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.
| Other PDB | Difference from Current Entry 7INS | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1B17 PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 5.00 COORDINATES) Deposited 1998-11-22 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5；pH 5.00
|
Resolution 1.70 Å R-free 0.219 |
| 1B17 PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 5.00 COORDINATES) Deposited 1998-11-22 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5；pH 5.00
|
Resolution 1.70 Å R-free 0.219 |
| 1B17 PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 5.00 COORDINATES) Deposited 1998-11-22 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5；pH 5.00
|
Resolution 1.70 Å R-free 0.219 |
| 1B18 PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 5.53 COORDINATES) Deposited 1998-11-26 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5.53；pH 5.53
|
Resolution 1.80 Å R-free 0.216 |
| 1B18 PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 5.53 COORDINATES) Deposited 1998-11-26 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5.53；pH 5.53
|
Resolution 1.80 Å R-free 0.216 |
| 1B18 PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 5.53 COORDINATES) Deposited 1998-11-26 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5.53；pH 5.53
|
Resolution 1.80 Å R-free 0.216 |
| 1B19 PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 5.80 COORDINATES) Deposited 1998-11-26 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5.8；pH 5.80
|
Resolution 1.80 Å R-free 0.231 |
| 1B19 PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 5.80 COORDINATES) Deposited 1998-11-26 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5.8；pH 5.80
|
Resolution 1.80 Å R-free 0.231 |
| 1B19 PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 5.80 COORDINATES) Deposited 1998-11-26 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5.8；pH 5.80
|
Resolution 1.80 Å R-free 0.231 |
| 1B2A PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 6.00 COORDINATES) Deposited 1998-11-26 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6；pH 6.00
|
Resolution 1.70 Å R-free 0.230 |
| 1B2A PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 6.00 COORDINATES) Deposited 1998-11-26 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6；pH 6.00
|
Resolution 1.70 Å R-free 0.230 |
| 1B2A PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 6.00 COORDINATES) Deposited 1998-11-26 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6；pH 6.00
|
Resolution 1.70 Å R-free 0.230 |
| 1B2B PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 6.16 COORDINATES) Deposited 1998-11-26 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.16；pH 6.16
|
Resolution 1.80 Å R-free 0.231 |
| 1B2B PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 6.16 COORDINATES) Deposited 1998-11-26 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.16；pH 6.16
|
Resolution 1.80 Å R-free 0.231 |
| 1B2B PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 6.16 COORDINATES) Deposited 1998-11-26 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.16；pH 6.16
|
Resolution 1.80 Å R-free 0.231 |
| 1B2C PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 6.26 COORDINATES) Deposited 1998-11-26 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.26；pH 6.26
|
Resolution 1.80 Å R-free 0.223 |
| 1B2C PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 6.26 COORDINATES) Deposited 1998-11-26 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.26；pH 6.26
|
Resolution 1.80 Å R-free 0.223 |
| 1B2D PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 6.35 COORDINATES) Deposited 1998-11-26 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.35；pH 6.35
|
Resolution 1.70 Å R-free 0.229 |
| 1B2D PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 6.35 COORDINATES) Deposited 1998-11-26 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.35；pH 6.35
|
Resolution 1.70 Å R-free 0.229 |
| 1B2D PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 6.35 COORDINATES) Deposited 1998-11-26 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.35；pH 6.35
|
Resolution 1.70 Å R-free 0.229 |
| 1B2E PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 6.50 COORDINATES) Deposited 1998-11-26 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；pH 6.50
|
Resolution 1.90 Å R-free 0.229 |
| 1B2E PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 6.50 COORDINATES) Deposited 1998-11-26 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；pH 6.50
|
Resolution 1.90 Å R-free 0.229 |
| 1B2E PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 6.50 COORDINATES) Deposited 1998-11-26 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；pH 6.50
|
Resolution 1.90 Å R-free 0.229 |
| 1B2F PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 6.98 COORDINATES) Deposited 1998-11-26 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.98；pH 6.98
|
Resolution 1.90 Å R-free 0.244 |
| 1B2F PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 6.98 COORDINATES) Deposited 1998-11-26 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.98；pH 6.98
|
Resolution 1.90 Å R-free 0.244 |
| 1B2G PH AFFECTS GLU B13 SWITCHING AND SULFATE BINDING IN CUBIC INSULIN CRYSTALS (PH 9.00 COORDINATES) Deposited 1998-11-26 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 9；pH 9.00
|
Resolution 1.80 Å R-free 0.226 |
| 1DEI DESHEPTAPEPTIDE (B24-B30) INSULIN Deposited 1996-05-15 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–47（23 aa）
|
Mutation：CHAIN B, DEL(24-30) Mutation：CHAIN B, DEL(24-30) | No recorded non-water small molecule | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.60 Å R-free 0.215 |
| 1DEI DESHEPTAPEPTIDE (B24-B30) INSULIN Deposited 1996-05-15 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
88–108（21 aa）
Chain D
25–47（23 aa）
|
Mutation：CHAIN B, DEL(24-30) Mutation：CHAIN B, DEL(24-30) | No recorded non-water small molecule | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.60 Å R-free 0.215 |
| 1DEI DESHEPTAPEPTIDE (B24-B30) INSULIN Deposited 1996-05-15 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–47（23 aa）
Chain C
88–108（21 aa）
Chain D
25–47（23 aa）
|
Mutation：CHAIN B, DEL(24-30) Mutation：CHAIN B, DEL(24-30) Mutation：CHAIN B, DEL(24-30) Mutation：CHAIN B, DEL(24-30) | No recorded non-water small molecule | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.60 Å R-free 0.215 |
| 1IZA ROLE OF B13 GLU IN INSULIN ASSEMBLY: THE HEXAMER STRUCTURE OF RECOMBINANT MUTANT (B13 GLU-> GLN) INSULIN Deposited 1992-10-16 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–53（29 aa）
|
Mutation：E13Q | No recorded non-water small molecule | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1IZA ROLE OF B13 GLU IN INSULIN ASSEMBLY: THE HEXAMER STRUCTURE OF RECOMBINANT MUTANT (B13 GLU-> GLN) INSULIN Deposited 1992-10-16 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
88–108（21 aa）
Chain D
25–53（29 aa）
|
Mutation：E13Q | No recorded non-water small molecule | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1IZA ROLE OF B13 GLU IN INSULIN ASSEMBLY: THE HEXAMER STRUCTURE OF RECOMBINANT MUTANT (B13 GLU-> GLN) INSULIN Deposited 1992-10-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric |
Chain A
88–108（21 aa）
Chain B
25–53（29 aa）
Chain C
88–108（21 aa）
Chain D
25–53（29 aa）
|
Mutation：E13Q Mutation：E13Q | No recorded non-water small molecule | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1IZA ROLE OF B13 GLU IN INSULIN ASSEMBLY: THE HEXAMER STRUCTURE OF RECOMBINANT MUTANT (B13 GLU-> GLN) INSULIN Deposited 1992-10-16 | Different construct Different mutation/modification Different ligand/ion Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–53（29 aa）
Chain C
88–108（21 aa）
Chain D
25–53（29 aa）
|
Mutation：E13Q Mutation：E13Q | No recorded non-water small molecule | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1IZB ROLE OF B13 GLU IN INSULIN ASSEMBLY: THE HEXAMER STRUCTURE OF RECOMBINANT MUTANT (B13 GLU-> GLN) INSULIN Deposited 1992-10-16 | Different construct Different mutation/modification Different ligand/ion | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–53（29 aa）
|
Mutation：E13Q | ZN ZINC ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 1IZB ROLE OF B13 GLU IN INSULIN ASSEMBLY: THE HEXAMER STRUCTURE OF RECOMBINANT MUTANT (B13 GLU-> GLN) INSULIN Deposited 1992-10-16 | Different construct Different mutation/modification Different ligand/ion | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
88–108（21 aa）
Chain D
25–53（29 aa）
|
Mutation：E13Q | ZN ZINC ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 1IZB ROLE OF B13 GLU IN INSULIN ASSEMBLY: THE HEXAMER STRUCTURE OF RECOMBINANT MUTANT (B13 GLU-> GLN) INSULIN Deposited 1992-10-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion | Assembly 3 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric |
Chain A
88–108（21 aa）
Chain B
25–53（29 aa）
Chain C
88–108（21 aa）
Chain D
25–53（29 aa）
|
Mutation：E13Q Mutation：E13Q | ZN ZINC ION × 6 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 1IZB ROLE OF B13 GLU IN INSULIN ASSEMBLY: THE HEXAMER STRUCTURE OF RECOMBINANT MUTANT (B13 GLU-> GLN) INSULIN Deposited 1992-10-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion | Assembly 4 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric |
Chain A
88–108（21 aa）
Chain B
25–53（29 aa）
Chain C
88–108（21 aa）
Chain D
25–53（29 aa）
|
Mutation：E13Q Mutation：E13Q | ZN ZINC ION × 6 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 1IZB ROLE OF B13 GLU IN INSULIN ASSEMBLY: THE HEXAMER STRUCTURE OF RECOMBINANT MUTANT (B13 GLU-> GLN) INSULIN Deposited 1992-10-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion | Assembly 5 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
88–108（21 aa）
Chain B
25–53（29 aa）
|
Mutation：E13Q | ZN ZINC ION × 3 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 1IZB ROLE OF B13 GLU IN INSULIN ASSEMBLY: THE HEXAMER STRUCTURE OF RECOMBINANT MUTANT (B13 GLU-> GLN) INSULIN Deposited 1992-10-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion | Assembly 6 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain C
88–108（21 aa）
Chain D
25–53（29 aa）
|
Mutation：E13Q | ZN ZINC ION × 3 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 1IZB ROLE OF B13 GLU IN INSULIN ASSEMBLY: THE HEXAMER STRUCTURE OF RECOMBINANT MUTANT (B13 GLU-> GLN) INSULIN Deposited 1992-10-16 | Different construct Different mutation/modification Different ligand/ion | Assembly 7 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–53（29 aa）
Chain C
88–108（21 aa）
Chain D
25–53（29 aa）
|
Mutation：E13Q Mutation：E13Q | ZN ZINC ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 1IZB ROLE OF B13 GLU IN INSULIN ASSEMBLY: THE HEXAMER STRUCTURE OF RECOMBINANT MUTANT (B13 GLU-> GLN) INSULIN Deposited 1992-10-16 | Different construct Different mutation/modification Different ligand/ion | Assembly 8 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–53（29 aa）
Chain C
88–108（21 aa）
Chain D
25–53（29 aa）
|
Mutation：E13Q Mutation：E13Q | ZN ZINC ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 1M5A Crystal Structure of 2-Co(2+)-Insulin at 1.2A Resolution Deposited 2002-07-09 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | CO COBALT (II) ION × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
SLOW COOLING；pH 6.3；300 K；cobalt acetate, trisodium citrate, acetone, hydrochloric acid, pH 6.3, SLOW COOLING, temperature 300K
|
Resolution 1.20 Å R-free 0.241 |
| 1MPJ X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL Deposited 1995-09-13 | Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | IPH PHENOL × 1 ZN ZINC ION × 1 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.30 Å |
| 1MPJ X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL Deposited 1995-09-13 | Different ligand/ion Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 1 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.30 Å |
| 1MPJ X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL Deposited 1995-09-13 | Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | IPH PHENOL × 3 ZN ZINC ION × 6 CL CHLORIDE ION × 6 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.30 Å |
| 1MPJ X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL Deposited 1995-09-13 | Different ligand/ion Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | IPH PHENOL × 1 ZN ZINC ION × 2 CL CHLORIDE ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.30 Å |
| 1MPJ X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL Deposited 1995-09-13 | Different ligand/ion Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | IPH PHENOL × 1 ZN ZINC ION × 2 CL CHLORIDE ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.30 Å |
| 1MPJ X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL Deposited 1995-09-13 | Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 6 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | IPH PHENOL × 3 ZN ZINC ION × 3 CL CHLORIDE ION × 3 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.30 Å |
| 1MPJ X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL Deposited 1995-09-13 | Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 7 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 3 CL CHLORIDE ION × 3 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.30 Å |
| 1SDB PORCINE DESB1-2 DESPENTAPEPTIDE(B26-B30) INSULIN Deposited 1996-01-29 | Different construct Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
27–49（23 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.65 Å R-free 0.220 |
| 1WAV CRYSTAL STRUCTURE OF FORM B MONOCLINIC CRYSTAL OF INSULIN Deposited 1996-02-28 | Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | IPH PHENOL × 1 ZN ZINC ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1WAV CRYSTAL STRUCTURE OF FORM B MONOCLINIC CRYSTAL OF INSULIN Deposited 1996-02-28 | Different ligand/ion Different structure-quality metrics | Assembly 10 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | IPH PHENOL × 2 ZN ZINC ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1WAV CRYSTAL STRUCTURE OF FORM B MONOCLINIC CRYSTAL OF INSULIN Deposited 1996-02-28 | Different ligand/ion Different structure-quality metrics | Assembly 11 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain E
88–108（21 aa）
Chain F
25–54（30 aa）
Chain G
88–108（21 aa）
Chain H
25–54（30 aa）
|
Not recorded | IPH PHENOL × 3 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1WAV CRYSTAL STRUCTURE OF FORM B MONOCLINIC CRYSTAL OF INSULIN Deposited 1996-02-28 | Different ligand/ion Different structure-quality metrics | Assembly 12 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain I
88–108（21 aa）
Chain J
25–54（30 aa）
Chain K
88–108（21 aa）
Chain L
25–54（30 aa）
|
Not recorded | IPH PHENOL × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1WAV CRYSTAL STRUCTURE OF FORM B MONOCLINIC CRYSTAL OF INSULIN Deposited 1996-02-28 | Different ligand/ion Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | IPH PHENOL × 1 ZN ZINC ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1WAV CRYSTAL STRUCTURE OF FORM B MONOCLINIC CRYSTAL OF INSULIN Deposited 1996-02-28 | Different ligand/ion Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
88–108（21 aa）
Chain F
25–54（30 aa）
|
Not recorded | IPH PHENOL × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1WAV CRYSTAL STRUCTURE OF FORM B MONOCLINIC CRYSTAL OF INSULIN Deposited 1996-02-28 | Different ligand/ion Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
88–108（21 aa）
Chain H
25–54（30 aa）
|
Not recorded | IPH PHENOL × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1WAV CRYSTAL STRUCTURE OF FORM B MONOCLINIC CRYSTAL OF INSULIN Deposited 1996-02-28 | Different ligand/ion Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
88–108（21 aa）
Chain J
25–54（30 aa）
|
Not recorded | IPH PHENOL × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1WAV CRYSTAL STRUCTURE OF FORM B MONOCLINIC CRYSTAL OF INSULIN Deposited 1996-02-28 | Different ligand/ion Different structure-quality metrics | Assembly 6 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain K
88–108（21 aa）
Chain L
25–54（30 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1WAV CRYSTAL STRUCTURE OF FORM B MONOCLINIC CRYSTAL OF INSULIN Deposited 1996-02-28 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 7 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
Chain E
88–108（21 aa）
Chain F
25–54（30 aa）
Chain G
88–108（21 aa）
Chain H
25–54（30 aa）
Chain I
88–108（21 aa）
Chain J
25–54（30 aa）
Chain K
88–108（21 aa）
Chain L
25–54（30 aa）
|
Not recorded | IPH PHENOL × 6 ZN ZINC ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1WAV CRYSTAL STRUCTURE OF FORM B MONOCLINIC CRYSTAL OF INSULIN Deposited 1996-02-28 | Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 8 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain E
88–108（21 aa）
Chain F
25–54（30 aa）
Chain I
88–108（21 aa）
Chain J
25–54（30 aa）
|
Not recorded | IPH PHENOL × 3 ZN ZINC ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1WAV CRYSTAL STRUCTURE OF FORM B MONOCLINIC CRYSTAL OF INSULIN Deposited 1996-02-28 | Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 9 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
Chain G
88–108（21 aa）
Chain H
25–54（30 aa）
Chain K
88–108（21 aa）
Chain L
25–54（30 aa）
|
Not recorded | IPH PHENOL × 3 ZN ZINC ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1ZEI CROSS-LINKED B28 ASP INSULIN Deposited 1998-07-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
1–51（51 aa）
Chain B
1–51（51 aa）
Chain C
1–51（51 aa）
Chain D
1–51（51 aa）
Chain E
1–51（51 aa）
Chain F
1–51（51 aa）
|
Mutation：P28D Mutation：P28D Mutation：P28D Mutation：P28D Mutation：P28D Mutation：P28D | CRS M-CRESOL × 8 ZN ZINC ION × 2 CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.4；pH 6.4
|
Resolution 1.90 Å R-free 0.232 |
| 1ZNI INSULIN Deposited 1997-09-23 | Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 2 CL CHLORIDE ION × 3 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.50 Å |
| 1ZNI INSULIN Deposited 1997-09-23 | Different ligand/ion Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.50 Å |
| 1ZNI INSULIN Deposited 1997-09-23 | Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 9 CL CHLORIDE ION × 9 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.50 Å |
| 1ZNI INSULIN Deposited 1997-09-23 | Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 9 CL CHLORIDE ION × 9 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.50 Å |
| 1ZNI INSULIN Deposited 1997-09-23 | Different ligand/ion Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 3 CL CHLORIDE ION × 3 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.50 Å |
| 1ZNI INSULIN Deposited 1997-09-23 | Different ligand/ion Different structure-quality metrics | Assembly 6 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 3 CL CHLORIDE ION × 3 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.50 Å |
| 1ZNI INSULIN Deposited 1997-09-23 | Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 7 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 6 CL CHLORIDE ION × 9 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.50 Å |
| 1ZNI INSULIN Deposited 1997-09-23 | Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 8 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 3 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.50 Å |
| 2EFA Neutron crystal structure of cubic insulin at pD6.6 Deposited 2007-02-22 | Different construct Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Fragment：Insulin A chain
Chain B
25–54（30 aa）
Fragment：Insulin B chain
|
Not recorded | No recorded non-water small molecule |
NEUTRON DIFFRACTION
X-ray crystallization conditions
MICRODIALYSIS；pH 6.6；298 K；0.2M Sodium phosphate, 8mM 3NaEDTA, pH 6.6(PD), MICRODIALYSIS, temperature 298K
|
Resolution 2.70 Å R-free 0.291 |
| 2EFA Neutron crystal structure of cubic insulin at pD6.6 Deposited 2007-02-22 | Different construct Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Fragment：Insulin A chain
Chain B
25–54（30 aa）
Fragment：Insulin B chain
|
Not recorded | No recorded non-water small molecule |
NEUTRON DIFFRACTION
X-ray crystallization conditions
MICRODIALYSIS；pH 6.6；298 K；0.2M Sodium phosphate, 8mM 3NaEDTA, pH 6.6(PD), MICRODIALYSIS, temperature 298K
|
Resolution 2.70 Å R-free 0.291 |
| 2G4M Insulin collected at 2.0 A wavelength Deposited 2006-02-22 | Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.80 Å R-free 0.223 |
| 2G4M Insulin collected at 2.0 A wavelength Deposited 2006-02-22 | Different ligand/ion Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.80 Å R-free 0.223 |
| 2TCI X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL Deposited 1995-09-13 | Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | SCN THIOCYANATE ION × 1 ZN ZINC ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.80 Å |
| 2TCI X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL Deposited 1995-09-13 | Different ligand/ion Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.80 Å |
| 2ZPP Neutron crystal structure of cubic insulin at pD9 Deposited 2008-07-26 | Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | No recorded non-water small molecule |
NEUTRON DIFFRACTION
X-ray crystallization conditions
MICRODIALYSIS；pH 9；298 K；0.2M sodium phosphate, 10mM 3NaEDTA, pH 9.0, MICRODIALYSIS, temperature 298K
|
Resolution 2.50 Å R-free 0.260 |
| 3FHP A neutron crystallographic analysis of a porcine 2Zn insulin at 2.0 A resolution Deposited 2008-12-09 | Different construct Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric |
Chain A
88–108（21 aa）
Fragment：UNP residues 88-108
Chain B
25–54（30 aa）
Fragment：UNP residues 25-54
Chain C
88–108（21 aa）
Fragment：UNP residues 88-108
Chain D
25–54（30 aa）
Fragment：UNP residues 25-54
|
Not recorded | ZN ZINC ION × 6 |
NEUTRON DIFFRACTION
X-ray crystallization conditions
LIQUID DIFFUSION；pH 6.3；293 K；2.3mg/ml insulin, 50mM sodium citrate, 6mM zinc acetate, 17% acetone, pH6.3, LIQUID DIFFUSION, temperature 293K
|
Resolution 2.00 Å R-free 0.247 |
| 3GKY The Structural Basis of an ER Stress-Associated Bottleneck in a Protein Folding Landscape Deposited 2009-03-11 | Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 6 CL CHLORIDE ION × 6 IPH PHENOL × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.1；298 K；0.02 M Tris, 0.05 M sodium citrate, 5% acetone, 0.03% phenol, 0.01% zinc acetate, pH 8.1, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.80 Å R-free 0.253 |
| 3INS STRUCTURE OF INSULIN. RESULTS OF JOINT NEUTRON AND X-RAY REFINEMENT Deposited 1988-10-14 | Different ligand/ion Different experimental method Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 1 | Experimental method not declared mmCIF provides none of the parsed conditions | Resolution not provided |
| 3INS STRUCTURE OF INSULIN. RESULTS OF JOINT NEUTRON AND X-RAY REFINEMENT Deposited 1988-10-14 | Different ligand/ion Different experimental method Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 1 | Experimental method not declared mmCIF provides none of the parsed conditions | Resolution not provided |
| 3INS STRUCTURE OF INSULIN. RESULTS OF JOINT NEUTRON AND X-RAY REFINEMENT Deposited 1988-10-14 | Different oligomeric state Different ligand/ion Different experimental method Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 6 | Experimental method not declared mmCIF provides none of the parsed conditions | Resolution not provided |
| 3INS STRUCTURE OF INSULIN. RESULTS OF JOINT NEUTRON AND X-RAY REFINEMENT Deposited 1988-10-14 | Different oligomeric state Different ligand/ion Different experimental method Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 6 | Experimental method not declared mmCIF provides none of the parsed conditions | Resolution not provided |
| 3MTH X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL Deposited 1995-09-13 | Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | MPB 4-HYDROXY-BENZOIC ACID METHYL ESTER × 1 ZN ZINC ION × 1 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.90 Å |
| 3MTH X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL Deposited 1995-09-13 | Different ligand/ion Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 1 CL CHLORIDE ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.90 Å |
| 3MTH X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL Deposited 1995-09-13 | Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | MPB 4-HYDROXY-BENZOIC ACID METHYL ESTER × 3 ZN ZINC ION × 6 CL CHLORIDE ION × 6 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.90 Å |
| 3MTH X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL Deposited 1995-09-13 | Different ligand/ion Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | MPB 4-HYDROXY-BENZOIC ACID METHYL ESTER × 1 ZN ZINC ION × 2 CL CHLORIDE ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.90 Å |
| 3MTH X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL Deposited 1995-09-13 | Different ligand/ion Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | MPB 4-HYDROXY-BENZOIC ACID METHYL ESTER × 1 ZN ZINC ION × 2 CL CHLORIDE ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.90 Å |
| 3MTH X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL Deposited 1995-09-13 | Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 6 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 3 CL CHLORIDE ION × 3 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.90 Å |
| 3MTH X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL Deposited 1995-09-13 | Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 7 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | MPB 4-HYDROXY-BENZOIC ACID METHYL ESTER × 3 ZN ZINC ION × 3 CL CHLORIDE ION × 3 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.90 Å |
| 3RTO Acoustically mounted porcine insulin microcrystals yield an X-ray SAD structure Deposited 2011-05-03 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric |
Chain A
88–108（21 aa）
Fragment：Insulin A chain (UNP residues 88-108)
Chain B
25–54（30 aa）
Fragment：Insulin B chain (UNP residues 25-54)
Chain C
88–108（21 aa）
Fragment：Insulin A chain (UNP residues 88-108)
Chain D
25–54（30 aa）
Fragment：Insulin B chain (UNP residues 25-54)
|
Not recorded | ZN ZINC ION × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
SMALL TUBES；pH 6；Microcrystals are obtained by dissolving 0.025 g protein in 5 mL of crystallizing solution (200 mL 0.02 M HCl, 100 mL 0.20 M sodium citrate, 60 mL acetone, 20 mL water, 20 mL 0.12 M zinc sulfate) at 315K. The solution is then rapidly quenched to 293K by immersing it in a cool water bath. Quenching speed determines the resulting crystal size. 20-micron crystals are obtained by quenching in a 293K water bath, 10-micron crystals by quenching in a 283K water bath, and 5-micron crystals by quenching in ice water. pH 6.0, SMALL TUBES
|
Resolution 1.80 Å R-free 0.223 |
| 3T2A TMAO-grown cubic insulin (porcine) Deposited 2011-07-22 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | TMO trimethylamine oxide × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；298 K；Protein: 10 mg/mL in 50 mM CAPS pH 11;
Well: 1.2 M TMAO, 0.1 M malate, pH 5.5
, VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
Resolution 2.10 Å R-free 0.223 |
| 3T2A TMAO-grown cubic insulin (porcine) Deposited 2011-07-22 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | TMO trimethylamine oxide × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.5；298 K；Protein: 10 mg/mL in 50 mM CAPS pH 11;
Well: 1.2 M TMAO, 0.1 M malate, pH 5.5
, VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
Resolution 2.10 Å R-free 0.223 |
| 4A7E X-ray crystal structure of porcine insulin flash-cooled at high pressure Deposited 2011-11-14 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 10；0.5 M SODIUM PHOSPHATE, 0.01 M EDTA, PH 10.0
|
Resolution 1.86 Å R-free 0.217 |
| 4INS THE STRUCTURE OF 2ZN PIG INSULIN CRYSTALS AT 1.5 ANGSTROMS RESOLUTION Deposited 1989-07-10 | Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.50 Å |
| 4INS THE STRUCTURE OF 2ZN PIG INSULIN CRYSTALS AT 1.5 ANGSTROMS RESOLUTION Deposited 1989-07-10 | Different ligand/ion Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.50 Å |
| 4INS THE STRUCTURE OF 2ZN PIG INSULIN CRYSTALS AT 1.5 ANGSTROMS RESOLUTION Deposited 1989-07-10 | Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 12 PDB declaration: dodecameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 6 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.50 Å |
| 4INS THE STRUCTURE OF 2ZN PIG INSULIN CRYSTALS AT 1.5 ANGSTROMS RESOLUTION Deposited 1989-07-10 | Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 3 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.50 Å |
| 4INS THE STRUCTURE OF 2ZN PIG INSULIN CRYSTALS AT 1.5 ANGSTROMS RESOLUTION Deposited 1989-07-10 | Different oligomeric state Different ligand/ion Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 3 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.50 Å |
| 4INS THE STRUCTURE OF 2ZN PIG INSULIN CRYSTALS AT 1.5 ANGSTROMS RESOLUTION Deposited 1989-07-10 | Different ligand/ion Different structure-quality metrics | Assembly 6 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.50 Å |
| 4INS THE STRUCTURE OF 2ZN PIG INSULIN CRYSTALS AT 1.5 ANGSTROMS RESOLUTION Deposited 1989-07-10 | Different ligand/ion Different structure-quality metrics | Assembly 7 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
Chain C
88–108（21 aa）
Chain D
25–54（30 aa）
|
Not recorded | ZN ZINC ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.50 Å |
| 5D52 In meso in situ serial X-ray crystallography structure of insulin at room temperature Deposited 2015-08-10 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | PO4 PHOSPHATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIPIDIC CUBIC PHASE；293 K；0.1-0.2 M sodium phosphate, pH 5.5-6.1, and 33-38 %(w/v) PEG400
|
Resolution 1.80 Å R-free 0.214 |
| 5D53 In meso in situ serial X-ray crystallography structure of insulin at 100 K Deposited 2015-08-10 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | PO4 PHOSPHATE ION × 2 PE5 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIPIDIC CUBIC PHASE；293 K；0.1-0.2 M sodium phosphate, pH 5.5-6.1, and 33-38 %(w/v) PEG400
|
Resolution 1.50 Å R-free 0.170 |
| 5D54 In meso X-ray crystallography structure of insulin at 100 K Deposited 2015-08-10 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | PO4 PHOSPHATE ION × 2 PE5 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIPIDIC CUBIC PHASE；293 K；0.1-0.2 M sodium phosphate, pH 5.5-6.1, and 33-38 %(w/v) PEG400
|
Resolution 1.50 Å R-free 0.188 |
| 5D5E In meso in situ serial X-ray crystallography structure of insulin by sulfur-SAD at 100 K Deposited 2015-08-10 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | PO4 PHOSPHATE ION × 2 PE5 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
LIPIDIC CUBIC PHASE；293 K；0.1-0.2 M sodium phosphate, pH 5.5-6.1, and 33-38 %(w/v) PEG400
|
Resolution 2.41 Å R-free 0.220 |
| 5FB6 Room-temperature macromolecular crystallography using a micro-patterned silicon chip with minimal background scattering Deposited 2015-12-14 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；0.6 M Na2HPO4 0.01 M EDTA
|
Resolution 1.90 Å R-free 0.173 |
| 5LIS Insulin solved by Native SAD from a dataset collected in one second Deposited 2016-07-15 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；30% ethylene glycol
|
Resolution 2.29 Å R-free 0.262 |
| 6INS X-RAY ANALYSIS OF THE SINGLE CHAIN B29-A1 PEPTIDE-LINKED INSULIN MOLECULE. A COMPLETELY INACTIVE ANALOGUE Deposited 1992-11-25 | Different construct Different ligand/ion | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
25–53（29 aa）
Chain E
88–108（21 aa）
Chain F
25–53（29 aa）
Chain F
88–108（21 aa）
|
Not recorded | ZN ZINC ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 6INS X-RAY ANALYSIS OF THE SINGLE CHAIN B29-A1 PEPTIDE-LINKED INSULIN MOLECULE. A COMPLETELY INACTIVE ANALOGUE Deposited 1992-11-25 | Different construct Different oligomeric state Different ligand/ion | Assembly 2 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric |
Chain E
25–53（29 aa）
Chain E
88–108（21 aa）
Chain F
25–53（29 aa）
Chain F
88–108（21 aa）
|
Not recorded | ZN ZINC ION × 6 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.00 Å |
| 6Z7Z Porcine insulin in complex with the analytical antibody OXI-005 Fab Deposited 2020-06-02 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain G
88–108（21 aa）
Chain H
25–54（30 aa）
|
Not recorded | MG MAGNESIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M magnesium chloride, 20 % (w/v) PEG 3350
|
Resolution 2.40 Å R-free 0.259 |
| 6Z7Z Porcine insulin in complex with the analytical antibody OXI-005 Fab Deposited 2020-06-02 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain E
88–108（21 aa）
Chain F
25–54（30 aa）
|
Not recorded | MG MAGNESIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M magnesium chloride, 20 % (w/v) PEG 3350
|
Resolution 2.40 Å R-free 0.259 |
| 7AC4 Structure of insulin collected by rotation serial crystallography on a COC membrane at a synchrotron source Deposited 2020-09-09 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | PGR R-1,2-PROPANEDIOL × 1 NA SODIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；50mM Na2HPO4, 10mM EDTA pH 10.8
|
Resolution 1.46 Å R-free 0.180 |
| 9INS MONOVALENT CATION BINDING IN CUBIC INSULIN CRYSTALS Deposited 1991-10-23 | Different ligand/ion Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.70 Å |
| 9INS MONOVALENT CATION BINDING IN CUBIC INSULIN CRYSTALS Deposited 1991-10-23 | Different ligand/ion Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric |
Chain A
88–108（21 aa）
Chain B
25–54（30 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 1.70 Å |
41 other PDB entries and 115 assemblies. Open the comparison page and filter oligomeric states
View Construct and Data Evidence
| UniProt name | INS_PIG |
| Isoform | — |
| PDB entities | 1, 2 |
| Chains and sequence ranges | Author chain A； PDBConstruct 1–21； UniProt 88–108 Author chain C； PDBConstruct 1–21； UniProt 88–108 Author chain E； PDBConstruct 1–21； UniProt 88–108 Author chain B； PDBConstruct 1–30； UniProt 25–54 Author chain D； PDBConstruct 1–30； UniProt 25–54 Author chain F； PDBConstruct 1–30； UniProt 25–54 |