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7r7p

Immature HIV-1 CACTD-SP1 lattice with Bevirimat (BVM) and Inositol hexakisphosphate (IP6)

Method: SOLID-STATE NMR Dmax: 80.0 Å Quality: EXCELLENT
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Gag polyprotein

Human immunodeficiency virus 1

UniProt Q72497

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein homooligomer Homooligomer Protein × 6 PDB declaration: hexameric（6） Consistent with protein copy count Chain G； UniProt 278–377 Chain H； UniProt 278–377 Chain I； UniProt 278–377 Chain J； UniProt 278–377 Chain K； UniProt 278–377 Chain L； UniProt 278–377 Mutation：P241T IHP INOSITOL HEXAKISPHOSPHATE × 1 2I4 3alpha-[(3-carboxy-3-methylbutanoyl)oxy]-8alpha,9beta,10alpha,13alpha,17alpha,19beta-lup-20(29)-en-28-oic acid × 1 SOLID-STATE NMR NMR measurement conditions：pH 8；277.15 K；Ionic strength (raw mmCIF value) 250；Pressure 1 NMR measurement conditions：pH 8；263.15 K；Ionic strength (raw mmCIF value) 250；Pressure 1 NMR measurement conditions：pH 8；277.15 K；Ionic strength (raw mmCIF value) 250；Pressure 1 NMR measurement conditions：pH 8；268.15 K；Ionic strength (raw mmCIF value) 250；Pressure 1 NMR sample composition：400 uM [U-100% 13C; U-100% 15N] HIV-1 CACTD-SP1, 400 uM IP6, 360 uM BVM, Protein buffer | Protein buffer NMR sample composition：400 uM [U-100% 13C; U-100% 15N; 99.9%-2H] HIV-1 CACTD-SP1, 400 uM IP6, 360 uM Bevirimat, protein buffer | protein buffer Resolution not provided

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 7R7P Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1L6N STRUCTURE OF THE N-TERMINAL 283-RESIDUE FRAGMENT OF THE HIV-1 GAG POLYPROTEIN Deposited 2002-03-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1–283（283 aa） Fragment：Residues 1-283
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 5；303 K；Ionic strength (raw mmCIF value) 50；Pressure 1
NMR sample composition 1mM U-15N,13C gag283, 50mM acetate buffer(pH5.0), 100mM NaCl, 5mM BME | 95% H2O/5% D2O
NMR sample composition 1mM U-15N,13C gag283, 50mM acetate buffer(pH5.0), 100mM NaCl, 5mM BME | 100% D2O
NMR sample composition 1mM U-15N,2H gag283, 50mM acetate buffer(pH5.0), 100mM NaCl, 5mM BME | 95% H2O/5% D2O
NMR sample composition 1mM U-15N gag283, 50mM acetate buffer(pH5.0), 100mM NaCl, 5mM BME | 95% H2O/5% D2O
Resolution not provided
1M9C X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type Complex. Deposited 2002-07-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 133–278（146 aa） Fragment：N-terminal domain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；294 K；PEG 8K, Bicine, LiCl, Tris, Beta-mercaptoethanol, pH 8.0, VAPOR DIFFUSION, SITTING DROP, temperature 294K
Resolution 2.00 Å R-free 0.259
1M9C X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type Complex. Deposited 2002-07-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 133–278（146 aa） Fragment：N-terminal domain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；294 K；PEG 8K, Bicine, LiCl, Tris, Beta-mercaptoethanol, pH 8.0, VAPOR DIFFUSION, SITTING DROP, temperature 294K
Resolution 2.00 Å R-free 0.259
1M9D X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) O-type chimera Complex. Deposited 2002-07-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 133–278（146 aa） Fragment：N-TERMINAL DOMAIN
Mutation：L83T, V86P, H87A, A88M, I91L, A92P, M96I No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；294 K；PEG 8K, Bicine, LiCl, Tris, Beta-mercaptoethanol, pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 294K
Resolution 1.90 Å R-free 0.232
1M9D X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) O-type chimera Complex. Deposited 2002-07-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 133–278（146 aa） Fragment：N-TERMINAL DOMAIN
Mutation：L83T, V86P, H87A, A88M, I91L, A92P, M96I No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；294 K；PEG 8K, Bicine, LiCl, Tris, Beta-mercaptoethanol, pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 294K
Resolution 1.90 Å R-free 0.232
1M9E X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A Complex. Deposited 2002-07-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 133–278（146 aa） Fragment：N-terminal domain
Mutation：H87A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；294 K；PEG 8K, Bicine, LiCl, Tris, Beta-mercaptoethanol, pH 8.0, VAPOR DIFFUSION, SITTING DROP, temperature 294K
Resolution 1.72 Å R-free 0.226
1M9E X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A Complex. Deposited 2002-07-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 133–278（146 aa） Fragment：N-terminal domain
Mutation：H87A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；294 K；PEG 8K, Bicine, LiCl, Tris, Beta-mercaptoethanol, pH 8.0, VAPOR DIFFUSION, SITTING DROP, temperature 294K
Resolution 1.72 Å R-free 0.226
1M9F X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A,A88M Complex. Deposited 2002-07-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 133–278（146 aa） Fragment：N-terminal domain
Mutation：H87A,A88M No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；294 K；PEG 8K, Bicine, LiCl, Tris, Beta-mercaptoethanol, pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 294K
Resolution 1.73 Å R-free 0.220
1M9F X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A,A88M Complex. Deposited 2002-07-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 133–278（146 aa） Fragment：N-terminal domain
Mutation：H87A,A88M No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；294 K；PEG 8K, Bicine, LiCl, Tris, Beta-mercaptoethanol, pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 294K
Resolution 1.73 Å R-free 0.220
1M9X X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A,A88M,G89A Complex. Deposited 2002-07-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 133–278（146 aa） Fragment：N-TERMINAL DOMAIN
Mutation：H87A,A88M,G89A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；294 K；PEG 8K, Bicine, LiCl, Tris, Beta-mercaptoethanol, pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 294K
Resolution 1.70 Å R-free 0.230
1M9X X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A,A88M,G89A Complex. Deposited 2002-07-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 133–278（146 aa） Fragment：N-TERMINAL DOMAIN
Mutation：H87A,A88M,G89A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；294 K；PEG 8K, Bicine, LiCl, Tris, Beta-mercaptoethanol, pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 294K
Resolution 1.70 Å R-free 0.230
1M9X X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A,A88M,G89A Complex. Deposited 2002-07-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain H 133–278（146 aa） Fragment：N-TERMINAL DOMAIN
Mutation：H87A,A88M,G89A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；294 K；PEG 8K, Bicine, LiCl, Tris, Beta-mercaptoethanol, pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 294K
Resolution 1.70 Å R-free 0.230
1M9X X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A,A88M,G89A Complex. Deposited 2002-07-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain G 133–278（146 aa） Fragment：N-TERMINAL DOMAIN
Mutation：H87A,A88M,G89A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；294 K；PEG 8K, Bicine, LiCl, Tris, Beta-mercaptoethanol, pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 294K
Resolution 1.70 Å R-free 0.230
1M9Y X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A,G89A Complex. Deposited 2002-07-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 133–278（146 aa） Fragment：N-terminal domain
Mutation：H87A,G89A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；294 K；PEG 8K, Bicine, LiCl, Tris, Beta-mercaptoethanol, pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 294K
Resolution 1.90 Å R-free 0.234
1M9Y X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A,G89A Complex. Deposited 2002-07-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 133–278（146 aa） Fragment：N-terminal domain
Mutation：H87A,G89A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；294 K；PEG 8K, Bicine, LiCl, Tris, Beta-mercaptoethanol, pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 294K
Resolution 1.90 Å R-free 0.234
1M9Y X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A,G89A Complex. Deposited 2002-07-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain H 133–278（146 aa） Fragment：N-terminal domain
Mutation：H87A,G89A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；294 K；PEG 8K, Bicine, LiCl, Tris, Beta-mercaptoethanol, pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 294K
Resolution 1.90 Å R-free 0.234
1M9Y X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A,G89A Complex. Deposited 2002-07-30 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain G 133–278（146 aa） Fragment：N-terminal domain
Mutation：H87A,G89A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；294 K；PEG 8K, Bicine, LiCl, Tris, Beta-mercaptoethanol, pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 294K
Resolution 1.90 Å R-free 0.234
2BUO HIV-1 capsid C-terminal domain in complex with an inhibitor of particle assembly Deposited 2005-06-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 278–363（86 aa） Fragment：C-TERMINAL DOMAIN, RESIDUES 278-363
Not recorded ACY ACETIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions 32% PEG 4000 100MM AMMONIUM SULFATE PH4.6 10MM MGCL2
Resolution 1.70 Å R-free 0.234
2JMG Solution structure of V7R mutant of HIV-1 myristoylated matrix protein Deposited 2006-11-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2–132（131 aa） Fragment：MATRIX DOMAIN, RESIDUES 2-132
Mutation：V7R MYR MYRISTIC ACID × 1 SOLUTION NMR
NMR measurement conditions pH 5.5；308 K；Pressure ambient
NMR sample composition 1 mM [U-100% 13C, U-100% 15N] HIV-1 V7R-myrMA, 50 mM Sodium phosphate, 100 mM NaCl, 5 mM DTT, 90% H2O, 10% D2O | 90% H2O/10% D2O
NMR sample composition 1 mM [U-100% 15N] HIV-1 V7R-myrMA, 50 mM Sodium phosphate, 100 mM NaCl, 5 mM DTT, 90% H2O, 10% D2O | 90% H2O/10% D2O
NMR sample composition 1 mM HIV-1 V7R-myrMA, 50 mM Sodium phosphate, 100 mM NaCl, 5 mM DTT, 90% H2O, 10% D2O | 90% H2O/10% D2O
Resolution not provided
2LF4 Structure of a monomeric mutant of the HIV-1 capsid protein Deposited 2011-06-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 133–363（231 aa）
Mutation：W184A, M185A No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 5.5；303 K；Pressure ambient
NMR sample composition 2 mM [U-98% 15N] HIV-1 CA, 25 mM sodium chloride, 25 mM [U-99% 2H] sodium acetate, 10 mM [U-99% 2H] DTT, 0.02 % sodium azide, 0.1 mM AEBSF protease inhibitor, 1 mM [U-99% 2H] EDTA, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 2 mM [U-98% 13C; U-98% 15N] HIV-1 CA, 25 mM sodium chloride, 25 mM [U-99% 2H] sodium acetate, 10 mM [U-99% 2H] DTT, 0.02 % sodium azide, 0.1 mM AEBSF protease inhibitor, 1 mM [U-99% 2H] EDTA, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 2 mM [U-98% 13C; U-98% 15N] HIV-1 CA, 25 mM sodium chloride, 25 mM [U-99% 2H] sodium acetate, 10 mM [U-99% 2H] DTT, 0.02 % sodium azide, 0.1 mM AEBSF protease inhibitor, 1 mM [U-99% 2H] EDTA, 100% D2O | 100% D2O
NMR sample composition 2 mM [U-98% 13C; U-98% 15N] HIV-1 CA, 25 mM sodium chloride, 25 mM [U-99% 2H] sodium acetate, 10 mM [U-99% 2H] DTT, 0.02 % sodium azide, 0.1 mM AEBSF protease inhibitor, 1 mM [U-99% 2H] EDTA, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 2 mM [U-98% 13C; U-98% 15N] HIV-1 CA, 25 mM sodium chloride, 25 mM [U-99% 2H] sodium acetate, 10 mM [U-99% 2H] DTT, 0.02 % sodium azide, 0.1 mM AEBSF protease inhibitor, 1 mM [U-99% 2H] EDTA, 100% D2O | 100% D2O
NMR sample composition 2 mM [U-98% 13C; U-98% 15N] HIV-1 CA, 25 mM sodium chloride, 25 mM [U-99% 2H] sodium acetate, 10 mM [U-99% 2H] DTT, 0.02 % sodium azide, 0.1 mM AEBSF protease inhibitor, 1 mM [U-99% 2H] EDTA, 100% D2O | 100% D2O
Resolution not provided
2NV3 Solution structure of L8A mutant of HIV-1 myristoylated matrix protein Deposited 2006-11-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2–132（131 aa） Fragment：matrix domain, residues 2-132
Mutation：L8A MYR MYRISTIC ACID × 1 SOLUTION NMR
NMR measurement conditions pH 5.5；308 K；Pressure ambient
NMR sample composition 1 mM [U-100% 13C, U-100% 15N] HIV-1 L8A-myrMA, 50 mM Sodium phosphate, 100 mM NaCl, 5 mM DTT, 90% H2O, 10% D2O | 90% H2O/10% D2O
NMR sample composition 1 mM [U-100% 15N] HIV-1 L8A-myrMA, 50 mM Sodium phosphate, 100 mM NaCl, 5 mM DTT, 90% H2O, 10% D2O | 90% H2O/10% D2O
NMR sample composition 1 mM HIV-1 L8A-myrMA, 50 mM Sodium phosphate, 100 mM NaCl, 5 mM DTT, 90% H2O, 10% D2O | 90% H2O/10% D2O
Resolution not provided
3DPH HIV-1 capsid C-terminal domain mutant (L211S) Deposited 2008-07-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 278–363（86 aa） Fragment：C-terminal domain, UNP residues 278 to 363
Chain B 278–363（86 aa） Fragment：C-terminal domain, UNP residues 278 to 363
Mutation：L211S Mutation：L211S No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；pH 7.5；292 K；30% PEG4000, 100mM NaHEPES, 200mM CaCl2, pH 7.5, EVAPORATION, temperature 292K
Resolution 2.01 Å R-free 0.254
3DS0 HIV-1 capsid C-terminal domain mutant (N183A) in complex with an inhibitor of particle assembly (CAI) Deposited 2008-07-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 278–363（86 aa） Fragment：C-terminal domain, residues 278-363
Mutation：N183A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；pH 4.2；298 K；32% PEG 4000, 100mM ammonium acetate pH4.2, 10mM MgCl2, EVAPORATION, temperature 298.0K
Resolution 1.60 Å R-free 0.245
3DS0 HIV-1 capsid C-terminal domain mutant (N183A) in complex with an inhibitor of particle assembly (CAI) Deposited 2008-07-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 278–363（86 aa） Fragment：C-terminal domain, residues 278-363
Mutation：N183A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；pH 4.2；298 K；32% PEG 4000, 100mM ammonium acetate pH4.2, 10mM MgCl2, EVAPORATION, temperature 298.0K
Resolution 1.60 Å R-free 0.245
3DS1 HIV-1 capsid C-terminal domain mutant (E187A) in complex with an inhibitor of particle assembly (CAI) Deposited 2008-07-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 278–363（86 aa） Fragment：C-terminal domain, UNP residues 278-363
Mutation：E187A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；pH 4.2；298 K；30% PEG 4000, 100mM ammonium acetate, 10mM MgCl2, pH 4.2, EVAPORATION, temperature 298.0K
Resolution 1.60 Å R-free 0.272
3DS1 HIV-1 capsid C-terminal domain mutant (E187A) in complex with an inhibitor of particle assembly (CAI) Deposited 2008-07-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 278–363（86 aa） Fragment：C-terminal domain, UNP residues 278-363
Mutation：E187A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；pH 4.2；298 K；30% PEG 4000, 100mM ammonium acetate, 10mM MgCl2, pH 4.2, EVAPORATION, temperature 298.0K
Resolution 1.60 Å R-free 0.272
3DS2 HIV-1 capsid C-terminal domain mutant (Y169A) Deposited 2008-07-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 278–363（86 aa） Fragment：C-terminal domain, UNP residues 278-363
Chain B 278–363（86 aa） Fragment：C-terminal domain, UNP residues 278-363
Mutation：Y169A Mutation：Y169A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；pH 7.5；298 K；20% PEG 3350, 200mM sodium iodide, pH 7.5, EVAPORATION, temperature 298.0K
Resolution 1.20 Å R-free 0.246
3DS3 HIV-1 capsid C-terminal domain mutant (Y169A) in complex with an inhibitor of particle assembly (CAI) Deposited 2008-07-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric
Chain A 278–363（86 aa） Fragment：C-terminal domain, UNP residues 278-363
Chain B 278–363（86 aa） Fragment：C-terminal domain, UNP residues 278-363
Mutation：Y169A Mutation：Y169A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；pH 4.6；298 K；30% PEG4000, 200mM ammonium acetate, 100mm sodium acetate pH 4.6, EVAPORATION, temperature 298K
Resolution 2.70 Å R-free 0.293
3DS4 HIV-1 capsid C-terminal domain mutant (L211S) in complex with an inhibitor of particle assembly (CAI) Deposited 2008-07-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric
Chain A 278–363（86 aa） Fragment：C-terminal domain, UNP residues 278-363
Chain B 278–363（86 aa） Fragment：C-terminal domain, UNP residues 278-363
Mutation：L211S Mutation：L211S No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；298 K；PEG4000, 200mM ammonium sulfate, EVAPORATION, temperature 298K
Resolution 1.12 Å R-free 0.234
3DS5 HIV-1 capsid C-terminal domain mutant (N183A) Deposited 2008-07-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain C 278–363（86 aa） Fragment：C-terminal domain, UNP residues 278-363
Chain D 278–363（86 aa） Fragment：C-terminal domain, UNP residues 278-363
Mutation：N183A Mutation：N183A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；pH 4.6；298 K；30% PEG 4000, 100mM ammonium acetate, 10mM MgCl2, pH 4.6, EVAPORATION, temperature 298.0K
Resolution 2.40 Å R-free 0.270
3DS5 HIV-1 capsid C-terminal domain mutant (N183A) Deposited 2008-07-11 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 278–363（86 aa） Fragment：C-terminal domain, UNP residues 278-363
Chain B 278–363（86 aa） Fragment：C-terminal domain, UNP residues 278-363
Mutation：N183A Mutation：N183A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；pH 4.6；298 K；30% PEG 4000, 100mM ammonium acetate, 10mM MgCl2, pH 4.6, EVAPORATION, temperature 298.0K
Resolution 2.40 Å R-free 0.270
3DTJ HIV-1 capsid C-terminal domain mutant (E187A) Deposited 2008-07-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain C 278–363（86 aa） Fragment：C-terminal domain, UNP residues 278-363
Chain D 278–363（86 aa） Fragment：C-terminal domain, UNP residues 278-363
Mutation：E187A Mutation：E187A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；pH 5；298 K；32% PEG 4,000, 100 mM ammonium acetate pH 5.0 and 10 mM MgCl2., EVAPORATION, temperature 298K
Resolution 4.00 Å
3DTJ HIV-1 capsid C-terminal domain mutant (E187A) Deposited 2008-07-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 278–363（86 aa） Fragment：C-terminal domain, UNP residues 278-363
Chain B 278–363（86 aa） Fragment：C-terminal domain, UNP residues 278-363
Mutation：E187A Mutation：E187A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；pH 5；298 K；32% PEG 4,000, 100 mM ammonium acetate pH 5.0 and 10 mM MgCl2., EVAPORATION, temperature 298K
Resolution 4.00 Å
3OBU Crystal structure of the Tsg101 UEV domain in complex with a HIV-1 PTAP peptide Deposited 2010-08-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 453–461（9 aa） Fragment：HIV-1 Gag PTAP motif (5-13)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；0.1M HEPES-NaOH (pH7.5), 25% PEG 3350, 0.2M Sodium Nitrate, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.60 Å R-free 0.236
3OBX Crystal structure of the Tsg101 UEV domain in complex with a HIV-1 Gag P7A mutant peptide Deposited 2010-08-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 453–461（9 aa） Fragment：HIV-1 Gag PTAP motif (5-13)
Mutation：P7A mutant No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；0.1M HEPES-NaOH (pH7.5), 25% PEG 3350, 0.2M Sodium Nitrate, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.60 Å R-free 0.230
3P05 X-ray structure of pentameric HIV-1 CA Deposited 2010-09-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric
Chain A 133–363（231 aa） Fragment：UNP residues 133-363
Chain B 133–363（231 aa） Fragment：UNP residues 133-363
Chain C 133–363（231 aa） Fragment：UNP residues 133-363
Chain D 133–363（231 aa） Fragment：UNP residues 133-363
Chain E 133–363（231 aa） Fragment：UNP residues 133-363
Mutation：N21C, A22C, W184A, M185A Mutation：N21C, A22C, W184A, M185A Mutation：N21C, A22C, W184A, M185A Mutation：N21C, A22C, W184A, M185A Mutation：N21C, A22C, W184A, M185A IOD IODIDE ION × 10 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；27-30% PEG 4000, 100 mM Tris, 0.2 M sodium iodide, pH 8-9, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 2.50 Å R-free 0.266
3P0A X-ray structure of pentameric HIV-1 CA Deposited 2010-09-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric
Chain A 133–363（231 aa） Fragment：UNP residues 133-363
Chain B 133–363（231 aa） Fragment：UNP residues 133-363
Chain C 133–363（231 aa） Fragment：UNP residues 133-363
Chain D 133–363（231 aa） Fragment：UNP residues 133-363
Chain E 133–363（231 aa） Fragment：UNP residues 133-363
Mutation：P17C, R18L, T19C, W184A, M185A Mutation：P17C, R18L, T19C, W184A, M185A Mutation：P17C, R18L, T19C, W184A, M185A Mutation：P17C, R18L, T19C, W184A, M185A Mutation：P17C, R18L, T19C, W184A, M185A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；30-32% PEG 2000 MME, 100 mM Tris, 0.4 M sodium iodide, pH 7-8, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 5.95 Å R-free 0.316
3P0A X-ray structure of pentameric HIV-1 CA Deposited 2010-09-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric
Chain F 133–363（231 aa） Fragment：UNP residues 133-363
Chain G 133–363（231 aa） Fragment：UNP residues 133-363
Chain H 133–363（231 aa） Fragment：UNP residues 133-363
Chain I 133–363（231 aa） Fragment：UNP residues 133-363
Chain J 133–363（231 aa） Fragment：UNP residues 133-363
Mutation：P17C, R18L, T19C, W184A, M185A Mutation：P17C, R18L, T19C, W184A, M185A Mutation：P17C, R18L, T19C, W184A, M185A Mutation：P17C, R18L, T19C, W184A, M185A Mutation：P17C, R18L, T19C, W184A, M185A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；30-32% PEG 2000 MME, 100 mM Tris, 0.4 M sodium iodide, pH 7-8, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 5.95 Å R-free 0.316
3P0A X-ray structure of pentameric HIV-1 CA Deposited 2010-09-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 3 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric
Chain K 133–363（231 aa） Fragment：UNP residues 133-363
Chain L 133–363（231 aa） Fragment：UNP residues 133-363
Chain M 133–363（231 aa） Fragment：UNP residues 133-363
Chain N 133–363（231 aa） Fragment：UNP residues 133-363
Chain O 133–363（231 aa） Fragment：UNP residues 133-363
Mutation：P17C, R18L, T19C, W184A, M185A Mutation：P17C, R18L, T19C, W184A, M185A Mutation：P17C, R18L, T19C, W184A, M185A Mutation：P17C, R18L, T19C, W184A, M185A Mutation：P17C, R18L, T19C, W184A, M185A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；30-32% PEG 2000 MME, 100 mM Tris, 0.4 M sodium iodide, pH 7-8, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 5.95 Å R-free 0.316
3P0A X-ray structure of pentameric HIV-1 CA Deposited 2010-09-27 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 4 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric
Chain P 133–363（231 aa） Fragment：UNP residues 133-363
Chain Q 133–363（231 aa） Fragment：UNP residues 133-363
Chain R 133–363（231 aa） Fragment：UNP residues 133-363
Chain S 133–363（231 aa） Fragment：UNP residues 133-363
Chain T 133–363（231 aa） Fragment：UNP residues 133-363
Mutation：P17C, R18L, T19C, W184A, M185A Mutation：P17C, R18L, T19C, W184A, M185A Mutation：P17C, R18L, T19C, W184A, M185A Mutation：P17C, R18L, T19C, W184A, M185A Mutation：P17C, R18L, T19C, W184A, M185A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；30-32% PEG 2000 MME, 100 mM Tris, 0.4 M sodium iodide, pH 7-8, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 5.95 Å R-free 0.316
4DGA TRIMCyp cyclophilin domain from Macaca mulatta: HIV-1 CA(O-loop) complex Deposited 2012-01-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 133–277（145 aa） Fragment：cyclophilin-binding domain (UNP residues 133-277)
Mutation：yes No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；290 K；20% w/v PEG5000 MME, 0.1 M Bis-Tris, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 290K
Resolution 1.90 Å R-free 0.243
4DGA TRIMCyp cyclophilin domain from Macaca mulatta: HIV-1 CA(O-loop) complex Deposited 2012-01-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 133–277（145 aa） Fragment：cyclophilin-binding domain (UNP residues 133-277)
Mutation：yes No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；290 K；20% w/v PEG5000 MME, 0.1 M Bis-Tris, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 290K
Resolution 1.90 Å R-free 0.243
4DGE TRIMCyp cyclophilin domain from Macaca mulatta: H70C mutant, HIV-1 CA(O-loop) complex Deposited 2012-01-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 133–277（145 aa） Fragment：cyclophilin-binding domain (UNP residues 133-277)
Mutation：yes No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.6；290 K；23.5% w/v PEG8000, 0.1 M HEPES, pH 7.6, VAPOR DIFFUSION, SITTING DROP, temperature 290K
Resolution 2.20 Å R-free 0.255
4DGE TRIMCyp cyclophilin domain from Macaca mulatta: H70C mutant, HIV-1 CA(O-loop) complex Deposited 2012-01-25 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 133–277（145 aa） Fragment：cyclophilin-binding domain (UNP residues 133-277)
Mutation：yes No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.6；290 K；23.5% w/v PEG8000, 0.1 M HEPES, pH 7.6, VAPOR DIFFUSION, SITTING DROP, temperature 290K
Resolution 2.20 Å R-free 0.255
7R7Q Immature HIV-1 CACTD-SP1 lattice with Inositol hexakisphosphate (IP6) Deposited 2021-06-25 Different ligand/ion Different experimental conditions Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric
Chain G 278–377（100 aa）
Chain H 278–377（100 aa）
Chain I 278–377（100 aa）
Chain J 278–377（100 aa）
Chain K 278–377（100 aa）
Chain L 278–377（100 aa）
Mutation：P241T Mutation：P241T Mutation：P241T Mutation：P241T Mutation：P241T Mutation：P241T IHP INOSITOL HEXAKISPHOSPHATE × 1 SOLID-STATE NMR
NMR measurement conditions pH 8；277.15 K；Ionic strength (raw mmCIF value) 250；Pressure 1
NMR measurement conditions pH 8；263.15 K；Ionic strength (raw mmCIF value) 250；Pressure 1
NMR measurement conditions pH 8；194.15 K；Ionic strength (raw mmCIF value) 250；Pressure 1
NMR measurement conditions pH 8；277.15 K；Ionic strength (raw mmCIF value) 250；Pressure 1
NMR measurement conditions pH 8；268.15 K；Ionic strength (raw mmCIF value) 250；Pressure 1
NMR measurement conditions pH 8；277.15 K；Ionic strength (raw mmCIF value) 250；Pressure 1
NMR sample composition 400 uM [U-100% 13C; U-100% 15N] HIV-1 CACTD-SP1, 400 uM IP6, Protein buffer | Protein buffer
NMR sample composition 400 uM [U-100% 13C; U-100% 15N; 99.9%-2H] HIV-1 CACTD-SP1, 400 uM IP6, Protein buffer | Protein buffer
NMR sample composition 400 uM [U-100% 13C; U-100% 15N; 99.9%-2H] HIV-1 CACTD-SP1, 400 uM IP6 S2, Protein buffer | Protein buffer
Resolution not provided
9RMX CryoEM reconstruction of integrase filament at the lumen of native HIV-1 cores (box size 34.2 nm) Deposited 2025-06-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 44 PDB declaration: 44-meric
Chain U 133–363（231 aa）
Chain V 133–363（231 aa）
Chain W 133–363（231 aa）
Chain X 133–363（231 aa）
Chain Y 133–363（231 aa）
Chain Z 133–363（231 aa）
Chain a 133–363（231 aa）
Chain b 133–363（231 aa）
Chain c 133–363（231 aa）
Chain d 133–363（231 aa）
Chain e 133–363（231 aa）
Chain f 133–363（231 aa）
Chain g 133–363（231 aa）
Chain h 133–363（231 aa）
Chain i 133–363（231 aa）
Chain j 133–363（231 aa）
Chain k 133–363（231 aa）
Chain l 133–363（231 aa）
Chain m 133–363（231 aa）
Chain n 133–363（231 aa）
Chain o 133–363（231 aa）
Chain p 133–363（231 aa）
Chain q 133–363（231 aa）
Chain r 133–363（231 aa）
Chain s 133–363（231 aa）
Chain t 133–363（231 aa）
Chain u 133–363（231 aa）
Chain v 133–363（231 aa）
Chain w 133–363（231 aa）
Chain x 133–363（231 aa）
Chain y 133–363（231 aa）
Chain z 133–363（231 aa）
Not recorded ZN ZINC ION × 12 IHP INOSITOL HEXAKISPHOSPHATE × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 4.63 Å

27 other PDB entries and 46 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name Q72497_9HIV1
Isoform —
PDB entities 1
Chains and sequence ranges Author chain G； PDBConstruct 3–102； UniProt 278–377 Author chain H； PDBConstruct 3–102； UniProt 278–377 Author chain I； PDBConstruct 3–102； UniProt 278–377 Author chain J； PDBConstruct 3–102； UniProt 278–377 Author chain K； PDBConstruct 3–102； UniProt 278–377 Author chain L； PDBConstruct 3–102； UniProt 278–377

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

SAXS scattering curve SAXS Profile

SAXS profile for 7r7p

P(r) Distance Distribution P(r) Distribution

P(r) distribution for 7r7p
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2. Structure Basics 2. Structure Basics

Entry ID entry_id7r7p
Deposition date deposition_date2021-06-25
Structure title titleImmature HIV-1 CACTD-SP1 lattice with Bevirimat (BVM) and Inositol hexakisphosphate (IP6)
Keywords keywordsHIV-1 capsid, maturation inhibitors, HIV-AIDS, PROTEIN BINDING; PROTEIN BINDING
Experimental Method methodSOLID-STATE NMR
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3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier26.14 Å
Radius of gyration Rg (electron density) rg_electron25.98 Å
Forward intensity I(0) i01748290000.00
Molecular weight molecular_weight338710.0 kDa
Excluded volume excluded_volume419240 ų
Envelope volume envelope_volume120170 ų
Hydration-shell volume shell_volume35888 ų
Envelope diameter envelope_diameter88.5 Å
Shell Rg shell_rg35.32 Å
Envelope Rg envelope_rg27.01 Å
Shape Rg shape_rg25.99 Å
Total Rg total_rg26.19 Å
Total atoms total_atoms47220
Residues n_residues3060
Spherical-harmonic order n_harmonics20
q range q_range— – 0.5000 Å−1
Data points n_points101
Shell type shell_typedirectional
Solvent electron density solvent_density0.3340 e/ų
Shell contrast contrast_shell0.0300 e/ų
CRYSOL version crysol_version4.1.3
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4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax80.0 Å
Rg (real space) rg_real25.99 Å
Rg uncertainty (real space) rg_real_error0.46 Å
I(0) (real space) i0_real1.7480e+09
I(0) uncertainty (real space) i0_real_error2.3700e+07
Rg (reciprocal space) rg_reciprocal26.04 Å
I(0) (reciprocal space) i0_reciprocal1748000000.0000
Solution quality estimate total_estimate0.9111
Solution quality rating solution_quality EXCELLENT a EXCELLENT solution
P(r) peaks n_peaks2
Primary peak position r_peak_primary32.8 Å
Skewness Skewness skewness0.115
Kurtosis Kurtosis kurtosis-0.538
Angular range angular_range— – 0.3050 Å−1
Current regularization parameter α current_alpha0.0000
Highest regularization parameter α highest_alpha6859000.0000
Real-space data points n_real_points62
GNOM version gnom_version4.1.3
Quality Criteria quality_criteria AN1: 0.000; Oscil: 0.954; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.992; Smooth: 0.986
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5. Crystallography and Experiment 5. Crystallography & Experiment

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6. Entities and Polymers Entities & Polymers (3)

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8. Citations (1)

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9. Files and Curves (10)