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7tbh

cryo-EM structure of MBP-KIX-apoferritin complex with peptide 7

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Isoform 2 of CREB-binding protein,Ferritin heavy chain, N-terminally processed

Homo sapiens

UniProt P09528

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 48 LEU-SER-ARG-ARG-PRO-SEP-TYR-ARG-LYS-ILE-LEU-ASN-ASP-LEU-SER-SER-ASP-ALA-PRO × 24 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
8j5a 8j5a

2 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers
22fx 22ix 23wj 3wnw 5oba 5obb 6s61 6sht 6v21 7a4m 7kod 8bk9

25 assemblies; showing the first 12

Heteromeric or nucleic-acid complex
7tb3 7tbh

2 assemblies

View Construct and Data Evidence
UniProt name FRIH_MOUSE
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 85–260； UniProt 7–182 Author chain B； PDBConstruct 85–260； UniProt 7–182 Author chain C； PDBConstruct 85–260； UniProt 7–182 Author chain D； PDBConstruct 85–260； UniProt 7–182 Author chain E； PDBConstruct 85–260； UniProt 7–182 Author chain F； PDBConstruct 85–260； UniProt 7–182 Author chain G； PDBConstruct 85–260； UniProt 7–182 Author chain H； PDBConstruct 85–260； UniProt 7–182 Author chain I； PDBConstruct 85–260； UniProt 7–182 Author chain J； PDBConstruct 85–260； UniProt 7–182 Author chain K； PDBConstruct 85–260； UniProt 7–182 Author chain L； PDBConstruct 85–260； UniProt 7–182 Author chain M； PDBConstruct 85–260； UniProt 7–182 Author chain N； PDBConstruct 85–260； UniProt 7–182 Author chain O； PDBConstruct 85–260； UniProt 7–182 Author chain P； PDBConstruct 85–260； UniProt 7–182 Author chain Q； PDBConstruct 85–260； UniProt 7–182 Author chain R； PDBConstruct 85–260； UniProt 7–182 Author chain S； PDBConstruct 85–260； UniProt 7–182 Author chain T； PDBConstruct 85–260； UniProt 7–182 Author chain U； PDBConstruct 85–260； UniProt 7–182 Author chain V； PDBConstruct 85–260； UniProt 7–182 Author chain W； PDBConstruct 85–260； UniProt 7–182 Author chain X； PDBConstruct 85–260； UniProt 7–182

Isoform 2 of CREB-binding protein,Ferritin heavy chain, N-terminally processed

Homo sapiens

UniProt Q92793

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 48 LEU-SER-ARG-ARG-PRO-SEP-TYR-ARG-LYS-ILE-LEU-ASN-ASP-LEU-SER-SER-ASP-ALA-PRO × 24 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1liq 1wo3 1wo4 1wo5 1wo6 1wo7 2d82 2l84 2l85 3dwy 3dwy 3p1c

194 assemblies; showing the first 12

Homodimer
7xne 7xng

2 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1jsp 1zoq 1zoq 2kje 2kwf 2lxs 2lxt 2n1a 2rny 4n3w 4n4f 5gh9

29 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name CBP_HUMAN
Isoform Q92793-2
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 3–84； UniProt 549–630 Author chain B； PDBConstruct 3–84； UniProt 549–630 Author chain C； PDBConstruct 3–84； UniProt 549–630 Author chain D； PDBConstruct 3–84； UniProt 549–630 Author chain E； PDBConstruct 3–84； UniProt 549–630 Author chain F； PDBConstruct 3–84； UniProt 549–630 Author chain G； PDBConstruct 3–84； UniProt 549–630 Author chain H； PDBConstruct 3–84； UniProt 549–630 Author chain I； PDBConstruct 3–84； UniProt 549–630 Author chain J； PDBConstruct 3–84； UniProt 549–630 Author chain K； PDBConstruct 3–84； UniProt 549–630 Author chain L； PDBConstruct 3–84； UniProt 549–630 Author chain M； PDBConstruct 3–84； UniProt 549–630 Author chain N； PDBConstruct 3–84； UniProt 549–630 Author chain O； PDBConstruct 3–84； UniProt 549–630 Author chain P； PDBConstruct 3–84； UniProt 549–630 Author chain Q； PDBConstruct 3–84； UniProt 549–630 Author chain R； PDBConstruct 3–84； UniProt 549–630 Author chain S； PDBConstruct 3–84； UniProt 549–630 Author chain T； PDBConstruct 3–84； UniProt 549–630 Author chain U； PDBConstruct 3–84； UniProt 549–630 Author chain V； PDBConstruct 3–84； UniProt 549–630 Author chain W； PDBConstruct 3–84； UniProt 549–630 Author chain X； PDBConstruct 3–84； UniProt 549–630

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id7tbh
Deposition date deposition_date2021-12-22
Structure title titlecryo-EM structure of MBP-KIX-apoferritin complex with peptide 7
Keywords keywordsProtein Engineering, Simulation, Peptide Therapeutics, Acute Myeloid Leukemia, STRUCTURAL PROTEIN; STRUCTURAL PROTEIN
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

7tbh__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

7tbh__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

7tbh__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）63.04 Å
Rg (electron density)62.09 Å
Total Rg62.35 Å
Atom count51576
Residues6264
Excluded volume910990 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 7tbh__assembly_1__model_1 48-meric （48） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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6. Fold Classification (SCOP + CATH) 48 domains

CATH v4.4 (48 domains)

Domain ID domain_id7tbhA01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology246 — Serum Albumin; Chain A, Domain 1
Homologous superfamily homologous superfamily20 — Coactivator CBP, KIX domain
Domain ID domain_id7tbhA02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1260 — Ferritin
Homologous superfamily homologous superfamily10 — Ferritin, core subunit, four-helix bundle
Domain ID domain_id7tbhB01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology246 — Serum Albumin; Chain A, Domain 1
Homologous superfamily homologous superfamily20 — Coactivator CBP, KIX domain
Domain ID domain_id7tbhB02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1260 — Ferritin
Homologous superfamily homologous superfamily10 — Ferritin, core subunit, four-helix bundle
Domain ID domain_id7tbhC01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology246 — Serum Albumin; Chain A, Domain 1
Homologous superfamily homologous superfamily20 — Coactivator CBP, KIX domain
Domain ID domain_id7tbhC02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1260 — Ferritin
Homologous superfamily homologous superfamily10 — Ferritin, core subunit, four-helix bundle
Domain ID domain_id7tbhD01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology246 — Serum Albumin; Chain A, Domain 1
Homologous superfamily homologous superfamily20 — Coactivator CBP, KIX domain
Domain ID domain_id7tbhD02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1260 — Ferritin
Homologous superfamily homologous superfamily10 — Ferritin, core subunit, four-helix bundle
Domain ID domain_id7tbhE01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology246 — Serum Albumin; Chain A, Domain 1
Homologous superfamily homologous superfamily20 — Coactivator CBP, KIX domain
Domain ID domain_id7tbhE02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1260 — Ferritin
Homologous superfamily homologous superfamily10 — Ferritin, core subunit, four-helix bundle
Domain ID domain_id7tbhF01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology246 — Serum Albumin; Chain A, Domain 1
Homologous superfamily homologous superfamily20 — Coactivator CBP, KIX domain
Domain ID domain_id7tbhF02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1260 — Ferritin
Homologous superfamily homologous superfamily10 — Ferritin, core subunit, four-helix bundle
Domain ID domain_id7tbhG01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology246 — Serum Albumin; Chain A, Domain 1
Homologous superfamily homologous superfamily20 — Coactivator CBP, KIX domain
Domain ID domain_id7tbhG02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1260 — Ferritin
Homologous superfamily homologous superfamily10 — Ferritin, core subunit, four-helix bundle
Domain ID domain_id7tbhH01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology246 — Serum Albumin; Chain A, Domain 1
Homologous superfamily homologous superfamily20 — Coactivator CBP, KIX domain
Domain ID domain_id7tbhH02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1260 — Ferritin
Homologous superfamily homologous superfamily10 — Ferritin, core subunit, four-helix bundle
Domain ID domain_id7tbhI01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology246 — Serum Albumin; Chain A, Domain 1
Homologous superfamily homologous superfamily20 — Coactivator CBP, KIX domain
Domain ID domain_id7tbhI02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1260 — Ferritin
Homologous superfamily homologous superfamily10 — Ferritin, core subunit, four-helix bundle
Domain ID domain_id7tbhJ01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology246 — Serum Albumin; Chain A, Domain 1
Homologous superfamily homologous superfamily20 — Coactivator CBP, KIX domain
Domain ID domain_id7tbhJ02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1260 — Ferritin
Homologous superfamily homologous superfamily10 — Ferritin, core subunit, four-helix bundle
Domain ID domain_id7tbhK01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology246 — Serum Albumin; Chain A, Domain 1
Homologous superfamily homologous superfamily20 — Coactivator CBP, KIX domain
Domain ID domain_id7tbhK02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1260 — Ferritin
Homologous superfamily homologous superfamily10 — Ferritin, core subunit, four-helix bundle
Domain ID domain_id7tbhL01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology246 — Serum Albumin; Chain A, Domain 1
Homologous superfamily homologous superfamily20 — Coactivator CBP, KIX domain
Domain ID domain_id7tbhL02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1260 — Ferritin
Homologous superfamily homologous superfamily10 — Ferritin, core subunit, four-helix bundle
Domain ID domain_id7tbhM01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology246 — Serum Albumin; Chain A, Domain 1
Homologous superfamily homologous superfamily20 — Coactivator CBP, KIX domain
Domain ID domain_id7tbhM02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1260 — Ferritin
Homologous superfamily homologous superfamily10 — Ferritin, core subunit, four-helix bundle
Domain ID domain_id7tbhN01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology246 — Serum Albumin; Chain A, Domain 1
Homologous superfamily homologous superfamily20 — Coactivator CBP, KIX domain
Domain ID domain_id7tbhN02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1260 — Ferritin
Homologous superfamily homologous superfamily10 — Ferritin, core subunit, four-helix bundle
Domain ID domain_id7tbhO01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology246 — Serum Albumin; Chain A, Domain 1
Homologous superfamily homologous superfamily20 — Coactivator CBP, KIX domain
Domain ID domain_id7tbhO02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1260 — Ferritin
Homologous superfamily homologous superfamily10 — Ferritin, core subunit, four-helix bundle
Domain ID domain_id7tbhP01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology246 — Serum Albumin; Chain A, Domain 1
Homologous superfamily homologous superfamily20 — Coactivator CBP, KIX domain
Domain ID domain_id7tbhP02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1260 — Ferritin
Homologous superfamily homologous superfamily10 — Ferritin, core subunit, four-helix bundle
Domain ID domain_id7tbhQ01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology246 — Serum Albumin; Chain A, Domain 1
Homologous superfamily homologous superfamily20 — Coactivator CBP, KIX domain
Domain ID domain_id7tbhQ02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1260 — Ferritin
Homologous superfamily homologous superfamily10 — Ferritin, core subunit, four-helix bundle
Domain ID domain_id7tbhR01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology246 — Serum Albumin; Chain A, Domain 1
Homologous superfamily homologous superfamily20 — Coactivator CBP, KIX domain
Domain ID domain_id7tbhR02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1260 — Ferritin
Homologous superfamily homologous superfamily10 — Ferritin, core subunit, four-helix bundle
Domain ID domain_id7tbhS01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology246 — Serum Albumin; Chain A, Domain 1
Homologous superfamily homologous superfamily20 — Coactivator CBP, KIX domain
Domain ID domain_id7tbhS02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1260 — Ferritin
Homologous superfamily homologous superfamily10 — Ferritin, core subunit, four-helix bundle
Domain ID domain_id7tbhT01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology246 — Serum Albumin; Chain A, Domain 1
Homologous superfamily homologous superfamily20 — Coactivator CBP, KIX domain
Domain ID domain_id7tbhT02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1260 — Ferritin
Homologous superfamily homologous superfamily10 — Ferritin, core subunit, four-helix bundle
Domain ID domain_id7tbhU01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology246 — Serum Albumin; Chain A, Domain 1
Homologous superfamily homologous superfamily20 — Coactivator CBP, KIX domain
Domain ID domain_id7tbhU02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1260 — Ferritin
Homologous superfamily homologous superfamily10 — Ferritin, core subunit, four-helix bundle
Domain ID domain_id7tbhV01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology246 — Serum Albumin; Chain A, Domain 1
Homologous superfamily homologous superfamily20 — Coactivator CBP, KIX domain
Domain ID domain_id7tbhV02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1260 — Ferritin
Homologous superfamily homologous superfamily10 — Ferritin, core subunit, four-helix bundle
Domain ID domain_id7tbhW01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology246 — Serum Albumin; Chain A, Domain 1
Homologous superfamily homologous superfamily20 — Coactivator CBP, KIX domain
Domain ID domain_id7tbhW02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1260 — Ferritin
Homologous superfamily homologous superfamily10 — Ferritin, core subunit, four-helix bundle
Domain ID domain_id7tbhX01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology246 — Serum Albumin; Chain A, Domain 1
Homologous superfamily homologous superfamily20 — Coactivator CBP, KIX domain
Domain ID domain_id7tbhX02
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology1260 — Ferritin
Homologous superfamily homologous superfamily10 — Ferritin, core subunit, four-helix bundle
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7. Citations (1)