7wts

Cryo-EM structure of a human pre-40S ribosomal subunit - State UTP14

Method: ELECTRON MICROSCOPY

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1. Protein Identity and Related Structures Protein Identity & Related Structures

40S ribosomal protein S27

OrganismNot specified

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 22 RNA 1	18S rRNA × 1 40S ribosomal protein S3a × 1 （P61247） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S30 × 1 （P62861） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S24 × 1 （P62847） RNA-binding protein PNO1 × 1 （Q9NRX1） 40S ribosomal protein S23 × 1 （P62266） 40S ribosomal protein S15a × 1 （P62244） Pre-rRNA-processing protein TSR1 homolog × 1 （Q2NL82） 40S ribosomal protein S14 × 1 （P62263） 40S ribosomal protein S13 × 1 （P62277） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S8 × 1 （P62241） Multifunctional methyltransferase subunit TRM112-like protein × 1 （Q9UI30） Probable 18S rRNA (guanine-N(7))-methyltransferase × 1 （O43709） RRP12-like protein × 1 （Q5JTH9） Ribosome biogenesis protein SLX9 homolog × 1 （Q9NSI2） U3 small nucleolar RNA-associated protein 14 homolog A × 1 （Q9BVJ6） Probable dimethyladenosine transferase × 1 （Q9UNQ2）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS27_HUMAN
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain b； PDBConstruct 1–84； UniProt 1–84

40S ribosomal protein S3a

OrganismNot specified

UniProt P61247

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 22 RNA 1	18S rRNA × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S30 × 1 （P62861） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S24 × 1 （P62847） RNA-binding protein PNO1 × 1 （Q9NRX1） 40S ribosomal protein S23 × 1 （P62266） 40S ribosomal protein S15a × 1 （P62244） Pre-rRNA-processing protein TSR1 homolog × 1 （Q2NL82） 40S ribosomal protein S14 × 1 （P62263） 40S ribosomal protein S13 × 1 （P62277） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S8 × 1 （P62241） Multifunctional methyltransferase subunit TRM112-like protein × 1 （Q9UI30） Probable 18S rRNA (guanine-N(7))-methyltransferase × 1 （O43709） RRP12-like protein × 1 （Q5JTH9） Ribosome biogenesis protein SLX9 homolog × 1 （Q9NSI2） U3 small nucleolar RNA-associated protein 14 homolog A × 1 （Q9BVJ6） Probable dimethyladenosine transferase × 1 （Q9UNQ2）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS3A_HUMAN
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain B； PDBConstruct 1–264； UniProt 1–264

40S ribosomal protein S4, X isoform

OrganismNot specified

UniProt P62701

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 22 RNA 1	18S rRNA × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S3a × 1 （P61247） 40S ribosomal protein S30 × 1 （P62861） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S24 × 1 （P62847） RNA-binding protein PNO1 × 1 （Q9NRX1） 40S ribosomal protein S23 × 1 （P62266） 40S ribosomal protein S15a × 1 （P62244） Pre-rRNA-processing protein TSR1 homolog × 1 （Q2NL82） 40S ribosomal protein S14 × 1 （P62263） 40S ribosomal protein S13 × 1 （P62277） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S8 × 1 （P62241） Multifunctional methyltransferase subunit TRM112-like protein × 1 （Q9UI30） Probable 18S rRNA (guanine-N(7))-methyltransferase × 1 （O43709） RRP12-like protein × 1 （Q5JTH9） Ribosome biogenesis protein SLX9 homolog × 1 （Q9NSI2） U3 small nucleolar RNA-associated protein 14 homolog A × 1 （Q9BVJ6） Probable dimethyladenosine transferase × 1 （Q9UNQ2）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS4X_HUMAN
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain E； PDBConstruct 1–263； UniProt 1–263

40S ribosomal protein S30

OrganismNot specified

UniProt P62861

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 22 RNA 1	18S rRNA × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S3a × 1 （P61247） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S24 × 1 （P62847） RNA-binding protein PNO1 × 1 （Q9NRX1） 40S ribosomal protein S23 × 1 （P62266） 40S ribosomal protein S15a × 1 （P62244） Pre-rRNA-processing protein TSR1 homolog × 1 （Q2NL82） 40S ribosomal protein S14 × 1 （P62263） 40S ribosomal protein S13 × 1 （P62277） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S8 × 1 （P62241） Multifunctional methyltransferase subunit TRM112-like protein × 1 （Q9UI30） Probable 18S rRNA (guanine-N(7))-methyltransferase × 1 （O43709） RRP12-like protein × 1 （Q5JTH9） Ribosome biogenesis protein SLX9 homolog × 1 （Q9NSI2） U3 small nucleolar RNA-associated protein 14 homolog A × 1 （Q9BVJ6） Probable dimethyladenosine transferase × 1 （Q9UNQ2）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS30_HUMAN
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain e； PDBConstruct 1–59； UniProt 1–59

40S ribosomal protein S7

OrganismNot specified

UniProt P62081

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 22 RNA 1	18S rRNA × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S3a × 1 （P61247） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S30 × 1 （P62861） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S24 × 1 （P62847） RNA-binding protein PNO1 × 1 （Q9NRX1） 40S ribosomal protein S23 × 1 （P62266） 40S ribosomal protein S15a × 1 （P62244） Pre-rRNA-processing protein TSR1 homolog × 1 （Q2NL82） 40S ribosomal protein S14 × 1 （P62263） 40S ribosomal protein S13 × 1 （P62277） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S8 × 1 （P62241） Multifunctional methyltransferase subunit TRM112-like protein × 1 （Q9UI30） Probable 18S rRNA (guanine-N(7))-methyltransferase × 1 （O43709） RRP12-like protein × 1 （Q5JTH9） Ribosome biogenesis protein SLX9 homolog × 1 （Q9NSI2） U3 small nucleolar RNA-associated protein 14 homolog A × 1 （Q9BVJ6） Probable dimethyladenosine transferase × 1 （Q9UNQ2）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS7_HUMAN
Isoform	—
PDB entities	6
Chains and sequence ranges	Author chain H； PDBConstruct 1–194； UniProt 1–194

40S ribosomal protein S6

OrganismNot specified

UniProt P62753

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 22 RNA 1	18S rRNA × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S3a × 1 （P61247） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S30 × 1 （P62861） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S24 × 1 （P62847） RNA-binding protein PNO1 × 1 （Q9NRX1） 40S ribosomal protein S23 × 1 （P62266） 40S ribosomal protein S15a × 1 （P62244） Pre-rRNA-processing protein TSR1 homolog × 1 （Q2NL82） 40S ribosomal protein S14 × 1 （P62263） 40S ribosomal protein S13 × 1 （P62277） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S8 × 1 （P62241） Multifunctional methyltransferase subunit TRM112-like protein × 1 （Q9UI30） Probable 18S rRNA (guanine-N(7))-methyltransferase × 1 （O43709） RRP12-like protein × 1 （Q5JTH9） Ribosome biogenesis protein SLX9 homolog × 1 （Q9NSI2） U3 small nucleolar RNA-associated protein 14 homolog A × 1 （Q9BVJ6） Probable dimethyladenosine transferase × 1 （Q9UNQ2）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS6_HUMAN
Isoform	—
PDB entities	7
Chains and sequence ranges	Author chain G； PDBConstruct 1–249； UniProt 1–249

40S ribosomal protein S24

OrganismNot specified

UniProt P62847

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 22 RNA 1	18S rRNA × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S3a × 1 （P61247） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S30 × 1 （P62861） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S6 × 1 （P62753） RNA-binding protein PNO1 × 1 （Q9NRX1） 40S ribosomal protein S23 × 1 （P62266） 40S ribosomal protein S15a × 1 （P62244） Pre-rRNA-processing protein TSR1 homolog × 1 （Q2NL82） 40S ribosomal protein S14 × 1 （P62263） 40S ribosomal protein S13 × 1 （P62277） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S8 × 1 （P62241） Multifunctional methyltransferase subunit TRM112-like protein × 1 （Q9UI30） Probable 18S rRNA (guanine-N(7))-methyltransferase × 1 （O43709） RRP12-like protein × 1 （Q5JTH9） Ribosome biogenesis protein SLX9 homolog × 1 （Q9NSI2） U3 small nucleolar RNA-associated protein 14 homolog A × 1 （Q9BVJ6） Probable dimethyladenosine transferase × 1 （Q9UNQ2）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS24_HUMAN
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain Y； PDBConstruct 1–133； UniProt 1–133

RNA-binding protein PNO1

OrganismNot specified

UniProt Q9NRX1

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 22 RNA 1	18S rRNA × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S3a × 1 （P61247） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S30 × 1 （P62861） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S24 × 1 （P62847） 40S ribosomal protein S23 × 1 （P62266） 40S ribosomal protein S15a × 1 （P62244） Pre-rRNA-processing protein TSR1 homolog × 1 （Q2NL82） 40S ribosomal protein S14 × 1 （P62263） 40S ribosomal protein S13 × 1 （P62277） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S8 × 1 （P62241） Multifunctional methyltransferase subunit TRM112-like protein × 1 （Q9UI30） Probable 18S rRNA (guanine-N(7))-methyltransferase × 1 （O43709） RRP12-like protein × 1 （Q5JTH9） Ribosome biogenesis protein SLX9 homolog × 1 （Q9NSI2） U3 small nucleolar RNA-associated protein 14 homolog A × 1 （Q9BVJ6） Probable dimethyladenosine transferase × 1 （Q9UNQ2）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PNO1_HUMAN
Isoform	—
PDB entities	9
Chains and sequence ranges	Author chain x； PDBConstruct 1–252； UniProt 1–252

40S ribosomal protein S23

OrganismNot specified

UniProt P62266

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 22 RNA 1	18S rRNA × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S3a × 1 （P61247） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S30 × 1 （P62861） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S24 × 1 （P62847） RNA-binding protein PNO1 × 1 （Q9NRX1） 40S ribosomal protein S15a × 1 （P62244） Pre-rRNA-processing protein TSR1 homolog × 1 （Q2NL82） 40S ribosomal protein S14 × 1 （P62263） 40S ribosomal protein S13 × 1 （P62277） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S8 × 1 （P62241） Multifunctional methyltransferase subunit TRM112-like protein × 1 （Q9UI30） Probable 18S rRNA (guanine-N(7))-methyltransferase × 1 （O43709） RRP12-like protein × 1 （Q5JTH9） Ribosome biogenesis protein SLX9 homolog × 1 （Q9NSI2） U3 small nucleolar RNA-associated protein 14 homolog A × 1 （Q9BVJ6） Probable dimethyladenosine transferase × 1 （Q9UNQ2）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS23_HUMAN
Isoform	—
PDB entities	10
Chains and sequence ranges	Author chain X； PDBConstruct 1–143； UniProt 1–143

40S ribosomal protein S15a

OrganismNot specified

UniProt P62244

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 22 RNA 1	18S rRNA × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S3a × 1 （P61247） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S30 × 1 （P62861） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S24 × 1 （P62847） RNA-binding protein PNO1 × 1 （Q9NRX1） 40S ribosomal protein S23 × 1 （P62266） Pre-rRNA-processing protein TSR1 homolog × 1 （Q2NL82） 40S ribosomal protein S14 × 1 （P62263） 40S ribosomal protein S13 × 1 （P62277） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S8 × 1 （P62241） Multifunctional methyltransferase subunit TRM112-like protein × 1 （Q9UI30） Probable 18S rRNA (guanine-N(7))-methyltransferase × 1 （O43709） RRP12-like protein × 1 （Q5JTH9） Ribosome biogenesis protein SLX9 homolog × 1 （Q9NSI2） U3 small nucleolar RNA-associated protein 14 homolog A × 1 （Q9BVJ6） Probable dimethyladenosine transferase × 1 （Q9UNQ2）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS15A_HUMAN
Isoform	—
PDB entities	11
Chains and sequence ranges	Author chain W； PDBConstruct 1–130； UniProt 1–130

Pre-rRNA-processing protein TSR1 homolog

OrganismNot specified

UniProt Q2NL82

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 22 RNA 1	18S rRNA × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S3a × 1 （P61247） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S30 × 1 （P62861） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S24 × 1 （P62847） RNA-binding protein PNO1 × 1 （Q9NRX1） 40S ribosomal protein S23 × 1 （P62266） 40S ribosomal protein S15a × 1 （P62244） 40S ribosomal protein S14 × 1 （P62263） 40S ribosomal protein S13 × 1 （P62277） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S8 × 1 （P62241） Multifunctional methyltransferase subunit TRM112-like protein × 1 （Q9UI30） Probable 18S rRNA (guanine-N(7))-methyltransferase × 1 （O43709） RRP12-like protein × 1 （Q5JTH9） Ribosome biogenesis protein SLX9 homolog × 1 （Q9NSI2） U3 small nucleolar RNA-associated protein 14 homolog A × 1 （Q9BVJ6） Probable dimethyladenosine transferase × 1 （Q9UNQ2）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TSR1_HUMAN
Isoform	—
PDB entities	12
Chains and sequence ranges	Author chain u； PDBConstruct 1–804； UniProt 1–804

40S ribosomal protein S14

OrganismNot specified

UniProt P62263

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 22 RNA 1	18S rRNA × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S3a × 1 （P61247） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S30 × 1 （P62861） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S24 × 1 （P62847） RNA-binding protein PNO1 × 1 （Q9NRX1） 40S ribosomal protein S23 × 1 （P62266） 40S ribosomal protein S15a × 1 （P62244） Pre-rRNA-processing protein TSR1 homolog × 1 （Q2NL82） 40S ribosomal protein S13 × 1 （P62277） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S8 × 1 （P62241） Multifunctional methyltransferase subunit TRM112-like protein × 1 （Q9UI30） Probable 18S rRNA (guanine-N(7))-methyltransferase × 1 （O43709） RRP12-like protein × 1 （Q5JTH9） Ribosome biogenesis protein SLX9 homolog × 1 （Q9NSI2） U3 small nucleolar RNA-associated protein 14 homolog A × 1 （Q9BVJ6） Probable dimethyladenosine transferase × 1 （Q9UNQ2）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS14_HUMAN
Isoform	—
PDB entities	13
Chains and sequence ranges	Author chain O； PDBConstruct 1–151； UniProt 1–151

40S ribosomal protein S13

OrganismNot specified

UniProt P62277

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 22 RNA 1	18S rRNA × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S3a × 1 （P61247） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S30 × 1 （P62861） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S24 × 1 （P62847） RNA-binding protein PNO1 × 1 （Q9NRX1） 40S ribosomal protein S23 × 1 （P62266） 40S ribosomal protein S15a × 1 （P62244） Pre-rRNA-processing protein TSR1 homolog × 1 （Q2NL82） 40S ribosomal protein S14 × 1 （P62263） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S8 × 1 （P62241） Multifunctional methyltransferase subunit TRM112-like protein × 1 （Q9UI30） Probable 18S rRNA (guanine-N(7))-methyltransferase × 1 （O43709） RRP12-like protein × 1 （Q5JTH9） Ribosome biogenesis protein SLX9 homolog × 1 （Q9NSI2） U3 small nucleolar RNA-associated protein 14 homolog A × 1 （Q9BVJ6） Probable dimethyladenosine transferase × 1 （Q9UNQ2）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS13_HUMAN
Isoform	—
PDB entities	14
Chains and sequence ranges	Author chain N； PDBConstruct 1–151； UniProt 1–151

40S ribosomal protein S11

OrganismNot specified

UniProt P62280

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 22 RNA 1	18S rRNA × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S3a × 1 （P61247） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S30 × 1 （P62861） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S24 × 1 （P62847） RNA-binding protein PNO1 × 1 （Q9NRX1） 40S ribosomal protein S23 × 1 （P62266） 40S ribosomal protein S15a × 1 （P62244） Pre-rRNA-processing protein TSR1 homolog × 1 （Q2NL82） 40S ribosomal protein S14 × 1 （P62263） 40S ribosomal protein S13 × 1 （P62277） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S8 × 1 （P62241） Multifunctional methyltransferase subunit TRM112-like protein × 1 （Q9UI30） Probable 18S rRNA (guanine-N(7))-methyltransferase × 1 （O43709） RRP12-like protein × 1 （Q5JTH9） Ribosome biogenesis protein SLX9 homolog × 1 （Q9NSI2） U3 small nucleolar RNA-associated protein 14 homolog A × 1 （Q9BVJ6） Probable dimethyladenosine transferase × 1 （Q9UNQ2）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS11_HUMAN
Isoform	—
PDB entities	15
Chains and sequence ranges	Author chain L； PDBConstruct 1–158； UniProt 1–158

40S ribosomal protein S9

OrganismNot specified

UniProt P46781

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 22 RNA 1	18S rRNA × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S3a × 1 （P61247） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S30 × 1 （P62861） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S24 × 1 （P62847） RNA-binding protein PNO1 × 1 （Q9NRX1） 40S ribosomal protein S23 × 1 （P62266） 40S ribosomal protein S15a × 1 （P62244） Pre-rRNA-processing protein TSR1 homolog × 1 （Q2NL82） 40S ribosomal protein S14 × 1 （P62263） 40S ribosomal protein S13 × 1 （P62277） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S8 × 1 （P62241） Multifunctional methyltransferase subunit TRM112-like protein × 1 （Q9UI30） Probable 18S rRNA (guanine-N(7))-methyltransferase × 1 （O43709） RRP12-like protein × 1 （Q5JTH9） Ribosome biogenesis protein SLX9 homolog × 1 （Q9NSI2） U3 small nucleolar RNA-associated protein 14 homolog A × 1 （Q9BVJ6） Probable dimethyladenosine transferase × 1 （Q9UNQ2）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS9_HUMAN
Isoform	—
PDB entities	16
Chains and sequence ranges	Author chain J； PDBConstruct 1–194； UniProt 1–194

40S ribosomal protein S8

OrganismNot specified

UniProt P62241

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 22 RNA 1	18S rRNA × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S3a × 1 （P61247） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S30 × 1 （P62861） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S24 × 1 （P62847） RNA-binding protein PNO1 × 1 （Q9NRX1） 40S ribosomal protein S23 × 1 （P62266） 40S ribosomal protein S15a × 1 （P62244） Pre-rRNA-processing protein TSR1 homolog × 1 （Q2NL82） 40S ribosomal protein S14 × 1 （P62263） 40S ribosomal protein S13 × 1 （P62277） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S9 × 1 （P46781） Multifunctional methyltransferase subunit TRM112-like protein × 1 （Q9UI30） Probable 18S rRNA (guanine-N(7))-methyltransferase × 1 （O43709） RRP12-like protein × 1 （Q5JTH9） Ribosome biogenesis protein SLX9 homolog × 1 （Q9NSI2） U3 small nucleolar RNA-associated protein 14 homolog A × 1 （Q9BVJ6） Probable dimethyladenosine transferase × 1 （Q9UNQ2）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RS8_HUMAN
Isoform	—
PDB entities	17
Chains and sequence ranges	Author chain I； PDBConstruct 1–208； UniProt 1–208

Multifunctional methyltransferase subunit TRM112-like protein

OrganismNot specified

UniProt Q9UI30

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 22 RNA 1	18S rRNA × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S3a × 1 （P61247） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S30 × 1 （P62861） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S24 × 1 （P62847） RNA-binding protein PNO1 × 1 （Q9NRX1） 40S ribosomal protein S23 × 1 （P62266） 40S ribosomal protein S15a × 1 （P62244） Pre-rRNA-processing protein TSR1 homolog × 1 （Q2NL82） 40S ribosomal protein S14 × 1 （P62263） 40S ribosomal protein S13 × 1 （P62277） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S8 × 1 （P62241） Probable 18S rRNA (guanine-N(7))-methyltransferase × 1 （O43709） RRP12-like protein × 1 （Q5JTH9） Ribosome biogenesis protein SLX9 homolog × 1 （Q9NSI2） U3 small nucleolar RNA-associated protein 14 homolog A × 1 （Q9BVJ6） Probable dimethyladenosine transferase × 1 （Q9UNQ2）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TR112_HUMAN
Isoform	—
PDB entities	18
Chains and sequence ranges	Author chain r； PDBConstruct 1–125； UniProt 1–125

Probable 18S rRNA (guanine-N(7))-methyltransferase

OrganismNot specified

UniProt O43709

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 22 RNA 1	18S rRNA × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S3a × 1 （P61247） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S30 × 1 （P62861） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S24 × 1 （P62847） RNA-binding protein PNO1 × 1 （Q9NRX1） 40S ribosomal protein S23 × 1 （P62266） 40S ribosomal protein S15a × 1 （P62244） Pre-rRNA-processing protein TSR1 homolog × 1 （Q2NL82） 40S ribosomal protein S14 × 1 （P62263） 40S ribosomal protein S13 × 1 （P62277） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S8 × 1 （P62241） Multifunctional methyltransferase subunit TRM112-like protein × 1 （Q9UI30） RRP12-like protein × 1 （Q5JTH9） Ribosome biogenesis protein SLX9 homolog × 1 （Q9NSI2） U3 small nucleolar RNA-associated protein 14 homolog A × 1 （Q9BVJ6） Probable dimethyladenosine transferase × 1 （Q9UNQ2）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	BUD23_HUMAN
Isoform	—
PDB entities	19
Chains and sequence ranges	Author chain q； PDBConstruct 1–281； UniProt 1–281

RRP12-like protein

OrganismNot specified

UniProt Q5JTH9

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 22 RNA 1	18S rRNA × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S3a × 1 （P61247） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S30 × 1 （P62861） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S24 × 1 （P62847） RNA-binding protein PNO1 × 1 （Q9NRX1） 40S ribosomal protein S23 × 1 （P62266） 40S ribosomal protein S15a × 1 （P62244） Pre-rRNA-processing protein TSR1 homolog × 1 （Q2NL82） 40S ribosomal protein S14 × 1 （P62263） 40S ribosomal protein S13 × 1 （P62277） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S8 × 1 （P62241） Multifunctional methyltransferase subunit TRM112-like protein × 1 （Q9UI30） Probable 18S rRNA (guanine-N(7))-methyltransferase × 1 （O43709） Ribosome biogenesis protein SLX9 homolog × 1 （Q9NSI2） U3 small nucleolar RNA-associated protein 14 homolog A × 1 （Q9BVJ6） Probable dimethyladenosine transferase × 1 （Q9UNQ2）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RRP12_HUMAN
Isoform	—
PDB entities	20
Chains and sequence ranges	Author chain K； PDBConstruct 1–1297； UniProt 1–1297

Ribosome biogenesis protein SLX9 homolog

OrganismNot specified

UniProt Q9NSI2

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 22 RNA 1	18S rRNA × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S3a × 1 （P61247） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S30 × 1 （P62861） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S24 × 1 （P62847） RNA-binding protein PNO1 × 1 （Q9NRX1） 40S ribosomal protein S23 × 1 （P62266） 40S ribosomal protein S15a × 1 （P62244） Pre-rRNA-processing protein TSR1 homolog × 1 （Q2NL82） 40S ribosomal protein S14 × 1 （P62263） 40S ribosomal protein S13 × 1 （P62277） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S8 × 1 （P62241） Multifunctional methyltransferase subunit TRM112-like protein × 1 （Q9UI30） Probable 18S rRNA (guanine-N(7))-methyltransferase × 1 （O43709） RRP12-like protein × 1 （Q5JTH9） U3 small nucleolar RNA-associated protein 14 homolog A × 1 （Q9BVJ6） Probable dimethyladenosine transferase × 1 （Q9UNQ2）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	SLX9_HUMAN
Isoform	—
PDB entities	21
Chains and sequence ranges	Author chain z； PDBConstruct 1–230； UniProt 1–230

U3 small nucleolar RNA-associated protein 14 homolog A

OrganismNot specified

UniProt Q9BVJ6

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 22 RNA 1	18S rRNA × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S3a × 1 （P61247） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S30 × 1 （P62861） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S24 × 1 （P62847） RNA-binding protein PNO1 × 1 （Q9NRX1） 40S ribosomal protein S23 × 1 （P62266） 40S ribosomal protein S15a × 1 （P62244） Pre-rRNA-processing protein TSR1 homolog × 1 （Q2NL82） 40S ribosomal protein S14 × 1 （P62263） 40S ribosomal protein S13 × 1 （P62277） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S8 × 1 （P62241） Multifunctional methyltransferase subunit TRM112-like protein × 1 （Q9UI30） Probable 18S rRNA (guanine-N(7))-methyltransferase × 1 （O43709） RRP12-like protein × 1 （Q5JTH9） Ribosome biogenesis protein SLX9 homolog × 1 （Q9NSI2） Probable dimethyladenosine transferase × 1 （Q9UNQ2）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	UT14A_HUMAN
Isoform	—
PDB entities	22
Chains and sequence ranges	Author chain 5； PDBConstruct 1–771； UniProt 1–771

Probable dimethyladenosine transferase

OrganismNot specified

UniProt Q9UNQ2

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–RNA	Heteromer	Protein 22 RNA 1	18S rRNA × 1 40S ribosomal protein S27 × 1 （P42677） 40S ribosomal protein S3a × 1 （P61247） 40S ribosomal protein S4, X isoform × 1 （P62701） 40S ribosomal protein S30 × 1 （P62861） 40S ribosomal protein S7 × 1 （P62081） 40S ribosomal protein S6 × 1 （P62753） 40S ribosomal protein S24 × 1 （P62847） RNA-binding protein PNO1 × 1 （Q9NRX1） 40S ribosomal protein S23 × 1 （P62266） 40S ribosomal protein S15a × 1 （P62244） Pre-rRNA-processing protein TSR1 homolog × 1 （Q2NL82） 40S ribosomal protein S14 × 1 （P62263） 40S ribosomal protein S13 × 1 （P62277） 40S ribosomal protein S11 × 1 （P62280） 40S ribosomal protein S9 × 1 （P46781） 40S ribosomal protein S8 × 1 （P62241） Multifunctional methyltransferase subunit TRM112-like protein × 1 （Q9UI30） Probable 18S rRNA (guanine-N(7))-methyltransferase × 1 （O43709） RRP12-like protein × 1 （Q5JTH9） Ribosome biogenesis protein SLX9 homolog × 1 （Q9NSI2） U3 small nucleolar RNA-associated protein 14 homolog A × 1 （Q9BVJ6）	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	DIM1_HUMAN
Isoform	—
PDB entities	23
Chains and sequence ranges	Author chain 3； PDBConstruct 1–313； UniProt 1–313

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	7wts
Deposition date deposition_date	2022-02-05
Structure title title	Cryo-EM structure of a human pre-40S ribosomal subunit - State UTP14
Keywords keywords	ribosome biogenesis, 40S ribosome, RIBOSOME; RIBOSOME
Experimental Method method	ELECTRON MICROSCOPY

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

7wts__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

7wts__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

7wts__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	72.40 Å
Rg (electron density)	71.91 Å
Total Rg	72.07 Å
Atom count	61945
Residues	5258
Excluded volume	992470 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`7wts__assembly_1__model_1`	23-meric （23）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (23)

Entity 1 Entity 1 polymer

Description description	18S rRNA
Molecular weight formula_weight	604102.8 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polyribonucleotide
Chain IDs strand_id	2
Atom count atom_count	61945

UACCUGGUUGAUCCUGCCAGUAGCAUAUGCUUGUCUCAAAGAUUAAGCCAUGCAUGUCUAAGUACGCACGGCCGGUACAGUGAAACUGCGAAUGGCUCAUUAAAUCAGUUAUGGUUCCUUUGGUCGCUCGCUCCUCUCCUACUUGGAUAACUGUGGUAAUUCUAGAGCUAAUACAUGCCGACGGGCGCUGACCCCCUUCGCGGGGGGGAUGCGUGCAUUUAUCAGAUCAAAACCAACCCGGUCAGCCCCUCUCCGGCCCCGGCCGGGGGGCGGGCGCCGGCGGCUUUGGUGACUCUAGAUAACCUCGGGCCGAUCGCACGCCCCCCGUGGCGGCGACGACCCAUUCGAACGUCUGCCCUAUCAACUUUCGAUGGUAGUCGCCGUGCCUACCAUGGUGACCACGGGUGACGGGGAAUCAGGGUUCGAUUCCGGAGAGGGAGCCUGAGAAACGGCUACCACAUCCAAGGAAGGCAGCAGGCGCGCAAAUUACCCACUCCCGACCCGGGGAGGUAGUGACGAAAAAUAACAAUACAGGACUCUUUCGAGGCCCUGUAAUUGGAAUGAGUCCACUUUAAAUCCUUUAACGAGGAUCCAUUGGAGGGCAAGUCUGGUGCCAGCAGCCGCGGUAAUUCCAGCUCCAAUAGCGUAUAUUAAAGUUGCUGCAGUUAAAAAGCUCGUAGUUGGAUCUUGGGAGCGGGCGGGCGGUCCGCCGCGAGGCGAGCCACCGCCCGUCCCCGCCCCUUGCCUCUCGGCGCCCCCUCGAUGCUCUUAGCUGAGUGUCCCGCGGGGCCCGAAGCGUUUACUUUGAAAAAAUUAGAGUGUUCAAAGCAGGCCCGAGCCGCCUGGAUACCGCAGCUAGGAAUAAUGGAAUAGGACCGCGGUUCUAUUUUGUUGGUUUUCGGAACUGAGGCCAUGAUUAAGAGGGACGGCCGGGGGCAUUCGUAUUGCGCCGCUAGAGGUGAAAUUCUUGGACCGGCGCAAGACGGACCAGAGCGAAAGCAUUUGCCAAGAAUGUUUUCAUUAAUCAAGAACGAAAGUCGGAGGUUCGAAGACGAUCAGAUACCGUCGUAGUUCCGACCAUAAACGAUGCCGACCGGCGAUGCGGCGGCGUUAUUCCCAUGACCCGCCGGGCAGCUUCCGGGAAACCAAAGUCUUUGGGUUCCGGGGGGAGUAUGGUUGCAAAGCUGAAACUUAAAGGAAUUGACGGAAGGGCACCACCAGGAGUGGAGCCUGCGGCUUAAUUUGACUCAACACGGGAAACCUCACCCGGCCCGGACACGGACAGGAUUGACAGAUUGAUAGCUCUUUCUCGAUUCCGUGGGUGGUGGUGCAUGGCCGUUCUUAGUUGGUGGAGCGAUUUGUCUGGUUAAUUCCGAUAACGAACGAGACUCUGGCAUGCUAACUAGUUACGCGACCCCCGAGCGGUCGGCGUCCCCCAACUUCUUAGAGGGACAAGUGGCGUUCAGCCACCCGAGAUUGAGCAAUAACAGGUCUGUGAUGCCCUUAGAUGUCCGGGGCUGCACGCGCGCUACACUGACUGGCUCAGCGUGUGCCUACCCUACGCCGGCAGGCGCGGGUAACCCGUUGAACCCCAUUCGUGAUGGGGAUCGGGGAUUGCAAUUAUUCCCCAUGAACGAGGAAUUCCCAGUAAGUGCGGGUCAUAAGCUUGCGUUGAUUAAGUCCCUGCCCUUUGUACACACCGCCCGUCGCUACUACCGAUUGGAUGGUUUAGUGAGGCCCUCGGAUCGGCCCCGCCGGGGUCGGCCCACGGCCCUGGCGGAGCGCUGAGAAGACGGUCGAACUUGACUAUCUAGAGGAAGUAAAAGUCGUAACAAGGUUUCCGUAGGUGAACCUGCGGAAGGAUCAUUAACGG

Entity 2 Entity 2 polymer

Description description	40S ribosomal protein S27
Molecular weight formula_weight	9480.2 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	b

MPLAKDLLHPSPEEEKRKHKKKRLVQSPNSYFMDVKCPGCYKITTVFSHAQTVVLCVGCSTVLCQPTGGKARLTEGCSFRRKQH

Entity 3 Entity 3 polymer

Description description	40S ribosomal protein S3a
Molecular weight formula_weight	30002.1 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B

MAVGKNKRLTKGGKKGAKKKVVDPFSKKDWYDVKAPAMFNIRNIGKTLVTRTQGTKIASDGLKGRVFEVSLADLQNDEVAFRKFKLITEDVQGKNCLTNFHGMDLTRDKMCSMVKKWQTMIEAHVDVKTTDGYLLRLFCVGFTKKRNNQIRKTSYAQHQQVRQIRKKMMEIMTREVQTNDLKEVVNKLIPDSIGKDIEKACQSIYPLHDVFVRKVKMLKKPKFELGKLMELHGEGSSSGKATGDETGAKVERADGYEPPVQESV

Entity 4 Entity 4 polymer

Description description	40S ribosomal protein S4, X isoform
Molecular weight formula_weight	29654.9 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	E

MARGPKKHLKRVAAPKHWMLDKLTGVFAPRPSTGPHKLRECLPLIIFLRNRLKYALTGDEVKKICMQRFIKIDGKVRTDITYPAGFMDVISIDKTGENFRLIYDTKGRFAVHRITPEEAKYKLCKVRKIFVGTKGIPHLVTHDARTIRYPDPLIKVNDTIQIDLETGKITDFIKFDTGNLCMVTGGANLGRIGVITNRERHPGSFDVVHVKDANGNSFATRLSNIFVIGKGNKPWISLPRGKGIRLTIAEERDKRLAAKQSSG

Entity 5 Entity 5 polymer

Description description	40S ribosomal protein S30
Molecular weight formula_weight	6668.9 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	e

KVHGSLARAGKVRGQTPKVAKQEKKKKKTGRAKRRMQYNRRFVNVVPTFGKKKGPNANS

Entity 6 Entity 6 polymer

Description description	40S ribosomal protein S7
Molecular weight formula_weight	22168.9 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	H

MFSSSAKIVKPNGEKPDEFESGISQALLELEMNSDLKAQLRELNITAAKEIEVGGGRKAIIIFVPVPQLKSFQKIQVRLVRELEKKFSGKHVVFIAQRRILPKPTRKSRTKNKQKRPRSRTLTAVHDAILEDLVFPSEIVGKRIRVKLDGSRLIKVHLDKAQQNNVEHKVETFSGVYKKLTGKDVNFEFPEFQL

Entity 7 Entity 7 polymer

Description description	40S ribosomal protein S6
Molecular weight formula_weight	28751.9 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	G

MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGKKPRTKAPKIQRLVTPRVLQHKRRRIALKKQRTKKNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSLRASTSKSESSQK

Entity 8 Entity 8 polymer

Description description	40S ribosomal protein S24
Molecular weight formula_weight	15463.3 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Y

MNDTVTIRTRKFMTNRLLQRKQMVIDVLHPGKATVPKTEIREKLAKMYKTTPDVIFVFGFRTHFGGGKTTGFGMIYDSLDYAKKNEPKHRLARHGLYEKKKTSRKQRKERKNRMKKVRGTAKANVGAGKKPKE

Entity 9 Entity 9 polymer

Description description	RNA-binding protein PNO1
Molecular weight formula_weight	27970.4 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	x

MESEMETQSARAEEGFTQVTRKGGRRAKKRQAEQLSAAGEGGDAGRMDTEEARPAKRPVFPPLCGDGLLSGKEETRKIPVPANRYTPLKENWMKIFTPIVEHLGLQIRFNLKSRNVEIRTCKETKDVSALTKAADFVKAFILGFQVEDALALIRLDDLFLESFEITDVKPLKGDHLSRAIGRIAGKGGKTKFTIENVTRTRIVLADVKVHILGSFQNIKMARTAICNLILGNPPSKVYGNIRAVASRSADRF

Entity 10 Entity 10 polymer

Description description	40S ribosomal protein S23
Molecular weight formula_weight	15844.7 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	X

MGKCRGLRTARKLRSHRRDQKWHDKQYKKAHLGTALKANPFGGASHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPNDGCLNFIEENDEVLVAGFGRKGHAVGDIPGVRFKVVKVANVSLLALYKGKKERPRS

Entity 11 Entity 11 polymer

Description description	40S ribosomal protein S15a
Molecular weight formula_weight	14865.6 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	W

MVRMNVLADALKSINNAEKRGKRQVLIRPCSKVIVRFLTVMMKHGYIGEFEIIDDHRAGKIVVNLTGRLNKCGVISPRFDVQLKDLEKWQNNLLPSRQFGFIVLTTSAGIMDHEEARRKHTGGKILGFFF

Entity 12 Entity 12 polymer

Description description	Pre-rRNA-processing protein TSR1 homolog
Molecular weight formula_weight	91951.2 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	u

MAAHRPGPLKQQNKAHKGGRHRGRGSAQRDGKGRLALKTLSKKVRKELSRVDQRHRASQLRKQKKEAVLAEKRQLGGKDGPPHQVLVVPLHSRISLPEAMQLLQDRDTGTVHLNELGNTQNFMLLCPRLKHRWFFTSARPGDLHVVLDMAKVADTILFLLDPLEGWDSTGDYCLSCLFAQGLPTYTLAVQGISGLPLKKQIDTRKKLSKAVEKRFPHDKLLLLDTQQEAGMLLRQLANQKQQHLAFRDRRAYLFAHAVDFVPSEENNLVGTLKISGYVRGQTLNVNRLLHIVGYGDFQMKQIDAPGDPFPLNPRGIKPQKDPDMAMEICATDAVDDMEEGLKVLMKADPGRQESLQAEVIPDPMEGEQTWPTEEELSEAKDFLKESSKVVKKVPKGTSSYQAEWILDGGSQSGGEGDEYEYDDMEHEDFMEEESQDESSEEEEEYETMTIGESVHDDLYDKKVDEEAEAKMLEKYKQERLEEMFPDEVDTPRDVAARIRFQKYRGLKSFRTSPWDPKENLPQDYARIFQFQNFTNTRKSIFKEVEEKEVEGAEVGWYVTLHVSEVPVSVVECFRQGTPLIAFSLLPHEQKMSVLNMVVRRDPGNTEPVKAKEELIFHCGFRRFRASPLFSQHTAADKHKLQRFLTADMALVATVYAPITFPPASVLLFKQKSNGMHSLIATGHLMSVDPDRMVIKRVVLSGHPFKIFTKMAVVRYMFFNREDVLWFKPVELRTKWGRRGHIKEPLGTHGHMKCSFDGKLKSQDTVLMNLYKRVFPKWTYDPYVPEPVPWLKSEISSTVPQGGME

Entity 13 Entity 13 polymer

Description description	40S ribosomal protein S14
Molecular weight formula_weight	16302.8 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	O

MAPRKGKEKKEEQVISLGPQVAEGENVFGVCHIFASFNDTFVHVTDLSGKETICRVTGGMKVKADRDESSPYAAMLAAQDVAQRCKELGITALHIKLRATGGNRTKTPGPGAQSALRALARSGMKIGRIEDVTPIPSDSTRRKGGRRGRRL

Entity 14 Entity 14 polymer

Description description	40S ribosomal protein S13
Molecular weight formula_weight	17259.4 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	N

MGRMHAPGKGLSQSALPYRRSVPTWLKLTSDDVKEQIYKLAKKGLTPSQIGVILRDSHGVAQVRFVTGNKILRILKSKGLAPDLPEDLYHLIKKAVAVRKHLERNRKDKDAKFRLILIESRIHRLARYYKTKRVLPPNWKYESSTASALVA

Entity 15 Entity 15 polymer

Description description	40S ribosomal protein S11
Molecular weight formula_weight	18468.8 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	L

MADIQTERAYQKQPTIFQNKKRVLLGETGKEKLPRYYKNIGLGFKTPKEAIEGTYIDKKCPFTGNVSIRGRILSGVVTKMKMQRTIVIRRDYLHYIRKYNRFEKRHKNMSVHLSPCFRDVQIGDIVTVGECRPLSKTVRFNVLKVTKAAGTKKQFQKF

Entity 16 Entity 16 polymer

Description description	40S ribosomal protein S9
Molecular weight formula_weight	22641.6 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	J

MPVARSWVCRKTYVTPRRPFEKSRLDQELKLIGEYGLRNKREVWRVKFTLAKIRKAARELLTLDEKDPRRLFEGNALLRRLVRIGVLDEGKMKLDYILGLKIEDFLERRLQTQVFKLGLAKSIHHARVLIRQRHIRVRKQVVNIPSFIVRLDSQKHIDFSLRSPYGGGRPGRVKRKNAKKGQGGAGAGDDEEED

Entity 17 Entity 17 polymer

Description description	40S ribosomal protein S8
Molecular weight formula_weight	24263.4 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	I

MGISRDNWHKRRKTGGKRKPYHKKRKYELGRPAANTKIGPRRIHTVRVRGGNKKYRALRLDVGNFSWGSECCTRKTRIIDVVYNASNNELVRTKTLVKNCIVLIDSTPYRQWYESHYALPLGRKKGAKLTPEEEEILNKKRSKKIQKKYDERKKNAKISSLLEEQFQQGKLLACIASRPGQCGRADGYVLEGKELEFYLRKIKARKGK

Entity 18 Entity 18 polymer

Description description	Multifunctional methyltransferase subunit TRM112-like protein
Molecular weight formula_weight	14215.4 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	r

MKLLTHNLLSSHVRGVGSRGFPLRLQATEVRICPVEFNPNFVARMIPKVEWSAFLEAADNLRLIQVPKGPVEGYEENEEFLRTMHHLLLEVEVIEGTLQCPESGRMFPISRGIPNMLLSEEETES

Entity 19 Entity 19 polymer

Description description	Probable 18S rRNA (guanine-N(7))-methyltransferase
Molecular weight formula_weight	31925.4 kDa
EC 编号 ec_number	2.1.1.-
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	q

MASRGRRPEHGGPPELFYDETEARKYVRNSRMIDIQTRMAGRALELLYLPENKPCYLLDIGCGTGLSGSYLSDEGHYWVGLDISPAMLDEAVDREIEGDLLLGDMGQGIPFKPGTFDGCISISAVQWLCNANKKSENPAKRLYCFFASLFSVLVRGSRAVLQLYPENSEQLELITTQATKAGFSGGMVVDYPNSAKAKKFYLCLFSGPSTFIPEGLSENQDEVEPRESVFTNERFPLRMSRRGMVRKSRAWVLEKKERHRRQGREVRPDTQYTGRKRKPRF

Entity 20 Entity 20 polymer

Description description	RRP12-like protein
Molecular weight formula_weight	143916.5 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	K

MGRSGKLPSGVSAKLKRWKKGHSSDSNPAICRHRQAARSRFFSRPSGRSDLTVDAVKLHNELQSGSLRLGKSEAPETPMEEEAELVLTEKSSGTFLSGLSDCTNVTFSKVQRFWESNSAAHKEICAVLAAVTEVIRSQGGKETETEYFAALMTTMEAVESPESLAAVAYLLNLVLKRVPSPVLIKKFSDTSKAFMDIMSAQASSGSTSVLRWVLSCLATLLRKQDLEAWGYPVTLQVYHGLLSFTVHPKPKIRKAAQHGVCSVLKGSEFMFEKAPAHHPAAISTAKFCIQEIEKSGGSKEATTTLHMLTLLKDLLPCFPEGLVKSCSETLLRVMTLSHVLVTACAMQAFHSLFHARPGLSTLSAELNAQIITALYDYVPSENDLQPLLAWLKVMEKAHINLVRLQWDLGLGHLPRFFGTAVTCLLSPHSQVLTAATQSLKEILKECVAPHMADIGSVTSSASGPAQSVAKMFRAVEEGLTYKFHAAWSSVLQLLCVFFEACGRQAHPVMRKCLQSLCDLRLSPHFPHTAALDQAVGAAVTSMGPEVVLQAVPLEIDGSEETLDFPRSWLLPVIRDHVQETRLGFFTTYFLPLANTLKSKAMDLAQAGSTVESKIYDTLQWQMWTLLPGFCTRPTDVAISFKGLARTLGMAISERPDLRVTVCQALRTLITKGCQAEADRAEVSRFAKNFLPILFNLYGQPVAAGDTPAPRRAVLETIRTYLTITDTQLVNSLLEKASEKVLDPASSDFTRLSVLDLVVALAPCADEAAISKLYSTIRPYLESKAHGVQKKAYRVLEEVCASPQGPGALFVQSHLEDLKKTLLDSLRSTSSPAKRPRLKCLLHIVRKLSAEHKEFITALIPEVILCTKEVSVGARKNAFALLVEMGHAFLRFGSNQEEALQCYLVLIYPGLVGAVTMVSCSILALTHLLFEFKGLMGTSTVEQLLENVCLLLASRTRDVVKSALGFIKVAVTVMDVAHLAKHVQLVMEAIGKLSDDMRRHFRMKLRNLFTKFIRKFGFELVKRLLPEEYHRVLVNIRKAEARAKRHRALSQAAVEEEEEEEEEEEPAQGKGDSIEEILADSEDEEDNEEEERSRGKEQRKLARQRSRAWLKEGGGDEPLNFLDPKVAQRVLATQPGPGRGRKKDHGFKVSADGRLIIREEADGNKMEEEEGAKGEDEEMADPMEDVIIRNKKHQKLKHQKEAEEEELEIPPQYQAGGSGIHRPVAKKAMPGAEYKAKKAKGDVKKKGRPDPYAYIPLNRSKLNRRKKMKLQGQFKGLVKAARRGSQVGHKNRRKDRRP

Entity 21 Entity 21 polymer

Description description	Ribosome biogenesis protein SLX9 homolog
Molecular weight formula_weight	25503.3 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	z

MGKVRGLRARVHQAAVRPKGEAAPGPAPPAPEATPPPASAAGKDWAFINTNIFARTKIDPSALVQKLELDVRSVTSVRRGEAGSSARSVPSIRRGAEAKTVLPKKEKMKLRREQWLQKIEAIKLAEQKHREERRRRATVVVGDLHPLRDALPELLGLEAGSRRQARSRESNKPRPSELSRMSAAQRQQLLEEERTRFQELLASPAYRASPLVAIGQTLARQMQLEDGGQL

Entity 22 Entity 22 polymer

Description description	U3 small nucleolar RNA-associated protein 14 homolog A
Molecular weight formula_weight	88129.1 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	5

MTANRLAESLLALSQQEELADLPKDYLLSESEDEGDNDGERKHQKLLEAISSLDGKNRRKLAERSEASLKVSEFNVSSEGSGEKLVLADLLEPVKTSSSLATVKKQLSRVKSKKTVELPLNKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEHVLSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAKMRRAELQRARALQSYYEAKARREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNPAAALEELEKIEKARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLSKNKELTQKLQVASESEEEEGGTEDVEELLVPDVVNEVQMNADGPNPWMLRSCTSDTKEAATQEDPEQLPELEAHGVSESEGEERPVAEEEILLREFEERRSLRKRSELSQDAEPAGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQKASSEGTIPQVQREEPAPEEEEPLLLQRPERVQTLEELEELGKEECFQNKELPRPVLEGQQSERTPNNRPDAPKEKKKKEQMIDLQNLLTTQSPSVKSLAVPTIEELEDEEERNHRQMIKEAFAGDDVIRDFLKEKREAVEASKPKDVDLTLPGWGEWGGVGLKPSAKKRRRFLIKAPEGPPRKDKNLPNVIINEKRNIHAAAHQVRVLPYPFTHHWQFERTIQTPIGSTWNTQRAFQKLTTPKVVTKPGHIINPIKAEDVGYRSSSRSDLSVIQRNPKRITTRHKKQLKKCSVD

Entity 23 Entity 23 polymer

Description description	Probable dimethyladenosine transferase
Molecular weight formula_weight	35292.4 kDa
EC 编号 ec_number	2.1.1.183
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	3

MPKVKSGAIGRRRGRQEQRRELKSAGGLMFNTGIGQHILKNPLIINSIIDKAALRPTDVVLEVGPGTGNMTVKLLEKAKKVVACELDPRLVAELHKRVQGTPVASKLQVLVGDVLKTDLPFFDTCVANLPYQISSPFVFKLLLHRPFFRCAILMFQREFALRLVAKPGDKLYCRLSINTQLLARVDHLMKVGKNNFRPPPKVESSVVRIEPKNPPPPINFQEWDGLVRITFVRKNKTLSAAFKSSAVQQLLEKNYRIHCSVHNIIIPEDFSIADKIQQILTSTGFSDKRARSMDIDDFIRLLHGFNAEGIHFS

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6. Fold Classification (SCOP + CATH) 1 domains

CATH v4.4 (1 domains)

Domain ID domain_id	7wtsY01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	70 — Alpha-Beta Plaits
Homologous superfamily homologous superfamily	3370 —

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Unit-cell length a length_a	1.000 Å
Unit-cell length b length_b	1.000 Å
Unit-cell length c length_c	1.000 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	—

Space group space_group	P 1
Space-group number int_tables_number	1
Crystal system crystal_system	triclinic

Resolution resolution	3.20 Å
Resolution测定Method resolution_method	—
颗粒数 num_particles	8843

Cryo-EM structure of a human pre-40S ribosomal subunit - State UTP14

1. Protein Identity and Related Structures Protein Identity & Related Structures

40S ribosomal protein S27

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

40S ribosomal protein S3a

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

40S ribosomal protein S4, X isoform

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

40S ribosomal protein S30

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

40S ribosomal protein S7

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

40S ribosomal protein S6

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

40S ribosomal protein S24

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

RNA-binding protein PNO1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

40S ribosomal protein S23

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

40S ribosomal protein S15a

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer