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8ave

Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (2:2 model)

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Leptin

Homo sapiens

UniProt P41159

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 Leptin receptor × 2 （P48357） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1ax8 8k6z

2 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers
1ax8

1 assemblies

Heteromeric or nucleic-acid complex
7z3q 7z3q 7z3q 8ave 8avf 8avo 8x80 8x81 8x85 9puo 9puo

11 assemblies

View Construct and Data Evidence
UniProt name LEP_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 26–171； UniProt 22–167 Author chain C； PDBConstruct 26–171； UniProt 22–167

Leptin receptor

Homo sapiens

UniProt P48357

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 Leptin × 2 （P41159） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
3v6o 3v6o 6e2p 6e2p 7z3q 7z3q 7z3q 8ave 8avf 8avo 8x80 8x81

13 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name LEPR_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–818； UniProt 22–839 Author chain D； PDBConstruct 1–818； UniProt 22–839

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8ave
Deposition date deposition_date2022-08-26
Structure title titleHuman leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (2:2 model)
Keywords keywordsleptin, LEP-R, obesity, metabolism, energy balance, CYTOKINE; CYTOKINE
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8ave__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8ave__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8ave__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）54.21 Å
Rg (electron density)54.06 Å
Total Rg54.09 Å
Atom count11874
Residues1484
Excluded volume213120 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8ave__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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7. Citations (1)