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8cqy

Crystal structure of the PTPN3 PDZ domain bound to the PBM TACE C-terminal peptide

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Tyrosine-protein phosphatase non-receptor type 3

Homo sapiens

UniProt P26045

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Disintegrin and metalloproteinase domain-containing protein 17 × 1 （P78536） SODIUM ION × 2 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2b49 4qun 4qun 4ri4 4ri4 4ri5 4ri5

7 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
4qum 4rh5 4rh9 4rhg 4s0g 6hks 6hks 6hks 6hks 6hks 6hks 6t36

15 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name PTN3_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 6–114； UniProt 489–597

Disintegrin and metalloproteinase domain-containing protein 17

OrganismNot specified

UniProt P78536

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Tyrosine-protein phosphatase non-receptor type 3 × 1 （P26045） SODIUM ION × 2 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1bkc 1bkc 1bkc 1bkc 1zxc 1zxc 2a8h 2a8h 2ddf 2ddf 2fv5 2fv5

47 assemblies; showing the first 12

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
3cki 8cqy 8snl 8snm 8snn 8sno 9e6k 9o54 9o58 9q7y 9xy4

11 assemblies

View Construct and Data Evidence
UniProt name ADA17_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–12； UniProt 813–824

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8cqy
Deposition date deposition_date2023-03-07
Structure title titleCrystal structure of the PTPN3 PDZ domain bound to the PBM TACE C-terminal peptide
Keywords keywordsprotein tyrosine phosphatase PTPN3, PDZ domains, PDZ-binding motif, HYDROLASE; HYDROLASE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8cqy__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8cqy__assembly_1__model_1 | I(q)

10-2 10-1 105 106 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8cqy__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）14.19 Å
Rg (electron density)12.62 Å
Total Rg13.95 Å
Atom count786
Residues99
Excluded volume13996 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8cqy__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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7. Citations (1)