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8cx3

Crystal structure of full-length mesothelin

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Isoform 4 of Mesothelin

Homo sapiens

UniProt Q13421

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein monomer Monomer Protein 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 PHOSPHATE ION × 1 GLYCEROL × 1 Consistent with protein count
2 Protein monomer Monomer Protein 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 PHOSPHATE ION × 2 GLYCEROL × 1 Consistent with protein count
3 Protein monomer Monomer Protein 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 PHOSPHATE ION × 1 GLYCEROL × 1 Consistent with protein count
4 Other combination Monomer Protein 1 其他Polymer 1 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 PHOSPHATE ION × 1 GLYCEROL × 1 Consistent with protein count
5 Protein monomer Monomer Protein 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 PHOSPHATE ION × 3 Consistent with protein count
6 Other combination Monomer Protein 1 其他Polymer 1 beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 1 PHOSPHATE ION × 2 GLYCEROL × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
7u9j 7u9j 8cx3 8cx3 8cx3 8cx3

6 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
4f3f 7u8c 7ued 8cx3 8cx3 8cxc 8cyh 8cz8 8cz8 8fsl 8fsl 8vm1

17 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name MSLN_HUMAN
Isoform Q13421-4
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 2–306； UniProt 295–599 Author chain B； PDBConstruct 2–306； UniProt 295–599 Author chain C； PDBConstruct 2–306； UniProt 295–599 Author chain D； PDBConstruct 2–306； UniProt 295–599 Author chain E； PDBConstruct 2–306； UniProt 295–599 Author chain F； PDBConstruct 2–306； UniProt 295–599

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8cx3
Deposition date deposition_date2022-05-19
Structure title titleCrystal structure of full-length mesothelin
Keywords keywordsMesothelin, CELL ADHESION; CELL ADHESION
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8cx3__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8cx3__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8cx3__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）25.62 Å
Rg (electron density)25.72 Å
Total Rg26.30 Å
Atom count1967
Residues245
Excluded volume35371 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8cx3__assembly_1__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 8cx3__assembly_2__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 8cx3__assembly_3__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 8cx3__assembly_4__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
5 1 8cx3__assembly_5__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
6 1 8cx3__assembly_6__model_1 monomeric （1） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (6)

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7. Citations (1)